TDMS Study 96021-01 Pathology Tables
NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03
Route: GAVAGE Time: 11:02:41
53 WEEK SSAC FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: 35065-27-1
Lock Date: 01/16/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 08/23/99 - 08/24/99
Treatment Groups: Include 001 0 UG/KG
Include 002 10 UG/KG
Include 003 100 UG/KG
Include 004 300 UG/KG
Include 005 1000 UG/KG
Include 006 3000 UG/KG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03
Route: GAVAGE Time: 11:02:41
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SPRAGUE-DAWLEY RATS FEMALE 0 UG/KG 10 UG/KG 100 300 1000 3000
UG/KG UG/KG UG/KG UG/KG
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DISPOSITION SUMMARY
Animals Initially in Study 98 86 98 98 98 80
Scheduled Sacrifice 13 12 13 13 13 9
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8 9
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ALIMENTARY SYSTEM
None
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Thyroid Gland (8) (8) (8) (8) (8) (9)
C-Cell, Adenoma 1 (13%) 1 (11%)
Follicle, Adenoma 1 (13%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (1)
Carcinoma 1 (100%)
Ovary (8) (1) (1) (1) (9)
Sertoli Cell Tumor Malignant 1 (100%)
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NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03
Route: GAVAGE Time: 11:02:41
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 UG/KG 10 UG/KG 100 300 1000 3000
UG/KG UG/KG UG/KG UG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
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INTEGUMENTARY SYSTEM
Mammary Gland (8) (2) (2) (2) (9)
Fibroadenoma 2 (100%) 2 (100%) 2 (100%) 2 (22%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
None
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
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NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03
Route: GAVAGE Time: 11:02:41
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 UG/KG 10 UG/KG 100 300 1000 3000
UG/KG UG/KG UG/KG UG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 3 3 2 1 2
Total Primary Neoplasms 1 3 3 2 1 3
Total Animals with Benign Neoplasms 2 3 2 1 2
Total Benign Neoplasms 2 3 2 1 3
Total Animals with Malignant Neoplasms 1 1
Total Malignant Neoplasms 1 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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