TDMS Study 91001-02 Pathology Tables

NTP Experiment-Test: 91001-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  O-CHLOROANILINE                                      Date: 10/20/04
Route: GAVAGE                                                                                                     Time: 13:36:43
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  95-51-2
       Lock Date:  09/03/92
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 91001-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  O-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 13:36:43    
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160MG/KG        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Dosing Accident                                                                                                     1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10            9           10           10            9           
    Dosing Accident                                                              1                                                  
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Parathyroid Gland                                  (7)                       (1)                                    (9)          
      Cyst                                                                                                              1 (11%)     
   Thyroid Gland                                      (10)                      (1)                                    (10)         
      Cyst                                                                                                              1 (10%)     
      Inflammation, Granulomatous                                                1 (100%)                                           
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (10)                      (1)          (1)                       (10)         
      Cyst                                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 91001-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  O-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 13:36:43    
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160MG/KG        
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                                                                     9 (90%)     10 (100%)    
      Pigmentation, Hemosiderin                                                              10 (100%)     9 (90%)     10 (100%)    
   Thymus                                             (10)                      (1)                                    (10)         
      Hemorrhage                                                                                                        1 (10%)     
      Inflammation, Granulomatous                                                1 (100%)                                           
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)                      (1)                                    (10)         
      Hemorrhage, Focal                                                                                                 1 (10%)     
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 91001-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  O-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 13:36:43    
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160MG/KG        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Dosing Accident                                                 1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9           10            9           10            9           
    Natural Death                                      1                                      1                         1           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Esophagus                                          (10)         (1)                       (1)                       (10)         
      Inflammation, Suppurative                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                                                        6 (60%)     10 (100%)    10 (100%)    
      Pigmentation, Hemosiderin                                                                            1 (10%)     10 (100%)    
   Thymus                                             (10)         (1)                       (1)                       (10)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 91001-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  O-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 13:36:43    
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160MG/KG        
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Inflammation, Suppurative                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Pleura                                                          (1)                                                              
      Inflammation, Suppurative                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (1)                       (1)                       (10)         
      Nephropathy                                      1 (10%)                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------