TDMS Study 96021-01 Pathology Tables
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
FINAL#4 RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 35065-27-1
Lock Date: 01/16/02
Cage Range: All
Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to days on test
Page 1
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 1| 9| 1| 1| 3| 4| 0| 0| 5| 5| 5| 5| 7| 9| 0| 0| 1| 1| 1| 2| 4| 4| 5| 6| 7|
| 1| 9| 0| 8| 7| 2| 2| 7| 1| 5| 5| 7| 1| 0| 3| 8| 3| 3| 3| 1| 1| 4| 6| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 7| 0| 6| 4| 3| 8| 1| 6| 2| 2| 7| 6| 1| 6| 7| 0| 2| 5| 9| 8| 8| 3| 5| 9| 3|
| 8| 4| 5| 4| 4| 0| 1| 3| 4| 2| 7| 4| 4| 7| 3| 3| 1| 9| 1| 5| 3| 3| 8| 3| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + +|
Peridontal Tissue, Neurofibrosarcoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + M + + + + + + + + + + + + + + + + + + + +|
Aorta, Hemangiosarcoma, Metastatic, | |
Heart | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 1| 9| 1| 1| 3| 4| 0| 0| 5| 5| 5| 5| 7| 9| 0| 0| 1| 1| 1| 2| 4| 4| 5| 6| 7|
| 1| 9| 0| 8| 7| 2| 2| 7| 1| 5| 5| 7| 1| 0| 3| 8| 3| 3| 3| 1| 1| 4| 6| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 7| 0| 6| 4| 3| 8| 1| 6| 2| 2| 7| 6| 1| 6| 7| 0| 2| 5| 9| 8| 8| 3| 5| 9| 3|
| 8| 4| 5| 4| 4| 0| 1| 3| 4| 2| 7| 4| 4| 7| 3| 3| 1| 9| 1| 5| 3| 3| 8| 3| 2|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Heart | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + M + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Neurofibrosarcoma, Metastatic, Tooth | X |
Pars Distalis, Adenoma | X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + M + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
|__________________________________________________________________________|
Oviduct | + + M + + + + + + + + + + + + + + + + + + + + M|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 1| 9| 1| 1| 3| 4| 0| 0| 5| 5| 5| 5| 7| 9| 0| 0| 1| 1| 1| 2| 4| 4| 5| 6| 7|
| 1| 9| 0| 8| 7| 2| 2| 7| 1| 5| 5| 7| 1| 0| 3| 8| 3| 3| 3| 1| 1| 4| 6| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 7| 0| 6| 4| 3| 8| 1| 6| 2| 2| 7| 6| 1| 6| 7| 0| 2| 5| 9| 8| 8| 3| 5| 9| 3|
| 8| 4| 5| 4| 4| 0| 1| 3| 4| 2| 7| 4| 4| 7| 3| 3| 1| 9| 1| 5| 3| 3| 8| 3| 2|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
Polyp Stromal, Multiple | |
|__________________________________________________________________________|
Vagina | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lipoma | |
|__________________________________________________________________________|
Lymph Node | + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + M + + + + + + + M M + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Heart | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Adenoma, Multiple | |
Carcinoma | X |
Fibroadenoma | X X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Vagina | |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 1| 9| 1| 1| 3| 4| 0| 0| 5| 5| 5| 5| 7| 9| 0| 0| 1| 1| 1| 2| 4| 4| 5| 6| 7|
| 1| 9| 0| 8| 7| 2| 2| 7| 1| 5| 5| 7| 1| 0| 3| 8| 3| 3| 3| 1| 1| 4| 6| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 7| 0| 6| 4| 3| 8| 1| 6| 2| 2| 7| 6| 1| 6| 7| 0| 2| 5| 9| 8| 8| 3| 5| 9| 3|
| 8| 4| 5| 4| 4| 0| 1| 3| 4| 2| 7| 4| 4| 7| 3| 3| 1| 9| 1| 5| 3| 3| 8| 3| 2|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Neurofibrosarcoma, Metastatic, Tooth | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + M + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Mediastinum, Hemangiosarcoma, | |
Metastatic, Heart | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Neurofibrosarcoma, Metastatic, Tooth | X |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Neurofibrosarcoma, Metastatic, Tooth | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 4| 7| 1| 4| 0| 0| 4| 5| 5| 5| 6| 7| 7| 9| 0| 1| 2| 3| 6| 6| 7| 8| 9| 3| 5|
| 1| 1| 2| 5| 1| 5| 2| 2| 5| 7| 1| 0| 6| 5| 2| 5| 5| 1| 0| 6| 4| 1| 7| 5| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + +|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + |
Peridontal Tissue, Neurofibrosarcoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Hemangiosarcoma, Metastatic, | |
Heart | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 4| 7| 1| 4| 0| 0| 4| 5| 5| 5| 6| 7| 7| 9| 0| 1| 2| 3| 6| 6| 7| 8| 9| 3| 5|
| 1| 1| 2| 5| 1| 5| 2| 2| 5| 7| 1| 0| 6| 5| 2| 5| 5| 1| 0| 6| 4| 1| 7| 5| 1|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Neurofibrosarcoma, Metastatic, Tooth | |
Pars Distalis, Adenoma | X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X X X X X |
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
|__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 7
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 4| 7| 1| 4| 0| 0| 4| 5| 5| 5| 6| 7| 7| 9| 0| 1| 2| 3| 6| 6| 7| 8| 9| 3| 5|
| 1| 1| 2| 5| 1| 5| 2| 2| 5| 7| 1| 0| 6| 5| 2| 5| 5| 1| 0| 6| 4| 1| 7| 5| 1|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X X|
Polyp Stromal, Multiple | X |
|__________________________________________________________________________|
Vagina | + |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lipoma | X |
|__________________________________________________________________________|
Lymph Node | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + M|
Hemangiosarcoma, Metastatic, Heart | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Adenoma, Multiple | X |
Carcinoma | X X X X X X X |
Fibroadenoma | X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X X X X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Vagina | X |
__________________________________________|__________________________________________________________________________|
Page 8
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 UG/KG | 4| 7| 1| 4| 0| 0| 4| 5| 5| 5| 6| 7| 7| 9| 0| 1| 2| 3| 6| 6| 7| 8| 9| 3| 5|
| 1| 1| 2| 5| 1| 5| 2| 2| 5| 7| 1| 0| 6| 5| 2| 5| 5| 1| 0| 6| 4| 1| 7| 5| 1|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Neurofibrosarcoma, Metastatic, Tooth | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Mediastinum, Hemangiosarcoma, | |
Metastatic, Heart | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Neurofibrosarcoma, Metastatic, Tooth | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Neurofibrosarcoma, Metastatic, Tooth | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 9
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 UG/KG | 5| 7| 7| | L |
| 4| 2| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
Leiomyoma | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 52 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
|__________________________________________________________________________|____________|
Oral Mucosa | + + | 21 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 51 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
|__________________________________________________________________________|____________|
Tooth | + + | 34 |
Peridontal Tissue, Neurofibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 UG/KG | 5| 7| 7| | L |
| 4| 2| 5| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Blood Vessel | + + + | 52 |
Aorta, Hemangiosarcoma, Metastatic, | | |
Heart | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + | 52 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 2 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Neurofibrosarcoma, Metastatic, Tooth | | 1 |
