TDMS Study 99022-02 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Southern Research Inst AZT TRANSPLACENTAL CARCINOGENESIS STUDY DATE: 10/08/03
EXPERIMENT: 99022 TEST: 02 TIME: 16:01:05
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: PERINATAL EXPOS ROUTE: IN-UTERO NTP: C99022
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FINAL/MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: MERGE 001 001,011 0 MG/KG/DY
MERGE 002 002,012 50 MG/KG/DY
MERGE 003 003,013 100 MG/KG/DY
MERGE 004 004,014 200 MG/KG/DY
MERGE 005 005,015 300 MG/KG/DY
MERGE 006 006,016 0 MG/KG/DY
MERGE 007 007,017 50 MG/KG/DY
MERGE 008 008,018 100 MG/KG/DY
MERGE 009 009,019 200 MG/KG/DY
MERGE 010 010,020 300 MG/KG/DY
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: SOUTHERN RESEARCH INSTITUTE AZT TRANSPLACENTAL CARCINOGENESIS STUDY DATE: 10/08/03
EXPERIMENT: 99022 TEST: 02 TIME: 16:09:47
SPECIES: MICE, SWISS
TEST TYPE: PERINATAL EXPOSURE ROUTE: IN-UTERO NTP: C99022
CONT: N01-ES-15328 CAS: 30516-87-1
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
PERINATAL EXPOSURE IN-UTERO STUDY OF AZT TRANSPLACENTAL CARCINOGENESIS STUDY
===================================================================================================================================
WEEK 0 MG/KG/DY 50 MG/KG/DY 100 MG/KG/DY 200 MG/KG/DY 300 MG/KG/DY
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
5 28.1 49* 26.3 93.6 44* 26.4 94.0 48* 26.9 95.7 37 25.6 91.1 32
9 40.3 50 37.6 93.3 49 38.1 94.5 50 38.7 96.0 37 36.9 91.6 30
13 44.6 50 42.6 95.5 49 42.9 96.2 50 43.7 98.0 37 41.4 92.8 30
17 48.8 48 46.4 95.1 49 46.6 95.5 50 45.8 93.9 37 44.7 91.6 30
21 49.6 48 48.4 97.6 49 48.2 97.2 50 47.5 95.8 37 46.1 92.9 30
25 52.6 48 50.1 95.2 46 50.6 96.2 49 50.6 96.2 34 47.6 90.5 30
29 53.3 48 51.3 96.2 46 50.7 95.1 48 50.9 95.5 34 48.9 91.7 29
33 54.8 48 51.7 94.3 46 51.2 93.4 47 52.0 94.9 34 48.8 89.1 27*
37 54.1 47* 51.3 94.8 38* 51.1 94.5 43* 51.6 95.4 34 49.5 91.5 28
41 55.4 48 53.1 95.8 43 52.6 94.9 45 52.3 94.4 34 50.7 91.5 28
45 56.1 47 53.3 95.0 40* 53.4 95.2 44 52.2 93.0 32 51.5 91.8 28
49 56.0 43* 53.5 95.5 36* 52.5 93.8 39* 52.7 94.1 29 52.5 93.8 25
53 56.3 44 55.1 97.9 38 53.3 94.7 41 53.9 95.7 28 52.0 92.4 25
57 56.0 42 54.9 98.0 35* 54.6 97.5 39 53.3 95.2 27 53.3 95.2 24
61 56.3 40 55.0 97.7 34* 54.2 96.3 38 52.2 92.7 26 53.4 94.8 23
65 56.5 39 54.7 96.8 32* 53.7 95.0 37 52.6 93.1 24* 53.6 94.9 23
69 55.4 36 54.8 98.9 29* 54.2 97.8 35 52.0 93.9 25 52.4 94.6 22
