TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 13:48:23 53 WEEK SSAC FINAL #1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFBINARYMIX Lock Date: 03/27/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 09/16/99 - 09/17/99 Treatment Groups: Include 001 0 NG / 0 UG Include 004 300 NG /100 UG Include 005 300 NG /300 UG Include 006 300 NG /3000 UG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 13:48:23 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG / 0 UG 100 UG 300 UG 3000 UG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 98 80 98 80 Scheduled Sacrifice 13 10 13 9 Early Deaths Survivors Animals Examined Microscopically 8 10 8 9 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (8) (10) (8) (9) Basophilic Focus 1 (10%) 1 (11%) Eosinophilic Focus 1 (10%) 1 (13%) 1 (11%) Eosinophilic Focus, Multiple 1 (10%) Fatty Change, Diffuse 1 (10%) 3 (38%) 9 (100%) Fatty Change, Focal 1 (10%) Hepatodiaphragmatic Nodule 1 (10%) Infiltration Cellular, Histiocyte 1 (13%) Inflammation 8 (100%) 10 (100%) 8 (100%) 9 (100%) Mixed Cell Focus 1 (13%) 1 (10%) 3 (33%) Mixed Cell Focus, Multiple 4 (50%) 8 (80%) 2 (25%) 3 (33%) Pigmentation 10 (100%) 8 (100%) 9 (100%) Toxic Hepatopathy 3 (30%) 6 (67%) Bile Duct, Fibrosis 1 (10%) Bile Duct, Hyperplasia 2 (20%) 5 (56%) Hepatocyte, Hypertrophy 10 (100%) 8 (100%) 9 (100%) Hepatocyte, Multinucleated 3 (30%) 2 (25%) 7 (78%) Oval Cell, Hyperplasia 1 (10%) 2 (22%) Pancreas (8) (10) (8) (9) Acinus, Atrophy 1 (11%) Acinus, Hyperplasia 1 (11%) Acinus, Vacuolization Cytoplasmic 6 (67%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 13:48:23 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG / 0 UG 100 UG 300 UG 3000 UG ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Adrenal Cortex (8) (10) (8) (9) Degeneration, Cystic 2 (25%) 1 (10%) 1 (13%) 1 (11%) Hyperplasia 1 (13%) 3 (30%) 1 (13%) 1 (11%) Hypertrophy 4 (50%) 5 (50%) 5 (63%) 3 (33%) Vacuolization Cytoplasmic 1 (11%) Thyroid Gland (8) (10) (8) (9) C-Cell, Hyperplasia 2 (25%) 1 (11%) Follicular Cell, Hypertrophy 7 (70%) 6 (75%) 6 (67%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (8) (10) (8) (9) Atrophy 7 (88%) 8 (80%) 7 (88%) 8 (89%) Cyst 1 (13%) 1 (13%) Inflammation, Suppurative 1 (11%) Uterus (8) (10) (8) (9) Inflammation, Suppurative 6 (67%) Metaplasia, Squamous 7 (88%) 9 (90%) 7 (88%) 7 (78%) Endometrium, Hyperplasia, Cystic 5 (63%) 2 (22%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (8) (9) Pigmentation 8 (100%) 9 (100%) Thymus (8) (10) (8) (9) Atrophy 5 (63%) 10 (100%) 8 (100%) 9 (100%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (8) (2) (5) (9) Cyst 1 (13%) 2 (40%) Hyperplasia 4 (50%) 1 (20%) Inflammation, Granulomatous 1 (20%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 13:48:23 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG / 0 UG 100 UG 300 UG 3000 UG ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (8) (10) (8) (9) Infiltration Cellular, Histiocyte 4 (50%) 2 (25%) 4 (44%) Alveolar Epithelium, Hyperplasia 1 (10%) Alveolar Epithelium, Metaplasia, Bronchiolar 3 (30%) 1 (13%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (1) Mineralization 1 (100%) Nephropathy 1 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------