TDMS Study 96021-01 Pathology Tables
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
FINAL #3
Facility: Battelle Columbus Laboratory
Chemical CAS #: 35065-27-1
Lock Date: 01/16/02
Cage Range: All
Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 5| 7| 5| 7| 6| 5| 5| 7| 7| 6| 6| 4| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 9| 3| 0| 0| 7| 3| 1| 5| 5| 3| 3| 7| 4| 3| 3| 9| 3| 1| 0| 3| 3| 3|
| 1| 2| 8| 9| 1| 2| 1| 1| 2| 3| 5| 1| 2| 2| 2| 4| 7| 3| 6| 1| 8| 1| 3| 1| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Lymphoid | 3|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 |
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X X X X X X X |
Clear Cell Focus | X X |
Clear Cell Focus, Multiple | X |
Eosinophilic Focus | X |
Eosinophilic Focus, Multiple | X X X |
Fatty Change, Diffuse | 1 1 |
Fatty Change, Focal | 1 1 |
Hematopoietic Cell Proliferation | 2 1 1 1 1 1 2 1 1 1 1 |
Inflammation | 1 1 1 2 1 2 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 2 1|
Mixed Cell Focus | X X X X|
Mixed Cell Focus, Multiple | X X X X X X X X |
Necrosis | 3 2 2 3 |
Pigmentation | |
Bile Duct, Cyst | 3 |
Bile Duct, Fibrosis | 1 |
Bile Duct, Hyperplasia | 1 2 |
Centrilobular, Degeneration | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 5| 7| 5| 7| 6| 5| 5| 7| 7| 6| 6| 4| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 9| 3| 0| 0| 7| 3| 1| 5| 5| 3| 3| 7| 4| 3| 3| 9| 3| 1| 0| 3| 3| 3|
| 1| 2| 8| 9| 1| 2| 1| 1| 2| 3| 5| 1| 2| 2| 2| 4| 7| 3| 6| 1| 8| 1| 3| 1| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | |
Acinus, Hyperplasia | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M M + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Mineralization | 2 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + +|
Degeneration | |
Peridontal Tissue, Inflammation | 1 1 1 1 1 1 1 2 1 2 1 1 2 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + M + + + + + + + +|
Aorta, Mineralization | 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + M + + + + + + + +|
Cardiomyopathy | 1 1 2 2 1 1 1 1 1 1 1 1 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 2 1 1 2 2 2 2 2|
Degeneration, Cystic | 2 2 2 2 3 |
Hyperplasia | 3 3 3 2 1 2 2 2 2 4 3|
Hypertrophy | 2 3 3 2 2 2 2 2 3 2 2 2 2 2 2 3 3 4 2 2|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 5| 7| 5| 7| 6| 5| 5| 7| 7| 6| 6| 4| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 9| 3| 0| 0| 7| 3| 1| 5| 5| 3| 3| 7| 4| 3| 3| 9| 3| 1| 0| 3| 3| 3|
| 1| 2| 8| 9| 1| 2| 1| 1| 2| 3| 5| 1| 2| 2| 2| 4| 7| 3| 6| 1| 8| 1| 3| 1| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Necrosis | 3 |
Vacuolization Cytoplasmic | 1 2 1 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 2 1 1 2 2 1|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + M + + + M M + + + + + + + +|
Cyst | |
Hyperplasia | 1 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 2 2 3 2 2|
Cytoplasmic Alteration | 1 2 |
Pars Distalis, Hyperplasia | 3 3 2 2 2 2 2 3 3|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M M + + + + + + + +|
C-Cell, Hyperplasia | 2 3 3 2 2 2 1 2 2 |
Follicular Cell, Hyperplasia | 2 |
Follicular Cell, Hypertrophy | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 1 2 2 1 2 1 1 2 2 2 1 2 3 1 1 1 1 2 2 2 2 2 3|
Duct, Cyst | 2 3 2 2 2 2 4 3 2 3 1 2 2 3 2 2 3 3 2 3 3 1|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 2 2 2 2|
Interstitial Cell, Hyperplasia | 2 |
|__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 5| 7| 5| 7| 6| 5| 5| 7| 7| 6| 6| 4| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 9| 3| 0| 0| 7| 3| 1| 5| 5| 3| 3| 7| 4| 3| 3| 9| 3| 1| 0| 3| 3| 3|
| 1| 2| 8| 9| 1| 2| 1| 1| 2| 3| 5| 1| 2| 2| 2| 4| 7| 3| 6| 1| 8| 1| 3| 1| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 1 2 |
Metaplasia, Squamous | 2 1 1 3 1 2 1 2 4 3 2 1|
Cervix, Hyperplasia, Stromal | |
Cervix, Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 2 3 2 3 3 3 2 1 2 3 1 3 2 2 2 3 3 2|
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 2 3 3 3 2 4 2 3 4 2 3 3 4 3 |
|__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Congestion | 2 2 2 |
Mediastinal, Hyperplasia, Histiocytic| 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M M + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 2 3 2 2 3 2 2 2 2 2 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hemorrhage | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 1 3 2 2 2 2 2 2 2 3 1 3 4 1 3 2 2 2 1 1 1|
Pigmentation | 1 2 1 2 1 1 1 1 1 1 1 2 1 1 1 2 1 2 1 2 1 2|
Lymphoid Follicle, Atrophy | |
|__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + M + + + + + M + +|
Atrophy | 2 4 3 2 2 2 2 3 2 2 3 2 3 3 3 2 2 4|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 5| 7| 5| 7| 6| 5| 5| 7| 7| 6| 6| 4| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 9| 3| 0| 0| 7| 3| 1| 5| 5| 3| 3| 7| 4| 3| 3| 9| 3| 1| 0| 3| 3| 3|
| 1| 2| 8| 9| 1| 2| 1| 1| 2| 3| 5| 1| 2| 2| 2| 4| 7| 3| 6| 1| 8| 1| 3| 1| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 4 |
Hyperplasia | 1 3 1 1 1 1 2 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 2 2 2 1 2 2 2 2 1 2 1 2 2 2 1 1 1 1 2|
Inflammation | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 2 1 1 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Nasolacrimal Duct, Inflammation | |
Septum, Inflammation | 1 |
Turbinate, Inflammation | 1 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Retina, Atrophy | 2 |
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 5| 7| 5| 7| 6| 5| 5| 7| 7| 6| 6| 4| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 9| 3| 0| 0| 7| 3| 1| 5| 5| 3| 3| 7| 4| 3| 3| 9| 3| 1| 0| 3| 3| 3|
| 1| 2| 8| 9| 1| 2| 1| 1| 2| 3| 5| 1| 2| 2| 2| 4| 7| 3| 6| 1| 8| 1| 3| 1| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X |
Casts Protein | 1 1 |
Cyst | |
Infarct | 3 |
Inflammation, Suppurative | 1 |
Mineralization | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
Pelvis, Inflammation | 2 |
Transitional Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 1 |
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 5| 7| 6| 7| 6| 7| 7| 7| 5| 2| 4| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 5| 1| 3| 3| 0| 5| 1| 3| 9| 3| 9| 3| 0| 3| 3| 3| 5| 1| 4| 3| 4| 2| 1|
| 1| 1| 6| 3| 2| 1| 7| 7| 0| 2| 0| 1| 6| 3| 3| 2| 3| 1| 5| 1| 2| 2| 1| 1| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9|
| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X |
Basophilic Focus, Multiple | |
Clear Cell Focus | X |
Clear Cell Focus, Multiple | X X |
Eosinophilic Focus | X X X |
Eosinophilic Focus, Multiple | X X X X |
Fatty Change, Diffuse | 1 |
Fatty Change, Focal | 1 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1|
Inflammation | 1 1 1 1 2 1 1 1 2 1 1 1 1 1 2 1 1 1 1|
Mixed Cell Focus | X X X X|
Mixed Cell Focus, Multiple | X X X X X X X X X X X |
Necrosis | 2 3 2 |
Pigmentation | 1 |
Bile Duct, Cyst | |
Bile Duct, Fibrosis | 1 |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Degeneration | |
__________________________________________|__________________________________________________________________________|
Page 8
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 5| 7| 6| 7| 6| 7| 7| 7| 5| 2| 4| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 5| 1| 3| 3| 0| 5| 1| 3| 9| 3| 9| 3| 0| 3| 3| 3| 5| 1| 4| 3| 4| 2| 1|
| 1| 1| 6| 3| 2| 1| 7| 7| 0| 2| 0| 1| 6| 3| 3| 2| 3| 1| 5| 1| 2| 2| 1| 1| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9|
| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + |
Gingival, Hyperplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 1 |
Acinus, Atrophy | 1 |
Acinus, Hyperplasia | 3 3 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | 1 2 2|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + |
Degeneration | |
Peridontal Tissue, Inflammation | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 1 1 1|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 2 2 2 3 2 2 2|
Degeneration, Cystic | 2 2 2 2 |
Hyperplasia | 2 2 2 2 3 2 |
Hypertrophy | 2 1 2 1 1 2 1 1 1 4 2 2 3 2 2 2 2 2 1 1 2 2 3 2 2|
__________________________________________|__________________________________________________________________________|
Page 9
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 5| 7| 6| 7| 6| 7| 7| 7| 5| 2| 4| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 5| 1| 3| 3| 0| 5| 1| 3| 9| 3| 9| 3| 0| 3| 3| 3| 5| 1| 4| 3| 4| 2| 1|
| 1| 1| 6| 3| 2| 1| 7| 7| 0| 2| 0| 1| 6| 3| 3| 2| 3| 1| 5| 1| 2| 2| 1| 1| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9|
| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Necrosis | |
Vacuolization Cytoplasmic | 1 1 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 2 2 2 4 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 1 2 2 3 2 |
Cytoplasmic Alteration | |
Pars Distalis, Hyperplasia | 2 3 1 2 2 2 3 3 2 3 2 3 2|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 2 1 2 2 1|
Follicular Cell, Hyperplasia | |
Follicular Cell, Hypertrophy | 1 4 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 2 2 1 2 1 1 2 1 2 3 1 1 2 2 2 1 1 2 1 1 1|
Duct, Cyst | 2 2 2 3 3 2 1 2 3 3 3 2 3 1 2 2 2 3 3 2 3 2 2 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 2 2 2 3 2 2 3 1 |
Interstitial Cell, Hyperplasia | |
|__________________________________________________________________________|
Oviduct | + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 10
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 5| 7| 6| 7| 6| 7| 7| 7| 5| 2| 4| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 5| 1| 3| 3| 0| 5| 1| 3| 9| 3| 9| 3| 0| 3| 3| 3| 5| 1| 4| 3| 4| 2| 1|
| 1| 1| 6| 3| 2| 1| 7| 7| 0| 2| 0| 1| 6| 3| 3| 2| 3| 1| 5| 1| 2| 2| 1| 1| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9|
| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | 3 |
Inflammation, Chronic Active | 2 4 |
Inflammation, Suppurative | 2 1 |
Metaplasia, Squamous | 3 2 2 4 2 2 2 2 2 4 4 |
Cervix, Hyperplasia, Stromal | 3 |
Cervix, Inflammation, Suppurative | 3 |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 3 2 4 2 2 3 3 2 3 4 2 1|
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 3 3 3 3 4 2 4 3 4 4|
|__________________________________________________________________________|
Lymph Node | |
Mediastinal, Congestion | |
Mediastinal, Hyperplasia, Histiocytic| |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 3 3 2 2 2 2 3 2 3 2 3 2 2 2 2 3 2 2|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2 1 1 1 2 1 3 3 1 1 1 1 1 2 2 1 3 2|
Pigmentation | 1 1 1 2 2 1 3 1 2 1 2 2 1 1 1 1 3 1 2 3 1 1|
Lymphoid Follicle, Atrophy | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + M + M + + + + + + + + + + + +|
Atrophy | 3 3 4 3 3 2 2 2 3 2 2 2 3 2 2 2 3 3|
__________________________________________|__________________________________________________________________________|
Page 11
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 5| 7| 6| 7| 6| 7| 7| 7| 5| 2| 4| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 5| 1| 3| 3| 0| 5| 1| 3| 9| 3| 9| 3| 0| 3| 3| 3| 5| 1| 4| 3| 4| 2| 1|
| 1| 1| 6| 3| 2| 1| 7| 7| 0| 2| 0| 1| 6| 3| 3| 2| 3| 1| 5| 1| 2| 2| 1| 1| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9|
| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 3 1 1 1 1 2 2 1 1 2 1|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2 2 2 1 1 1 2 2 2 2 1 1 2 2 2 2 1 2 1 2 2 1|
Inflammation | 2 3 2 2 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Nasolacrimal Duct, Inflammation | 3 |
Septum, Inflammation | 1 2 2 |
Turbinate, Inflammation | 1 1 1 1 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
Retina, Atrophy | 1 |
__________________________________________|__________________________________________________________________________|
Page 12
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 5| 7| 6| 7| 6| 7| 7| 7| 5| 2| 4| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 5| 1| 3| 3| 0| 5| 1| 3| 9| 3| 9| 3| 0| 3| 3| 3| 5| 1| 4| 3| 4| 2| 1|
| 1| 1| 6| 3| 2| 1| 7| 7| 0| 2| 0| 1| 6| 3| 3| 2| 3| 1| 5| 1| 2| 2| 1| 1| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9|
| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 1 |
Casts Protein | 1 |
Cyst | 2 |
Infarct | |
Inflammation, Suppurative | |
Mineralization | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 |
Pelvis, Inflammation | |
Transitional Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1|
__________________________________________|__________________________________________________________________________
Page 13
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 7| 7| | |
DAY ON TEST | 6| 3| 3| | |
| 4| 1| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 UG/KG | 9| 9| 9| | L |
| 3| 5| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 52 |
Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | 1 | 5 1.8|
Basophilic Focus | X X | 8 |
Basophilic Focus, Multiple | | 8 |
Clear Cell Focus | | 3 |
Clear Cell Focus, Multiple | | 3 |
Eosinophilic Focus | X | 5 |
Eosinophilic Focus, Multiple | | 7 |
Fatty Change, Diffuse | | 3 1.0|
Fatty Change, Focal | 1 | 4 1.0|
Hematopoietic Cell Proliferation | | 20 1.1|
Inflammation | 1 1 | 44 1.2|
Mixed Cell Focus | | 8 |
Mixed Cell Focus, Multiple | X X | 21 |
Necrosis | | 7 2.4|
Pigmentation | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 7| 7| | |
DAY ON TEST | 6| 3| 3| | |
| 4| 1| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 UG/KG | 9| 9| 9| | L |
| 3| 5| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Bile Duct, Cyst | 3 2 | 3 2.7|
Bile Duct, Fibrosis | | 2 1.0|
Bile Duct, Hyperplasia | 2 2 | 5 1.8|
Centrilobular, Degeneration | | 2 2.0|
|__________________________________________________________________________|____________|
Oral Mucosa | | 21 |
Gingival, Hyperplasia, Squamous | | 21 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Inflammation, Chronic Active | | 2 2.0|
Acinus, Atrophy | | 1 1.0|
Acinus, Hyperplasia | | 3 2.7|
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 51 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Hyperplasia, Squamous | | 3 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Erosion | | 1 2.0|
Mineralization | 2 | 5 1.8|
|__________________________________________________________________________|____________|
Tooth | + + | 34 |
Degeneration | 3 | 1 3.0|
Peridontal Tissue, Inflammation | 1 3 | 33 1.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 52 |
Aorta, Mineralization | | 2 2.0|
|__________________________________________________________________________|____________|
Heart | + + + | 52 |
Cardiomyopathy | 1 1 | 22 1.1|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 7| 7| | |
DAY ON TEST | 6| 3| 3| | |
| 4| 1| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 UG/KG | 9| 9| 9| | L |
| 3| 5| 7| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | | 21 1.9|
Degeneration, Cystic | | 9 2.1|
Hyperplasia | 3 | 18 2.4|
Hypertrophy | 2 2 2 | 48 2.1|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic | 2 | 10 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Hyperplasia | | 18 2.1|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 49 |
Cyst | | 1 2.0|
Hyperplasia | | 2 1.5|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Angiectasis | 2 | 15 2.0|
Cytoplasmic Alteration | | 2 1.5|
Pars Distalis, Hyperplasia | 4 | 23 2.4|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 51 |
C-Cell, Hyperplasia | 2 2 | 19 1.9|
Follicular Cell, Hyperplasia | | 1 2.0|
Follicular Cell, Hypertrophy | | 5 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 7| 7| | |
DAY ON TEST | 6| 3| 3| | |
| 4| 1| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 UG/KG | 9| 9| 9| | L |
| 3| 5| 7| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Clitoral Gland | + + + | 53 |
Inflammation | 1 1 2 | 52 1.6|
Duct, Cyst | 1 2 4 | 49 2.3|
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Atrophy | 4 4 | 47 4.0|
Cyst | 3 3 | 14 2.2|
Interstitial Cell, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Oviduct | + + + | 50 |
Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Adenomyosis | 4 | 2 3.5|
Inflammation, Chronic Active | | 2 3.0|
Inflammation, Suppurative | | 5 1.6|
Metaplasia, Squamous | | 23 2.3|
Cervix, Hyperplasia, Stromal | | 1 3.0|
Cervix, Inflammation, Suppurative | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 | 37 2.4|
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Hyperplasia | 2 2 2 | 34 2.9|
|__________________________________________________________________________|____________|
Lymph Node | | 3 |
Mediastinal, Congestion | | 3 2.0|
Mediastinal, Hyperplasia, Histiocytic| | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 7| 7| | |
DAY ON TEST | 6| 3| 3| | |
| 4| 1| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 UG/KG | 9| 9| 9| | L |
