https://ntp.niehs.nih.gov/go/16663

TDMS Study 89009-01 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                   PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2                    DATE: 10/18/04       
EXPERIMENT: 89009 TEST: 01                                                                                     TIME: 10:01:51       
TEST TYPE:  SUBCHRON 26-WEEK                                                                                   PAGE:       1        
CONT: NO1-ES-95275                              ROUTE: DOSED WATER                                             NTP C#: C89009       
PATHOLOGIST: DR. D. FARNELL                                                                                    CAS: PESTFERTMIX2    
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               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                   PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2                    DATE: 10/18/04       
EXPERIMENT: 89009 TEST: 01                                                                                     TIME: 10:01:51       
TEST TYPE:  SUBCHRON 26-WEEK                                                                                                        
CONT: NO1-ES-95275                              ROUTE: DOSED WATER                                             NTP C#: C89009       
PATHOLOGIST: DR. D. FARNELL                                                                                    CAS: PESTFERTMIX2    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF      PESTICIDE/FERTILIZER CONTAMINATION--M                                                                       
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Heart: Artery                          Inflammation Chronic                                                                         
Pancreas                               Atrophy Focal                                                                                
===============================================================                                                                     
       Date:  10/18/04                           EXPERIMENT: 89009 TEST: 01                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -       PESTICIDE/FERTILIZER CONTAMINATION--M           
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Artery                                                                                                                    | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/20 (0%)        0/20 (0%)        0/20 (0%)        0/20 (0%)        2/20 (10%)                       | 
|POLY-3 RATE (b)    |        0/11.27          0/11.27          0/11.27          0/11.27          2/11.27                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             17.8%                            | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)                        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)                       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              183 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.022 *        (e)              (e)              (e)              P=0.234                          | 
|POLY 3             |        P=0.019 *        (e)              (e)              (e)              P=0.228                          | 
|POLY 1.5           |        P=0.019 *        (e)              (e)              (e)              P=0.229                          | 
|POLY 6             |        P=0.019 *        (e)              (e)              (e)              P=0.227                          | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.228                          | 
|COCH-ARM / FISHERS |        P=0.022 *        (e)              (e)              (e)              P=0.244                          | 
|ORDER RESTRICTED   |        P=0.014 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Artery                                                                                                                    | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/20 (0%)        0/20 (0%)        0/20 (0%)        0/20 (0%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        0/11.27          0/11.27          0/11.27          0/11.27          0/11.27                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%                             | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)                        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/18/04                           EXPERIMENT: 89009 TEST: 01                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -       PESTICIDE/FERTILIZER CONTAMINATION--M            
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum                                                                                                          | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/20 (5%)        4/20 (20%)       1/20 (5%)        2/20 (10%)       2/20 (10%)                       | 
|POLY-3 RATE (b)    |        1/12.14          4/13.02          1/12.14          2/13.02          2/11.27                          | 
|POLY-3 PERCENT (g) |        8.2%             30.7%            8.2%             15.4%            17.8%                            | 
|INT SACRIFICE 1 (c)|        1/10 (10%)       2/10 (20%)       1/10 (10%)       2/10 (20%)       0/10 (0%)                        | 
|TERMINAL (d)       |        0/10 (0%)        2/10 (20%)       0/10 (0%)        0/10 (0%)        2/10 (20%)                       | 
