TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04
Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 14:19:45
53 WEEK SSAC FINAL #1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFBINARYMIX
Lock Date: 03/27/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 09/16/99 - 09/17/99
Treatment Groups: Include 001 0 NG / 0 UG
Include 002 10 NG / 10 UG
Include 003 100 NG /100 UG
Include 005 300 NG /300 UG
Include 007 1000 NG/1000 UG
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04
Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 14:19:45
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/
0 UG 10 UG 100 UG 300 UG 1000 UG
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DISPOSITION SUMMARY
Animals Initially In Study 98 86 98 98 98
Scheduled Sacrifice 13 13 13 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8
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ALIMENTARY SYSTEM
Liver (8) (8) (8) (8) (8)
Basophilic Focus 3 1 1
Cholangiofibrosis 1 [3.0]
Eosinophilic Focus 1
Eosinophilic Focus, Multiple 7
Fatty Change, Diffuse 3 [1.0] 8 [1.5]
Fatty Change, Focal 1 [3.0]
Hyperplasia, Nodular 2
Infiltration Cellular, Histiocyte 1 [1.0] 1 [1.0]
Inflammation 8 [1.0] 8 [1.0] 8 [1.0] 8 [1.0] 8 [1.5]
Mixed Cell Focus 1 1 4
Mixed Cell Focus, Multiple 4 7 2 2 1
Necrosis 1 [1.0]
Pigmentation 1 [1.0] 6 [1.0] 8 [1.4] 8 [2.1]
Toxic Hepatopathy 8 [1.6]
Bile Duct, Fibrosis 1 [1.0]
Bile Duct, Hyperplasia 8 [1.8]
Hepatocyte, Hypertrophy 2 [1.0] 2 [1.0] 8 [1.0] 8 [3.3]
Hepatocyte, Multinucleated 2 [1.0] 8 [1.9]
Oval Cell, Hyperplasia 4 [1.3]
Pancreas (8) (8) (8) (8) (8)
Inflammation, Chronic Active 1 [1.0] 1 [1.0]
Acinus, Atrophy 1 [1.0] 1 [1.0]
Acinus, Vacuolization Cytoplasmic 7 [1.0]
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CARDIOVASCULAR SYSTEM
Heart (1)
Pericardium, Inflammation, Chronic Active 1 [2.0]
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04
Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 14:19:45
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/
0 UG 10 UG 100 UG 300 UG 1000 UG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (8) (8) (8) (8) (8)
Degeneration, Cystic 2 [2.5] 1 [3.0] 1 [2.0]
Hyperplasia 1 [2.0] 4 [1.5] 1 [2.0] 1 [1.0] 1 [3.0]
Hypertrophy 4 [1.0] 4 [1.3] 5 [1.2] 5 [1.6] 2 [1.0]
Vacuolization Cytoplasmic 1 [1.0] 1 [1.0]
Thyroid Gland (8) (8) (8) (8) (8)
C-Cell, Hyperplasia 2 [1.5] 1 [1.0]
Follicular Cell, Hypertrophy 2 [1.0] 4 [1.0] 6 [1.2] 4 [1.0]
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (8) (8) (8) (8)
Atrophy 7 [4.0] 6 [4.0] 7 [4.0] 7 [4.0] 6 [3.8]
Cyst 1 [2.0] 1 [2.0] 1 [2.0]
Uterus (8) (8) (8) (8) (8)
Inflammation, Suppurative 1 [3.0]
Metaplasia, Squamous 7 [2.0] 6 [2.5] 7 [3.0] 7 [3.0] 3 [2.3]
Endometrium, Hyperplasia, Cystic 5 [1.8]
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HEMATOPOIETIC SYSTEM
Spleen (8)
Pigmentation 8 [1.5]
Thymus (8) (8) (8) (8) (8)
Atrophy 5 [1.2] 8 [1.4] 8 [2.0] 8 [2.4] 8 [2.9]
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INTEGUMENTARY SYSTEM
Mammary Gland (8) (2) (5) (1)
Cyst 1 [1.0] 2 [2.0] 2 [3.0]
Hyperplasia 4 [1.0] 2 [1.0] 1 [1.0]
Inflammation, Granulomatous 1 [2.0]
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04
Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 14:19:45
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/
0 UG 10 UG 100 UG 300 UG 1000 UG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (8) (8) (8) (8)
Hemorrhage 1 [1.0]
Infiltration Cellular, Histiocyte 4 [1.3] 5 [1.4] 5 [1.0] 2 [1.0] 1 [2.0]
Alveolar Epithelium, Metaplasia, Bronchiolar 1 [1.0] 3 [1.0]
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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