| 3| 5| 7| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mandibular | + + + | 51 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 2 3 2 | 37 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 52 |
Hemorrhage | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Hematopoietic Cell Proliferation | 1 1 1 | 46 1.7|
Pigmentation | 3 1 2 | 47 1.5|
Lymphoid Follicle, Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + | 48 |
Atrophy | 3 2 | 38 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Cyst | | 2 3.0|
Hyperplasia | 1 3 | 22 1.5|
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Hemorrhage | | 1 3.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 7| 7| | |
DAY ON TEST | 6| 3| 3| | |
| 4| 1| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 UG/KG | 9| 9| 9| | L |
| 3| 5| 7| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lung | + + + | 52 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 1 | 45 1.6|
Inflammation | 2 | 6 2.2|
Alveolar Epithelium, Hyperplasia | 1 | 20 1.1|
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation | | 1 1.0|
Nasolacrimal Duct, Inflammation | 3 | 2 3.0|
Septum, Inflammation | | 4 1.5|
Turbinate, Inflammation | | 8 1.1|
|__________________________________________________________________________|____________|
Trachea | + + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
Degeneration | | 1 3.0|
Retina, Atrophy | | 2 1.5|
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Inflammation | | 20 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Calculus Micro Observation Only | | 3 1.0|
Casts Protein | | 3 1.0|
Cyst | | 1 2.0|
Infarct | | 1 3.0|
Inflammation, Suppurative | | 1 1.0|
Mineralization | 1 1 1 | 40 1.1|
Nephropathy | 1 1 1 | 34 1.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 7| 7| | |
DAY ON TEST | 6| 3| 3| | |
| 4| 1| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 UG/KG | 9| 9| 9| | L |
| 3| 5| 7| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Pelvis, Inflammation | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Inflammation | | 8 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 3| 6| 6| 5| 6| 3| 2| 6| 2| 5| 7| 4| 4| 7| 7| 6| 7| 7| 3| 7|
DAY ON TEST | 3| 6| 9| 1| 2| 5| 2| 3| 0| 2| 1| 5| 1| 6| 0| 3| 7| 7| 3| 3| 2| 3| 3| 9| 3|
| 3| 3| 6| 3| 7| 2| 4| 7| 2| 4| 0| 0| 6| 1| 7| 2| 9| 9| 1| 1| 4| 1| 3| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 2 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X X X X X |
Clear Cell Focus | X X |
Clear Cell Focus, Multiple | |
Eosinophilic Focus | X |
Eosinophilic Focus, Multiple | X|
Fatty Change, Diffuse | 1 2 2 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1|
Inflammation | 1 1 1 1 2 1 1 2 1 1 2 1 1 1 1 1 1 2 1|
Mixed Cell Focus | X |
Mixed Cell Focus, Multiple | X X X X X X |
Necrosis | 2 2 2 3 |
Pigmentation | |
Bile Duct, Cyst | |
Bile Duct, Fibrosis | |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Degeneration | 3 3 2 1 |
Hepatocyte, Hypertrophy | 1 2|
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 3| 6| 6| 5| 6| 3| 2| 6| 2| 5| 7| 4| 4| 7| 7| 6| 7| 7| 3| 7|
DAY ON TEST | 3| 6| 9| 1| 2| 5| 2| 3| 0| 2| 1| 5| 1| 6| 0| 3| 7| 7| 3| 3| 2| 3| 3| 9| 3|
| 3| 3| 6| 3| 7| 2| 4| 7| 2| 4| 0| 0| 6| 1| 7| 2| 9| 9| 1| 1| 4| 1| 3| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + |
Gingival, Hyperplasia, Squamous | 3 1 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 2 2|
Mineralization | 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 |
|__________________________________________________________________________|
Tooth | + + + + + + |
Peridontal Tissue, Inflammation | 1 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 1 1 1 3 |
Inflammation | 3 |
Necrosis | 3 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 2 2 2 2 1 2 |
Degeneration, Cystic | 2 2 3 1 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 2 1 2 3 2 3 3 2 2 |
__________________________________________|__________________________________________________________________________|
Page 22
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 3| 6| 6| 5| 6| 3| 2| 6| 2| 5| 7| 4| 4| 7| 7| 6| 7| 7| 3| 7|
DAY ON TEST | 3| 6| 9| 1| 2| 5| 2| 3| 0| 2| 1| 5| 1| 6| 0| 3| 7| 7| 3| 3| 2| 3| 3| 9| 3|
| 3| 3| 6| 3| 7| 2| 4| 7| 2| 4| 0| 0| 6| 1| 7| 2| 9| 9| 1| 1| 4| 1| 3| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hypertrophy | 2 2 2 2 2 1 1 3 1 2 2 3 1 2 2 1 1|
Necrosis | 3 |
Vacuolization Cytoplasmic | 1 3 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 3 2 2 3|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + M M + + + +|
Fibrosis | 3 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 3 3|
Pars Distalis, Hyperplasia | 2 3 1 3 2 2 2 3 3 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
C-Cell, Hyperplasia | 2 2 1 2 3 3 2 2 |
Follicular Cell, Hypertrophy | 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 2 2 2 2 2 2 3 2 2 1 1 3 2 3 1 3 2 2 2 2|
Duct, Cyst | 2 2 4 3 3 2 1 3 2 3 2 3 2 2 3 3 4 3 1 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 2 2 |
|__________________________________________________________________________|
Oviduct | + M + M + M M M + M M + + + + + + + + + M + + M +|
Cyst | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 3| 6| 6| 5| 6| 3| 2| 6| 2| 5| 7| 4| 4| 7| 7| 6| 7| 7| 3| 7|
DAY ON TEST | 3| 6| 9| 1| 2| 5| 2| 3| 0| 2| 1| 5| 1| 6| 0| 3| 7| 7| 3| 3| 2| 3| 3| 9| 3|
| 3| 3| 6| 3| 7| 2| 4| 7| 2| 4| 0| 0| 6| 1| 7| 2| 9| 9| 1| 1| 4| 1| 3| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | 2 |
Angiectasis | 3|
Hemorrhage | 3 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 2 |
Metaplasia, Squamous | 2 3 2 3 4 1 3 1 2 2 2 1 1 |
Ulcer | |
Endometrium, Hyperplasia, Cystic | 2 2 1 3 2 2 1 3 1 3 3 2 3|
|__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 4 4 3 4 3 4 2 4 3 3 4 3 3 2 2 4|
|__________________________________________________________________________|
Lymph Node | + |
Hyperplasia, Plasma Cell | |
Lumbar, Ectasia | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 3 2 2 3 2 2 2 2 2 2 2 2 2 2 3|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 1 3 2 2 3 4 4 1 1 3 2 2 2 3 2 2 2 3|
Necrosis | |
Pigmentation | 2 1 2 2 1 1 1 2 1 1 2 3 1 1 2 1 1 2 1 2 2 2 |
Lymphoid Follicle, Atrophy | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 4 3 4 3 2 4 2 2 3 3 2 2 2 3 3 |
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 3| 6| 6| 5| 6| 3| 2| 6| 2| 5| 7| 4| 4| 7| 7| 6| 7| 7| 3| 7|
DAY ON TEST | 3| 6| 9| 1| 2| 5| 2| 3| 0| 2| 1| 5| 1| 6| 0| 3| 7| 7| 3| 3| 2| 3| 3| 9| 3|
| 3| 3| 6| 3| 7| 2| 4| 7| 2| 4| 0| 0| 6| 1| 7| 2| 9| 9| 1| 1| 4| 1| 3| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Cyst | 3 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hyperplasia | 1 2 1 1 2 1 2|
Inflammation, Granulomatous | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 1 1 2 2 3 2 2 1 3 2 3 2 2 1 2|
Inflammation | 1 2|
Alveolar Epithelium, Hyperplasia | 2 1 1 3 1 1 1 2 1 2 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation | 2 1 2 4 |
Respiratory Epithelium, | |
Mineralization | |
Septum, Inflammation | 2 2 |
Squamous Epithelium, Hyperplasia | |
Turbinate, Inflammation | 2 2 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 3| 6| 6| 5| 6| 3| 2| 6| 2| 5| 7| 4| 4| 7| 7| 6| 7| 7| 3| 7|
DAY ON TEST | 3| 6| 9| 1| 2| 5| 2| 3| 0| 2| 1| 5| 1| 6| 0| 3| 7| 7| 3| 3| 2| 3| 3| 9| 3|
| 3| 3| 6| 3| 7| 2| 4| 7| 2| 4| 0| 0| 6| 1| 7| 2| 9| 9| 1| 1| 4| 1| 3| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 3 1 |
Calculus Micro Observation Only | X |
Casts Protein | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 3 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis | 3 |
Nephropathy | 1 1 1 1 1 2 1 1 1 1 2 1|
Pelvis, Dilatation | 3 |
Pelvis, Inflammation | 2 2 |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation | 3 2 1 1 2 |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________|__________________________________________________________________________
Page 26
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 3| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 3| 5| 3| 4| 7| 5|
DAY ON TEST | 6| 3| 0| 4| 3| 3| 2| 2| 0| 3| 3| 7| 5| 3| 3| 3| 0| 5| 0| 3| 4| 1| 3| 3| 0|
| 0| 1| 5| 7| 2| 3| 2| 8| 1| 1| 1| 5| 7| 1| 1| 1| 0| 0| 1| 1| 5| 0| 8| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8|
| 1| 2| 3| 4| 5| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 6| 7| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X X X X X |
Clear Cell Focus | X |
Clear Cell Focus, Multiple | X X |
Eosinophilic Focus | |
Eosinophilic Focus, Multiple | |
Fatty Change, Diffuse | 2 1 1|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 2 2 1 |
Inflammation | 3 1 1 1 2 1 1 1 3 1 1 1 1 1 1 1|
Mixed Cell Focus | X X |
Mixed Cell Focus, Multiple | X X X X X X X X X X |
Necrosis | 3 1 |
Pigmentation | 1 |
Bile Duct, Cyst | 2 2 |
Bile Duct, Fibrosis | 1 |
Bile Duct, Hyperplasia | 2 2 |
Centrilobular, Degeneration | 3 2 3 2 |
Hepatocyte, Hypertrophy | 1 1 1|
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 3| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 3| 5| 3| 4| 7| 5|
DAY ON TEST | 6| 3| 0| 4| 3| 3| 2| 2| 0| 3| 3| 7| 5| 3| 3| 3| 0| 5| 0| 3| 4| 1| 3| 3| 0|
| 0| 1| 5| 7| 2| 3| 2| 8| 1| 1| 1| 5| 7| 1| 1| 1| 0| 0| 1| 1| 5| 0| 8| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8|
| 1| 2| 3| 4| 5| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 6| 7| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + |
Gingival, Hyperplasia, Squamous | 1 3 2 2 1 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 1 2 |
Mineralization | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 2 |
|__________________________________________________________________________|
Tooth | + + + + + + + |
Peridontal Tissue, Inflammation | 1 3 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1|
Inflammation | 3 |
Necrosis | |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 1 1 2 2 2 2 2 2 1 2 2 2 |
Degeneration, Cystic | 2 2 1 3 3 3 2 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 3 3 2 3 3 3 3 2 2 3 3 2 2 2 |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 3| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 3| 5| 3| 4| 7| 5|
DAY ON TEST | 6| 3| 0| 4| 3| 3| 2| 2| 0| 3| 3| 7| 5| 3| 3| 3| 0| 5| 0| 3| 4| 1| 3| 3| 0|
| 0| 1| 5| 7| 2| 3| 2| 8| 1| 1| 1| 5| 7| 1| 1| 1| 0| 0| 1| 1| 5| 0| 8| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8|
| 1| 2| 3| 4| 5| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 6| 7| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hypertrophy | 2 3 2 2 2 3 2 1 2 2 1 3 2 2 1 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 3 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 3 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + + + + + + + + + + + M + + + + +|
Fibrosis | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 2 3 2 3 1 2 3 3 2|
Pars Distalis, Hyperplasia | 2 2 1 1 2 3|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + M + + + + +|
Angiectasis | |
C-Cell, Hyperplasia | 2 2 2 3 3 2 2 1 |
Follicular Cell, Hypertrophy | 1 2 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + M M + + + + + + + + + + M + + + + + + + + + + +|
Inflammation | 2 2 2 3 2 2 1 2 2 3 2 1 2 3 2 2 1 1 1|
Duct, Cyst | 2 3 3 3 2 2 2 3 2 3 1 3 2 3 1 3 3|
|__________________________________________________________________________|
Ovary | + + M + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 3 2 3 2 |
|__________________________________________________________________________|
Oviduct | + + M + + M M M + + + + + + M M M + + + + + + + +|
Cyst | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 3| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 3| 5| 3| 4| 7| 5|
DAY ON TEST | 6| 3| 0| 4| 3| 3| 2| 2| 0| 3| 3| 7| 5| 3| 3| 3| 0| 5| 0| 3| 4| 1| 3| 3| 0|
| 0| 1| 5| 7| 2| 3| 2| 8| 1| 1| 1| 5| 7| 1| 1| 1| 0| 0| 1| 1| 5| 0| 8| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8|
| 1| 2| 3| 4| 5| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 6| 7| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | |
Angiectasis | |
Hemorrhage | 3|
Inflammation, Chronic Active | 3|
Inflammation, Suppurative | 2 3 1 |
Metaplasia, Squamous | 3 4 1 1 1 2 1 4 2 2 2 1 2 2 4|
Ulcer | 2|
Endometrium, Hyperplasia, Cystic | 1 1 2 1 3 1 3 2 2 3 1 2 2 3 |
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 2 4 3 3 4 4 4 2 3 4 4 3 4 3 3|
|__________________________________________________________________________|
Lymph Node | + |
Hyperplasia, Plasma Cell | |
Lumbar, Ectasia | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + M + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 2 2 2 2 3 2 1 2 3 3 2 2 2 2 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 4 3 2 1 2 2 1 2 1 4 2 2 2 3 3 1 2 3 3 2 2 |
Necrosis | |
Pigmentation | 2 1 1 2 3 2 1 1 1 2 1 1 1 1 2 1 1 2 3|
Lymphoid Follicle, Atrophy | 2 3 3 2|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 3 2 4 3 2 4 4 2 2 2 3 3 2 2 3|
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 3| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 3| 5| 3| 4| 7| 5|
DAY ON TEST | 6| 3| 0| 4| 3| 3| 2| 2| 0| 3| 3| 7| 5| 3| 3| 3| 0| 5| 0| 3| 4| 1| 3| 3| 0|
| 0| 1| 5| 7| 2| 3| 2| 8| 1| 1| 1| 5| 7| 1| 1| 1| 0| 0| 1| 1| 5| 0| 8| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8|
| 1| 2| 3| 4| 5| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 6| 7| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Cyst | |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 2 1 2 1 2 2 1 2 1 1 1 1 1 |
Inflammation, Granulomatous | 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 2 2 1 1 2 2 2 2 2 2 1 1 2 1 1 1 2 1 1 1 |
Inflammation | 2 3 1 2|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 3 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation | 2 |
Respiratory Epithelium, | |
Mineralization | 2 |
Septum, Inflammation | 2 |
Squamous Epithelium, Hyperplasia | 2 |
Turbinate, Inflammation | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 3| 7| 4| 6| 7| 7| 6| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 3| 5| 3| 4| 7| 5|
DAY ON TEST | 6| 3| 0| 4| 3| 3| 2| 2| 0| 3| 3| 7| 5| 3| 3| 3| 0| 5| 0| 3| 4| 1| 3| 3| 0|
| 0| 1| 5| 7| 2| 3| 2| 8| 1| 1| 1| 5| 7| 1| 1| 1| 0| 0| 1| 1| 5| 0| 8| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8|
| 1| 2| 3| 4| 5| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 6| 7| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation | 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 2 |
Calculus Micro Observation Only | X X X |
Casts Protein | |
Inflammation, Chronic Active | 1 1 |
Inflammation, Suppurative | 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 4 1 1 1 1 1 1|
Necrosis | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 2 |
Pelvis, Dilatation | 2 |
Pelvis, Inflammation | 2 2 |
Renal Tubule, Hyperplasia | 2 |
Transitional Epithelium, Hyperplasia | 2 1 2 |
|__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation | 1 3 2 1 1 1 |
Transitional Epithelium, Hyperplasia | 2 2 |
__________________________________________|__________________________________________________________________________
Page 32
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 5| 3| 2| 4| | |
DAY ON TEST | 9| 5| 6| 7| | |
| 0| 2| 1| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
10 UG/KG | 8| 8| 8| 8| | L |
| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
Muscularis, Inflammation | | 3 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 54 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 54 |
Parasite Metazoan | | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 54 |
|__________________________________________________________________________|____________|
Liver | + + + + | 54 |
Angiectasis | | 2 2.5|
Basophilic Focus | X | 5 |
Basophilic Focus, Multiple | | 12 |
Clear Cell Focus | | 3 |
Clear Cell Focus, Multiple | | 2 |
Eosinophilic Focus | | 1 |
Eosinophilic Focus, Multiple | | 1 |
Fatty Change, Diffuse | 1 | 7 1.4|
Hematopoietic Cell Proliferation | 1 1 1 | 22 1.1|
Inflammation | 1 1 1 1 | 39 1.2|
Mixed Cell Focus | | 3 |
Mixed Cell Focus, Multiple | | 16 |
Necrosis | 1 | 7 2.0|
Pigmentation | | 1 1.0|
Bile Duct, Cyst | | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 5| 3| 2| 4| | |
DAY ON TEST | 9| 5| 6| 7| | |
| 0| 2| 1| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
10 UG/KG | 8| 8| 8| 8| | L |
| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Bile Duct, Fibrosis | | 1 1.0|
Bile Duct, Hyperplasia | | 3 2.0|
Centrilobular, Degeneration | 2 3 | 10 2.4|
Hepatocyte, Hypertrophy | | 5 1.2|
|__________________________________________________________________________|____________|
Oral Mucosa | | 12 |
Gingival, Hyperplasia, Squamous | | 10 1.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + | 54 |
Degeneration | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + | 52 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
