TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 13:48:23
53 WEEK SSAC FINAL #1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFBINARYMIX
Lock Date: 03/27/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 09/16/99 - 09/17/99
Treatment Groups: Include 001 0 NG / 0 UG
Include 004 300 NG /100 UG
Include 005 300 NG /300 UG
Include 006 300 NG /3000 UG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 13:48:23
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 98 80 98 80
Scheduled Sacrifice 13 10 13 9
Early Deaths
Survivors
Animals Examined Microscopically 8 10 8 9
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ALIMENTARY SYSTEM
Liver (8) (10) (8) (9)
Basophilic Focus 1 (10%) 1 (11%)
Eosinophilic Focus 1 (10%) 1 (13%) 1 (11%)
Eosinophilic Focus, Multiple 1 (10%)
Fatty Change, Diffuse 1 (10%) 3 (38%) 9 (100%)
Fatty Change, Focal 1 (10%)
Hepatodiaphragmatic Nodule 1 (10%)
Infiltration Cellular, Histiocyte 1 (13%)
Inflammation 8 (100%) 10 (100%) 8 (100%) 9 (100%)
Mixed Cell Focus 1 (13%) 1 (10%) 3 (33%)
Mixed Cell Focus, Multiple 4 (50%) 8 (80%) 2 (25%) 3 (33%)
Pigmentation 10 (100%) 8 (100%) 9 (100%)
Toxic Hepatopathy 3 (30%) 6 (67%)
Bile Duct, Fibrosis 1 (10%)
Bile Duct, Hyperplasia 2 (20%) 5 (56%)
Hepatocyte, Hypertrophy 10 (100%) 8 (100%) 9 (100%)
Hepatocyte, Multinucleated 3 (30%) 2 (25%) 7 (78%)
Oval Cell, Hyperplasia 1 (10%) 2 (22%)
Pancreas (8) (10) (8) (9)
Acinus, Atrophy 1 (11%)
Acinus, Hyperplasia 1 (11%)
Acinus, Vacuolization Cytoplasmic 6 (67%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 13:48:23
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Adrenal Cortex (8) (10) (8) (9)
Degeneration, Cystic 2 (25%) 1 (10%) 1 (13%) 1 (11%)
Hyperplasia 1 (13%) 3 (30%) 1 (13%) 1 (11%)
Hypertrophy 4 (50%) 5 (50%) 5 (63%) 3 (33%)
Vacuolization Cytoplasmic 1 (11%)
Thyroid Gland (8) (10) (8) (9)
C-Cell, Hyperplasia 2 (25%) 1 (11%)
Follicular Cell, Hypertrophy 7 (70%) 6 (75%) 6 (67%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (10) (8) (9)
Atrophy 7 (88%) 8 (80%) 7 (88%) 8 (89%)
Cyst 1 (13%) 1 (13%)
Inflammation, Suppurative 1 (11%)
Uterus (8) (10) (8) (9)
Inflammation, Suppurative 6 (67%)
Metaplasia, Squamous 7 (88%) 9 (90%) 7 (88%) 7 (78%)
Endometrium, Hyperplasia, Cystic 5 (63%) 2 (22%)
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HEMATOPOIETIC SYSTEM
Spleen (8) (9)
Pigmentation 8 (100%) 9 (100%)
Thymus (8) (10) (8) (9)
Atrophy 5 (63%) 10 (100%) 8 (100%) 9 (100%)
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INTEGUMENTARY SYSTEM
Mammary Gland (8) (2) (5) (9)
Cyst 1 (13%) 2 (40%)
Hyperplasia 4 (50%) 1 (20%)
Inflammation, Granulomatous 1 (20%)
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 13:48:23
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (10) (8) (9)
Infiltration Cellular, Histiocyte 4 (50%) 2 (25%) 4 (44%)
Alveolar Epithelium, Hyperplasia 1 (10%)
Alveolar Epithelium, Metaplasia, Bronchiolar 3 (30%) 1 (13%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (1)
Mineralization 1 (100%)
Nephropathy 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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