Pars Distalis, Adenoma | X X | 18 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 51 |
Bilateral, C-Cell, Adenoma | X | 2 |
C-Cell, Adenoma | X | 14 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 UG/KG | 5| 7| 7| | L |
| 4| 2| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Cystadenoma | | 1 |
|__________________________________________________________________________|____________|
Oviduct | + + + | 50 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Polyp Stromal | | 6 |
Polyp Stromal, Multiple | | 1 |
|__________________________________________________________________________|____________|
Vagina | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Lipoma | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | | 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 52 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
|__________________________________________________________________________|____________|
Thymus | + + + | 48 |
Hemangiosarcoma, Metastatic, Heart | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 UG/KG | 5| 7| 7| | L |
| 4| 2| 5| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Mammary Gland | + + + | 53 |
Adenoma | | 1 |
Adenoma, Multiple | | 1 |
Carcinoma | | 8 |
Fibroadenoma | X | 22 |
Fibroadenoma, Multiple | X | 19 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Schwannoma Malignant, Metastatic, | | |
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Neurofibrosarcoma, Metastatic, Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 52 |
Alveolar/Bronchiolar Adenoma | | 1 |
Mediastinum, Hemangiosarcoma, | | |
Metastatic, Heart | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
Trachea | + + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 UG/KG | 5| 7| 7| | L |
| 4| 2| 5| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
Neurofibrosarcoma, Metastatic, Tooth | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Neurofibrosarcoma, Metastatic, Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|
DAY ON TEST | 5| 5| 6| 6| 1| 1| 3| 5| 5| 6| 9| 0| 3| 7| 7| 7| 0| 0| 0| 2| 2| 4| 5| 9| 0|
| 0| 0| 1| 1| 0| 0| 1| 2| 2| 0| 3| 5| 8| 9| 9| 9| 2| 6| 7| 7| 8| 5| 7| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 1| 6| 1| 8| 1| 7| 7| 0| 8| 3| 2| 3| 8| 2| 2| 8| 0| 8| 1| 0| 4| 7| 5| 8| 5|
| 6| 6| 8| 5| 4| 9| 7| 6| 4| 1| 9| 3| 0| 2| 3| 6| 9| 2| 9| 5| 0| 8| 0| 3| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oral Mucosa | + + + + + + |
Gingival, Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|
DAY ON TEST | 5| 5| 6| 6| 1| 1| 3| 5| 5| 6| 9| 0| 3| 7| 7| 7| 0| 0| 0| 2| 2| 4| 5| 9| 0|
| 0| 0| 1| 1| 0| 0| 1| 2| 2| 0| 3| 5| 8| 9| 9| 9| 2| 6| 7| 7| 8| 5| 7| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 1| 6| 1| 8| 1| 7| 7| 0| 8| 3| 2| 3| 8| 2| 2| 8| 0| 8| 1| 0| 4| 7| 5| 8| 5|
| 6| 6| 8| 5| 4| 9| 7| 6| 4| 1| 9| 3| 0| 2| 3| 6| 9| 2| 9| 5| 0| 8| 0| 3| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + M + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Oral Mucosa | |
Pars Distalis, Adenoma | X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | + + + + M + + M + + M M + + + + + + + + M + + + M|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Polyp Stromal | X X|
Schwannoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|
DAY ON TEST | 5| 5| 6| 6| 1| 1| 3| 5| 5| 6| 9| 0| 3| 7| 7| 7| 0| 0| 0| 2| 2| 4| 5| 9| 0|
| 0| 0| 1| 1| 0| 0| 1| 2| 2| 0| 3| 5| 8| 9| 9| 9| 2| 6| 7| 7| 8| 5| 7| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 1| 6| 1| 8| 1| 7| 7| 0| 8| 3| 2| 3| 8| 2| 2| 8| 0| 8| 1| 0| 4| 7| 5| 8| 5|
| 6| 6| 8| 5| 4| 9| 7| 6| 4| 1| 9| 3| 0| 2| 3| 6| 9| 2| 9| 5| 0| 8| 0| 3| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cervix, Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Vagina | + |
Fibrosarcoma | X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X X X X |
Fibroadenoma | X X X X X X X X X X X|
Fibroadenoma, Multiple | X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Fibrosarcoma | X |
Keratoacanthoma | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|
DAY ON TEST | 5| 5| 6| 6| 1| 1| 3| 5| 5| 6| 9| 0| 3| 7| 7| 7| 0| 0| 0| 2| 2| 4| 5| 9| 0|
| 0| 0| 1| 1| 0| 0| 1| 2| 2| 0| 3| 5| 8| 9| 9| 9| 2| 6| 7| 7| 8| 5| 7| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 1| 6| 1| 8| 1| 7| 7| 0| 8| 3| 2| 3| 8| 2| 2| 8| 0| 8| 1| 0| 4| 7| 5| 8| 5|
| 6| 6| 8| 5| 4| 9| 7| 6| 4| 1| 9| 3| 0| 2| 3| 6| 9| 2| 9| 5| 0| 8| 0| 3| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Oral Mucosa | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | X |
Carcinoma, Metastatic, Oral Mucosa | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Oral Mucosa | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Stromal Nephroma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 2| 2| 2| 3| 4| 6| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 6| 2| 4| 4| 4| 7| 7| 3| 5| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 0| 1| 3| 0| 1| 2| 0| 3| 0| 4| 0| 4| 7| 2| 2| 2| 3| 3| 4| 4| 5| 5| 5| 2| 3|
| 4| 7| 9| 7| 0| 6| 8| 4| 2| 9| 3| 6| 6| 4| 5| 7| 0| 2| 7| 8| 2| 3| 4| 1| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oral Mucosa | + + + + + + |
Gingival, Squamous Cell Carcinoma | X X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 2| 2| 2| 3| 4| 6| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 6| 2| 4| 4| 4| 7| 7| 3| 5| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 0| 1| 3| 0| 1| 2| 0| 3| 0| 4| 0| 4| 7| 2| 2| 2| 3| 3| 4| 4| 5| 5| 5| 2| 3|
| 4| 7| 9| 7| 0| 6| 8| 4| 2| 9| 3| 6| 6| 4| 5| 7| 0| 2| 7| 8| 2| 3| 4| 1| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M M + + M + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Oral Mucosa | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X X X X |
C-Cell, Adenoma | X X X X X |
C-Cell, Carcinoma | X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + M + + + +|
Carcinoma | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | M + M M M M M + M + + + + + + + + + + + + M M + +|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Polyp Stromal | X X X X X X|
Schwannoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 2| 2| 2| 3| 4| 6| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 6| 2| 4| 4| 4| 7| 7| 3| 5| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 0| 1| 3| 0| 1| 2| 0| 3| 0| 4| 0| 4| 7| 2| 2| 2| 3| 3| 4| 4| 5| 5| 5| 2| 3|
| 4| 7| 9| 7| 0| 6| 8| 4| 2| 9| 3| 6| 6| 4| 5| 7| 0| 2| 7| 8| 2| 3| 4| 1| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cervix, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Vagina | + |
Fibrosarcoma | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X X X X X X X|
Fibroadenoma, Multiple | X X X X X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Fibrosarcoma | |
Keratoacanthoma | X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 2| 2| 2| 3| 4| 6| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 6| 2| 4| 4| 4| 7| 7| 3| 5| 6| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 UG/KG | 0| 1| 3| 0| 1| 2| 0| 3| 0| 4| 0| 4| 7| 2| 2| 2| 3| 3| 4| 4| 5| 5| 5| 2| 3|
| 4| 7| 9| 7| 0| 6| 8| 4| 2| 9| 3| 6| 6| 4| 5| 7| 0| 2| 7| 8| 2| 3| 4| 1| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Oral Mucosa | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | |
Carcinoma, Metastatic, Oral Mucosa | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Oral Mucosa | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Stromal Nephroma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 22