Hyperkeratosis | | 1 2.0|
Hyperplasia, Squamous | | 4 1.8|
Mineralization | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
Mineralization | 1 | 8 1.3|
|__________________________________________________________________________|____________|
Tooth | | 13 |
Peridontal Tissue, Inflammation | | 13 1.4|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + | 54 |
Aorta, Mineralization | | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + | 54 |
Cardiomyopathy | 1 | 18 1.2|
Inflammation | | 2 3.0|
Necrosis | | 1 3.0|
Thrombosis | | 2 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 5| 3| 2| 4| | |
DAY ON TEST | 9| 5| 6| 7| | |
| 0| 2| 1| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
10 UG/KG | 8| 8| 8| 8| | L |
| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 54 |
Angiectasis | | 23 1.7|
Degeneration, Cystic | | 12 2.2|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 2 | 24 2.4|
Hypertrophy | 2 1 | 35 1.9|
Necrosis | | 2 2.5|
Vacuolization Cytoplasmic | | 8 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 54 |
Hyperplasia | 2 | 14 2.1|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 54 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M M + | 46 |
Fibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 54 |
Angiectasis | | 16 2.5|
Pars Distalis, Hyperplasia | 3 2 | 18 2.2|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 52 |
Angiectasis | | 1 2.0|
C-Cell, Hyperplasia | 2 | 17 2.1|
Follicular Cell, Hypertrophy | 2 | 9 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + | 51 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 5| 3| 2| 4| | |
DAY ON TEST | 9| 5| 6| 7| | |
| 0| 2| 1| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
10 UG/KG | 8| 8| 8| 8| | L |
| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation | 2 2 1 2 | 45 1.9|
Duct, Cyst | 3 4 3 | 40 2.5|
|__________________________________________________________________________|____________|
Ovary | + + + + | 53 |
Atrophy | 4 4 4 4 | 43 4.0|
Cyst | 2 | 7 2.3|
|__________________________________________________________________________|____________|
Oviduct | + + + + | 38 |
Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + | 54 |
Adenomyosis | | 1 2.0|
Angiectasis | | 1 3.0|
Hemorrhage | | 2 3.0|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | 1 | 6 1.8|
Metaplasia, Squamous | 1 | 29 2.1|
Ulcer | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 3 3 | 29 2.1|
|__________________________________________________________________________|____________|
Vagina | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
Hyperplasia | 4 4 4 3 | 41 3.3|
|__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Lumbar, Ectasia | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 52 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 5| 3| 2| 4| | |
DAY ON TEST | 9| 5| 6| 7| | |
| 0| 2| 1| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
10 UG/KG | 8| 8| 8| 8| | L |
| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 3 1 4 2 | 36 2.2|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 54 |
Ectasia | | 1 1.0|
|__________________________________________________________________________|____________|
Spleen | + + + + | 54 |
Hematopoietic Cell Proliferation | 4 3 3 3 | 48 2.3|
Necrosis | 2 | 1 2.0|
Pigmentation | 1 | 42 1.5|
Lymphoid Follicle, Atrophy | 2 | 6 2.3|
|__________________________________________________________________________|____________|
Thymus | + + + + | 53 |
Atrophy | 2 2 3 | 38 2.7|
Cyst | | 1 3.0|
Hemorrhage | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + | 54 |
Cyst | | 1 3.0|
Hyperplasia | 2 1 | 23 1.4|
Inflammation, Granulomatous | | 2 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + | 54 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + | 54 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 5| 3| 2| 4| | |
DAY ON TEST | 9| 5| 6| 7| | |
| 0| 2| 1| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
10 UG/KG | 8| 8| 8| 8| | L |
| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Glial Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Infiltration Cellular, Histiocyte | 1 1 | 40 1.6|
Inflammation | 2 | 7 1.9|
Alveolar Epithelium, Hyperplasia | | 21 1.4|
|__________________________________________________________________________|____________|
Nose | + + + + | 54 |
Cyst | | 1 3.0|
Inflammation | 1 | 6 2.0|
Respiratory Epithelium, | | |
Mineralization | | 1 2.0|
Septum, Inflammation | | 3 2.0|
Squamous Epithelium, Hyperplasia | | 1 2.0|
Turbinate, Inflammation | | 3 1.7|
|__________________________________________________________________________|____________|
Trachea | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + | 54 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + | 54 |
Atrophy | 1 | 1 1.0|
Inflammation | | 9 1.1|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + | 54 |
Accumulation, Hyaline Droplet | | 3 2.0|
Calculus Micro Observation Only | X | 5 |
Casts Protein | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 5| 3| 2| 4| | |
DAY ON TEST | 9| 5| 6| 7| | |
| 0| 2| 1| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
10 UG/KG | 8| 8| 8| 8| | L |
| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Inflammation, Chronic Active | | 2 1.0|
Inflammation, Suppurative | | 2 2.0|
Mineralization | 1 1 | 42 1.1|
Necrosis | | 1 3.0|
Nephropathy | | 23 1.1|
Pelvis, Dilatation | | 2 2.5|
Pelvis, Inflammation | | 4 2.0|
Renal Tubule, Hyperplasia | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 5 1.8|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 53 |
Calculus Micro Observation Only | | 1 |
Inflammation | | 11 1.6|
Transitional Epithelium, Hyperplasia | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 6| 7| 5| 6| 4| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 4| 8| 3| 5| 3| 5| 7| 1| 3| 3| 0| 0| 3| 0| 3| 3| 9| 3| 1|
| 3| 2| 2| 2| 4| 0| 3| 3| 1| 6| 2| 3| 4| 8| 2| 3| 1| 1| 1| 0| 3| 2| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
UG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 6| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1|
Basophilic Focus | X X X X X X X X |
Basophilic Focus, Multiple | X X X |
Clear Cell Focus | |
Clear Cell Focus, Multiple | |
Eosinophilic Focus | X X X X|
Eosinophilic Focus, Multiple | X X X X X |
Fatty Change, Diffuse | 1 1 |
Fatty Change, Focal | 1 |
Hematopoietic Cell Proliferation | 2 1 1 1 1 1 |
Inflammation | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X X X |
Mixed Cell Focus, Multiple | X X X X X X X X X X X|
Necrosis | 2 |
Pigmentation | |
Bile Duct, Cyst | 3 |
Bile Duct, Fibrosis | |
Bile Duct, Hyperplasia | 1 |
Centrilobular, Degeneration | 1 2 |
Hepatocyte, Hypertrophy | 1 1 2 |
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 6| 7| 5| 6| 4| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 4| 8| 3| 5| 3| 5| 7| 1| 3| 3| 0| 0| 3| 0| 3| 3| 9| 3| 1|
| 3| 2| 2| 2| 4| 0| 3| 3| 1| 6| 2| 3| 4| 8| 2| 3| 1| 1| 1| 0| 3| 2| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
UG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 6| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Serosa, Inflammation | 3 |
|__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + |
Gingival, Hyperplasia, Squamous | 1 2 1 1 1 1 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | |
Acinus, Atrophy | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 2 |
Serosa, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | 1 1 2 1 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + |
Peridontal Tissue, Inflammation | 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 1 1 1 2 1 2 2 2 2 2 1 3 2|
Degeneration, Cystic | 3 2 2 2 2 2 3 2 |
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 6| 7| 5| 6| 4| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 4| 8| 3| 5| 3| 5| 7| 1| 3| 3| 0| 0| 3| 0| 3| 3| 9| 3| 1|
| 3| 2| 2| 2| 4| 0| 3| 3| 1| 6| 2| 3| 4| 8| 2| 3| 1| 1| 1| 0| 3| 2| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
UG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 6| 8|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hyperplasia | 3 3 2 1 2 3 3 3 3 2 2 4 3 |
Hypertrophy | 2 2 2 1 2 2 2 2 3 2 2 2 1 1 1 2 2 2 2 2 2 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 2 2 2 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 1 3 3 1 1 1 2 1 3 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 3 3 3 3 2 |
Cyst | |
Cytoplasmic Alteration | 2 |
Pars Distalis, Hyperplasia | 2 2 2 3 2 2 2 1 2 3 1|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 3 2 4 2 2 1 2 |
Follicular Cell, Hypertrophy | 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 2 2 3 2 1 2 2 1 1 1 2 1 2 2 1 2 |
Duct, Cyst | 2 2 1 3 4 2 3 1 3 2 3 2 3 3 2 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 2 3 2 2 2 2 2|
Inflammation, Chronic Active | 4 |
Necrosis | 2 |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 6| 7| 5| 6| 4| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 4| 8| 3| 5| 3| 5| 7| 1| 3| 3| 0| 0| 3| 0| 3| 3| 9| 3| 1|
| 3| 2| 2| 2| 4| 0| 3| 3| 1| 6| 2| 3| 4| 8| 2| 3| 1| 1| 1| 0| 3| 2| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
UG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 6| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Oviduct | + + + M + M + + + + + + + + M + + + + + + + + + +|
Cyst | 3 |
Dilatation | |
Inflammation, Chronic Active | 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | 1 |
Metaplasia, Squamous | 3 2 2 1 4 2 2 2 2 |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 3 3 1 4 4 2 3 3 2 2 2 4 1 4 |
|__________________________________________________________________________|
Vagina | |
Inflammation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 4 3 3 4 2 2 2 4 4 2 4 3 2 2|
|__________________________________________________________________________|
Lymph Node | + + |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
Lumbar, Ectasia | 3 3 |
Lumbar, Hemorrhage | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | 2 2 2 2 3 2 2 2 2 2 2 2 3 2|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 3 1 2 3 1 3 2 2 2 2 3 2 1 1 2 2 1 1 2|
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 6| 7| 5| 6| 4| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 4| 8| 3| 5| 3| 5| 7| 1| 3| 3| 0| 0| 3| 0| 3| 3| 9| 3| 1|
| 3| 2| 2| 2| 4| 0| 3| 3| 1| 6| 2| 3| 4| 8| 2| 3| 1| 1| 1| 0| 3| 2| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
UG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 6| 8|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Necrosis | |
Pigmentation | 2 2 2 2 1 1 2 2 1 2 2 1 2 2 1 1 2 2 1 1 2 1 2|
Lymphoid Follicle, Atrophy | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 3 2 2 2 3 2 3 2 3 3 4 3 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 3 |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 3 2 1 1 2 3 2 2 2 2 2 3 2 1 2 2 1|
Inflammation | 2 2 |
Alveolar Epithelium, Hyperplasia | 2 2 2 2 2 1 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Goblet Cell, Hyperplasia | 2 3 |
Respiratory Epithelium, Hyperplasia | |
Septum, Inflammation | 1 2 |
Turbinate, Inflammation | 1 2 |
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 6| 7| 5| 6| 4| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 4| 8| 3| 5| 3| 5| 7| 1| 3| 3| 0| 0| 3| 0| 3| 3| 9| 3| 1|
| 3| 2| 2| 2| 4| 0| 3| 3| 1| 6| 2| 3| 4| 8| 2| 3| 1| 1| 1| 0| 3| 2| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
UG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 6| 8|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Retina, Atrophy | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Calculus Micro Observation Only | X X X |
Casts Protein | 1 |
Degeneration | 2 |
Hydronephrosis | |
Infarct | |
Inflammation, Suppurative | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 |
Pelvis, Inflammation | |
Renal Tubule, Degeneration | 3 |
Transitional Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Ureter | |
Cyst | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 45
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 5| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 5| 7| 7| 7| 5|
DAY ON TEST | 2| 9| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 0| 2|
| 2| 6| 3| 1| 2| 1| 1| 4| 1| 1| 2| 3| 9| 3| 1| 3| 9| 1| 4| 6| 0| 1| 2| 1| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
UG/KG | 1| 3| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X |
Basophilic Focus, Multiple | X X X X |
Clear Cell Focus | X X X |
Clear Cell Focus, Multiple | X |
Eosinophilic Focus | X X X |
Eosinophilic Focus, Multiple | X X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 1 1 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1|
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2|
Mixed Cell Focus | X X X X |
Mixed Cell Focus, Multiple | X X X X X X X X X |
Necrosis | 3 2 2 3 2|
Pigmentation | 2|
Bile Duct, Cyst | 2 |
Bile Duct, Fibrosis | 1 |
Bile Duct, Hyperplasia | 1 |
Centrilobular, Degeneration | 3 3|
Hepatocyte, Hypertrophy | 1 2 |
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 5| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 5| 7| 7| 7| 5|
DAY ON TEST | 2| 9| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 0| 2|
| 2| 6| 3| 1| 2| 1| 1| 4| 1| 1| 2| 3| 9| 3| 1| 3| 9| 1| 4| 6| 0| 1| 2| 1| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
UG/KG | 1| 3| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Serosa, Inflammation | 3 |
|__________________________________________________________________________|
Mesentery | |
Fat, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + |
Gingival, Hyperplasia, Squamous | 1 2 1 1 1 1 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic Active | 1 |
Acinus, Atrophy | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Serosa, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Mineralization | 1 1 1 |
|__________________________________________________________________________|
Tooth | + + + + + + + + |
Peridontal Tissue, Inflammation | 1 2 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 3 1 2 2 2 1 2 2 3 2 2 2 2 2 |
Degeneration, Cystic | 2 2 3 3 1 3 3 |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 5| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 5| 7| 7| 7| 5|
DAY ON TEST | 2| 9| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 0| 2|
| 2| 6| 3| 1| 2| 1| 1| 4| 1| 1| 2| 3| 9| 3| 1| 3| 9| 1| 4| 6| 0| 1| 2| 1| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
UG/KG | 1| 3| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hyperplasia | 3 3 3 2 2 3 2 3 2 3 3 3 2 |
Hypertrophy | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 1 2 2 2 |
Necrosis | |
Vacuolization Cytoplasmic | 1 2 2 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 3 1 1 2 2 2|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 2 3 2 2 2 3 2 3 |
Cyst | 2 |
Cytoplasmic Alteration | |
Pars Distalis, Hyperplasia | 2 2 3 1 4 4 3 3 3 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 2 2 2 3 2 2 3 3 |
Follicular Cell, Hypertrophy | 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 3 1 2 2 1 2 |
Duct, Cyst | 3 3 2 2 3 2 2 2 3 2 1 3 3 3 1 1 2 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 |
Cyst | 2 2 2 3 2 2 2 2 |
Inflammation, Chronic Active | 3 |
Necrosis | |
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 5| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 5| 7| 7| 7| 5|
DAY ON TEST | 2| 9| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 0| 2|
| 2| 6| 3| 1| 2| 1| 1| 4| 1| 1| 2| 3| 9| 3| 1| 3| 9| 1| 4| 6| 0| 1| 2| 1| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
UG/KG | 1| 3| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Oviduct | + + + + + M + M M + M + M + + M + + + + + + + + +|
Cyst | 3 |
Dilatation | 3 |
Inflammation, Chronic Active | 1 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 3 2 3 |
Inflammation, Suppurative | 2 1 3 2 |
Metaplasia, Squamous | 4 2 1 2 4 2 2 3 3 4 3 1 3 2 2|
Endometrium, Hyperplasia, Cystic | 2 3 1 3 3 3 1 3 2 2 1 2 1 4|
|__________________________________________________________________________|
Vagina | + + |
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 3 2 3 2 3 4 3 2 2 4 4 3 3 3 3 2 3 4|
|__________________________________________________________________________|
Lymph Node | + |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
Lumbar, Ectasia | |
Lumbar, Hemorrhage | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 2 2 3 3 3 3 3 2 3 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 1 4 2 2 1 2 2 3 2 2 3 3 2 2 3 2 1 3 2 2 3 3|
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 5| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 5| 7| 7| 7| 5|
DAY ON TEST | 2| 9| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 0| 2|
