TDMS Study 96021-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) DATE: 10/09/03
EXPERIMENT: 96021 TEST: 01 TIME: 09:47:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96021
PATHOLOGIST: SELLS, DONALD CAS: 35065-27-1
------------------------------------------------------------------------------------------------------------------------------------
FINAL #3
REASONS FOR REMOVAL: 25018 Dosing Accident
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) DATE: 10/09/03
EXPERIMENT: 96021 TEST: 01 TIME: 09:47:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96021
PATHOLOGIST: SELLS, DONALD CAS: 35065-27-1
TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 UG/KG |
| --------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 211 399 410 418 437 442 502 507 551 555 |
| 555 557 571 590 603 608 613 613 613 621 |
| 641 644 656 664 672 696 696 701 701 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 UG/KG |
| --------------------- |
| |
| TOTAL 54 UNCENSORED DEATHS 38 CENSORED DEATHS 0 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 250 250 261 261 310 310 331 352 352 360 |
| 393 405 438 479 479 479 502 506 507 527 |
| 528 545 557 590 600 613 616 622 624 624 |
| 624 637 647 663 675 696 701 701 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 UG/KG |
| ---------------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 418 429 429 443 501 501 514 514 514 522 |
| 527 530 530 553 591 636 656 674 674 683 |
| 696 700 701 701 701 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 300 UG/KG |
| ---------------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 31 CENSORED DEATHS 1 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 222 263 269 322 360 443 452 457 486 507 |
| 526 528 530 555 555 568 610 613 621 624 |
| 647 647 656 675 675 675 691 691 693 703 |
| 703 |
| CENSORED DEATHS |
| 59 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000 UG/KG |
| ---------------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 341 360 383 452 467 479 497 502 510 514 |
| 529 541 555 579 590 613 617 621 621 625 |
| 636 639 647 647 649 675 696 696 702 706 |
| 715 715 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3000 UG/KG |
| ---------------------------- |
| |
| TOTAL 51 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 79 360 387 387 393 432 438 442 443 452 |
| 479 486 501 505 509 514 514 548 557 583 |
| 586 591 612 613 621 641 668 672 675 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 3000 UG/KG STOP |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 183 191 245 360 400 437 452 467 514 528 |
| 575 590 591 591 611 624 627 637 639 656 |
| 668 669 670 671 691 701 701 722 728 730 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 UG/KG | 100.0 100.0 98.1 98.1 92.5 88.7 84.9 71.7 54.7 45.3 |
| | |
| | |
|10 UG/KG | 100.0 100.0 92.6 81.5 77.8 70.4 59.3 53.7 37.0 29.6 |
| | |
| | |
|100 | 100.0 100.0 100.0 100.0 98.1 92.5 75.5 71.7 67.9 52.8 |
|UG/KG | |
| | |
|300 | 100.0 100.0 94.2 90.4 90.4 84.6 75.0 69.2 55.8 40.4 |
|UG/KG | |
| | |
|1000 | 100.0 100.0 100.0 96.2 94.3 88.7 77.4 71.7 52.8 37.7 |
|UG/KG | |
| | |
|3000 | 98.0 98.0 98.0 96.1 90.2 78.4 66.7 56.9 49.0 41.2 |
|UG/KG | |
| | |
|3000 | 100.0 100.0 94.0 92.0 90.0 84.0 80.0 72.0 60.0 40.0 |
|UG/KG STOP | |
| | |
==================================================================================
TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 UG/KG 10 UG/KG 100 300 1000 3000 3000 |
| UG/KG UG/KG UG/KG UG/KG UG/KG STOP |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 45.3% 29.6% 52.8% 40.4% 37.7% 41.2% 40.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.867 P=0.051 P=0.518N P=0.715 P=0.658 P=0.469 P=0.825 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 567.1 500.4 573.5 547.3 583.3 513.7 562.3 |
|NATURAL DEATHS (C) | (21.2) (23.2) (19.8) (25.3) (18.6) (23.3) (28.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 641.3 568.7 656.7 610.9 639.0 603.2 629.8 |
|(STANDARD ERROR) | (16.1) (21.8) (14.3) (22.0) (15.2) (20.4) (20.7) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)
KAPLAN-MEIER SURVIVAL CURVES
0 UG/KG = 1
10 UG/KG = 2
100 UG/KG = 3
300 UG/KG = 4
1000 UG/KG = 5
3000 UG/KG = 6
3000 UG/KG STOP = 7
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 6 7 14 2 5 3
| 6 77 14 2 2 5 5 1 3 3
| 7 7 44 4 5 561 11 3 3 5
| 2 24 4 667 1 13 5 5 3
90 + 2 2 4 67 611 5 5
| 2 2 661 44 5 5113
P | 747 4 517 1
E | 22 2 6 6 4 43 37 11
R 80 + 22 6 6 45 33 5 7
C | 2 2 66 6 5 1 17 7
E | 2 2 66 3 34 15 1
N | 3 5 1 15 3
T 70 + 2 266 4 4 11573 3
| 226 6 3 3
S | 2 2 66 11577 33
U | 6 6 145147 3 3
R 60 + 2 2 2 6 6 55 7 7
V | 2 2 6 141 1 33
I | 22 4 114
V | 2 26 5 15 713 3
A 50 + 22 6 64 411
L | 22 55
| 66 4 1 7 1
| 22 6 5 56 7
40 + 2 2 2 4 56 4
| 2 2 5
| 2 2
| 22
30 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 81 obs hidden.