TDMS Study 96021-01 Pathology Tables
NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03
Route: GAVAGE Time: 10:52:01
53 WEEK SSAC FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: 35065-27-1
Lock Date: 01/16/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 08/23/99 - 08/24/99
Treatment Groups: Include 001 0 UG/KG
Include 002 10 UG/KG
Include 003 100 UG/KG
Include 004 300 UG/KG
Include 005 1000 UG/KG
Include 006 3000 UG/KG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03
Route: GAVAGE Time: 10:52:01
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 UG/KG 10 UG/KG 100 300 1000 3000
UG/KG UG/KG UG/KG UG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 98 86 98 98 98 80
Scheduled Sacrifice 13 12 13 13 13 9
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8 9
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ALIMENTARY SYSTEM
Liver (8) (8) (8) (8) (8) (9)
Basophilic Focus 1 (13%) 1 (13%)
Clear Cell Focus 1 (13%) 1 (13%)
Eosinophilic Focus 1 (13%) 1 (13%)
Fatty Change, Diffuse 2 (25%) 1 (11%)
Hematopoietic Cell Proliferation 1 (13%)
Inflammation 7 (88%) 6 (75%) 8 (100%) 7 (88%) 8 (100%) 8 (89%)
Mixed Cell Focus 2 (25%) 2 (25%) 3 (38%) 1 (13%) 1 (13%) 2 (22%)
Mixed Cell Focus, Multiple 4 (50%) 5 (63%) 1 (13%) 4 (50%)
Bile Duct, Fibrosis 1 (13%)
Hepatocyte, Hypertrophy 1 (13%) 3 (38%) 7 (88%) 8 (100%) 9 (100%)
Serosa, Pigmentation 1 (13%)
Stomach, Glandular (8) (9)
Erosion 1 (13%)
Glands, Cyst 1 (11%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (8) (9)
Hyperplasia 1 (13%)
Hypertrophy 4 (50%) 4 (44%)
Vacuolization Cytoplasmic 1 (13%) 1 (11%)
Pituitary Gland (8) (9)
Cyst 1 (11%)
Thyroid Gland (8) (8) (8) (8) (8) (9)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03
Route: GAVAGE Time: 10:52:01
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 UG/KG 10 UG/KG 100 300 1000 3000
UG/KG UG/KG UG/KG UG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
C-Cell, Hyperplasia 3 (38%) 2 (22%)
Follicular Cell, Hypertrophy 1 (13%) 2 (25%) 1 (13%) 1 (13%) 3 (33%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (1) (1) (1) (9)
Atrophy 8 (100%) 7 (78%)
Cyst 1 (13%) 1 (100%) 1 (100%)
Uterus (8) (9)
Inflammation, Chronic Active 1 (11%)
Inflammation, Suppurative 2 (25%) 1 (11%)
Metaplasia, Squamous 5 (63%) 6 (67%)
Endometrium, Hyperplasia, Cystic 5 (63%) 1 (11%)
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HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Hemorrhage 1 (100%)
Mediastinal, Hyperplasia, Plasma Cell 1 (100%)
Spleen (8) (9)
Hematopoietic Cell Proliferation 1 (13%)
Pigmentation 7 (88%) 9 (100%)
Thymus (8) (9)
Atrophy 2 (25%) 1 (11%)
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03
Route: GAVAGE Time: 10:52:01
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 UG/KG 10 UG/KG 100 300 1000 3000
UG/KG UG/KG UG/KG UG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (8) (8) (8) (8) (9)
Infiltration Cellular, Histiocyte 3 (38%) 1 (11%)
Inflammation 1 (13%)
Inflammation, Chronic 1 (13%)
Alveolar Epithelium, Hyperplasia 1 (13%) 1 (13%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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