TDMS Study 91001-02 Pathology Tables
NTP Experiment-Test: 91001-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 13:36:43
Facility: Battelle Columbus Laboratory
Chemical CAS #: 95-51-2
Lock Date: 09/03/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 91001-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 13:36:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Dosing Accident 1
Survivors
Terminal Sacrifice 10 10 9 10 10 9
Dosing Accident 1
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
None
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Parathyroid Gland (7) (1) (9)
Cyst 1 (11%)
Thyroid Gland (10) (1) (10)
Cyst 1 (10%)
Inflammation, Granulomatous 1 (100%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (1) (1) (10)
Cyst 1 (100%)
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HEMATOPOIETIC SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 91001-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 13:36:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 9 (90%) 10 (100%)
Pigmentation, Hemosiderin 10 (100%) 9 (90%) 10 (100%)
Thymus (10) (1) (10)
Hemorrhage 1 (10%)
Inflammation, Granulomatous 1 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (1) (10)
Hemorrhage, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 91001-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 13:36:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Dosing Accident 1
Survivors
Terminal Sacrifice 9 9 10 9 10 9
Natural Death 1 1 1
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (10) (1) (1) (10)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 6 (60%) 10 (100%) 10 (100%)
Pigmentation, Hemosiderin 1 (10%) 10 (100%)
Thymus (10) (1) (1) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 91001-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY O-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 13:36:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Pleura (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (1) (1) (10)
Nephropathy 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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