| 2| 6| 3| 1| 2| 1| 1| 4| 1| 1| 2| 3| 9| 3| 1| 3| 9| 1| 4| 6| 0| 1| 2| 1| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
UG/KG | 1| 3| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Necrosis | 2|
Pigmentation | 1 2 1 2 2 1 2 2 2 1 1 1 2 2 1 1 2 1 1 2 2 1 |
Lymphoid Follicle, Atrophy | 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
Atrophy | 3 3 2 4 4 3 2 2 2 3 3 2 4 3 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 1 1 1 2 1 1 2 2 1 1 1 2 2|
Inflammation, Chronic Active | 3 |
Inflammation, Granulomatous | 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 1 2 1 2 1 1 2 1 2 4 1 2 1 1 1 1 2 2 |
Inflammation | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 3 |
Goblet Cell, Hyperplasia | |
Respiratory Epithelium, Hyperplasia | 2 2 |
Septum, Inflammation | 2 3 1 |
Turbinate, Inflammation | 1 1 2 |
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 5| 6| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 5| 7| 7| 7| 5|
DAY ON TEST | 2| 9| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 7| 3| 3| 3| 3| 0| 2|
| 2| 6| 3| 1| 2| 1| 1| 4| 1| 1| 2| 3| 9| 3| 1| 3| 9| 1| 4| 6| 0| 1| 2| 1| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
UG/KG | 1| 3| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Retina, Atrophy | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 3 |
Calculus Micro Observation Only | X |
Casts Protein | 1 |
Degeneration | |
Hydronephrosis | 3|
Infarct | 3 |
Inflammation, Suppurative | 1 1 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Inflammation | 2 3 |
Renal Tubule, Degeneration | |
Transitional Epithelium, Hyperplasia | 2 3 |
|__________________________________________________________________________|
Ureter | +|
Cyst | 3|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 3 |
Transitional Epithelium, Hyperplasia | 2 3 |
__________________________________________|__________________________________________________________________________
Page 51
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 0| 3| | |
| 1| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
100 | 9| 9| 9| | L |
UG/KG | 0| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
Parasite Metazoan | | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | | 2 1.0|
Basophilic Focus | | 16 |
Basophilic Focus, Multiple | X X | 9 |
Clear Cell Focus | X | 4 |
Clear Cell Focus, Multiple | | 1 |
Eosinophilic Focus | X | 8 |
Eosinophilic Focus, Multiple | X | 8 |
Fatty Change, Diffuse | | 2 1.0|
Fatty Change, Focal | | 3 1.0|
Hematopoietic Cell Proliferation | | 13 1.1|
Inflammation | 1 1 1 | 44 1.1|
Mixed Cell Focus | | 7 |
Mixed Cell Focus, Multiple | X X | 22 |
Necrosis | 1 | 7 2.1|
Pigmentation | 1 | 2 1.5|
Bile Duct, Cyst | | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 0| 3| | |
| 1| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
100 | 9| 9| 9| | L |
UG/KG | 0| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Bile Duct, Fibrosis | 2 | 2 1.5|
Bile Duct, Hyperplasia | | 2 1.0|
Centrilobular, Degeneration | | 4 2.3|
Hepatocyte, Hypertrophy | | 5 1.4|
Serosa, Inflammation | | 2 3.0|
|__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | | 16 |
Gingival, Hyperplasia, Squamous | | 16 1.1|
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Cyst | | 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
Acinus, Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Hyperplasia, Squamous | | 2 2.0|
Serosa, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Erosion | | 1 2.0|
Mineralization | 2 | 8 1.3|
|__________________________________________________________________________|____________|
Tooth | | 19 |
Peridontal Tissue, Inflammation | | 19 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 0| 3| | |
| 1| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
100 | 9| 9| 9| | L |
UG/KG | 0| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Heart | + + + | 53 |
Cardiomyopathy | 1 | 19 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | 1 2 | 34 1.8|
Degeneration, Cystic | | 15 2.3|
Hyperplasia | 2 | 27 2.6|
Hypertrophy | 1 2 | 45 1.8|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 1 1 | 14 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Angiectasis | | 1 2.0|
Hyperplasia | 2 2 3 | 19 1.9|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Angiectasis | 4 2 | 20 2.5|
Cyst | | 1 2.0|
Cytoplasmic Alteration | | 1 2.0|
Pars Distalis, Hyperplasia | 3 | 22 2.4|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Hyperplasia | 1 1 | 23 2.0|
Follicular Cell, Hypertrophy | | 9 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 0| 3| | |
| 1| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
100 | 9| 9| 9| | L |
UG/KG | 0| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | M + + | 52 |
Inflammation | 1 2 | 41 1.8|
Duct, Cyst | 2 4 | 36 2.4|
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Atrophy | 4 4 | 42 4.0|
Cyst | 3 3 | 17 2.2|
Inflammation, Chronic Active | | 2 3.5|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Oviduct | + + + | 44 |
Cyst | | 2 3.0|
Dilatation | | 1 3.0|
Inflammation, Chronic Active | | 2 2.5|
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Cyst | | 1 3.0|
Inflammation, Chronic Active | 3 | 5 2.4|
Inflammation, Suppurative | 2 | 6 1.8|
Metaplasia, Squamous | 4 2 4 | 27 2.5|
Endometrium, Hyperplasia, Cystic | | 32 2.4|
|__________________________________________________________________________|____________|
Vagina | | 2 |
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Hyperplasia | 4 4 | 40 3.0|
|__________________________________________________________________________|____________|
Lymph Node | | 3 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 0| 3| | |
| 1| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
100 | 9| 9| 9| | L |
UG/KG | 0| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Plasma Cell | | 1 3.0|
Lumbar, Ectasia | | 2 3.0|
Lumbar, Hemorrhage | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 53 |
Ectasia | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia, Plasma Cell | 2 2 | 30 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Hematopoietic Cell Proliferation | 2 3 2 | 52 2.2|
Necrosis | | 1 2.0|
Pigmentation | 1 2 | 47 1.6|
Lymphoid Follicle, Atrophy | | 2 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + | 52 |
Atrophy | 3 3 2 | 37 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Hyperplasia | 1 1 | 32 1.2|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Granulomatous | | 2 2.0|
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 0| 3| | |
| 1| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
100 | 9| 9| 9| | L |
UG/KG | 0| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Infiltration Cellular, Histiocyte | 2 2 2 | 40 1.8|
Inflammation | | 2 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 | 16 1.3|
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation | | 3 2.0|
Goblet Cell, Hyperplasia | | 2 2.5|
Respiratory Epithelium, Hyperplasia | | 2 2.0|
Septum, Inflammation | | 5 1.8|
Turbinate, Inflammation | | 5 1.4|
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
Retina, Atrophy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Inflammation | 1 | 13 1.1|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Accumulation, Hyaline Droplet | | 1 3.0|
Calculus Micro Observation Only | | 4 |
Casts Protein | | 2 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 0| 3| | |
| 1| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
100 | 9| 9| 9| | L |
UG/KG | 0| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Degeneration | | 1 2.0|
Hydronephrosis | | 1 3.0|
Infarct | | 1 3.0|
Inflammation, Suppurative | | 3 1.0|
Mineralization | 1 | 41 1.0|
Nephropathy | 1 | 24 1.0|
Pelvis, Inflammation | | 2 2.5|
Renal Tubule, Degeneration | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 2 2.5|
|__________________________________________________________________________|____________|
Ureter | | 1 |
Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Inflammation | | 6 1.7|
Transitional Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|
DAY ON TEST | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|
| 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
UG/KG | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | |
Periesophageal Tissue, Hemorrhage | |
Periesophageal Tissue, Inflammation | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X|
Basophilic Focus, Multiple | X X X X |
Eosinophilic Focus | X X X X |
Eosinophilic Focus, Multiple | X X X X X X X |
Fatty Change, Diffuse | 1 1 1 |
Fatty Change, Focal | 2 1 |
Hematopoietic Cell Proliferation | 1 1 1 2 1 3 1 2 1 2 |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 2 1 1 1 1|
Mixed Cell Focus | |
Mixed Cell Focus, Multiple | X X X X X X X X X X X X X |
Necrosis | 2 2 |
Pigmentation | 2 2 |
Bile Duct, Cyst | 2 2 |
Bile Duct, Fibrosis | 1 1 |
Bile Duct, Hyperplasia | 3 3 2 1 1 1 1|
Centrilobular, Degeneration | 1 |
Hepatocyte, Hypertrophy | 1 1 1 1 2 2 1 1 1 1 1|
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|
DAY ON TEST | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|
| 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
UG/KG | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Oval Cell, Hyperplasia | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 1 1 1 2 1|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | |
Acinus, Vacuolization Cytoplasmic | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 2 |
Inflammation | 2 2 2 |
Mineralization | |
Ulcer | 3 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation | |
Mineralization | 1 1 3 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + +|
Peridontal Tissue, Inflammation | 1 1 1 2 1 1 1 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 1 2 1 1 1 1 1 1 1 1|
Inflammation | 2 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|
DAY ON TEST | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|
| 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
UG/KG | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 2 1 1 1 1 2 2 2 1 1 |
Atrophy | 2|
Degeneration, Cystic | 3 1 3 2 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 3 2 3 2 2 3 2 2 1 3 2 2 |
Hypertrophy | 2 2 2 2 2 2 1 2 2 2 2 3 2 2 3 2 2 2|
Inflammation | 1 |
Mineralization | 1 3 |
Necrosis | 3 4 |
Vacuolization Cytoplasmic | 2 2 2 2 2 2 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 1 4 4 2 2 3 2 2 3|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + M + + + + + + + + + M + + + + + +|
Angiectasis | |
Hyperplasia | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 1 2 2 2 1 2 2 3 3 2 2|
Atypia Cellular | |
Pars Distalis, Hyperplasia | 3 1 2 2 3 2 3 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 2 1 1 |
Follicular Cell, Hypertrophy | 1 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|
DAY ON TEST | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|
| 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
UG/KG | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation | 1 1 1 2 2 2 2 2 3 3 2 1 1 2 1 1 2 1 2 1 1 1 1|
Duct, Cyst | 1 1 2 2 3 4 3 2 2 3 1 2 3 1 1 3 2 2 1 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4|
Cyst | 3 2 3 2 2 2 3 2 3 |
Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Oviduct | + + M + + + + + + + M M M M M M M M + + + M + M M|
Cyst | |
Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | |
Congestion | |
Cyst | 3 |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 1 |
Metaplasia, Squamous | 4 3 2 1 2 2 2 4 4 |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 2 3 3 2 3 2 3 2 3 2 3 2 1 2 2|
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 4 3 3 3 4 4 4 2 3 4 2 3 3 4 4 |
|__________________________________________________________________________|
Lymph Node | + |
Renal, Inflammation, Chronic Active | 4 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 3 2 2 2 4 2 2 3 2 3 3 2 3 3 2 2|
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|
DAY ON TEST | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|
| 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
UG/KG | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 1 2 3 1 2 2 3 3 1 4 1 1 1 1 2 3 1 4 3 3 1|
Pigmentation | 2 1 1 1 1 1 1 1 1 1 2 2 1 3 1 1 2 1 1 2 1 1 1|
Lymphoid Follicle, Atrophy | 2 4 2 |
Red Pulp, Atrophy | 2 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 3 2 3 2 3 2 3 4 2 4 2 2 3 3 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 1 1 1 1 1 2 2 1 1 1 2 1 1 |
Inflammation, Granulomatous | 2 2 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | 2 |
Hyperplasia, Histiocytic | 3 |
Mineralization | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 2 2 2 1 1 1 2 2 1 1 2 3 1 2 2 1 1|
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|
DAY ON TEST | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|
| 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
UG/KG | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Inflammation | 2 4 |
Metaplasia, Squamous | 1 |
Mineralization | 3 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 2 2 1 |
Mediastinum, Hemorrhage | |
Serosa, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 1 3 |
Goblet Cell, Hyperplasia | 2 |
Septum, Inflammation | 1 1 1 |
Turbinate, Inflammation | 1 2 2 1 2 1 1 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Degeneration | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Casts Protein | 2 |
Cyst | 2 |
Infarct | 2 |
Inflammation, Suppurative | 1 |
Mineralization | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1|
Pelvis, Inflammation | 2 2 2|
Transitional Epithelium, Hyperplasia | 2 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 2 1 2 |
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 5| 5| 6| 7| 5| 6| 4| 7| 3| 7| 7| 7| 6| 7| 7| 5| 4| 6| 6| 5| 7|
DAY ON TEST | 5| 1| 3| 3| 6| 5| 1| 3| 3| 9| 4| 3| 6| 3| 3| 3| 2| 3| 3| 2| 8| 7| 7| 0| 3|
| 5| 0| 3| 1| 8| 5| 3| 2| 0| 1| 3| 2| 0| 1| 1| 3| 1| 1| 2| 8| 6| 5| 5| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
UG/KG | 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 5| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Transitional Epithelium, Hyperplasia | 2 1 |
__________________________________________|__________________________________________________________________________
Page 65
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|
DAY ON TEST | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|
| 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|
UG/KG | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 2 |
Periesophageal Tissue, Hemorrhage | 3 |
Periesophageal Tissue, Inflammation | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Basophilic Focus, Multiple | X X X |
Eosinophilic Focus | X X X |
Eosinophilic Focus, Multiple | X X X X |
Fatty Change, Diffuse | 1 1 1 1 1 1 1|
Fatty Change, Focal | 1 1 1 |
Hematopoietic Cell Proliferation | 2 1 1 1 1 1 1 1 |
Inflammation | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Mixed Cell Focus | X X X X X |
Mixed Cell Focus, Multiple | X X X X X X |
Necrosis | 1 1 2 |
Pigmentation | 1 2 1 |
Bile Duct, Cyst | 2 |
Bile Duct, Fibrosis | |
Bile Duct, Hyperplasia | 1 1 2 1 1 2 |
Centrilobular, Degeneration | 3 |
Hepatocyte, Hypertrophy | 2 1 2 1 2 2 2 1 1 1 2 2|
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|
DAY ON TEST | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|
| 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|
UG/KG | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Oval Cell, Hyperplasia | 1 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + |
Gingival, Hyperplasia, Squamous | 1 1 1 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Acinus, Atrophy | 2 |
Acinus, Vacuolization Cytoplasmic | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +|
Ectopic Tissue | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 1 2 1|
Inflammation | |
Mineralization | 1 2 |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation | 2 2 |
Mineralization | 1 1 1 1 2 2 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + |
Peridontal Tissue, Inflammation | 1 2 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 |
Inflammation | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|
DAY ON TEST | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|
| 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|
UG/KG | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 2 1 2 2 2 2 1 2 |
Atrophy | |
Degeneration, Cystic | 3 3 1 3 2 2 3 1 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 3 2 3 3 2 3 3 3 2 2 4 3 |
Hypertrophy | 2 2 2 1 2 2 1 2 2 2 2 1 2 2 1|
Inflammation | |
Mineralization | |
Necrosis | |
Vacuolization Cytoplasmic | 2 2 1 2 3 1 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 3 2 1 1 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M M + M + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 2 2 2 2 2 2 3 2 2 1 3|
