TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04
Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 14:20:54
53 WEEK SSAC FINAL #1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFBINARYMIX
Lock Date: 03/27/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 09/16/99 - 09/17/99
Treatment Groups: Include 001 0 NG / 0 UG
Include 004 300 NG /100 UG
Include 005 300 NG /300 UG
Include 006 300 NG /3000 UG
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04
Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 14:20:54
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
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DISPOSITION SUMMARY
Animals Initially In Study 98 80 98 80
Scheduled Sacrifice 13 10 13 9
Early Deaths
Survivors
Animals Examined Microscopically 8 10 8 9
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ALIMENTARY SYSTEM
Liver (8) (10) (8) (9)
Basophilic Focus 1 1
Eosinophilic Focus 1 1 1
Eosinophilic Focus, Multiple 1
Fatty Change, Diffuse 1 [1.0] 3 [1.0] 9 [1.7]
Fatty Change, Focal 1 [1.0]
Hepatodiaphragmatic Nodule 1
Infiltration Cellular, Histiocyte 1 [1.0]
Inflammation 8 [1.0] 10 [1.0] 8 [1.0] 9 [1.1]
Mixed Cell Focus 1 1 3
Mixed Cell Focus, Multiple 4 8 2 3
Pigmentation 10 [1.4] 8 [1.4] 9 [2.1]
Toxic Hepatopathy 3 [1.0] 6 [1.0]
Bile Duct, Fibrosis 1 [1.0]
Bile Duct, Hyperplasia 2 [1.0] 5 [1.4]
Hepatocyte, Hypertrophy 10 [1.0] 8 [1.0] 9 [2.4]
Hepatocyte, Multinucleated 3 [1.0] 2 [1.0] 7 [1.1]
Oval Cell, Hyperplasia 1 [1.0] 2 [1.0]
Pancreas (8) (10) (8) (9)
Acinus, Atrophy 1 [1.0]
Acinus, Hyperplasia 1 [2.0]
Acinus, Vacuolization Cytoplasmic 6 [1.0]
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04
Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 14:20:54
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Adrenal Cortex (8) (10) (8) (9)
Degeneration, Cystic 2 [2.5] 1 [2.0] 1 [2.0] 1 [2.0]
Hyperplasia 1 [2.0] 3 [1.7] 1 [1.0] 1 [2.0]
Hypertrophy 4 [1.0] 5 [1.4] 5 [1.6] 3 [1.7]
Vacuolization Cytoplasmic 1 [1.0]
Thyroid Gland (8) (10) (8) (9)
C-Cell, Hyperplasia 2 [1.5] 1 [1.0]
Follicular Cell, Hypertrophy 7 [1.0] 6 [1.2] 6 [1.2]
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (10) (8) (9)
Atrophy 7 [4.0] 8 [4.0] 7 [4.0] 8 [4.0]
Cyst 1 [2.0] 1 [2.0]
Inflammation, Suppurative 1 [1.0]
Uterus (8) (10) (8) (9)
Inflammation, Suppurative 6 [1.5]
Metaplasia, Squamous 7 [2.0] 9 [2.3] 7 [3.0] 7 [3.0]
Endometrium, Hyperplasia, Cystic 5 [1.8] 2 [1.5]
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HEMATOPOIETIC SYSTEM
Spleen (8) (9)
Pigmentation 8 [1.5] 9 [1.8]
Thymus (8) (10) (8) (9)
Atrophy 5 [1.2] 10 [2.3] 8 [2.4] 9 [2.1]
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INTEGUMENTARY SYSTEM
Mammary Gland (8) (2) (5) (9)
Cyst 1 [1.0] 2 [3.0]
Hyperplasia 4 [1.0] 1 [1.0]
Inflammation, Granulomatous 1 [2.0]
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/03/04
Route: GAVAGE TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Time: 14:20:54
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 300 NG / 300 NG / 300 NG /
0 UG 100 UG 300 UG 3000 UG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (10) (8) (9)
Infiltration Cellular, Histiocyte 4 [1.3] 2 [1.0] 4 [1.0]
Alveolar Epithelium, Hyperplasia 1 [2.0]
Alveolar Epithelium, Metaplasia, Bronchiolar 3 [1.0] 1 [1.0]
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (1)
Mineralization 1 [2.0]
Nephropathy 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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