TDMS Study 89010-01 Pathology Tables
NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:29:54
Facility: Southern Research Institute
Chemical CAS #: PESTFERTMIX3
Lock Date: 09/08/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 40 40 40 40 40
Scheduled Sacrifice 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 30 30 30 30 30
Animals Examined Microscopically 20 20 20 20 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (20) (20) (20) (20) (20)
Parasite Metazoan 1 (5%) 1 (5%)
Intestine Large, Rectum (20) (20) (19) (20) (20)
Parasite Metazoan 2 (10%) 2 (10%) 3 (16%) 2 (10%) 1 (5%)
Intestine Small, Ileum (20) (20) (20) (20) (20)
Lymphoid Tissue, Inflammation, Chronic 1 (5%)
Liver (20) (20) (20) (20) (20)
Fibrosis, Focal 1 (5%)
Hepatodiaphragmatic Nodule 1 (5%) 3 (15%) 1 (5%) 3 (15%) 3 (15%)
Necrosis, Focal 1 (5%)
Serosa, Inflammation, Chronic 1 (5%)
Mesentery (1)
Fat, Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (20) (20) (20) (20) (20)
Accessory Adrenal Cortical Nodule 2 (10%)
Angiectasis 1 (5%)
Angiectasis, Focal 1 (5%)
Hyperplasia, Focal 1 (5%)
Adrenal Medulla (20) (20) (20) (20) (20)
Angiectasis 1 (5%)
Pituitary Gland (19) (20) (20) (20) (20)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Cyst 1 (5%) 1 (5%) 2 (10%)
Pars Distalis, Hyperplasia, Focal 1 (5%)
Thyroid Gland (20) (20) (20) (20) (20)
Ultimobranchial Cyst 3 (15%) 2 (10%) 2 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (20) (20) (20) (20) (20)
Cyst 1 (5%) 1 (5%)
Uterus (20) (20) (20) (20) (20)
Hydrometra 4 (20%) 4 (20%) 6 (30%) 4 (20%) 5 (25%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (20) (20) (20) (20) (20)
Hemorrhage 1 (5%)
Spleen (20) (20) (20) (20) (20)
Congestion 1 (5%)
Fibrosis, Focal 1 (5%)
Thymus (20) (19) (20) (19) (20)
Hemorrhage 1 (5%) 1 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (20) (20) (20) (20) (20)
Nipple, Cyst Epithelial Inclusion 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (20) (20) (20) (20)
Infiltration Cellular, Focal, Lymphocyte 1 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 40 40 40 40 40
Scheduled Sacrifice 10 10 10 10 10
Early Deaths
Accidently Killed 1
Survivors
Terminal Sacrifice 29 30 30 30 30
Animals Examined Microscopically 20 20 20 20 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (20) (20) (20) (20) (20)
Parasite Metazoan 3 (15%) 1 (5%) 3 (15%) 1 (5%)
Liver (20) (20) (20) (20) (20)
Hepatodiaphragmatic Nodule 1 (5%) 2 (10%) 2 (10%)
Mesentery (1)
Fat, Necrosis 1 (100%)
Pancreas (20) (20) (20) (20) (20)
Atrophy, Focal 2 (10%) 2 (10%) 3 (15%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (20) (20) (20) (20) (20)
Artery, Inflammation, Chronic 1 (5%) 2 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (20) (20) (20) (20) (20)
Accessory Adrenal Cortical Nodule 1 (5%)
Pituitary Gland (20) (20) (20) (20) (18)
Angiectasis 1 (5%)
Cyst 4 (20%) 1 (5%)
Pars Distalis, Hyperplasia, Focal 2 (11%)
Thyroid Gland (20) (20) (20) (20) (20)
Ultimobranchial Cyst 2 (10%) 1 (5%) 3 (15%) 1 (5%)
Follicular Cell, Hyperplasia 1 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (20) (20) (20) (20) (20)
Inflammation, Chronic 3 (15%) 3 (15%) 1 (5%) 1 (5%) 3 (15%)
Prostate (20) (20) (20) (20) (20)
Inflammation, Suppurative 4 (20%) 5 (25%) 5 (25%) 6 (30%) 3 (15%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Hemorrhage 1 (100%)
Lymph Node, Mandibular (20) (20) (20) (20) (20)
Hyperplasia 1 (5%)
Thymus (20) (20) (20) (20) (20)
Hemorrhage 1 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Nose (20) (20) (20) (20) (20)
Inflammation, Suppurative 1 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 89010-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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