|FIRST INCIDENCE    |        92 (I)           92 (I)           92 (I)           92 (I)           183 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.646N         P=0.175          P=0.766          P=0.500          P=0.500                          | 
|POLY 3             |        P=0.613          P=0.179          P=0.765          P=0.525          P=0.473                          | 
|POLY 1.5           |        P=0.629          P=0.173          P=0.764          P=0.516          P=0.483                          | 
|POLY 6             |        P=0.603          P=0.183          P=0.765          P=0.531          P=0.466                          | 
|LOGISTIC REGRESSION|        P=0.647N         P=0.169          (e)              P=0.500          P=0.500                          | 
|COCH-ARM / FISHERS |        P=0.647N         P=0.171          P=0.756N         P=0.500          P=0.500                          | 
|ORDER RESTRICTED   |        P=0.457          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum                                                                                                          | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/20 (5%)        0/20 (0%)        0/19 (0%)        2/20 (10%)       3/20 (15%)                       | 
|POLY-3 RATE (b)    |        1/12.14          0/11.27          0/11.14          2/12.14          3/13.02                          | 
|POLY-3 PERCENT (g) |        8.2%             0.0%             0.0%             16.5%            23.1%                            | 
|INT SACRIFICE 1 (c)|        1/10 (10%)       0/10 (0%)        0/9 (0%)         1/10 (10%)       2/10 (20%)                       | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       1/10 (10%)                       | 
|FIRST INCIDENCE    |        92 (I)           ---              ---              92 (I)           92 (I)                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.068          P=0.500N         P=0.521N         P=0.500          P=0.301                          | 
|POLY 3             |        P=0.078          P=0.515N         P=0.517N         P=0.500          P=0.320                          | 
|POLY 1.5           |        P=0.072          P=0.509N         P=0.515N         P=0.500          P=0.312                          | 
|POLY 6             |        P=0.083          P=0.519N         P=0.519N         P=0.500          P=0.326                          | 
|LOGISTIC REGRESSION|        P=0.066          (e)              (e)              P=0.500          P=0.296                          | 
|COCH-ARM / FISHERS |        P=0.066          P=0.500N         P=0.513N         P=0.500          P=0.302                          | 
|ORDER RESTRICTED   |        P=0.061          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/18/04                           EXPERIMENT: 89009 TEST: 01                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -       PESTICIDE/FERTILIZER CONTAMINATION--M            
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/20 (10%)       1/20 (5%)        0/20 (0%)        1/20 (5%)        2/20 (10%)                       | 
|POLY-3 RATE (b)    |        2/11.27          1/12.14          0/11.27          1/12.14          2/12.14                          | 
|POLY-3 PERCENT (g) |        17.8%            8.2%             0.0%             8.2%             16.5%                            | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        1/10 (10%)       0/10 (0%)        1/10 (10%)       1/10 (10%)                       | 
|TERMINAL (d)       |        2/10 (20%)       0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)                       | 
|FIRST INCIDENCE    |        183 (T)          92 (I)           ---              92 (I)           92 (I)                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.367          P=0.500N         P=0.234N         P=0.500N         P=0.699                          | 
|POLY 3             |        P=0.381          P=0.473N         P=0.228N         P=0.473N         P=0.677N                         | 
|POLY 1.5           |        P=0.375          P=0.483N         P=0.229N         P=0.483N         P=0.686N                         | 
|POLY 6             |        P=0.384          P=0.466N         P=0.227N         P=0.466N         P=0.670N                         | 
|LOGISTIC REGRESSION|        P=0.366          P=0.500N         P=0.228N         P=0.500N         P=0.704N                         | 
|COCH-ARM / FISHERS |        P=0.366          P=0.500N         P=0.244N         P=0.500N         P=0.698N                         | 
|ORDER RESTRICTED   |        P=0.401N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/20 (5%)        0/20 (0%)        1/20 (5%)        1/20 (5%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        1/11.27          0/11.27          1/11.27          1/12.14          0/11.27                          | 
|POLY-3 PERCENT (g) |        8.9%             0.0%             8.9%             8.2%             0.0%                             | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       0/10 (0%)                        | 
|TERMINAL (d)       |        1/10 (10%)       0/10 (0%)        1/10 (10%)       0/10 (0%)        0/10 (0%)                        | 
|FIRST INCIDENCE    |        183 (T)          ---              183 (T)          92 (I)           ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.437N         P=0.500N         P=0.766          P=0.760          P=0.500N                         | 