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
10 UG/KG | 0| 2| 3| 8| | L |
| 1| 8| 8| 1| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 54 |
|__________________________________________________________________________|____________|
Liver | + + + + | 54 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 12 |
Gingival, Squamous Cell Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + | 54 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + | 52 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
|__________________________________________________________________________|____________|
Tooth | | 13 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + | 54 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
10 UG/KG | 0| 2| 3| 8| | L |
| 1| 8| 8| 1| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Heart | + + + + | 54 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 54 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 54 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 54 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 54 |
Carcinoma, Metastatic, Oral Mucosa | | 1 |
Pars Distalis, Adenoma | X X X | 19 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 52 |
Bilateral, C-Cell, Adenoma | | 4 |
C-Cell, Adenoma | X X | 9 |
C-Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + | 51 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
10 UG/KG | 0| 2| 3| 8| | L |
| 1| 8| 8| 1| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Ovary | + + + + | 53 |
|__________________________________________________________________________|____________|
Oviduct | + + M + | 38 |
|__________________________________________________________________________|____________|
Uterus | + + + + | 54 |
Carcinoma | | 1 |
Polyp Stromal | X | 9 |
Schwannoma Malignant | | 1 |
Cervix, Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Vagina | + | 3 |
Fibrosarcoma | X | 2 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
|__________________________________________________________________________|____________|
Lymph Node | | 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 52 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 54 |
|__________________________________________________________________________|____________|
Spleen | + + + + | 54 |
|__________________________________________________________________________|____________|
Thymus | + + + + | 53 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
10 UG/KG | 0| 2| 3| 8| | L |
| 1| 8| 8| 1| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Mammary Gland | + + + + | 54 |
Carcinoma | | 6 |
Fibroadenoma | X | 21 |
Fibroadenoma, Multiple | | 13 |
|__________________________________________________________________________|____________|
Skin | + + + + | 54 |
Basal Cell Carcinoma | | 1 |
Fibrosarcoma | | 1 |
Keratoacanthoma | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + | 54 |
Carcinoma, Metastatic, Oral Mucosa | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
Carcinoma, Metastatic, Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + | 54 |
|__________________________________________________________________________|____________|
Trachea | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| | |
| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
10 UG/KG | 0| 2| 3| 8| | L |
| 1| 8| 8| 1| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Eye | + + + + | 54 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + | 54 |
Carcinoma, Metastatic, Oral Mucosa | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + | 54 |
Stromal Nephroma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 4| 0| 0| 1| 1| 1| 2| 2| 3| 3| 5| 9| 3| 5| 7| 7| 8| 9| 0| 0| 0| 0|
| 8| 9| 9| 3| 1| 1| 4| 4| 4| 2| 7| 0| 0| 3| 1| 6| 6| 4| 4| 3| 6| 0| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 2| 7| 7| 1| 2| 6| 0| 3| 6| 5| 8| 1| 8| 1| 3| 8| 1| 1| 8| 1| 5| 2| 2| 8| 9|
UG/KG | 0| 3| 8| 2| 3| 1| 5| 8| 7| 1| 8| 1| 4| 8| 0| 2| 6| 9| 0| 3| 3| 7| 4| 7| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Mesentery | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 4| 0| 0| 1| 1| 1| 2| 2| 3| 3| 5| 9| 3| 5| 7| 7| 8| 9| 0| 0| 0| 0|
| 8| 9| 9| 3| 1| 1| 4| 4| 4| 2| 7| 0| 0| 3| 1| 6| 6| 4| 4| 3| 6| 0| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 2| 7| 7| 1| 2| 6| 0| 3| 6| 5| 8| 1| 8| 1| 3| 8| 1| 1| 8| 1| 5| 2| 2| 8| 9|
UG/KG | 0| 3| 8| 2| 3| 1| 5| 8| 7| 1| 8| 1| 4| 8| 0| 2| 6| 9| 0| 3| 3| 7| 4| 7| 6|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X X X|
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | X |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | |
Granulosa-Theca Tumor Benign | |
Schwannoma Malignant | X |
|__________________________________________________________________________|
Oviduct | + M + + + + + + M + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Polyp Stromal | X |
Squamous Cell Carcinoma | |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 4| 0| 0| 1| 1| 1| 2| 2| 3| 3| 5| 9| 3| 5| 7| 7| 8| 9| 0| 0| 0| 0|
| 8| 9| 9| 3| 1| 1| 4| 4| 4| 2| 7| 0| 0| 3| 1| 6| 6| 4| 4| 3| 6| 0| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 2| 7| 7| 1| 2| 6| 0| 3| 6| 5| 8| 1| 8| 1| 3| 8| 1| 1| 8| 1| 5| 2| 2| 8| 9|
UG/KG | 0| 3| 8| 2| 3| 1| 5| 8| 7| 1| 8| 1| 4| 8| 0| 2| 6| 9| 0| 3| 3| 7| 4| 7| 6|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cervix, Carcinoma | X |
Cervix, Schwannoma Malignant | X|
|__________________________________________________________________________|
Vagina | + |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X X X X |
Fibroadenoma | X X X X X X X X X X X |
Fibroadenoma, Multiple | X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Fibrous Histiocytoma | X |
Lipoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 4| 0| 0| 1| 1| 1| 2| 2| 3| 3| 5| 9| 3| 5| 7| 7| 8| 9| 0| 0| 0| 0|
| 8| 9| 9| 3| 1| 1| 4| 4| 4| 2| 7| 0| 0| 3| 1| 6| 6| 4| 4| 3| 6| 0| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 2| 7| 7| 1| 2| 6| 0| 3| 6| 5| 8| 1| 8| 1| 3| 8| 1| 1| 8| 1| 5| 2| 2| 8| 9|
UG/KG | 0| 3| 8| 2| 3| 1| 5| 8| 7| 1| 8| 1| 4| 8| 0| 2| 6| 9| 0| 3| 3| 7| 4| 7| 6|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal Tubule, Adenoma | X |
|__________________________________________________________________________|
Ureter | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 1| 2| 6| 6| 6| 6| 7| 7| 8| 9| 0| 0| 0| 1| 2| 2| 3| 6| 7| 8| 0| 2| 2| 5| 7|
UG/KG | 5| 5| 3| 6| 8| 9| 5| 9| 5| 0| 2| 3| 4| 7| 1| 9| 6| 2| 0| 6| 1| 2| 8| 4| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 1| 2| 6| 6| 6| 6| 7| 7| 8| 9| 0| 0| 0| 1| 2| 2| 3| 6| 7| 8| 0| 2| 2| 5| 7|
UG/KG | 5| 5| 3| 6| 8| 9| 5| 9| 5| 0| 2| 3| 4| 7| 1| 9| 6| 2| 0| 6| 1| 2| 8| 4| 1|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X X|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + M + + M + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X X X X X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X |
Granulosa-Theca Tumor Benign | X |
Schwannoma Malignant | |
|__________________________________________________________________________|
Oviduct | + + M + M + + + + + + + M + M + + + M + + + + + +|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Polyp Stromal | X X |
Squamous Cell Carcinoma | X X|
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 1| 2| 6| 6| 6| 6| 7| 7| 8| 9| 0| 0| 0| 1| 2| 2| 3| 6| 7| 8| 0| 2| 2| 5| 7|