73 55.7 33 55.3 99.3 30 55.0 98.7 31 51.1 91.7 23 53.8 96.6 20
77 53.6 14* 55.2 103.0 16* 54.0 100.7 13* 52.4 97.8 11* 51.8 96.6 16*
81 54.8 30 52.2 95.3 28 55.4 101.1 25 49.5 90.3 19 53.5 97.6 17
85 54.2 28 55.0 101.5 24 54.1 99.8 23 49.0 90.4 17 51.6 95.2 16
89 55.4 24 53.1 95.8 23 53.3 96.2 18 48.6 87.7 13 50.5 91.2 15
93 54.5 21 52.2 95.8 21 52.8 96.9 14 50.2 92.1 8 51.9 95.2 10
TERM. SAC. 19 21 13 7 8
===================================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
PERINATAL EXPOSURE IN-UTERO STUDY OF AZT TRANSPLACENTAL CARCINOGENESIS STUDY
===================================================================================================================================
WEEK 0 MG/KG/DY 50 MG/KG/DY 100 MG/KG/DY 200 MG/KG/DY 300 MG/KG/DY
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
5 21.4 48* 20.2 94.4 45* 20.4 95.3 46* 22.3 104.2 40 19.4 90.7 42
9 30.2 50 28.5 94.4 50 28.7 95.0 50 30.6 101.3 40 28.4 94.0 40
13 35.2 50 33.2 94.3 50 33.5 95.2 50 35.5 100.9 40 34.1 96.9 40
17 39.9 49 36.9 92.5 50 37.4 93.7 50 39.9 100.0 40 39.9 100.0 40
21 41.9 49 38.8 92.6 50 39.7 94.7 50 41.9 100.0 40 41.8 99.8 40
25 45.3 49 42.3 93.4 45* 42.8 94.5 50 45.4 100.2 40 45.3 100.0 40
29 46.7 48 44.1 94.4 50 44.4 95.1 48 46.3 99.1 40 46.3 99.1 40
33 48.7 24* 46.6 95.7 24* 42.1 86.4 23* 48.6 99.8 17* 45.4 93.2 24*
37 48.2 46 46.9 97.3 48 48.2 100.0 47 49.5 102.7 40 50.0 103.7 39
41 51.3 46 49.7 96.9 48 49.9 97.3 47 51.2 99.8 40 51.2 99.8 39
45 52.7 21* 52.7 100.0 24* 49.4 93.7 22* 54.4 103.2 17* 49.1 93.2 24*
49 51.1 45 50.5 98.8 46 51.9 101.6 44 52.1 102.0 40 51.8 101.4 37
53 53.1 44 51.9 97.7 43 53.2 100.2 43 52.9 99.6 39 52.6 99.1 37
57 55.3 20* 55.2 99.8 22* 53.0 95.8 21* 55.8 100.9 16* 49.7 89.9 23*
61 54.7 22* 53.6 98.0 17* 58.4 106.8 21* 53.5 97.8 22* 62.9 115.0 14*
65 54.8 40 55.2 100.7 38 56.2 102.6 41 53.1 96.9 38 52.8 96.4 36
69 55.6 39 54.5 98.0 34 55.9 100.5 40 52.1 93.7 38 54.0 97.1 31
73 56.7 38 54.4 95.9 30* 57.3 101.1 38 52.6 92.8 36 55.3 97.5 29
77 55.9 17* 52.8 94.5 18* 57.1 102.1 18* 52.6 94.1 15* 46.5 83.2 14*
80 50.4 NA 1*
81 56.3 35 55.3 98.2 24 57.8 102.7 35 55.4 98.4 27* 56.7 100.7 26
85 56.2 30 55.4 98.6 21 57.7 102.7 32 53.5 95.2 27 55.8 99.3 24
89 56.2 24 55.6 98.9 20 57.8 102.8 29 51.9 92.3 23* 56.5 100.5 21
93 54.4 22 56.6 104.0 19 57.2 105.1 27 50.2 92.3 22 58.3 107.2 19
TERM. SAC. 20 18 24 20 19
===================================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.