TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
53 WEEK SSAC FINAL #1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFBINARYMIX
Lock Date: 03/27/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 09/16/99 - 09/17/99
Treatment Groups: Include 001 0 NG / 0 UG
Include 002 10 NG / 10 UG
Include 003 100 NG /100 UG
Include 005 300 NG /300 UG
Include 007 1000 NG/1000 UG
Page 1
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG / | 0| 0| 1| 3| 4| 4| 4| 5| 7| 7| 7| 7| 8| | L |
0 UG | 2| 6| 6| 8| 6| 7| 9| 0| 2| 3| 4| 5| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0|
Mixed Cell Focus | X | 1 |
Mixed Cell Focus, Multiple | X X X X | 4 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Degeneration, Cystic | 2 3 | 2 2.5|
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 1 1 1 1 | 4 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
C-Cell, Hyperplasia | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG / | 0| 0| 1| 3| 4| 4| 4| 5| 7| 7| 7| 7| 8| | L |
0 UG | 2| 6| 6| 8| 6| 7| 9| 0| 2| 3| 4| 5| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 4 | 7 4.0|
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Metaplasia, Squamous | 2 2 2 2 1 2 3 | 7 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 1 | 5 1.8|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
Pigmentation | 1 1 2 1 2 2 1 2 | 8 1.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 1 1 1 1 2 | 5 1.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
Cyst | 1 | 1 1.0|
Hyperplasia | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG / | 0| 0| 1| 3| 4| 4| 4| 5| 7| 7| 7| 7| 8| | L |
0 UG | 2| 6| 6| 8| 6| 7| 9| 0| 2| 3| 4| 5| 5| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Infiltration Cellular, Histiocyte | 1 2 1 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
10 NG / | 0| 0| 0| 0| 1| 3| 3| 5| 5| 6| 6| 6| 7| | L |
10 UG | 2| 6| 7| 9| 0| 0| 5| 0| 3| 6| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X X X | 3 |
Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0|
Mixed Cell Focus | X | 1 |
Mixed Cell Focus, Multiple | X X X X X X X | 7 |
Pigmentation | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
Inflammation, Chronic Active | 1 | 1 1.0|
Acinus, Atrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Degeneration, Cystic | 3 | 1 3.0|
Hyperplasia | 2 2 1 1 | 4 1.5|
Hypertrophy | 1 2 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
C-Cell, Hyperplasia | 1 | 1 1.0|
Follicular Cell, Hypertrophy | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 | 6 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
10 NG / | 0| 0| 0| 0| 1| 3| 3| 5| 5| 6| 6| 6| 7| | L |
10 UG | 2| 6| 7| 9| 0| 0| 5| 0| 3| 6| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Metaplasia, Squamous | 2 3 3 2 2 3 | 6 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 2 2 1 2 1 1 1 1 | 8 1.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
Cyst | 2 2 | 2 2.0|
Hyperplasia | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 2 2 1 1 1 | 5 1.4|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
100 NG / | 0| 1| 1| 1| 2| 2| 2| 2| 3| 4| 5| 7| 8| | L |
100 UG | 4| 7| 8| 9| 0| 6| 7| 8| 0| 9| 4| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X | 1 |
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0|
Mixed Cell Focus | X X X X | 4 |
Mixed Cell Focus, Multiple | X X | 2 |
Pigmentation | 1 1 1 1 1 1 | 6 1.0|
Hepatocyte, Hypertrophy | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 1 2 1 1 1 | 5 1.2|
Vacuolization Cytoplasmic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
Follicular Cell, Hypertrophy | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 4 | 7 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
100 NG / | 0| 1| 1| 1| 2| 2| 2| 2| 3| 4| 5| 7| 8| | L |