Atypia Cellular | 2 |
Pars Distalis, Hyperplasia | 1 4 3 2 2 2 2 4 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 1 2 2 2 2 2|
Follicular Cell, Hypertrophy | 2 2 1 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|
DAY ON TEST | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|
| 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|
UG/KG | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Inflammation | 3 3 2 2 3 2 3 2 1 1 1 1 2 1 2 1 1 1 1 1 2 1 2|
Duct, Cyst | 2 4 2 2 4 1 3 2 3 1 3 2 2 4 2 3 3 3 3 3 4 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 1 2 2 2 2 2 |
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Oviduct | + M + + + + + + M M + + + + + M + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | 2 |
Congestion | 1 |
Cyst | |
Inflammation, Chronic Active | 2 3 |
Inflammation, Suppurative | 1 |
Metaplasia, Squamous | 2 1 3 2 1 2 1|
Thrombosis | 3 |
Endometrium, Hyperplasia, Cystic | 3 2 4 3 1 2 1 2 3 2 2 3 2 |
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 4 3 3 3 4 4 3 4 2 3 4 2 2 2 3 2 |
|__________________________________________________________________________|
Lymph Node | + |
Renal, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 2 2 3 3 2 2 2 2 2 3 2 2 2 |
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|
DAY ON TEST | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|
| 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|
UG/KG | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 3 2 1 1 3 3 4 1 2 2 2 1 2 3 1 2 1 2 2 |
Pigmentation | 2 2 2 2 1 1 1 1 1 1 2 1 1 1 2 1 1 1 2 1 2 2 2|
Lymphoid Follicle, Atrophy | |
Red Pulp, Atrophy | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 3 2 4 2 2 3 2 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hyperplasia | 2 1 1 1 2 3 1 3 1 3 1 |
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hydrocephalus | 2 |
Hyperplasia, Histiocytic | |
Mineralization | 2 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 2 1 1 1 1 2 1 2 2 1 1 1 1 1 1 1 1 2|
__________________________________________|__________________________________________________________________________|
Page 70
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|
DAY ON TEST | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|
| 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|
UG/KG | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Inflammation | 1 2 2 2 |
Metaplasia, Squamous | |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 |
Mediastinum, Hemorrhage | 3 |
Serosa, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Goblet Cell, Hyperplasia | |
Septum, Inflammation | |
Turbinate, Inflammation | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Degeneration | 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X X X |
Casts Protein | |
Cyst | |
Infarct | 3 |
Inflammation, Suppurative | 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1|
Pelvis, Inflammation | 3 |
Transitional Epithelium, Hyperplasia | 2 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 1 3 |
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 4| 3| 7| 2| 7| 6| 6| 6| 2| 7| 6| 7| 6| 6| 7| 7| 4| 7| 7| 5|
DAY ON TEST | 3| 3| 0| 5| 0| 5| 2| 3| 6| 3| 4| 5| 9| 2| 3| 4| 3| 9| 7| 3| 3| 5| 3| 3| 2|
| 1| 2| 3| 9| 3| 7| 2| 2| 3| 1| 7| 6| 1| 2| 1| 7| 1| 3| 5| 2| 1| 2| 3| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9|
UG/KG | 4| 5| 6| 9| 0| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________|__________________________________________________________________________
Page 72
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 2| 6| | |
DAY ON TEST | 3| 6| 2| | |
| 1| 9| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
300 | 9| 9| 9| | L |
UG/KG | 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
Muscularis, Inflammation | | 1 2.0|
Periesophageal Tissue, Hemorrhage | | 1 3.0|
Periesophageal Tissue, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
Parasite Metazoan | | 7 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | | 1 1.0|
Basophilic Focus | X | 6 |
Basophilic Focus, Multiple | | 7 |
Eosinophilic Focus | | 7 |
Eosinophilic Focus, Multiple | X | 12 |
Fatty Change, Diffuse | 1 | 11 1.0|
Fatty Change, Focal | | 5 1.2|
Hematopoietic Cell Proliferation | | 18 1.3|
Inflammation | 1 1 1 | 47 1.1|
Mixed Cell Focus | X | 6 |
Mixed Cell Focus, Multiple | | 19 |
Necrosis | | 5 1.6|
Pigmentation | | 5 1.6|
Bile Duct, Cyst | | 3 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 2| 6| | |
DAY ON TEST | 3| 6| 2| | |
| 1| 9| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
300 | 9| 9| 9| | L |
UG/KG | 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Bile Duct, Fibrosis | | 2 1.0|
Bile Duct, Hyperplasia | 2 | 14 1.6|
Centrilobular, Degeneration | | 2 2.0|
Hepatocyte, Hypertrophy | 2 | 24 1.4|
Oval Cell, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Oral Mucosa | | 12 |
Gingival, Hyperplasia, Squamous | | 11 1.1|
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Inflammation, Chronic Active | | 1 2.0|
Acinus, Atrophy | | 1 2.0|
Acinus, Vacuolization Cytoplasmic | | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
Ectopic Tissue | | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Hyperplasia, Squamous | | 6 1.7|
Inflammation | | 3 2.0|
Mineralization | | 2 1.5|
Ulcer | | 2 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Erosion | | 2 2.0|
Inflammation | | 2 2.0|
Mineralization | 2 | 10 1.5|
|__________________________________________________________________________|____________|
Tooth | + | 22 |
Peridontal Tissue, Inflammation | 2 | 21 1.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 2| 6| | |
DAY ON TEST | 3| 6| 2| | |
| 1| 9| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
300 | 9| 9| 9| | L |
UG/KG | 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Aorta, Mineralization | | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Cardiomyopathy | | 19 1.2|
Inflammation | | 1 2.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | 2 | 25 1.6|
Atrophy | | 1 2.0|
Degeneration, Cystic | | 13 2.2|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 2 1 2 | 27 2.4|
Hypertrophy | 3 2 | 35 1.9|
Inflammation | | 1 1.0|
Mineralization | | 2 2.0|
Necrosis | | 2 3.5|
Vacuolization Cytoplasmic | | 16 1.8|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Angiectasis | 2 | 1 2.0|
Hyperplasia | | 14 2.3|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 47 |
Angiectasis | | 1 1.0|
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Angiectasis | 3 | 26 2.2|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 2| 6| | |
DAY ON TEST | 3| 6| 2| | |
| 1| 9| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
300 | 9| 9| 9| | L |
UG/KG | 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Atypia Cellular | | 1 2.0|
Pars Distalis, Hyperplasia | | 16 2.4|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Hyperplasia | 2 | 17 1.6|
Follicular Cell, Hypertrophy | 2 | 12 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
Atrophy | | 1 2.0|
Inflammation | 1 1 | 48 1.6|
Duct, Cyst | 3 | 43 2.4|
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Atrophy | | 38 4.0|
Cyst | 2 2 | 17 2.2|
Inflammation, Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Oviduct | + M | 35 |
Cyst | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Adenomyosis | | 1 2.0|
Congestion | | 1 1.0|
Cyst | | 1 3.0|
Inflammation, Chronic Active | 3 | 4 2.8|
Inflammation, Suppurative | | 2 1.0|
Metaplasia, Squamous | 3 | 17 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 2| 6| | |
DAY ON TEST | 3| 6| 2| | |
| 1| 9| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
300 | 9| 9| 9| | L |
UG/KG | 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Thrombosis | | 1 3.0|
Endometrium, Hyperplasia, Cystic | | 28 2.3|
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Hyperplasia | 3 2 | 38 3.1|
|__________________________________________________________________________|____________|
Lymph Node | | 2 |
Renal, Inflammation, Chronic Active | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M | 51 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 3 3 | 33 2.4|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Hematopoietic Cell Proliferation | 2 2 2 | 48 1.9|
Pigmentation | 2 1 1 | 49 1.4|
Lymphoid Follicle, Atrophy | | 3 2.7|
Red Pulp, Atrophy | | 2 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + | 53 |
Atrophy | 3 2 | 35 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Cyst | | 2 2.5|
Hyperplasia | 2 1 1 | 27 1.4|
Inflammation, Granulomatous | | 3 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 2| 6| | |
DAY ON TEST | 3| 6| 2| | |
| 1| 9| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
300 | 9| 9| 9| | L |
UG/KG | 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Hemorrhage | | 1 2.0|
Hydrocephalus | | 2 2.0|
Hyperplasia, Histiocytic | | 1 3.0|
Mineralization | | 1 2.0|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Infiltration Cellular, Histiocyte | 1 2 | 40 1.4|
Inflammation | | 6 2.2|
Metaplasia, Squamous | | 1 1.0|
Mineralization | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 11 1.2|
Mediastinum, Hemorrhage | | 1 3.0|
Serosa, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation | 1 | 6 1.5|
Goblet Cell, Hyperplasia | | 1 2.0|
Septum, Inflammation | | 3 1.0|
Turbinate, Inflammation | | 9 1.4|
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 7| 2| 6| | |
DAY ON TEST | 3| 6| 2| | |
| 1| 9| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
300 | 9| 9| 9| | L |
UG/KG | 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
Lens, Degeneration | | 1 1.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Inflammation | 1 1 | 16 1.1|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Calculus Micro Observation Only | X X | 7 |
Casts Protein | | 1 2.0|
Cyst | | 1 2.0|
Infarct | | 2 2.5|
Inflammation, Suppurative | | 2 1.0|
Mineralization | 1 1 | 39 1.1|
Nephropathy | 1 1 | 33 1.1|
Pelvis, Inflammation | | 4 2.3|
Transitional Epithelium, Hyperplasia | | 4 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Inflammation | | 8 2.0|
Transitional Epithelium, Hyperplasia | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 7| 5| 7| 6| 6| 6| 7| 3| 4| 7| 7| 7| 6| 6| 4| 6| 7| 5| 4| 7|
DAY ON TEST | 3| 1| 4| 1| 3| 1| 9| 0| 2| 4| 2| 3| 6| 5| 3| 3| 3| 9| 4| 9| 1| 3| 5| 7| 3|
| 2| 3| 7| 4| 9| 5| 0| 2| 1| 9| 1| 3| 0| 2| 1| 1| 1| 6| 7| 7| 7| 3| 5| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4|
UG/KG | 6| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 2| 4| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 1 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 2 2 3|
Basophilic Focus | X |
Basophilic Focus, Multiple | X X X |
Cholangiofibrosis | 2 |
Eosinophilic Focus | X X X X X X X X X |
Eosinophilic Focus, Multiple | X X X X X|
Fatty Change, Diffuse | 1 1 2 1 1 1 1 1 3 1 1 |
Fatty Change, Focal | 1 1 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Nodular | X |
Inflammation | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X |
Mixed Cell Focus, Multiple | X X X X X X X X|
Necrosis | 3 1 3 1 |
Pigmentation | 1 1 1 |
Bile Duct, Cyst | 2 4 2 |
Bile Duct, Fibrosis | 1|
Bile Duct, Hyperplasia | 2 2 1 2 |
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 7| 5| 7| 6| 6| 6| 7| 3| 4| 7| 7| 7| 6| 6| 4| 6| 7| 5| 4| 7|
DAY ON TEST | 3| 1| 4| 1| 3| 1| 9| 0| 2| 4| 2| 3| 6| 5| 3| 3| 3| 9| 4| 9| 1| 3| 5| 7| 3|
| 2| 3| 7| 4| 9| 5| 0| 2| 1| 9| 1| 3| 0| 2| 1| 1| 1| 6| 7| 7| 7| 3| 5| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4|
UG/KG | 6| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 2| 4| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Centrilobular, Degeneration | |
Hepatocyte, Hypertrophy | 2 1 2 2 1 3 1 2 1 2 2 2 3 2 3 3 2 2 2 3|
|__________________________________________________________________________|
Mesentery | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + |
Gingival, Hyperplasia, Squamous | 1 2 1 1 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Vacuolization Cytoplasmic | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 2 2 |
Inflammation | 2 |
Mineralization | 2 |
Ulcer | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 1 2 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + |
Peridontal Tissue, Inflammation | 1 1 2 2 1 1 1 3 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 1 2 2 2 2 1 2 2 2 2 2 2 1|
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 7| 5| 7| 6| 6| 6| 7| 3| 4| 7| 7| 7| 6| 6| 4| 6| 7| 5| 4| 7|
DAY ON TEST | 3| 1| 4| 1| 3| 1| 9| 0| 2| 4| 2| 3| 6| 5| 3| 3| 3| 9| 4| 9| 1| 3| 5| 7| 3|
| 2| 3| 7| 4| 9| 5| 0| 2| 1| 9| 1| 3| 0| 2| 1| 1| 1| 6| 7| 7| 7| 3| 5| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4|
UG/KG | 6| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 2| 4| 6|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Atrophy | 2 |
Degeneration, Cystic | 1 2 3 2 2 1 2 2|
Hyperplasia | 2 3 3 3 2 3 2 2 2 2 2 2 2 2 3|
Hypertrophy | 2 2 2 1 2 2 1 2 2 2 2 3 2 2 2 2 1 2 1 2 2|
Mineralization | |
Necrosis | 2 3 |
Vacuolization Cytoplasmic | 1 1 1 1 1 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 3 2 2 2 1 1 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 3 3 3 3 3 2 2 3 2 3|
Cytoplasmic Alteration | |
Vacuolization Cytoplasmic | |
Pars Distalis, Hyperplasia | 3 2 1 3 2 2 1 3 2 3 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
C-Cell, Hyperplasia | 2 1 2 2 2 2 2 2 2 2|
Follicular Cell, Hyperplasia | 2 2 |
Follicular Cell, Hypertrophy | 4 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Inflammation | 2 2 2 1 1 1 2 2 1 1 2 2 2 2 1 2 1 2 1 2 1 1 1 2|
Duct, Cyst | 4 3 2 3 3 2 3 1 2 1 3 3 4 2 3 2 2 1 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4|
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 7| 5| 7| 6| 6| 6| 7| 3| 4| 7| 7| 7| 6| 6| 4| 6| 7| 5| 4| 7|
DAY ON TEST | 3| 1| 4| 1| 3| 1| 9| 0| 2| 4| 2| 3| 6| 5| 3| 3| 3| 9| 4| 9| 1| 3| 5| 7| 3|
| 2| 3| 7| 4| 9| 5| 0| 2| 1| 9| 1| 3| 0| 2| 1| 1| 1| 6| 7| 7| 7| 3| 5| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4|
UG/KG | 6| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 2| 4| 6|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Cyst | 2 3 2 2 2 2 3 2 |
Inflammation, Chronic Active | 3 4|
|__________________________________________________________________________|
Oviduct | + + + + + + + + M M + + + + + + + M + + + + + + +|
Cyst | 3 |
Inflammation, Chronic Active | 2 4 4|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 2 2 2 1 3 3 3 2|
Metaplasia, Squamous | 1 3 2 1 3 4 3 3 2 4 3 3 2 4 3|
Thrombosis | |
Cervix, Hyperplasia, Stromal | 3 3 |
Endometrium, Hyperplasia, Cystic | 1 2 2 2 3 3 2 2 3 2 3 3 1 1 |
Endometrium, Hyperplasia, Stromal | 3 |
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 2 4 4 3 4 4 3 3 4 3 2 4 3 4 2 3 4 2|
|__________________________________________________________________________|
Lymph Node | + |
Iliac, Ectasia | |
Iliac, Hyperplasia, Plasma Cell | |
Lumbar, Hyperplasia, Histiocytic | |
Lumbar, Hyperplasia, Plasma Cell | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | |
Hyperplasia, Lymphoid | 2 3 2 |
Hyperplasia, Plasma Cell | 2 3 2 2 3 3 2 2 2 2 3 3 2 3 3 2 3 3 2 3|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 7| 5| 7| 6| 6| 6| 7| 3| 4| 7| 7| 7| 6| 6| 4| 6| 7| 5| 4| 7|
DAY ON TEST | 3| 1| 4| 1| 3| 1| 9| 0| 2| 4| 2| 3| 6| 5| 3| 3| 3| 9| 4| 9| 1| 3| 5| 7| 3|
| 2| 3| 7| 4| 9| 5| 0| 2| 1| 9| 1| 3| 0| 2| 1| 1| 1| 6| 7| 7| 7| 3| 5| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4|
UG/KG | 6| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 2| 4| 6|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 2 3 3 1 2 1 2 1 2 2 1 2 3 1 1 2 1|
Pigmentation | 2 1 1 1 1 2 1 2 1 1 1 2 1 1 2 1 2 1 2 3 2 1 1 2|
Lymphoid Follicle, Atrophy | 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 4 2 3 4 2 2 4 2 2 2 2 3 3 4 2 2 2 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 2 1 1 1 1 2 2 2 2 1 1 1 1 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 2 2 1 2 2 1 |
Inflammation | 2 |
Metaplasia, Squamous | |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 7| 5| 7| 6| 6| 6| 7| 3| 4| 7| 7| 7| 6| 6| 4| 6| 7| 5| 4| 7|
DAY ON TEST | 3| 1| 4| 1| 3| 1| 9| 0| 2| 4| 2| 3| 6| 5| 3| 3| 3| 9| 4| 9| 1| 3| 5| 7| 3|
| 2| 3| 7| 4| 9| 5| 0| 2| 1| 9| 1| 3| 0| 2| 1| 1| 1| 6| 7| 7| 7| 3| 5| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4|
UG/KG | 6| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 2| 4| 6|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 |
Goblet Cell, Hyperplasia | |
Respiratory Epithelium, Hyperplasia | 2 |
Septum, Inflammation | 1 1 1 |
Turbinate, Inflammation | 2 2 2 2 2 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + M + + + + + + + + + + + + + + + + + + + + + +|
