TDMS Study 89010-01 Pathology Tables
NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:29:54 Facility: Southern Research Institute Chemical CAS #: PESTFERTMIX3 Lock Date: 09/08/92 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:29:54 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 40 40 40 40 40 Scheduled Sacrifice 10 10 10 10 10 Early Deaths Survivors Terminal Sacrifice 30 30 30 30 30 Animals Examined Microscopically 20 20 20 20 20 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (20) (20) (20) (20) (20) Parasite Metazoan 1 (5%) 1 (5%) Intestine Large, Rectum (20) (20) (19) (20) (20) Parasite Metazoan 2 (10%) 2 (10%) 3 (16%) 2 (10%) 1 (5%) Intestine Small, Ileum (20) (20) (20) (20) (20) Lymphoid Tissue, Inflammation, Chronic 1 (5%) Liver (20) (20) (20) (20) (20) Fibrosis, Focal 1 (5%) Hepatodiaphragmatic Nodule 1 (5%) 3 (15%) 1 (5%) 3 (15%) 3 (15%) Necrosis, Focal 1 (5%) Serosa, Inflammation, Chronic 1 (5%) Mesentery (1) Fat, Necrosis 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (20) (20) (20) (20) (20) Accessory Adrenal Cortical Nodule 2 (10%) Angiectasis 1 (5%) Angiectasis, Focal 1 (5%) Hyperplasia, Focal 1 (5%) Adrenal Medulla (20) (20) (20) (20) (20) Angiectasis 1 (5%) Pituitary Gland (19) (20) (20) (20) (20) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:29:54 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Cyst 1 (5%) 1 (5%) 2 (10%) Pars Distalis, Hyperplasia, Focal 1 (5%) Thyroid Gland (20) (20) (20) (20) (20) Ultimobranchial Cyst 3 (15%) 2 (10%) 2 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (20) (20) (20) (20) (20) Cyst 1 (5%) 1 (5%) Uterus (20) (20) (20) (20) (20) Hydrometra 4 (20%) 4 (20%) 6 (30%) 4 (20%) 5 (25%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (20) (20) (20) (20) (20) Hemorrhage 1 (5%) Spleen (20) (20) (20) (20) (20) Congestion 1 (5%) Fibrosis, Focal 1 (5%) Thymus (20) (19) (20) (19) (20) Hemorrhage 1 (5%) 1 (5%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (20) (20) (20) (20) (20) Nipple, Cyst Epithelial Inclusion 1 (5%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:29:54 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (20) (20) (20) (20) (20) Infiltration Cellular, Focal, Lymphocyte 1 (5%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:29:54 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 40 40 40 40 40 Scheduled Sacrifice 10 10 10 10 10 Early Deaths Accidently Killed 1 Survivors Terminal Sacrifice 29 30 30 30 30 Animals Examined Microscopically 20 20 20 20 20 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Rectum (20) (20) (20) (20) (20) Parasite Metazoan 3 (15%) 1 (5%) 3 (15%) 1 (5%) Liver (20) (20) (20) (20) (20) Hepatodiaphragmatic Nodule 1 (5%) 2 (10%) 2 (10%) Mesentery (1) Fat, Necrosis 1 (100%) Pancreas (20) (20) (20) (20) (20) Atrophy, Focal 2 (10%) 2 (10%) 3 (15%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (20) (20) (20) (20) (20) Artery, Inflammation, Chronic 1 (5%) 2 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (20) (20) (20) (20) (20) Accessory Adrenal Cortical Nodule 1 (5%) Pituitary Gland (20) (20) (20) (20) (18) Angiectasis 1 (5%) Cyst 4 (20%) 1 (5%) Pars Distalis, Hyperplasia, Focal 2 (11%) Thyroid Gland (20) (20) (20) (20) (20) Ultimobranchial Cyst 2 (10%) 1 (5%) 3 (15%) 1 (5%) Follicular Cell, Hyperplasia 1 (5%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:29:54 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (20) (20) (20) (20) (20) Inflammation, Chronic 3 (15%) 3 (15%) 1 (5%) 1 (5%) 3 (15%) Prostate (20) (20) (20) (20) (20) Inflammation, Suppurative 4 (20%) 5 (25%) 5 (25%) 6 (30%) 3 (15%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) Mediastinal, Hemorrhage 1 (100%) Lymph Node, Mandibular (20) (20) (20) (20) (20) Hyperplasia 1 (5%) Thymus (20) (20) (20) (20) (20) Hemorrhage 1 (5%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Nose (20) (20) (20) (20) (20) Inflammation, Suppurative 1 (5%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:29:54 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------