TDMS Study 91001-01 Pathology Tables
NTP Experiment-Test: 91001-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 13:20:52
Facility: Battelle Columbus Laboratory
Chemical CAS #: 95-51-2
Lock Date: 09/03/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 001 0 MG/KG
Include 004 10 MG/KG
Include 003 10 MG/KG
Include 006 20 MG/KG
Include 005 20 MG/KG
Include 008 40 MG/KG
Include 007 40 MG/KG
Include 010 80 MG/KG
Include 009 80 MG/KG
Include 012 160 MG/KG
Include 011 160 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 91001-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 13:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 10 10 9 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (1) (10)
Pigmentation, Hemosiderin 10 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (1) (10)
Myocardium, Degeneration, Chronic, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (1) (10)
Inflammation, Chronic Active 3 (30%) 1 (10%)
Ovary (10) (1) (10)
Periovarian Tissue, Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 91001-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 13:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Erythroid Cell, Hyperplasia 10 (100%) 10 (100%)
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 10 (100%) 10 (100%)
Pigmentation, Hemosiderin 9 (90%) 9 (90%)
Capsule, Fibrosis 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Mineralization, Diffuse 10 (100%) 10 (100%) 9 (90%) 10 (100%) 10 (100%) 9 (90%)
Cortex, Pigmentation, Diffuse, Hemosiderin 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 91001-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 13:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 10 10 10 9 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (1) (1) (10)
Hepatodiaphragmatic Nodule 1 (10%)
Pigmentation, Hemosiderin 10 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (1) (10)
Myocardium, Degeneration, Chronic, Focal 2 (20%) 2 (20%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (1) (10)
Inflammation, Chronic Active 6 (60%) 6 (60%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Erythroid Cell, Hyperplasia 1 (10%) 10 (100%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 91001-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 13:20:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 10 (100%) 10 (100%)
Pigmentation, Hemosiderin 9 (90%)
Capsule, Fibrosis 10 (100%) 9 (90%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Mineralization, Diffuse 9 (90%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 9 (90%)
Mineralization, Focal 1 (10%)
Cortex, Pigmentation, Diffuse, Hemosiderin 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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