Anterior Chamber, Exudate | |
Retina, Atrophy | 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Hydronephrosis | |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | |
Mineralization | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
Pelvis, Inflammation | 1 2 2 |
Transitional Epithelium, Hyperplasia | 1 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 85
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 1| 1| 9| 4| 0| 3| 3| 2| 3| 3| 2| 3| 4| 3| 7| 3| 3| 3| 2| 3| 0| 3| 6|
| 3| 1| 0| 5| 6| 1| 6| 3| 1| 9| 1| 3| 9| 1| 1| 1| 5| 1| 2| 1| 5| 2| 2| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
UG/KG | 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X X X|
Cholangiofibrosis | |
Eosinophilic Focus | X X X |
Eosinophilic Focus, Multiple | X X X X |
Fatty Change, Diffuse | 1 1 2 1 2 1 1 1 2|
Fatty Change, Focal | 1 1 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Nodular | |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X |
Mixed Cell Focus, Multiple | X X X X X X X X X X X |
Necrosis | 2 2 2 2 3 1 2|
Pigmentation | 2 1 |
Bile Duct, Cyst | 3 2 |
Bile Duct, Fibrosis | 1 |
Bile Duct, Hyperplasia | 1 3 2 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 1| 1| 9| 4| 0| 3| 3| 2| 3| 3| 2| 3| 4| 3| 7| 3| 3| 3| 2| 3| 0| 3| 6|
| 3| 1| 0| 5| 6| 1| 6| 3| 1| 9| 1| 3| 9| 1| 1| 1| 5| 1| 2| 1| 5| 2| 2| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
UG/KG | 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Centrilobular, Degeneration | 2 |
Hepatocyte, Hypertrophy | 2 3 1 3 3 2 2 2 3 1 1 1 2 3 2 3 1 |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + |
Gingival, Hyperplasia, Squamous | 2 2 2 1 1 1 1 2 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Vacuolization Cytoplasmic | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 1 2 |
Inflammation | 2 |
Mineralization | |
Ulcer | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 1 2|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + |
Peridontal Tissue, Inflammation | 1 1 2 1 1 3 1 3 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 2|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 1 1 2 1 1 1 2 2 2 2 |
__________________________________________|__________________________________________________________________________|
Page 87
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 1| 1| 9| 4| 0| 3| 3| 2| 3| 3| 2| 3| 4| 3| 7| 3| 3| 3| 2| 3| 0| 3| 6|
| 3| 1| 0| 5| 6| 1| 6| 3| 1| 9| 1| 3| 9| 1| 1| 1| 5| 1| 2| 1| 5| 2| 2| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
UG/KG | 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Atrophy | 2 |
Degeneration, Cystic | 3 2 1 3 |
Hyperplasia | 4 3 2 2 2 3 2 2 3 2 3 2 3 |
Hypertrophy | 1 3 2 2 3 2 2 2 2 2 1 2 2 2 1 2 2 2 2 3 |
Mineralization | 2|
Necrosis | 3|
Vacuolization Cytoplasmic | 2 3 2 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 1 2 4 3 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + M M M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 4 2 3 2 2 1 1 3 2 2 |
Cytoplasmic Alteration | 2 |
Vacuolization Cytoplasmic | 1 |
Pars Distalis, Hyperplasia | 2 2 3 3 1 3 3 3 2 3 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
C-Cell, Hyperplasia | 2 1 2 2 3 1 2 2 |
Follicular Cell, Hyperplasia | |
Follicular Cell, Hypertrophy | 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation | 3 2 2 1 1 1 2 1 2 2 2 2 1 2 1 1 2 1 2 1 1 |
Duct, Cyst | 1 3 2 2 2 3 3 1 2 1 2 2 3 2 3 3 3 1 3 1 3 2 2 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4 3 4 |
__________________________________________|__________________________________________________________________________|
Page 88
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 1| 1| 9| 4| 0| 3| 3| 2| 3| 3| 2| 3| 4| 3| 7| 3| 3| 3| 2| 3| 0| 3| 6|
| 3| 1| 0| 5| 6| 1| 6| 3| 1| 9| 1| 3| 9| 1| 1| 1| 5| 1| 2| 1| 5| 2| 2| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
UG/KG | 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Cyst | 2 2 2 2 3 3 2 2 |
Inflammation, Chronic Active | 3 3 2 |
|__________________________________________________________________________|
Oviduct | + + M + + + + M M + + + + M + M + + M M + + M|
Cyst | |
Inflammation, Chronic Active | 3 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 2 2 2 1 2 1 2 2 |
Metaplasia, Squamous | 4 3 4 3 4 3 2 3 1 2 |
Thrombosis | 3 3 |
Cervix, Hyperplasia, Stromal | |
Endometrium, Hyperplasia, Cystic | 3 2 2 3 3 3 2 3 1 1 |
Endometrium, Hyperplasia, Stromal | |
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 4 4 3 4 4 4 4 2 3 3 3 4 2 3 3 2 3|
|__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Ectasia | 2 |
Iliac, Hyperplasia, Plasma Cell | 3 |
Lumbar, Hyperplasia, Histiocytic | 2 |
Lumbar, Hyperplasia, Plasma Cell | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Ectasia | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 2 2 2 2 2 2 2 2 3 2 2 2 2 3 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 89
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 1| 1| 9| 4| 0| 3| 3| 2| 3| 3| 2| 3| 4| 3| 7| 3| 3| 3| 2| 3| 0| 3| 6|
| 3| 1| 0| 5| 6| 1| 6| 3| 1| 9| 1| 3| 9| 1| 1| 1| 5| 1| 2| 1| 5| 2| 2| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
UG/KG | 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 4 1 1 3 2 2 2 2 2 2 2 2 2 1 2 1 1 1 2 1 3|
Pigmentation | 1 2 1 1 1 1 3 1 1 2 1 2 2 2 1 2 1 2 2 1 1 2 1|
Lymphoid Follicle, Atrophy | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 3 3 2 3 3 3 3 2 3 2 2 3 2 2 2 2 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 1 1 1 2 1 1 1 2 2 1 1 1 2 1 1|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hydrocephalus | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Histiocyte | 2 2 1 2 1 1 1 1 2 1 2 1 1 1 |
Inflammation | 3 1 2 2|
Metaplasia, Squamous | 2 |
Mineralization | 3|
Alveolar Epithelium, Hyperplasia | 1 2 1 1 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 90
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 6| 7| 7| 7| 6| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 1| 1| 9| 4| 0| 3| 3| 2| 3| 3| 2| 3| 4| 3| 7| 3| 3| 3| 2| 3| 0| 3| 6|
| 3| 1| 0| 5| 6| 1| 6| 3| 1| 9| 1| 3| 9| 1| 1| 1| 5| 1| 2| 1| 5| 2| 2| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
UG/KG | 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 3 2 |
Goblet Cell, Hyperplasia | 2 2 |
Respiratory Epithelium, Hyperplasia | |
Septum, Inflammation | 2 2 1 |
Turbinate, Inflammation | 2 1 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anterior Chamber, Exudate | |
Retina, Atrophy | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X X X |
Hydronephrosis | 3 |
Inflammation, Chronic Active | 2 1 |
Inflammation, Suppurative | 1 1 |
Mineralization | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3|
Nephropathy | 1 3 1 1 1 1 1 2 1 1 1 |
Pelvis, Inflammation | 2 2 |
Transitional Epithelium, Hyperplasia | 2 2 2 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 1 1 2 1 1 1|
Transitional Epithelium, Hyperplasia | 2 2 |
__________________________________________|__________________________________________________________________________
Page 91
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 3| 5| | |
DAY ON TEST | 3| 8| 7| | |
| 6| 3| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1000 | 9| 9| 9| | L |
UG/KG | 3| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
Muscularis, Inflammation | 3 | 2 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
Parasite Metazoan | | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | | 8 1.9|
Basophilic Focus | | 3 |
Basophilic Focus, Multiple | | 7 |
Cholangiofibrosis | | 1 2.0|
Eosinophilic Focus | X X | 14 |
Eosinophilic Focus, Multiple | | 9 |
Fatty Change, Diffuse | 1 | 21 1.3|
Fatty Change, Focal | | 4 1.0|
Hematopoietic Cell Proliferation | 1 | 16 1.0|
Hepatodiaphragmatic Nodule | | 1 |
Hyperplasia, Nodular | | 1 |
Inflammation | 1 2 | 48 1.1|
Mixed Cell Focus | | 5 |
Mixed Cell Focus, Multiple | | 19 |
Necrosis | 3 | 12 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 3| 5| | |
DAY ON TEST | 3| 8| 7| | |
| 6| 3| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1000 | 9| 9| 9| | L |
UG/KG | 3| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Pigmentation | | 5 1.2|
Bile Duct, Cyst | | 5 2.6|
Bile Duct, Fibrosis | | 2 1.0|
Bile Duct, Hyperplasia | | 10 1.6|
Centrilobular, Degeneration | 2 | 2 2.0|
Hepatocyte, Hypertrophy | 1 2 | 39 2.0|
|__________________________________________________________________________|____________|
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | + | 16 |
Gingival, Hyperplasia, Squamous | 1 | 16 1.4|
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Acinus, Vacuolization Cytoplasmic | | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Hyperkeratosis | | 1 2.0|
Hyperplasia, Squamous | | 4 1.8|
Inflammation | 1 | 3 1.7|
Mineralization | 2 | 2 2.0|
Ulcer | 2 | 3 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Mineralization | 2 | 10 1.5|
|__________________________________________________________________________|____________|
Tooth | + | 23 |
Peridontal Tissue, Inflammation | 1 | 23 1.4|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
Aorta, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 3| 5| | |
DAY ON TEST | 3| 8| 7| | |
| 6| 3| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1000 | 9| 9| 9| | L |
UG/KG | 3| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Cardiomyopathy | 1 1 | 23 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | 1 | 29 1.6|
Atrophy | | 2 2.0|
Degeneration, Cystic | | 12 2.0|
Hyperplasia | | 28 2.4|
Hypertrophy | 1 | 42 1.9|
Mineralization | | 1 2.0|
Necrosis | | 3 2.7|
Vacuolization Cytoplasmic | | 12 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Hyperplasia | | 20 2.1|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + | 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Angiectasis | 3 3 | 28 2.4|
Cytoplasmic Alteration | | 1 2.0|
Vacuolization Cytoplasmic | | 1 1.0|
Pars Distalis, Hyperplasia | | 23 2.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
Angiectasis | | 1 2.0|
C-Cell, Hyperplasia | 2 | 19 1.9|
Follicular Cell, Hyperplasia | | 2 2.0|
Follicular Cell, Hypertrophy | | 10 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 3| 5| | |
DAY ON TEST | 3| 8| 7| | |
| 6| 3| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1000 | 9| 9| 9| | L |
UG/KG | 3| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 51 |
Inflammation | 3 2 2 | 48 1.6|
Duct, Cyst | 2 3 3 | 45 2.3|
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Atrophy | 4 4 4 | 44 3.9|
Cyst | | 16 2.3|
Inflammation, Chronic Active | | 5 3.0|
|__________________________________________________________________________|____________|
Oviduct | + M + | 39 |
Cyst | | 1 3.0|
Inflammation, Chronic Active | | 5 3.2|
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Angiectasis | | 1 3.0|
Inflammation, Chronic Active | | 2 3.0|
Inflammation, Suppurative | | 16 2.0|
Metaplasia, Squamous | 2 1 | 27 2.7|
Thrombosis | | 2 3.0|
Cervix, Hyperplasia, Stromal | | 2 3.0|
Endometrium, Hyperplasia, Cystic | 2 | 25 2.2|
Endometrium, Hyperplasia, Stromal | | 1 3.0|
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Hyperplasia | 2 4 3 | 42 3.2|
|__________________________________________________________________________|____________|
Lymph Node | | 5 |
Iliac, Ectasia | | 1 2.0|
Iliac, Hyperplasia, Plasma Cell | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 3| 5| | |
DAY ON TEST | 3| 8| 7| | |
| 6| 3| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1000 | 9| 9| 9| | L |
UG/KG | 3| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lumbar, Hyperplasia, Histiocytic | | 1 2.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 53 |
Congestion | | 1 2.0|
Ectasia | | 1 2.0|
Hyperplasia, Lymphoid | | 3 2.3|
Hyperplasia, Plasma Cell | 2 | 37 2.4|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Hematopoietic Cell Proliferation | 1 3 1 | 46 1.8|
Pigmentation | 2 2 | 49 1.5|
Lymphoid Follicle, Atrophy | | 3 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + | 53 |
Atrophy | 3 3 | 41 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Cyst | | 1 2.0|
Hyperplasia | 1 1 | 32 1.3|
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Cyst Epithelial Inclusion | X | 1 |
Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 3| 5| | |
DAY ON TEST | 3| 8| 7| | |
| 6| 3| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1000 | 9| 9| 9| | L |
UG/KG | 3| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Hemorrhage | 3 | 2 3.0|
Hydrocephalus | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Congestion | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 | 27 1.4|
Inflammation | 1 1 | 7 1.7|
Metaplasia, Squamous | | 1 2.0|
Mineralization | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 9 1.1|
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation | 1 | 6 1.8|
Goblet Cell, Hyperplasia | | 2 2.0|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
Septum, Inflammation | 2 | 7 1.4|
Turbinate, Inflammation | 1 | 10 1.7|
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 52 |
Anterior Chamber, Exudate | 2 | 1 2.0|
Retina, Atrophy | | 1 1.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Inflammation | | 16 1.1|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| 3| 5| | |
DAY ON TEST | 3| 8| 7| | |
| 6| 3| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1000 | 9| 9| 9| | L |
UG/KG | 3| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Calculus Micro Observation Only | X | 5 |
Hydronephrosis | | 1 3.0|
Inflammation, Chronic Active | | 3 1.7|
Inflammation, Suppurative | | 2 1.0|
Mineralization | 1 1 | 40 1.1|
Nephropathy | 3 | 28 1.2|
Pelvis, Inflammation | | 5 1.8|
Transitional Epithelium, Hyperplasia | | 6 1.8|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Inflammation | 1 | 13 1.2|
Transitional Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|
DAY ON TEST | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|
| 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | |
|__________________________________________________________________________|
Intestine Large, Colon | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | X|
|__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + M + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X |
Basophilic Focus, Multiple | X |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X|
Eosinophilic Focus, Multiple | X X X X X |
Fatty Change, Diffuse | 1 1 1 1 1 2 1 2 1 1 |
Fatty Change, Focal | 1 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation | 1 1 2 2 2 1 1 1 1 2 1 1 1 1 1 1 1 1 2 2 1 1 |
Mixed Cell Focus | X X |
Mixed Cell Focus, Multiple | X X X X X X X |
Necrosis | 2 2 3 3 1 3 3|
__________________________________________|__________________________________________________________________________|
Page 99
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|
DAY ON TEST | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|
| 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pigmentation | 1 1 1 |
Bile Duct, Cyst | 3 2 |
Bile Duct, Fibrosis | 1 |
Bile Duct, Hyperplasia | 3 1 2 1 1 1 2 2 2 |
Centrilobular, Degeneration | 2 2 3 |
Hepatocyte, Hypertrophy | 3 1 2 1 2 2 2 2 2 2 3 3 3 3 3 3 3 1 1 3 1|
Oval Cell, Hyperplasia | 1 1 |
Serosa, Fibrosis | 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + |
Gingival, Hyperplasia, Squamous | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | |
Acinus, Vacuolization Cytoplasmic | 1 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 3 2 |
Inflammation | |
Ulcer | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + |
Peridontal Tissue, Inflammation | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 1 1 1 1 2 |
Inflammation | 1 |
__________________________________________|__________________________________________________________________________|
Page 100
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|
DAY ON TEST | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|
| 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 2 2 1 |
Degeneration, Cystic | 2 2 2 2 1 2 1 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 3 2 4 2 |
Hypertrophy | 4 1 4 1 2 3 1 1 2 2 3 3 3 3 1 1 3 1|
Inflammation | |
Necrosis | 3 |
Vacuolization Cytoplasmic | 1 2 1 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | 3 2 2 3 2 |
Cyst | 2 |
Pars Distalis, Hyperplasia | 3 2 1 3 3 1 1 2 1 4 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 1|
Follicular Cell, Hyperplasia | 2 1 |
Follicular Cell, Hypertrophy | 2 2 2 2 1 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation | 1 2 1 1 2 1 1 2 2 1 1 1 2 1 1 2 2 1 1 1 1 2 |
Duct, Cyst | 2 1 1 3 1 2 1 3 2 2 2 2 3 3 3 1 2 3 3 2|