|POLY 3             |        P=0.441N         P=0.500N         P=0.766          P=0.748N         P=0.500N                         | 
|POLY 1.5           |        P=0.439N         P=0.500N         P=0.765          P=0.754N         P=0.500N                         | 
|POLY 6             |        P=0.442N         P=0.500N         P=0.766          P=0.744N         P=0.500N                         | 
|LOGISTIC REGRESSION|        P=0.436N         (e)              P=0.772N         P=0.766N         (e)                              | 
|COCH-ARM / FISHERS |        P=0.436N         P=0.500N         P=0.756N         P=0.756N         P=0.500N                         | 
|ORDER RESTRICTED   |        P=0.306N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/18/04                           EXPERIMENT: 89009 TEST: 01                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -       PESTICIDE/FERTILIZER CONTAMINATION--M            
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/1 (100%)       0/0 (0%)         1/1 (100%)       0/0 (0%)         1/2 (50%)                        | 
|POLY-3 RATE (b)    |        1/1.00           0/0.00           1/1.00           0/0.00           1/2.00                           | 
|POLY-3 PERCENT (g) |        100.0%           0.0%             100.0%           0.0%             50.0%                            | 
|INT SACRIFICE 1 (c)|        1/1 (100%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         1/1 (100%)       0/0 (0%)         1/2 (50%)                        | 
|FIRST INCIDENCE    |        92 (I)           ---              183 (T)          ---              183 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.601N         (e)              (e)              (e)              P=1.000N                         | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.614N                         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.614N                         | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.614N                         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=1.000N                         | 
|COCH-ARM / FISHERS |        P=0.456N         (e)              (e)              (e)              P=0.667N                         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/0 (0%)         2/2 (100%)       0/0 (0%)         1/1 (100%)       0/1 (0%)                         | 
|POLY-3 RATE (b)    |        0/0.00           2/2.00           0/0.00           1/1.00           0/1.00                           | 
|POLY-3 PERCENT (g) |        0.0%             100.0%           0.0%             100.0%           0.0%                             | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|TERMINAL (d)       |        0/0 (0%)         2/2 (100%)       0/0 (0%)         1/1 (100%)       0/1 (0%)                         | 
|FIRST INCIDENCE    |        ---              183 (T)          ---              183 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.257N         (e)              (e)              (e)              (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.225N         (e)              (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/18/04                           EXPERIMENT: 89009 TEST: 01                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -       PESTICIDE/FERTILIZER CONTAMINATION--M            
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/20 (15%)       0/20 (0%)        0/20 (0%)        0/20 (0%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        3/13.02          0/11.27          0/11.27          0/11.27          0/11.27                          | 
|POLY-3 PERCENT (g) |        23.1%            0.0%             0.0%             0.0%             0.0%                             | 
|INT SACRIFICE 1 (c)|        2/10 (20%)       0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)                        | 
|TERMINAL (d)       |        1/10 (10%)       0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)                        | 
|FIRST INCIDENCE    |        92 (I)           ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.374N         P=0.120N         P=0.120N         P=0.120N         P=0.120N                         | 
|POLY 3             |        P=0.335N         P=0.132N         P=0.132N         P=0.132N         P=0.132N                         | 
|POLY 1.5           |        P=0.346N         P=0.122N         P=0.122N         P=0.122N         P=0.122N                         | 
|POLY 6             |        P=0.329N         P=0.139N         P=0.139N         P=0.139N         P=0.139N                         | 
|LOGISTIC REGRESSION|        P=0.372N         P=0.114N         P=0.114N         P=0.114N         P=0.114N                         | 
|COCH-ARM / FISHERS |        P=0.373N         P=0.115N         P=0.115N         P=0.115N         P=0.115N                         | 
|ORDER RESTRICTED   |        P=0.005N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/20 (0%)        0/20 (0%)        0/20 (0%)        0/20 (0%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        0/11.27          0/11.27          0/11.27          0/11.27          0/11.27                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%                             | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)                        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/18/04                           EXPERIMENT: 89009 TEST: 01                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -       PESTICIDE/FERTILIZER CONTAMINATION--M            
