TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 13:47:44 53 WEEK SSAC FINAL #1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFBINARYMIX Lock Date: 03/27/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 09/16/99 - 09/17/99 Treatment Groups: Include 001 0 NG / 0 UG Include 002 10 NG / 10 UG Include 003 100 NG /100 UG Include 005 300 NG /300 UG Include 007 1000 NG/1000 UG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 13:47:44 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ 0 UG 10 UG 100 UG 300 UG 1000 UG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 98 86 98 98 98 Scheduled Sacrifice 13 13 13 13 13 Early Deaths Survivors Animals Examined Microscopically 8 8 8 8 8 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (8) (8) (8) (8) (8) Basophilic Focus 3 (38%) 1 (13%) 1 (13%) Cholangiofibrosis 1 (13%) Eosinophilic Focus 1 (13%) Eosinophilic Focus, Multiple 7 (88%) Fatty Change, Diffuse 3 (38%) 8 (100%) Fatty Change, Focal 1 (13%) Hyperplasia, Nodular 2 (25%) Infiltration Cellular, Histiocyte 1 (13%) 1 (13%) Inflammation 8 (100%) 8 (100%) 8 (100%) 8 (100%) 8 (100%) Mixed Cell Focus 1 (13%) 1 (13%) 4 (50%) Mixed Cell Focus, Multiple 4 (50%) 7 (88%) 2 (25%) 2 (25%) 1 (13%) Necrosis 1 (13%) Pigmentation 1 (13%) 6 (75%) 8 (100%) 8 (100%) Toxic Hepatopathy 8 (100%) Bile Duct, Fibrosis 1 (13%) Bile Duct, Hyperplasia 8 (100%) Hepatocyte, Hypertrophy 2 (25%) 2 (25%) 8 (100%) 8 (100%) Hepatocyte, Multinucleated 2 (25%) 8 (100%) Oval Cell, Hyperplasia 4 (50%) Pancreas (8) (8) (8) (8) (8) Inflammation, Chronic Active 1 (13%) 1 (13%) Acinus, Atrophy 1 (13%) 1 (13%) Acinus, Vacuolization Cytoplasmic 7 (88%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (1) Pericardium, Inflammation, Chronic Active 1 (100%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 13:47:44 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ 0 UG 10 UG 100 UG 300 UG 1000 UG ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (8) (8) (8) (8) (8) Degeneration, Cystic 2 (25%) 1 (13%) 1 (13%) Hyperplasia 1 (13%) 4 (50%) 1 (13%) 1 (13%) 1 (13%) Hypertrophy 4 (50%) 4 (50%) 5 (63%) 5 (63%) 2 (25%) Vacuolization Cytoplasmic 1 (13%) 1 (13%) Thyroid Gland (8) (8) (8) (8) (8) C-Cell, Hyperplasia 2 (25%) 1 (13%) Follicular Cell, Hypertrophy 2 (25%) 4 (50%) 6 (75%) 4 (50%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (8) (8) (8) (8) (8) Atrophy 7 (88%) 6 (75%) 7 (88%) 7 (88%) 6 (75%) Cyst 1 (13%) 1 (13%) 1 (13%) Uterus (8) (8) (8) (8) (8) Inflammation, Suppurative 1 (13%) Metaplasia, Squamous 7 (88%) 6 (75%) 7 (88%) 7 (88%) 3 (38%) Endometrium, Hyperplasia, Cystic 5 (63%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (8) Pigmentation 8 (100%) Thymus (8) (8) (8) (8) (8) Atrophy 5 (63%) 8 (100%) 8 (100%) 8 (100%) 8 (100%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (8) (2) (5) (1) Cyst 1 (13%) 2 (100%) 2 (40%) Hyperplasia 4 (50%) 2 (100%) 1 (20%) Inflammation, Granulomatous 1 (20%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 13:47:44 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ 0 UG 10 UG 100 UG 300 UG 1000 UG ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (8) (8) (8) (8) (8) Hemorrhage 1 (13%) Infiltration Cellular, Histiocyte 4 (50%) 5 (63%) 5 (63%) 2 (25%) 1 (13%) Alveolar Epithelium, Metaplasia, Bronchiolar 1 (13%) 3 (38%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------