TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04 Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 13:41:03 31 WEEK SSAC FINAL #1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFBINARYMIX Lock Date: 03/27/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 04/14/99 - 04/15/99 Treatment Groups: Include 001 0 NG / 0 UG Include 004 300 NG /100 UG Include 005 300 NG /300 UG Include 006 300 NG /3000 UG a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 1 NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04 Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 13:41:03 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG / 0 UG 100 UG 300 UG 3000 UG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 98 80 98 80 Scheduled Sacrifice 16 10 16 10 Early Deaths Survivors Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (1) Periesophageal Tissue, Pigmentation 1 [2.0] Liver (10) (10) (10) (10) Eosinophilic Focus, Multiple 3 Fatty Change, Diffuse 1 [1.0] 7 [2.0] Inflammation 10 [1.0] 10 [1.6] 10 [1.0] 10 [1.1] Mixed Cell Focus 1 2 3 2 Mixed Cell Focus, Multiple 1 3 Necrosis 1 [1.0] Pigmentation 10 [1.0] 10 [1.0] 8 [1.5] Toxic Hepatopathy 3 [1.0] Bile Duct, Hyperplasia 1 [1.0] 1 [1.0] Bile Duct, Inflammation, Chronic Active, Focal 1 [2.0] Hepatocyte, Hypertrophy 10 [1.0] 10 [1.0] 10 [1.9] Pancreas (10) (10) (10) (10) Basophilic Focus 1 Inflammation, Chronic Active 1 [1.0] 2 [1.0] 1 [1.0] Acinus, Atrophy 1 [1.0] 1 [2.0] 1 [1.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) Hyperplasia 1 [1.0] 1 [2.0] Hypertrophy 3 [1.0] 5 [1.0] 4 [1.0] 2 [2.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 2 NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04 Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 13:41:03 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG / 0 UG 100 UG 300 UG 3000 UG ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Thyroid Gland (10) (10) (10) (10) Follicular Cell, Hypertrophy 6 [1.2] 7 [1.0] 10 [1.1] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (10) (10) (10) (10) Atrophy 6 [4.0] 8 [3.9] 10 [4.0] 10 [4.0] Uterus (10) (10) (10) (10) Inflammation, Suppurative 1 [2.0] Metaplasia, Squamous 6 [1.7] 8 [1.4] 9 [2.2] 9 [2.2] Vagina (10) (10) Inflammation, Suppurative 1 [2.0] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (10) (10) Pigmentation 10 [1.0] 10 [1.2] Thymus (10) (10) (10) (10) Atrophy 6 [1.2] 6 [1.2] 7 [1.0] 6 [1.5] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 3 NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04 Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 13:41:03 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG / 0 UG 100 UG 300 UG 3000 UG ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) Hemorrhage 1 [1.0] Infiltration Cellular, Histiocyte 2 [1.0] 1 [1.0] 2 [1.0] Inflammation 2 [1.0] Inflammation, Granulomatous 1 [2.0] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------