TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 13:47:44
53 WEEK SSAC FINAL #1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFBINARYMIX
Lock Date: 03/27/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 09/16/99 - 09/17/99
Treatment Groups: Include 001 0 NG / 0 UG
Include 002 10 NG / 10 UG
Include 003 100 NG /100 UG
Include 005 300 NG /300 UG
Include 007 1000 NG/1000 UG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 13:47:44
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SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/
0 UG 10 UG 100 UG 300 UG 1000 UG
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DISPOSITION SUMMARY
Animals Initially In Study 98 86 98 98 98
Scheduled Sacrifice 13 13 13 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8
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ALIMENTARY SYSTEM
Liver (8) (8) (8) (8) (8)
Basophilic Focus 3 (38%) 1 (13%) 1 (13%)
Cholangiofibrosis 1 (13%)
Eosinophilic Focus 1 (13%)
Eosinophilic Focus, Multiple 7 (88%)
Fatty Change, Diffuse 3 (38%) 8 (100%)
Fatty Change, Focal 1 (13%)
Hyperplasia, Nodular 2 (25%)
Infiltration Cellular, Histiocyte 1 (13%) 1 (13%)
Inflammation 8 (100%) 8 (100%) 8 (100%) 8 (100%) 8 (100%)
Mixed Cell Focus 1 (13%) 1 (13%) 4 (50%)
Mixed Cell Focus, Multiple 4 (50%) 7 (88%) 2 (25%) 2 (25%) 1 (13%)
Necrosis 1 (13%)
Pigmentation 1 (13%) 6 (75%) 8 (100%) 8 (100%)
Toxic Hepatopathy 8 (100%)
Bile Duct, Fibrosis 1 (13%)
Bile Duct, Hyperplasia 8 (100%)
Hepatocyte, Hypertrophy 2 (25%) 2 (25%) 8 (100%) 8 (100%)
Hepatocyte, Multinucleated 2 (25%) 8 (100%)
Oval Cell, Hyperplasia 4 (50%)
Pancreas (8) (8) (8) (8) (8)
Inflammation, Chronic Active 1 (13%) 1 (13%)
Acinus, Atrophy 1 (13%) 1 (13%)
Acinus, Vacuolization Cytoplasmic 7 (88%)
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CARDIOVASCULAR SYSTEM
Heart (1)
Pericardium, Inflammation, Chronic Active 1 (100%)
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 13:47:44
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/
0 UG 10 UG 100 UG 300 UG 1000 UG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (8) (8) (8) (8) (8)
Degeneration, Cystic 2 (25%) 1 (13%) 1 (13%)
Hyperplasia 1 (13%) 4 (50%) 1 (13%) 1 (13%) 1 (13%)
Hypertrophy 4 (50%) 4 (50%) 5 (63%) 5 (63%) 2 (25%)
Vacuolization Cytoplasmic 1 (13%) 1 (13%)
Thyroid Gland (8) (8) (8) (8) (8)
C-Cell, Hyperplasia 2 (25%) 1 (13%)
Follicular Cell, Hypertrophy 2 (25%) 4 (50%) 6 (75%) 4 (50%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (8) (8) (8) (8)
Atrophy 7 (88%) 6 (75%) 7 (88%) 7 (88%) 6 (75%)
Cyst 1 (13%) 1 (13%) 1 (13%)
Uterus (8) (8) (8) (8) (8)
Inflammation, Suppurative 1 (13%)
Metaplasia, Squamous 7 (88%) 6 (75%) 7 (88%) 7 (88%) 3 (38%)
Endometrium, Hyperplasia, Cystic 5 (63%)
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HEMATOPOIETIC SYSTEM
Spleen (8)
Pigmentation 8 (100%)
Thymus (8) (8) (8) (8) (8)
Atrophy 5 (63%) 8 (100%) 8 (100%) 8 (100%) 8 (100%)
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INTEGUMENTARY SYSTEM
Mammary Gland (8) (2) (5) (1)
Cyst 1 (13%) 2 (100%) 2 (40%)
Hyperplasia 4 (50%) 2 (100%) 1 (20%)
Inflammation, Granulomatous 1 (20%)
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 13:47:44
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/
0 UG 10 UG 100 UG 300 UG 1000 UG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (8) (8) (8) (8)
Hemorrhage 1 (13%)
Infiltration Cellular, Histiocyte 4 (50%) 5 (63%) 5 (63%) 2 (25%) 1 (13%)
Alveolar Epithelium, Metaplasia, Bronchiolar 1 (13%) 3 (38%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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