https://ntp.niehs.nih.gov/go/15780

TDMS Study 96020-01 Pathology Tables

NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 13:41:03
                                                     31 WEEK SSAC FINAL #1
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  TEFBINARYMIX
       Lock Date:  03/27/02
       Cage Range:  All
       Reasons For Removal:    25017 Scheduled Sacrifice
       Removal Date Range:     04/14/99 - 04/15/99
       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 004    300 NG /100 UG
                               Include 005    300 NG /300 UG
                               Include 006    300 NG /3000 UG
a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
                                                              Page   1
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 13:41:03    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          98           80           98           80                                     
  Scheduled Sacrifice                                 16           10           16           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                    10           10           10           10                                     
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 ALIMENTARY SYSTEM                                                                                                                  
   Esophagus                                                                                 (1)                                    
      Periesophageal Tissue, Pigmentation                                                     1 [2.0]                               
   Liver                                              (10)         (10)         (10)         (10)                                   
      Eosinophilic Focus, Multiple                                                            3                                     
      Fatty Change, Diffuse                                                      1 [1.0]      7 [2.0]                               
      Inflammation                                    10 [1.0]     10 [1.6]     10 [1.0]     10 [1.1]                               
      Mixed Cell Focus                                 1            2            3            2                                     
      Mixed Cell Focus, Multiple                       1                         3                                                  
      Necrosis                                                                                1 [1.0]                               
      Pigmentation                                                 10 [1.0]     10 [1.0]      8 [1.5]                               
      Toxic Hepatopathy                                                                       3 [1.0]                               
      Bile Duct, Hyperplasia                                                     1 [1.0]      1 [1.0]                               
      Bile Duct, Inflammation, Chronic Active,                                                                                      
         Focal                                                                                1 [2.0]                               
      Hepatocyte, Hypertrophy                                      10 [1.0]     10 [1.0]     10 [1.9]                               
   Pancreas                                           (10)         (10)         (10)         (10)                                   
      Basophilic Focus                                                           1                                                  
      Inflammation, Chronic Active                     1 [1.0]      2 [1.0]      1 [1.0]                                            
      Acinus, Atrophy                                  1 [1.0]      1 [2.0]      1 [1.0]                                            
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 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hyperplasia                                                                1 [1.0]      1 [2.0]                               
      Hypertrophy                                      3 [1.0]      5 [1.0]      4 [1.0]      2 [2.0]                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    2                                                              
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 13:41:03    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Follicular Cell, Hypertrophy                                  6 [1.2]      7 [1.0]     10 [1.1]                               
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Atrophy                                          6 [4.0]      8 [3.9]     10 [4.0]     10 [4.0]                               
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Inflammation, Suppurative                        1 [2.0]                                                                      
      Metaplasia, Squamous                             6 [1.7]      8 [1.4]      9 [2.2]      9 [2.2]                               
   Vagina                                             (10)                                   (10)                                   
      Inflammation, Suppurative                                                               1 [2.0]                               
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 HEMATOPOIETIC SYSTEM                                                                                                               
   Spleen                                             (10)                                   (10)                                   
      Pigmentation                                    10 [1.0]                               10 [1.2]                               
   Thymus                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                          6 [1.2]      6 [1.2]      7 [1.0]      6 [1.5]                               
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 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
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 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    3                                                              
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 13:41:03    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)         (10)         (10)         (10)                                   
      Hemorrhage                                                                 1 [1.0]                                            
      Infiltration Cellular, Histiocyte                2 [1.0]                   1 [1.0]      2 [1.0]                               
      Inflammation                                                  2 [1.0]                                                         
      Inflammation, Granulomatous                                                             1 [2.0]                               
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
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