__________________________________________|__________________________________________________________________________|
Page 101
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|
DAY ON TEST | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|
| 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Ovary | + + M + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 2 2 2 2 3 1 2 |
Inflammation, Chronic Active | |
Interstitial Cell, Hyperplasia | |
|__________________________________________________________________________|
Oviduct | + + M + + + M + + + + + + + + + + + + + M + + + +|
Dilatation | 4 |
Inflammation, Chronic Active | 2 2 |
|__________________________________________________________________________|
Uterus | + + M + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | |
Inflammation, Chronic Active | 4 3 2 3 |
Inflammation, Suppurative | 1 2 2 2 1|
Metaplasia, Squamous | 4 2 4 4 2 1 2 2 3 4 1 4 3 2 2 3 2|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 2 3 2 3 |
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 4 3 2 2 3 2 2 2 3 2 3 4 2 2 3 3 3 4 3 3 3|
|__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Ectasia | 3 |
Lumbar, Hemorrhage | 2 |
Lumbar, Hyperplasia, Plasma Cell | |
Mediastinal, Ectasia | 3 |
Renal, Ectasia | 4 |
Renal, Hyperplasia, Plasma Cell | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 3 2 |
Inflammation | |
__________________________________________|__________________________________________________________________________|
Page 102
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|
DAY ON TEST | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|
| 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 2 1 3 1 2 1 1 3 1 3 3 1 2 1 1 1 1 1 1 1 1|
Hemorrhage | |
Infarct | 3 |
Necrosis | |
Pigmentation | 1 1 1 1 2 1 2 1 1 1 1 2 1 2 1 1 1 3 1 2 1 1|
Lymphoid Follicle, Atrophy | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 3 3 2 2 3 3 2 3 2 3 3 2|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 |
Hyperplasia | 2 1 1 1 1 1 1 2 1 |
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 103
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|
DAY ON TEST | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|
| 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 2 1 1 1 1 |
Inflammation | 1 2 1 |
Metaplasia, Squamous | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Nasolacrimal Duct, Inflammation | 3 |
Septum, Inflammation | 1|
Turbinate, Inflammation | 1 1 1 1 2|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + M + M + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 1 |
Calculus Micro Observation Only | X |
Casts Protein | |
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | |
Mineralization | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
Pelvis, Inflammation | 2 2 2|
Renal Tubule, Degeneration | |
Transitional Epithelium, Hyperplasia | 3 2 2|
|__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 104
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 4| 3| 7| 4| 4| 5| 5| 5| 5| 0| 7| 4| 6| 7| 4| 7| 5| 7| 4| 5| 3| 3| 7| 3|
DAY ON TEST | 3| 5| 9| 3| 4| 8| 4| 8| 0| 5| 7| 3| 3| 1| 3| 3| 3| 9| 3| 7| 8| 8| 6| 3| 8|
| 3| 2| 3| 1| 3| 6| 8| 6| 9| 7| 9| 2| 8| 2| 1| 2| 3| 1| 1| 9| 3| 7| 0| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Inflammation | 2 1 3 1 2|
Transitional Epithelium, Hyperplasia | 3 2|
__________________________________________|__________________________________________________________________________
Page 105
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|
| 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
UG/KG | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Parasite Metazoan | X X X X|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 1 |
Basophilic Focus | X X X X X |
Basophilic Focus, Multiple | X |
Clear Cell Focus | X X |
Eosinophilic Focus | |
Eosinophilic Focus, Multiple | X X X X X X X|
Fatty Change, Diffuse | 2 1 1 1 1 1 |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation | 1 3 2 1 1 1 |
Hepatodiaphragmatic Nodule | |
Inflammation | 2 1 1 1 1 2 2 3 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
Mixed Cell Focus | X |
Mixed Cell Focus, Multiple | X X X X X |
Necrosis | 3 2 1 |
__________________________________________|__________________________________________________________________________|
Page 106
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|
| 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
UG/KG | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pigmentation | 1 1 1 1 1 1 |
Bile Duct, Cyst | |
Bile Duct, Fibrosis | 1 1 |
Bile Duct, Hyperplasia | 1 1 2 2 2 1 1 3 |
Centrilobular, Degeneration | 2 1 |
Hepatocyte, Hypertrophy | 2 1 3 3 2 2 3 2 3 3 2 2 3 2 3 3 2 3 2|
Oval Cell, Hyperplasia | 1 2 |
Serosa, Fibrosis | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + |
Gingival, Hyperplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Acinus, Atrophy | 1 2 |
Acinus, Vacuolization Cytoplasmic | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 2 3 |
Inflammation | 3 3 |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + |
Peridontal Tissue, Inflammation | 1 1 1 1 1 4 4 1 1 1 1 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 1 1 1|
Inflammation | |
__________________________________________|__________________________________________________________________________|
Page 107
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|
| 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
UG/KG | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 2 3 2 2 2 1 2 1 2 2 2 2 1 |
Degeneration, Cystic | 2 2 2 2 2 1 |
Hematopoietic Cell Proliferation | 1 2 |
Hyperplasia | 3 3 1 3 2 2 2|
Hypertrophy | 2 1 2 3 2 3 3 2 2 2 1 1 1 1 1 3 3 1 1 1 3 1|
Inflammation | 1 |
Necrosis | 2 1 |
Vacuolization Cytoplasmic | 1 2 1 1 2 1 2 2 2 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2 3 1 2 2 2 2 1|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + M + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 4 2 1 |
Cyst | |
Pars Distalis, Hyperplasia | 1 2 3 3 2 3 1 3 2 2 2 3 2 2 2|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 1 2 2 2 2 1 2 3 2|
Follicular Cell, Hyperplasia | |
Follicular Cell, Hypertrophy | 2 2 3 1 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Inflammation | 1 1 1 3 1 1 1 1 1 3 2 1 1 2 4 1 1 1 1 2 2 1 2|
Duct, Cyst | 1 2 4 3 2 3 3 2 2 2 3 2 2 3 2 3 2 3 3 2|
__________________________________________|__________________________________________________________________________|
Page 108
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|
| 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
UG/KG | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 3 4 4 4 4 4 2 4 4 4 4 4|
Cyst | 3 2 4 2 2 3 2 2 2 2|
Inflammation, Chronic Active | 4 3 4 4 3 3 |
Interstitial Cell, Hyperplasia | 3 |
|__________________________________________________________________________|
Oviduct | + + + M + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic Active | 4 4 4 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | 3 |
Inflammation, Chronic Active | 1 4 3 4 |
Inflammation, Suppurative | 1 1 3 |
Metaplasia, Squamous | 4 2 2 3 1 2 2 1 4 2 4 2 4 1|
Endometrium, Hyperplasia, Cystic | 2 2 2 1 2 2 3 1 2 1 4|
|__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 4 2 4 4 3 4 2 3 4 2 3 3 3 2 2 2 2 2 4|
|__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Ectasia | 2 |
Lumbar, Hemorrhage | |
Lumbar, Hyperplasia, Plasma Cell | 2 2 |
Mediastinal, Ectasia | 1 |
Renal, Ectasia | 3 |
Renal, Hyperplasia, Plasma Cell | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 2 2 2 3 2 3 3 2 2 2 3 3 2 3 3 2 2 3|
Inflammation | 3 |
__________________________________________|__________________________________________________________________________|
Page 109
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|
| 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
UG/KG | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 |
Inflammation, Chronic Active | 4 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 1 3 1 2 3 3 3 1 1 2 3 2 1 1 3 2 1 1 1 2 3|
Hemorrhage | 3 |
Infarct | |
Necrosis | 3 |
Pigmentation | 2 1 2 2 1 1 1 1 2 2 1 1 1 2 1 1 1 2 3 2 1 2 1|
Lymphoid Follicle, Atrophy | 3 3 |
|__________________________________________________________________________|
Thymus | + + + + M M + + + + + + + + + + + + + + + + + + M|
Atrophy | 2 3 3 4 4 3 4 2 2 4 2 2 2 2 3 |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hyperplasia | 1 1 1 2 1 2 2 1 2 1 1 1 3 |
Inflammation, Granulomatous | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 110
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|
| 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
UG/KG | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 1 2 2 2 1 1 1 1 2 1 |
Inflammation | 1 2 2 2 2 2|
Metaplasia, Squamous | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 2 |
Nasolacrimal Duct, Inflammation | 2 |
Septum, Inflammation | 2 3 1 1 1 |
Turbinate, Inflammation | 1 3 3 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 3 1 1 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Calculus Micro Observation Only | |
Casts Protein | 2 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 2 2 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Inflammation | 2 |
Renal Tubule, Degeneration | |
Transitional Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 111
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 6| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 0| 3| 3| 3| 3| 6| 0| 2| 3| 3| 3| 4| 4| 3| 1| 1| 3| 1| 7| 3| 3| 3| 3|
| 2| 1| 5| 1| 2| 1| 3| 8| 1| 3| 3| 3| 1| 2| 1| 1| 3| 4| 3| 4| 5| 2| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
3000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
UG/KG | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Inflammation | 2 3 1 2|
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________
Page 112
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 7| | |
| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 6| | A |
3000 | 2| | L |
UG/KG | 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + | 51 |
Muscularis, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + | 50 |
Inflammation, Chronic Active | | 1 3.0|
Parasite Metazoan | | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 50 |
Inflammation, Chronic Active | | 1 3.0|
Parasite Metazoan | | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 50 |
Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 51 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 50 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 50 |
|__________________________________________________________________________|____________|
Liver | + | 51 |
Angiectasis | | 4 1.5|
Basophilic Focus | | 8 |
Basophilic Focus, Multiple | | 2 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | | 6 |
Eosinophilic Focus, Multiple | | 12 |
Fatty Change, Diffuse | 1 | 17 1.2|
Fatty Change, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | | 14 1.2|
Hepatodiaphragmatic Nodule | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 7| | |
| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 6| | A |
3000 | 2| | L |
UG/KG | 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation | 1 | 45 1.3|
Mixed Cell Focus | | 3 |
Mixed Cell Focus, Multiple | | 12 |
Necrosis | | 10 2.3|
Pigmentation | | 9 1.0|
Bile Duct, Cyst | | 2 2.5|
Bile Duct, Fibrosis | | 3 1.0|
Bile Duct, Hyperplasia | | 17 1.6|
Centrilobular, Degeneration | | 5 2.0|
Hepatocyte, Hypertrophy | 2 | 41 2.3|
Oval Cell, Hyperplasia | | 4 1.3|
Serosa, Fibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 25 |
Gingival, Hyperplasia, Squamous | 3 | 25 1.1|
|__________________________________________________________________________|____________|
Pancreas | + | 51 |
Inflammation, Chronic Active | | 2 1.0|
Acinus, Atrophy | | 2 1.5|
Acinus, Vacuolization Cytoplasmic | | 2 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Hyperkeratosis | | 2 2.0|
Hyperplasia, Squamous | | 4 2.5|
Inflammation | | 2 3.0|
Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Mineralization | | 2 1.5|
|__________________________________________________________________________|____________|
Tooth | + | 35 |
Peridontal Tissue, Inflammation | 2 | 35 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 7| | |
| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 6| | A |
3000 | 2| | L |
UG/KG | 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 51 |
|__________________________________________________________________________|____________|
Heart | + | 51 |
Cardiomyopathy | 1 | 24 1.1|
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Angiectasis | | 21 1.9|
Degeneration, Cystic | | 13 1.8|
Hematopoietic Cell Proliferation | | 3 1.3|
Hyperplasia | | 11 2.5|
Hypertrophy | 1 | 41 2.0|
Inflammation | | 1 1.0|
Necrosis | | 3 2.0|
Vacuolization Cytoplasmic | | 14 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Hyperplasia | | 12 1.9|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + | 48 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + | 50 |
Angiectasis | 3 | 14 2.3|
Cyst | | 1 2.0|
Pars Distalis, Hyperplasia | | 25 2.2|
|__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
C-Cell, Hyperplasia | | 16 1.9|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 7| | |
| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 6| | A |
3000 | 2| | L |
UG/KG | 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Follicular Cell, Hyperplasia | | 2 1.5|
Follicular Cell, Hypertrophy | | 17 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + | 50 |
Inflammation, Chronic Active | | 1 4.0|
Inflammation | 1 | 46 1.4|
Duct, Cyst | 2 | 41 2.3|
|__________________________________________________________________________|____________|
Ovary | + | 50 |
Atrophy | 4 | 39 3.9|
Cyst | | 17 2.2|
Inflammation, Chronic Active | 4 | 7 3.6|
Interstitial Cell, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Oviduct | + | 45 |
Dilatation | | 1 4.0|
Inflammation, Chronic Active | 4 | 7 3.3|
|__________________________________________________________________________|____________|
Uterus | + | 50 |
Adenomyosis | | 1 3.0|
Inflammation, Chronic Active | | 8 3.0|
Inflammation, Suppurative | | 8 1.6|
Metaplasia, Squamous | 3 | 32 2.6|
Endometrium, Hyperplasia, Cystic | | 21 2.1|
|__________________________________________________________________________|____________|
Vagina | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 7| | |
| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 6| | A |
3000 | 2| | L |
UG/KG | 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Bone Marrow | + | 51 |
Hyperplasia | 2 | 46 2.9|
|__________________________________________________________________________|____________|
Lymph Node | | 6 |
Lumbar, Ectasia | | 2 2.5|
Lumbar, Hemorrhage | | 1 2.0|
Lumbar, Hyperplasia, Plasma Cell | | 2 2.0|
Mediastinal, Ectasia | | 2 2.0|
Renal, Ectasia | | 2 3.5|
Renal, Hyperplasia, Plasma Cell | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 51 |
Ectasia | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 3 | 38 2.3|
Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 51 |
Hyperplasia, Plasma Cell | | 1 3.0|
Inflammation, Chronic Active | | 1 4.0|
|__________________________________________________________________________|____________|
Spleen | + | 51 |
Hematopoietic Cell Proliferation | 1 | 47 1.7|
Hemorrhage | | 1 3.0|
Infarct | | 1 3.0|
Necrosis | | 1 3.0|
Pigmentation | 2 | 46 1.4|
Lymphoid Follicle, Atrophy | | 3 2.7|
|__________________________________________________________________________|____________|
Thymus | + | 47 |
Atrophy | | 30 2.6|
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 7| | |
| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 6| | A |
3000 | 2| | L |
UG/KG | 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
Cyst | | 3 2.7|
Hyperplasia | | 22 1.4|
Inflammation, Granulomatous | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + | 51 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + | 51 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + | 51 |
Vacuolization Cytoplasmic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + | 51 |
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | 1 | 28 1.3|
Inflammation | | 9 1.7|
Metaplasia, Squamous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 6 1.0|
|__________________________________________________________________________|____________|
Nose | + | 51 |
Inflammation | | 3 2.0|
Nasolacrimal Duct, Inflammation | | 2 2.5|
Septum, Inflammation | | 6 1.5|
Turbinate, Inflammation | 1 | 10 1.5|
|__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 7| | |
| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 6| | A |
3000 | 2| | L |
