TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 14:09:15 53 WEEK SSAC FINAL #1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFBINARYMIX Lock Date: 03/27/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 09/16/99 - 09/17/99 Treatment Groups: Include 001 0 NG / 0 UG Include 004 300 NG /100 UG Include 005 300 NG /300 UG Include 006 300 NG /3000 UG Page 1 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 14:09:15 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 NG / | 0| 0| 1| 3| 4| 4| 4| 5| 7| 7| 7| 7| 8| | L | 0 UG | 2| 6| 6| 8| 6| 7| 9| 0| 2| 3| 4| 5| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0| Mixed Cell Focus | X | 1 | Mixed Cell Focus, Multiple | X X X X | 4 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | Degeneration, Cystic | 2 3 | 2 2.5| Hyperplasia | 2 | 1 2.0| Hypertrophy | 1 1 1 1 | 4 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | C-Cell, Hyperplasia | 2 1 | 2 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 14:09:15 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 NG / | 0| 0| 1| 3| 4| 4| 4| 5| 7| 7| 7| 7| 8| | L | 0 UG | 2| 6| 6| 8| 6| 7| 9| 0| 2| 3| 4| 5| 5| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | Atrophy | 4 4 4 4 4 4 4 | 7 4.0| Cyst | 2 | 1 2.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + | 8 | Metaplasia, Squamous | 2 2 2 2 1 2 3 | 7 2.0| Endometrium, Hyperplasia, Cystic | 2 2 2 2 1 | 5 1.8| |__________________________________________________________________________|____________| Vagina | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + | 8 | Pigmentation | 1 1 2 1 2 2 1 2 | 8 1.5| |__________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | Atrophy | 1 1 1 1 2 | 5 1.2| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 8 | Cyst | 1 | 1 1.0| Hyperplasia | 1 1 1 1 | 4 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 14:09:15 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 NG / | 0| 0| 1| 3| 4| 4| 4| 5| 7| 7| 7| 7| 8| | L | 0 UG | 2| 6| 6| 8| 6| 7| 9| 0| 2| 3| 4| 5| 5| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Infiltration Cellular, Histiocyte | 1 2 1 1 | 4 1.3| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 14:09:15 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 300 NG / | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | 100 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X | 1 | Eosinophilic Focus | X | 1 | Eosinophilic Focus, Multiple | X | 1 | Fatty Change, Diffuse | 1 | 1 1.0| Fatty Change, Focal | 1 | 1 1.0| Hepatodiaphragmatic Nodule | X | 1 | Inflammation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Mixed Cell Focus | X | 1 | Mixed Cell Focus, Multiple | X X X X X X X X | 8 | Pigmentation | 1 2 2 1 1 1 2 2 1 1 | 10 1.4| Toxic Hepatopathy | 1 1 1 | 3 1.0| Bile Duct, Fibrosis | 1 | 1 1.0| Bile Duct, Hyperplasia | 1 1 | 2 1.0| Hepatocyte, Hypertrophy | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Hepatocyte, Multinucleated | 1 1 1 | 3 1.0| Oval Cell, Hyperplasia | 1 | 1 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Degeneration, Cystic | 2 | 1 2.0| Hyperplasia | 1 1 3 | 3 1.7| Hypertrophy | 1 3 1 1 1 | 5 1.4| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Follicular Cell, Hypertrophy | 1 1 1 1 1 1 1 | 7 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 14:09:15 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 300 NG / | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | 100 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Atrophy | 4 4 4 4 4 4 4 4 | 8 4.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Metaplasia, Squamous | 3 2 2 3 3 1 4 1 2 | 9 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 3 2 3 2 2 2 2 2 3 2 | 10 2.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 14:09:15 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 300 NG / | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | 100 UG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Kidney | + | 1 | Mineralization | 2 | 1 2.0| Nephropathy | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 14:09:15 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 300 NG / | 1| 2| 3| 3| 3| 3| 5| 6| 6| 6| 6| 7| 7| | L | 300 UG | 5| 9| 2| 3| 4| 5| 9| 4| 7| 8| 9| 0| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | Eosinophilic Focus | X | 1 | Fatty Change, Diffuse | 1 1 1 | 3 1.0| Infiltration Cellular, Histiocyte | 1 | 1 1.0| Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0| Mixed Cell Focus, Multiple | X X | 2 | Pigmentation | 2 2 1 1 1 1 1 2 | 8 1.4| Hepatocyte, Hypertrophy | 1 1 1 1 1 1 1 1 | 8 1.0| Hepatocyte, Multinucleated | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | Degeneration, Cystic | 2 | 1 2.0| Hyperplasia | 1 | 1 1.0| Hypertrophy | 2 3 1 1 1 | 5 1.6| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | Follicular Cell, Hypertrophy | 1 1 1 1 1 2 | 6 1.