UG/KG | 5| 5| 3| 6| 8| 9| 5| 9| 5| 0| 2| 3| 4| 7| 1| 9| 6| 2| 0| 6| 1| 2| 8| 4| 1|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cervix, Carcinoma | |
Cervix, Schwannoma Malignant | |
|__________________________________________________________________________|
Vagina | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X |
Fibroadenoma | X X X X X X X X X X X|
Fibroadenoma, Multiple | X X X X X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X|
Fibrous Histiocytoma | |
Lipoma | X |
Subcutaneous Tissue, Sarcoma | X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 1| 2| 6| 6| 6| 6| 7| 7| 8| 9| 0| 0| 0| 1| 2| 2| 3| 6| 7| 8| 0| 2| 2| 5| 7|
UG/KG | 5| 5| 3| 6| 8| 9| 5| 9| 5| 0| 2| 3| 4| 7| 1| 9| 6| 2| 0| 6| 1| 2| 8| 4| 1|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal Tubule, Adenoma | |
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
100 | 7| 7| 9| | L |
UG/KG | 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
|__________________________________________________________________________|____________|
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | + + | 16 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
|__________________________________________________________________________|____________|
Tooth | + + | 19 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
100 | 7| 7| 9| | L |
UG/KG | 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Pheochromocytoma Benign | X | 4 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Pars Distalis, Adenoma | X X | 19 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Adenoma | X | 17 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 52 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
100 | 7| 7| 9| | L |
UG/KG | 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Granulosa Cell Tumor Benign | | 1 |
Granulosa-Theca Tumor Benign | | 1 |
Schwannoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Oviduct | + M + | 44 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Carcinoma | | 1 |
Polyp Stromal | X | 4 |
Squamous Cell Carcinoma | | 2 |
Cervix, Carcinoma | | 1 |
Cervix, Schwannoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Vagina | | 2 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | | 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
|__________________________________________________________________________|____________|
Thymus | + + + | 52 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
100 | 7| 7| 9| | L |
UG/KG | 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Mammary Gland | + + + | 53 |
Adenoma | | 1 |
Carcinoma | | 7 |
Fibroadenoma | | 22 |
Fibroadenoma, Multiple | X | 14 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Fibroma | | 2 |
Fibrous Histiocytoma | | 1 |
Lipoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
100 | 7| 7| 9| | L |
UG/KG | 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Renal Tubule, Adenoma | | 1 |
|__________________________________________________________________________|____________|
Ureter | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 0| 2| 2| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 5| 2| 6| 6| 2| 6| 4| 5| 5| 8| 0| 2| 2| 3| 5| 5| 6| 1| 1| 2| 2| 4| 4| 5| 7|
| 9| 2| 3| 9| 2| 0| 3| 2| 7| 6| 7| 6| 8| 0| 5| 5| 8| 0| 3| 1| 4| 7| 7| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 7| 7| 9| 5| 2| 1| 9| 5| 3| 4| 9| 3| 1| 0| 0| 0| 0| 0| 2| 9| 7| 7| 7| 3|
UG/KG | 9| 7| 1| 7| 9| 3| 5| 2| 8| 3| 2| 5| 2| 2| 1| 7| 6| 2| 9| 9| 8| 3| 9| 4| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Oral Mucosa | + +|
Gingival, Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Tooth | + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 0| 2| 2| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 5| 2| 6| 6| 2| 6| 4| 5| 5| 8| 0| 2| 2| 3| 5| 5| 6| 1| 1| 2| 2| 4| 4| 5| 7|
| 9| 2| 3| 9| 2| 0| 3| 2| 7| 6| 7| 6| 8| 0| 5| 5| 8| 0| 3| 1| 4| 7| 7| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 7| 7| 9| 5| 2| 1| 9| 5| 3| 4| 9| 3| 1| 0| 0| 0| 0| 0| 2| 9| 7| 7| 7| 3|
UG/KG | 9| 7| 1| 7| 9| 3| 5| 2| 8| 3| 2| 5| 2| 2| 1| 7| 6| 2| 9| 9| 8| 3| 9| 4| 4|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + M + + + + + + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Adenoma, Multiple | |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
|__________________________________________________________________________|
Oviduct | + + M M + M M + + + M + + + + + + + + M + M + M|
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 0| 2| 2| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 5| 2| 6| 6| 2| 6| 4| 5| 5| 8| 0| 2| 2| 3| 5| 5| 6| 1| 1| 2| 2| 4| 4| 5| 7|
| 9| 2| 3| 9| 2| 0| 3| 2| 7| 6| 7| 6| 8| 0| 5| 5| 8| 0| 3| 1| 4| 7| 7| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 7| 7| 9| 5| 2| 1| 9| 5| 3| 4| 9| 3| 1| 0| 0| 0| 0| 0| 2| 9| 7| 7| 7| 3|
UG/KG | 9| 7| 1| 7| 9| 3| 5| 2| 8| 3| 2| 5| 2| 2| 1| 7| 6| 2| 9| 9| 8| 3| 9| 4| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
Polyp Stromal | X X |
Schwannoma Malignant | X |
|__________________________________________________________________________|
Vagina | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + M + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X |
Carcinoma, Multiple | |
Fibroadenoma | X X X X X X X X X X X X|
Fibroadenoma, Multiple | X X X |
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 0| 2| 2| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 5| 2| 6| 6| 2| 6| 4| 5| 5| 8| 0| 2| 2| 3| 5| 5| 6| 1| 1| 2| 2| 4| 4| 5| 7|
| 9| 2| 3| 9| 2| 0| 3| 2| 7| 6| 7| 6| 8| 0| 5| 5| 8| 0| 3| 1| 4| 7| 7| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 7| 7| 9| 5| 2| 1| 9| 5| 3| 4| 9| 3| 1| 0| 0| 0| 0| 0| 2| 9| 7| 7| 7| 3|
UG/KG | 9| 7| 1| 7| 9| 3| 5| 2| 8| 3| 2| 5| 2| 2| 1| 7| 6| 2| 9| 9| 8| 3| 9| 4| 4|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Histiocytic Sarcoma | X |
Keratoacanthoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Nephroblastoma | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 0| 2| 2| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 5| 2| 6| 6| 2| 6| 4| 5| 5| 8| 0| 2| 2| 3| 5| 5| 6| 1| 1| 2| 2| 4| 4| 5| 7|
| 9| 2| 3| 9| 2| 0| 3| 2| 7| 6| 7| 6| 8| 0| 5| 5| 8| 0| 3| 1| 4| 7| 7| 6| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 7| 7| 9| 5| 2| 1| 9| 5| 3| 4| 9| 3| 1| 0| 0| 0| 0| 0| 2| 9| 7| 7| 7| 3|
UG/KG | 9| 7| 1| 7| 9| 3| 5| 2| 8| 3| 2| 5| 2| 2| 1| 7| 6| 2| 9| 9| 8| 3| 9| 4| 4|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 7| 9| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 5| 1| 1| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 8| 1| 7| 8| 4| 5| 0| 2| 2| 3| 4| 4| 7| 7| 8| 9| 9| 1| 2| 3| 4| 6| 8| 0|
UG/KG | 1| 4| 3| 6| 1| 6| 0| 4| 4| 5| 0| 3| 4| 2| 8| 0| 1| 6| 1| 1| 1| 5| 0| 5| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 7| 9| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 5| 1| 1| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 8| 1| 7| 8| 4| 5| 0| 2| 2| 3| 4| 4| 7| 7| 8| 9| 9| 1| 2| 3| 4| 6| 8| 0|
UG/KG | 1| 4| 3| 6| 1| 6| 0| 4| 4| 5| 0| 3| 4| 2| 8| 0| 1| 6| 1| 1| 1| 5| 0| 5| 3|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + M + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X X X X X |
C-Cell, Adenoma, Multiple | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X |
|__________________________________________________________________________|