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/20 (10%)       0/20 (0%)        0/20 (0%)        2/20 (10%)       2/20 (10%)                       | 
|POLY-3 RATE (b)    |        2/11.27          0/11.27          0/11.27          2/13.02          2/12.14                          | 
|POLY-3 PERCENT (g) |        17.8%            0.0%             0.0%             15.4%            16.5%                            | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       1/10 (10%)                       | 
|TERMINAL (d)       |        2/10 (20%)       0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)                       | 
|FIRST INCIDENCE    |        183 (T)          ---              ---              92 (I)           92 (I)                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.328          P=0.234N         P=0.234N         P=0.696          P=0.699                          | 
|POLY 3             |        P=0.355          P=0.228N         P=0.228N         P=0.649N         P=0.677N                         | 
|POLY 1.5           |        P=0.343          P=0.229N         P=0.229N         P=0.668N         P=0.686N                         | 
|POLY 6             |        P=0.362          P=0.227N         P=0.227N         P=0.636N         P=0.670N                         | 
|LOGISTIC REGRESSION|        P=0.327          P=0.228N         P=0.228N         P=0.701N         P=0.704N                         | 
|COCH-ARM / FISHERS |        P=0.327          P=0.244N         P=0.244N         P=0.698N         P=0.698N                         | 
|ORDER RESTRICTED   |        P=0.347          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|INT SACRIFICE 1 (c)|                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
       Date:  10/18/04                           EXPERIMENT: 89009 TEST: 01                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -       PESTICIDE/FERTILIZER CONTAMINATION--M            
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/20 (5%)        1/20 (5%)        3/20 (15%)       0/20 (0%)        3/20 (15%)                       | 
|POLY-3 RATE (b)    |        1/12.14          1/11.27          3/11.27          0/11.27          3/13.89                          | 
|POLY-3 PERCENT (g) |        8.2%             8.9%             26.6%            0.0%             21.6%                            | 
|INT SACRIFICE 1 (c)|        1/10 (10%)       0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)                       | 
|TERMINAL (d)       |        0/10 (0%)        1/10 (10%)       3/10 (30%)       0/10 (0%)        0/10 (0%)                        | 
|FIRST INCIDENCE    |        92 (I)           183 (T)          183 (T)          ---              92 (I)                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.227          P=0.760          P=0.301          P=0.500N         P=0.293                          | 
|POLY 3             |        P=0.287          P=0.748          P=0.264          P=0.515N         P=0.347                          | 
|POLY 1.5           |        P=0.261          P=0.754          P=0.277          P=0.509N         P=0.329                          | 
|POLY 6             |        P=0.305          P=0.744          P=0.257          P=0.519N         P=0.358                          | 
|LOGISTIC REGRESSION|        P=0.224          P=0.766N         P=0.296          (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.224          P=0.756N         P=0.302          P=0.500N         P=0.302                          | 
|ORDER RESTRICTED   |        P=0.253          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|INT SACRIFICE 1 (c)|                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
       Date:  10/18/04                           EXPERIMENT: 89009 TEST: 01                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -       PESTICIDE/FERTILIZER CONTAMINATION--M            
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/20 (10%)       0/20 (0%)        0/20 (0%)        0/20 (0%)        1/20 (5%)                        | 
|POLY-3 RATE (b)    |        2/13.02          0/11.27          0/11.27          0/11.27          1/12.14                          | 
|POLY-3 PERCENT (g) |        15.4%            0.0%             0.0%             0.0%             8.2%                             | 
|INT SACRIFICE 1 (c)|        2/10 (20%)       0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)                       | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)                        | 
|FIRST INCIDENCE    |        92 (I)           ---              ---              ---              92 (I)                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.570          P=0.234N         P=0.234N         P=0.234N         P=0.500N                         | 
|POLY 3             |        P=0.604          P=0.264N         P=0.264N         P=0.264N         P=0.525N                         | 
|POLY 1.5           |        P=0.592          P=0.251N         P=0.251N         P=0.251N         P=0.516N                         | 
|POLY 6             |        P=0.612          P=0.272N         P=0.272N         P=0.272N         P=0.531N                         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.500N                         | 
|COCH-ARM / FISHERS |        P=0.569          P=0.244N         P=0.244N         P=0.244N         P=0.500N                         | 
