TDMS Study 91001-01 Pathology Tables
NTP Experiment-Test: 91001-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04 Route: GAVAGE Time: 13:20:52 Facility: Battelle Columbus Laboratory Chemical CAS #: 95-51-2 Lock Date: 09/03/92 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include 002 0 MG/KG Include 001 0 MG/KG Include 004 10 MG/KG Include 003 10 MG/KG Include 006 20 MG/KG Include 005 20 MG/KG Include 008 40 MG/KG Include 007 40 MG/KG Include 010 80 MG/KG Include 009 80 MG/KG Include 012 160 MG/KG Include 011 160 MG/KG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 91001-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04 Route: GAVAGE Time: 13:20:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Natural Death 1 Survivors Terminal Sacrifice 10 10 9 10 10 10 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (1) (10) Pigmentation, Hemosiderin 10 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (1) (10) Myocardium, Degeneration, Chronic, Focal 1 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (10) (1) (10) Inflammation, Chronic Active 3 (30%) 1 (10%) Ovary (10) (1) (10) Periovarian Tissue, Cyst 1 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (10) (10) (10) (10) (10) (10) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 91001-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04 Route: GAVAGE Time: 13:20:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160 MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Erythroid Cell, Hyperplasia 10 (100%) 10 (100%) Spleen (10) (10) (10) (10) (10) (10) Hematopoietic Cell Proliferation 10 (100%) 10 (100%) Pigmentation, Hemosiderin 9 (90%) 9 (90%) Capsule, Fibrosis 10 (100%) 10 (100%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) (10) (10) Mineralization, Diffuse 10 (100%) 10 (100%) 9 (90%) 10 (100%) 10 (100%) 9 (90%) Cortex, Pigmentation, Diffuse, Hemosiderin 10 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 91001-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04 Route: GAVAGE Time: 13:20:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Natural Death 1 Survivors Terminal Sacrifice 10 10 10 9 10 10 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (1) (1) (10) Hepatodiaphragmatic Nodule 1 (10%) Pigmentation, Hemosiderin 10 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (1) (10) Myocardium, Degeneration, Chronic, Focal 2 (20%) 2 (20%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (10) (1) (10) Inflammation, Chronic Active 6 (60%) 6 (60%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (10) (10) (10) (10) (10) (10) Erythroid Cell, Hyperplasia 1 (10%) 10 (100%) 10 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 91001-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04 Route: GAVAGE Time: 13:20:52 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160 MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Spleen (10) (10) (10) (10) (10) (10) Hematopoietic Cell Proliferation 10 (100%) 10 (100%) Pigmentation, Hemosiderin 9 (90%) Capsule, Fibrosis 10 (100%) 9 (90%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) (10) (10) Mineralization, Diffuse 9 (90%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 9 (90%) Mineralization, Focal 1 (10%) Cortex, Pigmentation, Diffuse, Hemosiderin 10 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------