Oviduct | + + + + + + + + M M M M + M + + + + + M + M + + M|
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 7| 9| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 5| 1| 1| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 8| 1| 7| 8| 4| 5| 0| 2| 2| 3| 4| 4| 7| 7| 8| 9| 9| 1| 2| 3| 4| 6| 8| 0|
UG/KG | 1| 4| 3| 6| 1| 6| 0| 4| 4| 5| 0| 3| 4| 2| 8| 0| 1| 6| 1| 1| 1| 5| 0| 5| 3|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X X |
Polyp Stromal | X X X X |
Schwannoma Malignant | |
|__________________________________________________________________________|
Vagina | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Histiocytic Sarcoma | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X |
Carcinoma, Multiple | X |
Fibroadenoma | X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 7| 9| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 5| 1| 1| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 8| 1| 7| 8| 4| 5| 0| 2| 2| 3| 4| 4| 7| 7| 8| 9| 9| 1| 2| 3| 4| 6| 8| 0|
UG/KG | 1| 4| 3| 6| 1| 6| 0| 4| 4| 5| 0| 3| 4| 2| 8| 0| 1| 6| 1| 1| 1| 5| 0| 5| 3|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Histiocytic Sarcoma | |
Keratoacanthoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Nephroblastoma | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 7| 9| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 5| 1| 1| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 4| 8| 1| 7| 8| 4| 5| 0| 2| 2| 3| 4| 4| 7| 7| 8| 9| 9| 1| 2| 3| 4| 6| 8| 0|
UG/KG | 1| 4| 3| 6| 1| 6| 0| 4| 4| 5| 0| 3| 4| 2| 8| 0| 1| 6| 1| 1| 1| 5| 0| 5| 3|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
300 | 2| 9| 9| | L |
UG/KG | 8| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | + | 12 |
Gingival, Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Tooth | + | 22 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
300 | 2| 9| 9| | L |
UG/KG | 8| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Histiocytic Sarcoma | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Pheochromocytoma Benign | | 4 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Pars Distalis, Adenoma | X | 19 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Adenoma | X | 11 |
C-Cell, Adenoma, Multiple | | 1 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
300 | 2| 9| 9| | L |
UG/KG | 8| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Clitoral Gland | + + + | 53 |
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Granulosa Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Oviduct | M + + | 35 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Leiomyosarcoma | X | 3 |
Polyp Stromal | | 6 |
Schwannoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Vagina | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | | 2 |
Mediastinal, Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
300 | 2| 9| 9| | L |
UG/KG | 8| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenoma | | 1 |
Carcinoma | | 4 |
Carcinoma, Multiple | | 1 |
Fibroadenoma | X | 22 |
Fibroadenoma, Multiple | X | 13 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Fibroma | | 1 |
Histiocytic Sarcoma | | 1 |
Keratoacanthoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Astrocytoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
300 | 2| 9| 9| | L |
UG/KG | 8| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Histiocytic Sarcoma | | 1 |
Nephroblastoma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 6| 8| 5| 6| 7| 9| 0| 1| 1| 2| 4| 5| 7| 9| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|
| 1| 0| 3| 2| 7| 9| 7| 2| 0| 4| 9| 1| 5| 9| 0| 3| 7| 1| 1| 5| 6| 9| 7| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 7| 2| 9| 2| 9| 4| 3| 8| 4| 1| 7| 5| 4| 9| 2| 0| 3| 2| 2| 8| 9| 1| 1| 3| 2|
UG/KG | 9| 6| 7| 7| 1| 4| 4| 9| 9| 6| 0| 3| 2| 8| 0| 9| 5| 2| 4| 7| 3| 7| 0| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uterus | |
Cholangioma | |
|__________________________________________________________________________|
Mesentery | |
Carcinoma, Metastatic, Uterus | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 6| 8| 5| 6| 7| 9| 0| 1| 1| 2| 4| 5| 7| 9| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|
| 1| 0| 3| 2| 7| 9| 7| 2| 0| 4| 9| 1| 5| 9| 0| 3| 7| 1| 1| 5| 6| 9| 7| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 7| 2| 9| 2| 9| 4| 3| 8| 4| 1| 7| 5| 4| 9| 2| 0| 3| 2| 2| 8| 9| 1| 1| 3| 2|
UG/KG | 9| 6| 7| 7| 1| 4| 4| 9| 9| 6| 0| 3| 2| 8| 0| 9| 5| 2| 4| 7| 3| 7| 0| 2| 3|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + M + + + +|
Adenoma | X |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M M + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | + + M + M + + + M + + + + + + + M + M + + + + M|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 57
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 6| 8| 5| 6| 7| 9| 0| 1| 1| 2| 4| 5| 7| 9| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|
| 1| 0| 3| 2| 7| 9| 7| 2| 0| 4| 9| 1| 5| 9| 0| 3| 7| 1| 1| 5| 6| 9| 7| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 7| 2| 9| 2| 9| 4| 3| 8| 4| 1| 7| 5| 4| 9| 2| 0| 3| 2| 2| 8| 9| 1| 1| 3| 2|
UG/KG | 9| 6| 7| 7| 1| 4| 4| 9| 9| 6| 0| 3| 2| 8| 0| 9| 5| 2| 4| 7| 3| 7| 0| 2| 3|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Carcinoma | |
Polyp Stromal | X X |
|__________________________________________________________________________|
Vagina | + |
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | |
Mediastinal, Carcinoma, Metastatic, | |
Uterus | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uterus | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X |
Fibroadenoma | X X X X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 6| 8| 5| 6| 7| 9| 0| 1| 1| 2| 4| 5| 7| 9| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|
| 1| 0| 3| 2| 7| 9| 7| 2| 0| 4| 9| 1| 5| 9| 0| 3| 7| 1| 1| 5| 6| 9| 7| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 7| 2| 9| 2| 9| 4| 3| 8| 4| 1| 7| 5| 4| 9| 2| 0| 3| 2| 2| 8| 9| 1| 1| 3| 2|
UG/KG | 9| 6| 7| 7| 1| 4| 4| 9| 9| 6| 0| 3| 2| 8| 0| 9| 5| 2| 4| 7| 3| 7| 0| 2| 3|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroma | |
Fibrosarcoma | |
Fibrous Histiocytoma | X |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Mammary Gland | X |
Carcinoma, Metastatic, Uterus | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________|__________________________________________________________________________
| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 6| 8| 5| 6| 7| 9| 0| 1| 1| 2| 4| 5| 7| 9| 1| 1| 2| 2| 2| 3| 3| 4| 4| 4|
| 1| 0| 3| 2| 7| 9| 7| 2| 0| 4| 9| 1| 5| 9| 0| 3| 7| 1| 1| 5| 6| 9| 7| 7| 9|
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 7| 2| 9| 2| 9| 4| 3| 8| 4| 1| 7| 5| 4| 9| 2| 0| 3| 2| 2| 8| 9| 1| 1| 3| 2|
UG/KG | 9| 6| 7| 7| 1| 4| 4| 9| 9| 6| 0| 3| 2| 8| 0| 9| 5| 2| 4| 7| 3| 7| 0| 2| 3|
_____________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant | X X |
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 6| 6| 2| 6| 5| 5| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 8| 3| 5| 2| 5| 1| 5| 6| 2| 2| 3| 4| 6| 6| 7| 8| 8| 8| 0| 8| 8| 2| 4| 4| 4|
UG/KG | 1| 1| 2| 1| 4| 9| 1| 7| 8| 9| 0| 8| 6| 8| 8| 0| 3| 5| 6| 4| 8| 5| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uterus | X |
Cholangioma | X X |
|__________________________________________________________________________|
Mesentery | + |
