TDMS Study 89009-01 Pathology Tables
NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04
Route: DOSED WATER Time: 09:54:37
Facility: Southern Research Institute
Chemical CAS #: PESTFERTMIX2
Lock Date: 05/22/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04
Route: DOSED WATER Time: 09:54:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 40 40 40 40 40
Scheduled Sacrifice 10 10 10 10 10
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 30 30 30 30 29
Animals Examined Microscopically 20 20 20 20 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (20) (20) (20) (20) (20)
Parasite Metazoan 1 (5%)
Intestine Large, Rectum (20) (20) (19) (20) (20)
Parasite Metazoan 1 (5%) 2 (10%) 3 (15%)
Liver (20) (20) (20) (20) (20)
Hepatodiaphragmatic Nodule 1 (5%) 1 (5%) 1 (5%)
Mesentery (2) (1) (1)
Accessory Spleen 1 (100%)
Fat, Necrosis 2 (100%) 1 (100%)
Stomach, Forestomach (20) (20) (20) (20) (20)
Mucosa, Hyperplasia 1 (5%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (20) (20) (20) (20) (20)
Accessory Adrenal Cortical Nodule 1 (5%)
Pituitary Gland (19) (20) (20) (20) (20)
Cyst 1 (5%) 1 (5%) 1 (5%)
Pars Distalis, Hyperplasia, Focal 1 (5%)
Thyroid Gland (20) (20) (20) (20) (20)
Ultimobranchial Cyst 4 (20%) 2 (10%) 3 (15%) 1 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04
Route: DOSED WATER Time: 09:54:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (20) (20) (20) (20) (20)
Cyst 1 (5%) 1 (5%)
Uterus (20) (20) (20) (20) (20)
Hydrometra 4 (20%) 3 (15%) 2 (10%) 5 (25%) 5 (25%)
Inflammation, Suppurative 1 (5%)
Endometrium, Hyperplasia, Cystic 1 (5%) 1 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04
Route: DOSED WATER Time: 09:54:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04
Route: DOSED WATER Time: 09:54:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 40 40 40 40 40
Scheduled Sacrifice 10 10 10 10 10
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 30 30 30 29 30
Animals Examined Microscopically 20 20 20 20 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (20) (20) (20) (20) (20)
Parasite Metazoan 1 (5%)
Intestine Large, Rectum (20) (20) (20) (20) (20)
Parasite Metazoan 1 (5%) 4 (20%) 1 (5%) 2 (10%) 2 (10%)
Liver (20) (20) (20) (20) (20)
Fibrosis, Focal 1 (5%) 1 (5%)
Hepatodiaphragmatic Nodule 2 (10%) 1 (5%) 1 (5%) 2 (10%)
Mesentery (1) (1) (2)
Inflammation, Chronic, Focal 1 (50%)
Fat, Necrosis 1 (100%) 1 (100%) 1 (50%)
Pancreas (20) (20) (20) (20) (20)
Atrophy, Focal 3 (15%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (20) (20) (20) (20) (20)
Artery, Inflammation, Chronic 2 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (20) (20) (20) (20) (20)
Accessory Adrenal Cortical Nodule 1 (5%) 1 (5%)
Pituitary Gland (20) (19) (20) (20) (20)
Cyst 1 (5%) 1 (5%)
Pars Distalis, Focal Cellular Change 1 (5%) 1 (5%)
Thyroid Gland (20) (20) (20) (20) (20)
Ultimobranchial Cyst 3 (15%) 2 (10%) 2 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04
Route: DOSED WATER Time: 09:54:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ductus Deferens (1)
Inflammation, Chronic 1 (100%)
Preputial Gland (20) (20) (20) (20) (20)
Inflammation, Chronic 2 (10%) 2 (10%) 2 (10%)
Prostate (20) (20) (20) (20) (20)
Inflammation, Suppurative 1 (5%) 1 (5%) 3 (15%) 3 (15%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Hemorrhage 1 (100%)
Lymph Node, Mandibular (20) (20) (20) (20) (18)
Hyperplasia 1 (6%)
Lymph Node, Mesenteric (20) (20) (20) (20) (20)
Hyperplasia, Lymphoid 1 (5%)
Thymus (20) (20) (20) (20) (20)
Hemorrhage 2 (10%) 1 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 89009-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04
Route: DOSED WATER Time: 09:54:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (19) (20) (20) (20) (20)
Hemorrhage, Focal 1 (5%)
Alveolar Epithelium, Hyperplasia 1 (5%)
Nose (20) (20) (20) (20) (20)
Inflammation, Suppurative 1 (5%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (20) (20) (20) (20)
Renal Tubule, Dilatation, Focal 1 (5%)
Urinary Bladder (20) (20) (20) (20) (20)
Calculus Gross Observation 1 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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