UG/KG | 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 51 |
|__________________________________________________________________________|____________|
Harderian Gland | + | 49 |
Inflammation | | 16 1.2|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + | 51 |
Accumulation, Hyaline Droplet | | 1 1.0|
Calculus Micro Observation Only | | 1 |
Casts Protein | | 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
Inflammation, Suppurative | | 3 2.0|
Mineralization | 1 | 41 1.0|
Nephropathy | 3 | 34 1.1|
Pelvis, Inflammation | | 4 2.0|
Renal Tubule, Degeneration | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | | 4 2.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
Inflammation | | 9 1.9|
Transitional Epithelium, Hyperplasia | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 119
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 2| 7| 5| 7| 7| 5| 5| 3| 7| 5| 7| 4| 7| 5| 6| 6| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 3| 4| 3| 9| 3| 3| 9| 1| 6| 3| 9| 2| 3| 3| 2| 7| 2| 3| 9| 3| 3| 0| 7| 5| 3|
| 2| 5| 1| 1| 1| 3| 0| 4| 0| 1| 1| 2| 7| 3| 8| 1| 7| 0| 1| 1| 3| 1| 5| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 UG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
KG STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +|
Muscularis, Inflammation | 1 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Ulcer | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 1 |
Basophilic Focus | X X X X |
Basophilic Focus, Multiple | X |
Clear Cell Focus | X |
Degeneration, Cystic | 2 |
Eosinophilic Focus | X X |
Eosinophilic Focus, Multiple | X X X X X X X X |
Fatty Change, Diffuse | 1 2 2 1 1 1 1 1 1 |
Fatty Change, Focal | 1 1 1 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 3 1 1 1 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Histiocytic | |
Hyperplasia, Nodular | X |
Inflammation | 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1|
Mixed Cell Focus | X X X X |
Mixed Cell Focus, Multiple | X X X X X X X X |
Necrosis | 2 3 2 3 |
Pigmentation | |
__________________________________________|__________________________________________________________________________|
Page 120
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 2| 7| 5| 7| 7| 5| 5| 3| 7| 5| 7| 4| 7| 5| 6| 6| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 3| 4| 3| 9| 3| 3| 9| 1| 6| 3| 9| 2| 3| 3| 2| 7| 2| 3| 9| 3| 3| 0| 7| 5| 3|
| 2| 5| 1| 1| 1| 3| 0| 4| 0| 1| 1| 2| 7| 3| 8| 1| 7| 0| 1| 1| 3| 1| 5| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 UG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
KG STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Cyst | 3 1 |
Bile Duct, Fibrosis | 2 1 1 |
Bile Duct, Hyperplasia | 1 1 2 2 3 3 1 1|
Centrilobular, Degeneration | 3 1 3 |
Hepatocyte, Hypertrophy | 2 2 2 1 1 2 2 2 2 2 2 1 3 3 1|
Oval Cell, Hyperplasia | 1 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 1 1 2 1 1 1 1 1 2 1|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Acinus, Atrophy | 2 |
Acinus, Hyperplasia | 3 1|
Acinus, Vacuolization Cytoplasmic | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + M +|
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | |
Inflammation | |
Mineralization | 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Mineralization | 1 |
Ulcer | |
Serosa, Inflammation | 2 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + +|
Peridontal Tissue, Inflammation | 2 2 1 2 3 1 1 1 1 1 1 1 2 1 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 121
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 2| 7| 5| 7| 7| 5| 5| 3| 7| 5| 7| 4| 7| 5| 6| 6| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 3| 4| 3| 9| 3| 3| 9| 1| 6| 3| 9| 2| 3| 3| 2| 7| 2| 3| 9| 3| 3| 0| 7| 5| 3|
| 2| 5| 1| 1| 1| 3| 0| 4| 0| 1| 1| 2| 7| 3| 8| 1| 7| 0| 1| 1| 3| 1| 5| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 UG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
KG STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 1 1 1 1 1 1 |
Epicardium, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 1 2 2 2 1 1 1 3 2 2|
Degeneration, Cystic | 2 2 1 3 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 3 2 4 2 2 2 3 2 2 2|
Hypertrophy | 2 2 1 2 2 1 3 2 2 2 2 2 2 2 2 3 2 2|
Necrosis | |
Vacuolization Cytoplasmic | 1 1 1 1 1 1 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 3 3 2 1 3 2 2 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + M + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 3 3 2 3 3 3 3 1|
Pars Distalis, Hyperplasia | 2 3 3 2 2 3 3|
Rathke's Cleft, Pars Nervosa, Cyst | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 2 2 2 3 |
Follicular Cell, Hypertrophy | 2 2 1 2 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 122
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 2| 7| 5| 7| 7| 5| 5| 3| 7| 5| 7| 4| 7| 5| 6| 6| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 3| 4| 3| 9| 3| 3| 9| 1| 6| 3| 9| 2| 3| 3| 2| 7| 2| 3| 9| 3| 3| 0| 7| 5| 3|
| 2| 5| 1| 1| 1| 3| 0| 4| 0| 1| 1| 2| 7| 3| 8| 1| 7| 0| 1| 1| 3| 1| 5| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 UG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
KG STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation | 1 1 2 1 1 1 1 1 1 1 2 1 2 1 1 2 2 2 3 1 2 1|
Duct, Cyst | 3 2 2 1 3 2 1 3 2 3 2 3 2 3 2 3 2 1 2 1|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 3 4 4 4 4|
Cyst | 2 2 3 2 2 3 2 2 3 |
|__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic Active | 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 3 3 2 |
Metaplasia, Squamous | 2 2 3 3 2 4 3 2 4 2|
Cervix, Cyst | |
Cervix, Hyperplasia, Stromal | 3 3 |
Endometrium, Hyperplasia, Cystic | 2 3 1 1 3 2 1 2 3 1 1|
|__________________________________________________________________________|
Vagina | + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 3 3 3 2 3 4 4 3 3 3 4 2 3 4 4 4 2 |
|__________________________________________________________________________|
Lymph Node | |
Mediastinal, Hemorrhage | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + M +|
Ectasia | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 3 3 2 3 2 2 3 2 2 2 3 3 2 3 2 3 2 3|
Inflammation | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 123
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 2| 7| 5| 7| 7| 5| 5| 3| 7| 5| 7| 4| 7| 5| 6| 6| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 3| 4| 3| 9| 3| 3| 9| 1| 6| 3| 9| 2| 3| 3| 2| 7| 2| 3| 9| 3| 3| 0| 7| 5| 3|
| 2| 5| 1| 1| 1| 3| 0| 4| 0| 1| 1| 2| 7| 3| 8| 1| 7| 0| 1| 1| 3| 1| 5| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 UG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
KG STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Congestion | 3 |
Hematopoietic Cell Proliferation | 1 3 3 1 2 2 2 2 2 2 2 3 2 2 4 2 2 1 1 3 2|
Hemorrhage | 2 |
Pigmentation | 1 1 2 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 2 1 3 2 1|
Lymphoid Follicle, Atrophy | 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +|
Atrophy | 2 4 2 3 2 2 2 4 3 2 2 2 2 2 2|
Hemorrhage | 3 |
Inflammation | 3 |
Necrosis, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Cyst, Multiple | 3 |
Hyperplasia | 1 2 2 2 1 1 1 2 2 1 1 1 1 2 1 |
Inflammation, Granulomatous | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 124
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
_____________________________________________________________________________________________________________________
| 7| 2| 7| 5| 7| 7| 5| 5| 3| 7| 5| 7| 4| 7| 5| 6| 6| 7| 6| 7| 7| 7| 5| 6| 7|
DAY ON TEST | 3| 4| 3| 9| 3| 3| 9| 1| 6| 3| 9| 2| 3| 3| 2| 7| 2| 3| 9| 3| 3| 0| 7| 5| 3|
| 2| 5| 1| 1| 1| 3| 0| 4| 0| 1| 1| 2| 7| 3| 8| 1| 7| 0| 1| 1| 3| 1| 5| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 UG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
KG STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 1 1 1 1 2 1 2 2 1 2 1 1 1 1|
Inflammation | 1 1 2 1 2 |
Alveolar Epithelium, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 |
Septum, Inflammation | 1 2 |
Turbinate, Inflammation | 1 1 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Retina, Atrophy | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 |
Cyst | 2 |
Fibrosis | 1 |
Inflammation, Chronic Active | 4 1 |
Inflammation, Suppurative | 2 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 3 1 1 1 1 1 1 1|
Pelvis, Inflammation | 2 1 1 |
Transitional Epithelium, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 2 2 1 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________
Page 125
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6| |
DAY ON TEST | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2| |
| 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| A |
3000 UG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
KG STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Muscularis, Inflammation | 1 2 | 3 1.3|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 3 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + M + + + + +| 48 |
Inflammation | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + M + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 1 1 | 8 1.6|
Basophilic Focus | X X X X | 8 |
Basophilic Focus, Multiple | X | 2 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | | 1 2.0|
Eosinophilic Focus | X X | 4 |
Eosinophilic Focus, Multiple | X X | 10 |
Fatty Change, Diffuse | 1 1 1 1 1 1 | 15 1.1|
Fatty Change, Focal | 1 2 1| 6 1.2|
Hematopoietic Cell Proliferation | 1 1 1 1 2 2 | 17 1.2|
Hepatodiaphragmatic Nodule | X X | 2 |
Hyperplasia, Histiocytic | 2 | 1 2.0|
Hyperplasia, Nodular | | 1 |
Inflammation | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 44 1.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 126
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6| |
DAY ON TEST | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2| |
| 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| A |
3000 UG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
KG STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mixed Cell Focus | X X X | 7 |
Mixed Cell Focus, Multiple | X X X X X | 13 |
Necrosis | 3 3 3 2 3 | 9 2.7|
Pigmentation | 1 1 2 | 3 1.3|
Bile Duct, Cyst | 2 | 3 2.0|
Bile Duct, Fibrosis | 1 1 | 5 1.2|
Bile Duct, Hyperplasia | 1 2 2 1 | 12 1.7|
Centrilobular, Degeneration | 2 2 | 5 2.2|
Hepatocyte, Hypertrophy | 1 2 2 2 2 1 2 2 1 1 3 1 2 2 3 1 2| 32 1.8|
Oval Cell, Hyperplasia | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + | 15 |
Gingival, Hyperplasia, Squamous | 1 1 1 1 | 15 1.1|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 2 1.0|
Acinus, Atrophy | 2 2 | 3 2.0|
Acinus, Hyperplasia | | 2 2.0|
Acinus, Vacuolization Cytoplasmic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 2 | 2 2.0|
Hyperplasia, Squamous | 4 2 1 1 2 | 5 2.0|
Inflammation | 2 1 1 2 | 4 1.5|
Mineralization | 1 3 | 3 1.7|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 1 3.0|
Mineralization | 2 1 | 3 1.3|
Ulcer | 3 | 1 3.0|
Serosa, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 127
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6| |
DAY ON TEST | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2| |
| 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| A |
3000 UG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
KG STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + +| 27 |
Peridontal Tissue, Inflammation | 1 1 1 1 1 1 2 1 2 1 1 2| 27 1.4|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 | 15 1.1|
Epicardium, Inflammation | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 1 2 2 2 1| 20 1.7|
Degeneration, Cystic | 2 1 1 | 7 1.7|
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Hyperplasia | 2 2 2 3 2 2 1 3 | 18 2.3|
Hypertrophy | 2 2 1 2 2 1 2 2 1 2 2 1 1 2 1 1 2| 35 1.8|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 1 1 1 1 1 | 12 1.1|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hyperplasia | 3 2 3 1 2 2 1 2 1 4 2| 19 2.2|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + M + + + + + + + + M +| 45 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 2 1 3 3 1 2 3 2 3 2 3| 24 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 128
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6| |
DAY ON TEST | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2| |
| 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| A |
3000 UG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
KG STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pars Distalis, Hyperplasia | 3 3 2 3 4 2 1 2 2 2 2 | 18 2.4|
Rathke's Cleft, Pars Nervosa, Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 2 1 2 2 3 | 13 1.9|
Follicular Cell, Hypertrophy | 2 2 2 | 12 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Inflammation | 1 2 1 1 3 1 1 1 2 2 3 1 1 1 1 1 1 2 2 3 2 2| 44 1.5|
Duct, Cyst | 2 3 3 2 2 3 2 2 3 3 4 2 2 1 1 3 3 3 3 3 3| 41 2.3|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Atrophy | 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 41 3.9|
Cyst | 3 3 2 3 2 2 3 | 16 2.4|
|__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + M + + + + + + + M + +| 46 |
Dilatation | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 2 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Cyst | | 1 4.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Inflammation, Suppurative | 2 1 2 3 3 1 | 9 2.2|
Metaplasia, Squamous | 2 3 2 2 4 3 3 4 3 4 3 2 1 2| 24 2.7|
Cervix, Cyst | 3 | 1 3.0|
Cervix, Hyperplasia, Stromal | | 2 3.0|
Endometrium, Hyperplasia, Cystic | 1 2 2 2 1 2 1 1 1 4 3 2| 23 1.8|
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 129
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6| |
DAY ON TEST | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2| |
| 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| A |
3000 UG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
KG STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 4 2 4 2 3 2 2 3 3 2 3 2 4 4 3 3 3 4 2| 40 3.1|
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Mediastinal, Hemorrhage | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectasia | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia, Plasma Cell | 2 3 2 4 3 3 2 2 3 2 3 2 2 3 2 3 3 3| 37 2.5|
Inflammation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | 3 1 2 2 1 3 2 1 2 1 2 1 1 3 1 1 1 3 1 1 1 3 1| 44 1.9|
Hemorrhage | | 1 2.0|
Pigmentation | 1 2 1 1 2 2 1 1 2 2 1 1 1 1 2 1 1 1 1 1 1 1 2 1 2| 50 1.3|
Lymphoid Follicle, Atrophy | 3 2 | 4 2.3|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 3 3 2 3 3 2 2 2 3 2 3 2 2 | 29 2.4|
Hemorrhage | | 1 3.0|
Inflammation | | 1 3.0|
Necrosis, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 130
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6| |
DAY ON TEST | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2| |
| 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| A |
3000 UG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
KG STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 2| 3 2.3|
Cyst, Multiple | | 1 3.0|
Hyperplasia | 1 1 2 1 2 2 2 2 2 2 1 1| 27 1.5|
Inflammation, Granulomatous | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 2 2 1 2 1 1 2 2 1| 37 1.3|
Inflammation | 2 3 2 2 | 9 1.8|
Alveolar Epithelium, Hyperplasia | 2 1 | 4 1.3|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 2 1.5|
Septum, Inflammation | 1 1 | 4 1.3|
Turbinate, Inflammation | 1 1 | 5 1.2|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 131
NTP Experiment-Test: 96021-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 10/09/03
Route: GAVAGE Time: 09:34:57
__________________________________________________________________________________________________________________________________
| 4| 7| 1| 4| 6| 7| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 1| 6| |
DAY ON TEST | 5| 3| 9| 6| 6| 3| 1| 3| 3| 0| 3| 3| 6| 3| 2| 7| 3| 3| 0| 3| 3| 3| 3| 8| 2| |
| 2| 2| 1| 7| 8| 1| 1| 3| 1| 0| 1| 1| 9| 2| 8| 0| 3| 2| 1| 7| 9| 1| 1| 3| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| A |
3000 UG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
KG STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Retina, Atrophy | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 1 2 1 2 1 | 15 1.2|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts Protein | 1 1 | 4 1.0|
Cyst | | 1 2.0|
Fibrosis | | 1 1.0|
Inflammation, Chronic Active | 3 | 3 2.7|
Inflammation, Suppurative | 2 | 2 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.0|
Nephropathy | 1 3 1 1 1 1 1 1 1 1 1 1 1| 22 1.2|
Pelvis, Inflammation | | 3 1.3|
Transitional Epithelium, Hyperplasia | 2 2 | 4 1.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Inflammation | 2 1 1 2 2 1 | 10 1.7|
Transitional Epithelium, Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 132
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