Carcinoma, Metastatic, Uterus | X |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 6| 6| 2| 6| 5| 5| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 8| 3| 5| 2| 5| 1| 5| 6| 2| 2| 3| 4| 6| 6| 7| 8| 8| 8| 0| 8| 8| 2| 4| 4| 4|
UG/KG | 1| 1| 2| 1| 4| 9| 1| 7| 8| 9| 0| 8| 6| 8| 8| 0| 3| 5| 6| 4| 8| 5| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + M + + + M M + M + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X X X X |
C-Cell, Adenoma | X X X X X X X X X X X X|
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | + M + + + + M + + + + + M + M M + + + M + + + +|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 6| 6| 2| 6| 5| 5| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 8| 3| 5| 2| 5| 1| 5| 6| 2| 2| 3| 4| 6| 6| 7| 8| 8| 8| 0| 8| 8| 2| 4| 4| 4|
UG/KG | 1| 1| 2| 1| 4| 9| 1| 7| 8| 9| 0| 8| 6| 8| 8| 0| 3| 5| 6| 4| 8| 5| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Carcinoma | X |
Polyp Stromal | X |
|__________________________________________________________________________|
Vagina | |
Fibrous Histiocytoma, Metastatic, | |
Skin | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | X |
Mediastinal, Carcinoma, Metastatic, | |
Uterus | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uterus | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X X X X |
Fibroadenoma | X X X X X X X X X X X X X|
Fibroadenoma, Multiple | X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 6| 6| 2| 6| 5| 5| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 8| 3| 5| 2| 5| 1| 5| 6| 2| 2| 3| 4| 6| 6| 7| 8| 8| 8| 0| 8| 8| 2| 4| 4| 4|
UG/KG | 1| 1| 2| 1| 4| 9| 1| 7| 8| 9| 0| 8| 6| 8| 8| 0| 3| 5| 6| 4| 8| 5| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroma | X |
Fibrosarcoma | X |
Fibrous Histiocytoma | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Mammary Gland | |
Carcinoma, Metastatic, Uterus | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________|__________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 6| 6| 2| 6| 5| 5| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 | 8| 3| 5| 2| 5| 1| 5| 6| 2| 2| 3| 4| 6| 6| 7| 8| 8| 8| 0| 8| 8| 2| 4| 4| 4|
UG/KG | 1| 1| 2| 1| 4| 9| 1| 7| 8| 9| 0| 8| 6| 8| 8| 0| 3| 5| 6| 4| 8| 5| 1| 6| 7|
_____________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1000 | 5| 6| 9| | L |
UG/KG | 5| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Carcinoma, Metastatic, Uterus | | 1 |
Cholangioma | | 2 |
|__________________________________________________________________________|____________|
Mesentery | | 1 |
Carcinoma, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | + + | 16 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
|__________________________________________________________________________|____________|
Tooth | + + | 23 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1000 | 5| 6| 9| | L |
UG/KG | 5| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Pheochromocytoma Benign | X | 2 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 46 |
Adenoma | | 2 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Pars Distalis, Adenoma | X X | 24 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
Bilateral, C-Cell, Adenoma | | 5 |
C-Cell, Adenoma | X X | 17 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 51 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1000 | 5| 6| 9| | L |
UG/KG | 5| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Ovary | + + + | 53 |
|__________________________________________________________________________|____________|
Oviduct | + + + | 39 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Carcinoma | | 1 |
Polyp Stromal | | 3 |
|__________________________________________________________________________|____________|
Vagina | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | + | 5 |
Deep Cervical, Carcinoma, Metastatic,| | |
Thyroid Gland | | 1 |
Mediastinal, Carcinoma, Metastatic, | | |
Uterus | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Carcinoma, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
|__________________________________________________________________________|____________|
Thymus | + + + | 53 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1000 | 5| 6| 9| | L |
UG/KG | 5| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenoma | | 3 |
Carcinoma | | 6 |
Fibroadenoma | X | 27 |
Fibroadenoma, Multiple | X | 12 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Basal Cell Adenoma | | 1 |
Fibroma | | 1 |
Fibrosarcoma | | 1 |
Fibrous Histiocytoma | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
Carcinoma, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
1000 | 5| 6| 9| | L |
UG/KG | 5| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 52 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 0| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
DAY ON TEST | 7| 6| 8| 8| 9| 3| 3| 4| 4| 5| 7| 8| 0| 0| 0| 1| 1| 4| 5| 8| 8| 9| 1| 1| 2|
| 9| 0| 7| 7| 3| 2| 8| 2| 3| 2| 9| 6| 1| 5| 9| 4| 4| 8| 7| 3| 6| 1| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 5|
3000 | 1| 3| 3| 3| 0| 2| 2| 0| 0| 0| 2| 0| 4| 3| 0| 1| 1| 0| 1| 3| 0| 2| 2| 1| 3|
UG/KG | 1| 2| 1| 4| 3| 5| 2| 3| 5| 2| 9| 6| 3| 7| 9| 2| 4| 7| 0| 0| 8| 7| 3| 1| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + +|
Gingival, Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 0| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
DAY ON TEST | 7| 6| 8| 8| 9| 3| 3| 4| 4| 5| 7| 8| 0| 0| 0| 1| 1| 4| 5| 8| 8| 9| 1| 1| 2|
| 9| 0| 7| 7| 3| 2| 8| 2| 3| 2| 9| 6| 1| 5| 9| 4| 4| 8| 7| 3| 6| 1| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 5|
3000 | 1| 3| 3| 3| 0| 2| 2| 0| 0| 0| 2| 0| 4| 3| 0| 1| 1| 0| 1| 3| 0| 2| 2| 1| 3|
UG/KG | 1| 2| 1| 4| 3| 5| 2| 3| 5| 2| 9| 6| 3| 7| 9| 2| 4| 7| 0| 0| 8| 7| 3| 1| 6|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
Pars Distalis, Carcinoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
C-Cell, Adenoma, Multiple | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | + + + + M + + + + + + + + + + + + M + M + + + + +|
|__________________________________________________________________________|
Uterus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | |
Cervix, Schwannoma Malignant, | |
Metastatic, Vagina | X |
|__________________________________________________________________________|
Vagina | + + |
Schwannoma Malignant | X X |
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 0| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
DAY ON TEST | 7| 6| 8| 8| 9| 3| 3| 4| 4| 5| 7| 8| 0| 0| 0| 1| 1| 4| 5| 8| 8| 9| 1| 1| 2|
| 9| 0| 7| 7| 3| 2| 8| 2| 3| 2| 9| 6| 1| 5| 9| 4| 4| 8| 7| 3| 6| 1| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 5|
3000 | 1| 3| 3| 3| 0| 2| 2| 0| 0| 0| 2| 0| 4| 3| 0| 1| 1| 0| 1| 3| 0| 2| 2| 1| 3|
UG/KG | 1| 2| 1| 4| 3| 5| 2| 3| 5| 2| 9| 6| 3| 7| 9| 2| 4| 7| 0| 0| 8| 7| 3| 1| 6|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X |
Fibroadenoma | X X X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 0| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
DAY ON TEST | 7| 6| 8| 8| 9| 3| 3| 4| 4| 5| 7| 8| 0| 0| 0| 1| 1| 4| 5| 8| 8| 9| 1| 1| 2|
| 9| 0| 7| 7| 3| 2| 8| 2| 3| 2| 9| 6| 1| 5| 9| 4| 4| 8| 7| 3| 6| 1| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 5|
3000 | 1| 3| 3| 3| 0| 2| 2| 0| 0| 0| 2| 0| 4| 3| 0| 1| 1| 0| 1| 3| 0| 2| 2| 1| 3|
