TDMS Study 96021-01 Pathology Tables
NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/05/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Time: 11:04:23
53 WEEK SSAC FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: 35065-27-1
Lock Date: 01/16/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 08/23/99 - 08/24/99
Treatment Groups: Include 001 0 UG/KG
Include 002 10 UG/KG
Include 003 100 UG/KG
Include 004 300 UG/KG
Include 005 1000 UG/KG
Include 006 3000 UG/KG
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/05/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Time: 11:04:23
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SPRAGUE-DAWLEY RATS FEMALE 0 UG/KG 10 UG/KG 100 300 1000 3000
UG/KG UG/KG UG/KG UG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 98 86 98 98 98 80
Scheduled Sacrifice 13 12 13 13 13 9
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8 9
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ALIMENTARY SYSTEM
Liver (8) (8) (8) (8) (8) (9)
Basophilic Focus 1 1
Clear Cell Focus 1 1
Eosinophilic Focus 1 1
Fatty Change, Diffuse 2 [1.0] 1 [2.0]
Hematopoietic Cell Proliferation 1 [1.0]
Inflammation 7 [1.0] 6 [1.0] 8 [1.0] 7 [1.0] 8 [1.1] 8 [1.0]
Mixed Cell Focus 2 2 3 1 1 2
Mixed Cell Focus, Multiple 4 5 1 4
Bile Duct, Fibrosis 1 [1.0]
Hepatocyte, Hypertrophy 1 [1.0] 3 [1.0] 7 [1.1] 8 [1.8] 9 [2.4]
Serosa, Pigmentation 1 [2.0]
Stomach, Glandular (8) (9)
Erosion 1 [1.0]
Glands, Cyst 1 [1.0]
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (8) (9)
Hyperplasia 1 [2.0]
Hypertrophy 4 [1.0] 4 [2.0]
Vacuolization Cytoplasmic 1 [1.0] 1 [1.0]
Pituitary Gland (8) (9)
Cyst 1 [2.0]
Thyroid Gland (8) (8) (8) (8) (8) (9)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/05/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Time: 11:04:23
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 UG/KG 10 UG/KG 100 300 1000 3000
UG/KG UG/KG UG/KG UG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
C-Cell, Hyperplasia 3 [1.7] 2 [1.0]
Follicular Cell, Hypertrophy 1 [1.0] 2 [1.5] 1 [1.0] 1 [1.0] 3 [1.0]
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (1) (1) (1) (9)
Atrophy 8 [4.0] 7 [4.0]
Cyst 1 [1.0] 1 [2.0] 1 [2.0]
Uterus (8) (9)
Inflammation, Chronic Active 1 [2.0]
Inflammation, Suppurative 2 [1.5] 1 [1.0]
Metaplasia, Squamous 5 [1.6] 6 [2.7]
Endometrium, Hyperplasia, Cystic 5 [2.8] 1 [1.0]
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HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Hemorrhage 1 [2.0]
Mediastinal, Hyperplasia, Plasma Cell 1 [2.0]
Spleen (8) (9)
Hematopoietic Cell Proliferation 1 [3.0]
Pigmentation 7 [1.1] 9 [1.6]
Thymus (8) (9)
Atrophy 2 [2.5] 1 [2.0]
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/05/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Time: 11:04:23
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 UG/KG 10 UG/KG 100 300 1000 3000
UG/KG UG/KG UG/KG UG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (8) (8) (8) (8) (9)
Infiltration Cellular, Histiocyte 3 [1.0] 1 [1.0]
Inflammation 1 [2.0]
Inflammation, Chronic 1 [1.0]
Alveolar Epithelium, Hyperplasia 1 [1.0] 1 [2.0]
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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