100 UG | 4| 7| 8| 9| 0| 6| 7| 8| 0| 9| 4| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Metaplasia, Squamous | 4 3 2 3 2 4 3 | 7 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 2 2 2 1 3 2 2 2 | 8 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
300 NG / | 1| 2| 3| 3| 3| 3| 5| 6| 6| 6| 6| 7| 7| | L |
300 UG | 5| 9| 2| 3| 4| 5| 9| 4| 7| 8| 9| 0| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Eosinophilic Focus | X | 1 |
Fatty Change, Diffuse | 1 1 1 | 3 1.0|
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0|
Mixed Cell Focus, Multiple | X X | 2 |
Pigmentation | 2 2 1 1 1 1 1 2 | 8 1.4|
Hepatocyte, Hypertrophy | 1 1 1 1 1 1 1 1 | 8 1.0|
Hepatocyte, Multinucleated | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Degeneration, Cystic | 2 | 1 2.0|
Hyperplasia | 1 | 1 1.0|
Hypertrophy | 2 3 1 1 1 | 5 1.6|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
Follicular Cell, Hypertrophy | 1 1 1 1 1 2 | 6 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 4 | 7 4.0|
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
300 NG / | 1| 2| 3| 3| 3| 3| 5| 6| 6| 6| 6| 7| 7| | L |
300 UG | 5| 9| 2| 3| 4| 5| 9| 4| 7| 8| 9| 0| 7| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Metaplasia, Squamous | 4 2 2 3 2 4 4 | 7 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 2 3 3 2 2 2 3 2 | 8 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
Cyst | 3 3 | 2 3.0|
Hyperplasia | 1 | 1 1.0|
Inflammation, Granulomatous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 | 2 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
300 NG / | 1| 2| 3| 3| 3| 3| 5| 6| 6| 6| 6| 7| 7| | L |
300 UG | 5| 9| 2| 3| 4| 5| 9| 4| 7| 8| 9| 0| 7| | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 6| 6| 6| 6| 7| 6| 6| 6| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1000 NG/ | 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 6| 7| | L |
1000 UG | 0| 1| 2| 3| 5| 1| 1| 2| 3| 5| 5| 8| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X | 1 |
Cholangiofibrosis | 3 | 1 3.0|
Eosinophilic Focus, Multiple | X X X X X X X | 7 |
Fatty Change, Diffuse | 1 1 3 1 2 1 2 1 | 8 1.5|
Fatty Change, Focal | 3 | 1 3.0|
Hyperplasia, Nodular | X X | 2 |
Inflammation | 1 1 2 2 1 2 1 2 | 8 1.5|
Mixed Cell Focus, Multiple | X | 1 |
Necrosis | 1 | 1 1.0|
Pigmentation | 3 2 2 2 2 2 2 2 | 8 2.1|
Toxic Hepatopathy | 3 2 1 1 2 2 1 1 | 8 1.6|
Bile Duct, Fibrosis | 1 | 1 1.0|
Bile Duct, Hyperplasia | 3 2 1 2 2 2 1 1 | 8 1.8|
Hepatocyte, Hypertrophy | 4 3 3 3 3 4 3 3 | 8 3.3|
Hepatocyte, Multinucleated | 2 1 2 2 2 2 2 2 | 8 1.9|
Oval Cell, Hyperplasia | 1 2 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
Inflammation, Chronic Active | 1 | 1 1.0|
Acinus, Atrophy | 1 | 1 1.0|
Acinus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + | 1 |
Pericardium, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 6| 6| 6| 6| 7| 6| 6| 6| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1000 NG/ | 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 6| 7| | L |
1000 UG | 0| 1| 2| 3| 5| 1| 1| 2| 3| 5| 5| 8| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hypertrophy | 1 1 | 2 1.0|
Vacuolization Cytoplasmic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
Follicular Cell, Hypertrophy | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 3 4 4 4 4 | 6 3.8|
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Inflammation, Suppurative | 3 | 1 3.0|
Metaplasia, Squamous | 1 2 4 | 3 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 3 1 3 2 3 4 3 4 | 8 2.9|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 14:05:30
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 6| 6| 6| 6| 7| 6| 6| 6| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1000 NG/ | 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 6| 7| | L |
1000 UG | 0| 1| 2| 3| 5| 1| 1| 2| 3| 5| 5| 8| 5| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------