UG/KG | 1| 2| 1| 4| 3| 5| 2| 3| 5| 2| 9| 6| 3| 7| 9| 2| 4| 7| 0| 0| 8| 7| 3| 1| 6|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma, Metastatic, | |
Skin | X |
Carcinoma, Metastatic, Mammary Gland | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + M + M + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | |
Stromal Nephroma | X |
Bilateral, Renal Tubule, Carcinoma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 7| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 8| 2| 5| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 5| 5| 5| 5| 6|
3000 | 0| 4| 2| 1| 4| 0| 2| 2| 3| 4| 0| 0| 1| 1| 1| 2| 3| 3| 3| 1| 0| 2| 4| 4| 0|
UG/KG | 4| 2| 0| 5| 4| 4| 4| 8| 8| 0| 2| 5| 7| 8| 9| 1| 3| 5| 9| 6| 1| 6| 1| 5| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 7| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 8| 2| 5| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 5| 5| 5| 5| 6|
3000 | 0| 4| 2| 1| 4| 0| 2| 2| 3| 4| 0| 0| 1| 1| 1| 2| 3| 3| 3| 1| 0| 2| 4| 4| 0|
UG/KG | 4| 2| 0| 5| 4| 4| 4| 8| 8| 0| 2| 5| 7| 8| 9| 1| 3| 5| 9| 6| 1| 6| 1| 5| 1|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Carcinoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X X |
C-Cell, Adenoma, Multiple | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
Cervix, Schwannoma Malignant, | |
Metastatic, Vagina | |
|__________________________________________________________________________|
Vagina | + |
Schwannoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 7| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 8| 2| 5| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 5| 5| 5| 5| 6|
3000 | 0| 4| 2| 1| 4| 0| 2| 2| 3| 4| 0| 0| 1| 1| 1| 2| 3| 3| 3| 1| 0| 2| 4| 4| 0|
UG/KG | 4| 2| 0| 5| 4| 4| 4| 8| 8| 0| 2| 5| 7| 8| 9| 1| 3| 5| 9| 6| 1| 6| 1| 5| 1|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + M + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Fibroadenoma | X X X X X X X X X X X X|
Fibroadenoma, Multiple | X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 77
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 7| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 8| 2| 5| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 5| 5| 5| 5| 6|
3000 | 0| 4| 2| 1| 4| 0| 2| 2| 3| 4| 0| 0| 1| 1| 1| 2| 3| 3| 3| 1| 0| 2| 4| 4| 0|
UG/KG | 4| 2| 0| 5| 4| 4| 4| 8| 8| 0| 2| 5| 7| 8| 9| 1| 3| 5| 9| 6| 1| 6| 1| 5| 1|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma, Metastatic, | |
Skin | |
Carcinoma, Metastatic, Mammary Gland | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | X |
Stromal Nephroma | |
Bilateral, Renal Tubule, Carcinoma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 6| | A |
3000 | 1| | L |
UG/KG | 3| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + | 51 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + | 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 50 |
|__________________________________________________________________________|____________|
Liver | + | 51 |
Hepatocellular Adenoma | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 25 |
Gingival, Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + | 51 |
|__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
|__________________________________________________________________________|____________|
Tooth | + | 35 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 79
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 6| | A |
3000 | 1| | L |
UG/KG | 3| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Blood Vessel | + | 51 |
|__________________________________________________________________________|____________|
Heart | + | 51 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Pheochromocytoma Benign | | 2 |
Bilateral, Pheochromocytoma Benign | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + | 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + | 50 |
Pars Distalis, Adenoma | | 11 |
Pars Distalis, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
C-Cell, Adenoma | X | 6 |
C-Cell, Adenoma, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + | 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 6| | A |
3000 | 1| | L |
UG/KG | 3| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Ovary | + | 50 |
|__________________________________________________________________________|____________|
Oviduct | + | 45 |
|__________________________________________________________________________|____________|
Uterus | + | 50 |
Polyp Stromal | X | 2 |
Cervix, Schwannoma Malignant, | | |
Metastatic, Vagina | | 1 |
|__________________________________________________________________________|____________|
Vagina | | 3 |
Schwannoma Malignant | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
|__________________________________________________________________________|____________|
Lymph Node | | 6 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 51 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 51 |
|__________________________________________________________________________|____________|
Spleen | + | 51 |
|__________________________________________________________________________|____________|
Thymus | + | 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
Adenoma | | 2 |
Carcinoma | | 2 |
Fibroadenoma | | 24 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 6| | A |
3000 | 1| | L |
UG/KG | 3| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Fibroadenoma, Multiple | X | 8 |
|__________________________________________________________________________|____________|
Skin | + | 51 |
Basal Cell Carcinoma | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + | 51 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + | 51 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + | 51 |
Basal Cell Carcinoma, Metastatic, | | |
Skin | | 1 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
|__________________________________________________________________________|____________|
Nose | + | 51 |
|__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 51 |
|__________________________________________________________________________|____________|
Harderian Gland | + | 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| | T |
ANIMAL ID | 6| | A |
3000 | 1| | L |
UG/KG | 3| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + | 51 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
Stromal Nephroma | | 1 |
Bilateral, Renal Tubule, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 83
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 1| 1| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 9| 4| 6| 0| 3| 5| 6| 1| 2| 7| 9| 9| 9| 1| 2| 2| 3| 3| 5| 6| 6| 7| 7| 9|
| 3| 1| 5| 0| 0| 7| 2| 7| 4| 8| 5| 0| 1| 1| 1| 4| 7| 7| 9| 6| 8| 9| 0| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 UG/ | 9| 7| 5| 5| 8| 6| 7| 7| 5| 6| 7| 5| 5| 6| 8| 0| 6| 9| 9| 7| 8| 8| 9| 6| 6|
KG STOP | 9| 8| 2| 9| 5| 3| 6| 9| 8| 5| 3| 7| 4| 1| 2| 0| 7| 5| 6| 4| 0| 8| 1| 6| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + M + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangioma | |
Cholangioma, Multiple | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + +|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Adenoma | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + M + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 1| 1| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 9| 4| 6| 0| 3| 5| 6| 1| 2| 7| 9| 9| 9| 1| 2| 2| 3| 3| 5| 6| 6| 7| 7| 9|