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | Atrophy | 4 4 4 4 4 4 4 | 7 4.0| Cyst | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 14:09:15 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 300 NG / | 1| 2| 3| 3| 3| 3| 5| 6| 6| 6| 6| 7| 7| | L | 300 UG | 5| 9| 2| 3| 4| 5| 9| 4| 7| 8| 9| 0| 7| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Uterus | + + + + + + + + | 8 | Metaplasia, Squamous | 4 2 2 3 2 4 4 | 7 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | Atrophy | 2 3 3 2 2 2 3 2 | 8 2.4| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + | 5 | Cyst | 3 3 | 2 3.0| Hyperplasia | 1 | 1 1.0| Inflammation, Granulomatous | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | Infiltration Cellular, Histiocyte | 1 1 | 2 1.0| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 14:09:15 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 300 NG / | 1| 2| 3| 3| 3| 3| 5| 6| 6| 6| 6| 7| 7| | L | 300 UG | 5| 9| 2| 3| 4| 5| 9| 4| 7| 8| 9| 0| 7| | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 14:09:15 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 300 NG / | 0| 0| 0| 1| 7| 7| 7| 7| 8| | L | 3000 UG | 6| 8| 9| 0| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + | 9 | Basophilic Focus | X | 1 | Eosinophilic Focus | X | 1 | Fatty Change, Diffuse | 1 2 2 2 1 2 2 1 2 | 9 1.7| Inflammation | 2 1 1 1 1 1 1 1 1 | 9 1.1| Mixed Cell Focus | X X X | 3 | Mixed Cell Focus, Multiple | X X X | 3 | Pigmentation | 3 2 2 2 2 2 2 2 2 | 9 2.1| Toxic Hepatopathy | 1 1 1 1 1 1 | 6 1.0| Bile Duct, Hyperplasia | 1 2 1 1 2 | 5 1.4| Hepatocyte, Hypertrophy | 3 2 3 3 1 2 2 3 3 | 9 2.4| Hepatocyte, Multinucleated | 1 1 1 1 1 1 2 | 7 1.1| Oval Cell, Hyperplasia | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + | 9 | Acinus, Atrophy | 1 | 1 1.0| Acinus, Hyperplasia | 2 | 1 2.0| Acinus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 | 6 1.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + | 9 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + | 9 | Degeneration, Cystic | 2 | 1 2.0| Hyperplasia | 2 | 1 2.0| Hypertrophy | 2 2 1 | 3 1.7| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 14:09:15 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 300 NG / | 0| 0| 0| 1| 7| 7| 7| 7| 8| | L | 3000 UG | 6| 8| 9| 0| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Vacuolization Cytoplasmic | 1 | 1 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + | 9 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + | 9 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + | 9 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + | 9 | C-Cell, Hyperplasia | 1 | 1 1.0| Follicular Cell, Hypertrophy | 1 1 1 2 1 1 | 6 1.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + | 9 | Atrophy | 4 4 4 4 4 4 4 4 | 8 4.0| Inflammation, Suppurative | 1 | 1 1.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + | 9 | Inflammation, Suppurative | 2 3 1 1 1 1 | 6 1.5| Metaplasia, Squamous | 4 3 3 2 2 3 4 | 7 3.0| Endometrium, Hyperplasia, Cystic | 2 1 | 2 1.5| |__________________________________________________________________________|____________| Vagina | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + | 9 | Pigmentation | 2 1 2 2 1 2 2 2 2 | 9 1.8| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 96020-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04 Route: GAVAGE Time: 14:09:15 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 300 NG / | 0| 0| 0| 1| 7| 7| 7| 7| 8| | L | 3000 UG | 6| 8| 9| 0| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Atrophy | 3 2 2 2 2 2 3 1 2 | 9 2.1| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + | 9 | Infiltration Cellular, Histiocyte | 1 1 1 1 | 4 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------