| 3| 1| 5| 0| 0| 7| 2| 7| 4| 8| 5| 0| 1| 1| 1| 4| 7| 7| 9| 6| 8| 9| 0| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 UG/ | 9| 7| 5| 5| 8| 6| 7| 7| 5| 6| 7| 5| 5| 6| 8| 0| 6| 9| 9| 7| 8| 8| 9| 6| 6|
KG STOP | 9| 8| 2| 9| 5| 3| 6| 9| 8| 5| 3| 7| 4| 1| 2| 0| 7| 5| 6| 4| 0| 8| 1| 6| 9|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
|__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + + + + + + + + + M + + + + M + + +|
Adenoma | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Carcinoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
C-Cell, Adenoma | X X X X X |
C-Cell, Carcinoma | X X|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 1| 1| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 9| 4| 6| 0| 3| 5| 6| 1| 2| 7| 9| 9| 9| 1| 2| 2| 3| 3| 5| 6| 6| 7| 7| 9|
| 3| 1| 5| 0| 0| 7| 2| 7| 4| 8| 5| 0| 1| 1| 1| 4| 7| 7| 9| 6| 8| 9| 0| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 UG/ | 9| 7| 5| 5| 8| 6| 7| 7| 5| 6| 7| 5| 5| 6| 8| 0| 6| 9| 9| 7| 8| 8| 9| 6| 6|
KG STOP | 9| 8| 2| 9| 5| 3| 6| 9| 8| 5| 3| 7| 4| 1| 2| 0| 7| 5| 6| 4| 0| 8| 1| 6| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Granulosa-Theca Tumor Benign | |
|__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Polyp Stromal | X X |
Cervix, Schwannoma Malignant | X |
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + M + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X X X|
Fibroadenoma | X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Fibroma | X |
Fibrosarcoma | X X |
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 1| 1| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 9| 4| 6| 0| 3| 5| 6| 1| 2| 7| 9| 9| 9| 1| 2| 2| 3| 3| 5| 6| 6| 7| 7| 9|
| 3| 1| 5| 0| 0| 7| 2| 7| 4| 8| 5| 0| 1| 1| 1| 4| 7| 7| 9| 6| 8| 9| 0| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 UG/ | 9| 7| 5| 5| 8| 6| 7| 7| 5| 6| 7| 5| 5| 6| 8| 0| 6| 9| 9| 7| 8| 8| 9| 6| 6|
KG STOP | 9| 8| 2| 9| 5| 3| 6| 9| 8| 5| 3| 7| 4| 1| 2| 0| 7| 5| 6| 4| 0| 8| 1| 6| 9|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibrous Histiocytoma | X |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Skin | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Meninges, Sarcoma | X |
Meninges, Schwannoma Malignant, | |
Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | X |
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma, Metastatic, | |
Skin | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Optic Nerve, Schwannoma Malignant, | |
Metastatic, Skin | X |
__________________________________________|__________________________________________________________________________|
Page 87
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
_____________________________________________________________________________________________________________________
| 1| 1| 2| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 9| 4| 6| 0| 3| 5| 6| 1| 2| 7| 9| 9| 9| 1| 2| 2| 3| 3| 5| 6| 6| 7| 7| 9|
| 3| 1| 5| 0| 0| 7| 2| 7| 4| 8| 5| 0| 1| 1| 1| 4| 7| 7| 9| 6| 8| 9| 0| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5|
3000 UG/ | 9| 7| 5| 5| 8| 6| 7| 7| 5| 6| 7| 5| 5| 6| 8| 0| 6| 9| 9| 7| 8| 8| 9| 6| 6|
KG STOP | 9| 8| 2| 9| 5| 3| 6| 9| 8| 5| 3| 7| 4| 1| 2| 0| 7| 5| 6| 4| 0| 8| 1| 6| 9|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Skin | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Stromal Nephroma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 88
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 2| 8| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
3000 UG/ | 7| 9| 6| 9| 6| 5| 5| 6| 7| 8| 8| 8| 8| 9| 9| 5| 7| 7| 8| 9| 5| 6| 7| 8| 9| L |
KG STOP | 2| 4| 2| 0| 8| 3| 5| 0| 0| 1| 4| 6| 7| 7| 8| 1| 5| 7| 9| 3| 6| 4| 1| 3| 2| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosarcoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cholangioma | X | 1 |
Cholangioma, Multiple | X | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + +| 15 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + +| 27 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 89
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 2| 8| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
3000 UG/ | 7| 9| 6| 9| 6| 5| 5| 6| 7| 8| 8| 8| 8| 9| 9| 5| 7| 7| 8| 9| 5| 6| 7| 8| 9| L |
KG STOP | 2| 4| 2| 0| 8| 3| 5| 0| 0| 1| 4| 6| 7| 7| 8| 1| 5| 7| 9| 3| 6| 4| 1| 3| 2| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X X X X | 6 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 45 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X | 23 |
Pars Distalis, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Adenoma | X X X X X X X X X X X X X| 18 |
C-Cell, Carcinoma | X | 3 |
Follicular Cell, Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 90
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 2| 8| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
3000 UG/ | 7| 9| 6| 9| 6| 5| 5| 6| 7| 8| 8| 8| 8| 9| 9| 5| 7| 7| 8| 9| 5| 6| 7| 8| 9| L |
KG STOP | 2| 4| 2| 0| 8| 3| 5| 0| 0| 1| 4| 6| 7| 7| 8| 1| 5| 7| 9| 3| 6| 4| 1| 3| 2| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + M M + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Ovary | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Cystadenoma | X | 1 |
Granulosa-Theca Tumor Benign | X | 1 |
|__________________________________________________________________________|____________|
Oviduct | + + + M + + + + + + + + + + M + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Uterus | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma | X | 1 |
Polyp Stromal | X X | 4 |
Cervix, Schwannoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 91
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 2| 8| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
3000 UG/ | 7| 9| 6| 9| 6| 5| 5| 6| 7| 8| 8| 8| 8| 9| 9| 5| 7| 7| 8| 9| 5| 6| 7| 8| 9| L |
KG STOP | 2| 4| 2| 0| 8| 3| 5| 0| 0| 1| 4| 6| 7| 7| 8| 1| 5| 7| 9| 3| 6| 4| 1| 3| 2| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Carcinoma | X X X X X X | 10 |
Fibroadenoma | X X X X X X X | 16 |
Fibroadenoma, Multiple | X X X X X X X X | 14 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basal Cell Carcinoma | X | 1 |
Fibroma | X | 2 |
Fibrosarcoma | X X | 4 |
Fibrous Histiocytoma | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Schwannoma Malignant, Metastatic, | | |
Skin | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
Meninges, Sarcoma | | 1 |
Meninges, Schwannoma Malignant, | | |
Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 92
NTP Experiment-Test: 96021-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 12/15/03
Route: GAVAGE Time: 11:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 2| 8| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
3000 UG/ | 7| 9| 6| 9| 6| 5| 5| 6| 7| 8| 8| 8| 8| 9| 9| 5| 7| 7| 8| 9| 5| 6| 7| 8| 9| L |
KG STOP | 2| 4| 2| 0| 8| 3| 5| 0| 0| 1| 4| 6| 7| 7| 8| 1| 5| 7| 9| 3| 6| 4| 1| 3| 2| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basal Cell Carcinoma, Metastatic, | | |
Skin | X | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Optic Nerve, Schwannoma Malignant, | | |
Metastatic, Skin | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Schwannoma Malignant, Metastatic, | | |
Skin | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Stromal Nephroma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 93
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