|ORDER RESTRICTED   |        P=0.092N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/20 (0%)        0/20 (0%)        0/20 (0%)        0/20 (0%)        0/20 (0%)                        | 
|POLY-3 RATE (b)    |        0/11.27          0/11.27          0/11.27          0/11.27          0/11.27                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%                             | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)                        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/18/04                           EXPERIMENT: 89009 TEST: 01                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -       PESTICIDE/FERTILIZER CONTAMINATION--M            
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/20 (15%)       0/20 (0%)        0/20 (0%)        2/20 (10%)       2/20 (10%)                       | 
|POLY-3 RATE (b)    |        3/12.14          0/11.27          0/11.27          2/13.02          2/12.14                          | 
|POLY-3 PERCENT (g) |        24.7%            0.0%             0.0%             15.4%            16.5%                            | 
|INT SACRIFICE 1 (c)|        1/10 (10%)       0/10 (0%)        0/10 (0%)        2/10 (20%)       1/10 (10%)                       | 
|TERMINAL (d)       |        2/10 (20%)       0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)                       | 
|FIRST INCIDENCE    |        92 (I)           ---              ---              92 (I)           92 (I)                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.423          P=0.120N         P=0.120N         P=0.500N         P=0.500N                         | 
|POLY 3             |        P=0.454          P=0.116N         P=0.116N         P=0.466N         P=0.500N                         | 
|POLY 1.5           |        P=0.442          P=0.113N         P=0.113N         P=0.478N         P=0.500N                         | 
|POLY 6             |        P=0.462          P=0.119N         P=0.119N         P=0.458N         P=0.500N                         | 
|LOGISTIC REGRESSION|        P=0.423          P=0.114N         P=0.114N         P=0.500N         P=0.500N                         | 
|COCH-ARM / FISHERS |        P=0.423          P=0.115N         P=0.115N         P=0.500N         P=0.500N                         | 
|ORDER RESTRICTED   |        P=0.167N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/20 (20%)       0/20 (0%)        2/20 (10%)       3/20 (15%)       1/20 (5%)                        | 
|POLY-3 RATE (b)    |        4/13.02          0/11.27          2/11.27          3/12.14          1/12.14                          | 
|POLY-3 PERCENT (g) |        30.7%            0.0%             17.8%            24.7%            8.2%                             | 
|INT SACRIFICE 1 (c)|        2/10 (20%)       0/10 (0%)        0/10 (0%)        1/10 (10%)       1/10 (10%)                       | 
|TERMINAL (d)       |        2/10 (20%)       0/10 (0%)        2/10 (20%)       2/10 (20%)       0/10 (0%)                        | 
|FIRST INCIDENCE    |        92 (I)           ---              183 (T)          92 (I)           92 (I)                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.351N         P=0.062N         P=0.331N         P=0.500N         P=0.175N                         | 
|POLY 3             |        P=0.313N         P=0.062N         P=0.395N         P=0.543N         P=0.179N                         | 
|POLY 1.5           |        P=0.325N         P=0.056N         P=0.369N         P=0.527N         P=0.173N                         | 
|POLY 6             |        P=0.307N         P=0.067N         P=0.413N         P=0.552N         P=0.183N                         | 
|LOGISTIC REGRESSION|        P=0.350N         P=0.057N         P=0.327N         P=0.500N         P=0.169N                         | 
|COCH-ARM / FISHERS |        P=0.350N         P=0.053N         P=0.331N         P=0.500N         P=0.171N                         | 
|ORDER RESTRICTED   |        P=0.090N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/18/04                           EXPERIMENT: 89009 TEST: 01                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -       PESTICIDE/FERTILIZER CONTAMINATION--M            
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|INT SACRIFICE 1 (c)|                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        VEHICLE          0.1X             1X               10X              100X                             | 
|                   |        CONTROL                                                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/20 (20%)       3/20 (15%)       2/20 (10%)       5/20 (25%)       5/20 (25%)                       | 
|POLY-3 RATE (b)    |        4/14.76          3/12.14          2/12.14          5/14.76          5/13.89                          | 
|POLY-3 PERCENT (g) |        27.1%            24.7%            16.5%            33.9%            36.0%                            | 
|INT SACRIFICE 1 (c)|        4/10 (40%)       1/10 (10%)       1/10 (10%)       4/10 (40%)       3/10 (30%)                       | 
|TERMINAL (d)       |        0/10 (0%)        2/10 (20%)       1/10 (10%)       1/10 (10%)       2/10 (20%)                       | 
|FIRST INCIDENCE    |        92 (I)           92 (I)           92 (I)           92 (I)           92 (I)                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.288          P=0.500N         P=0.327N         P=0.500          P=0.500                          | 
|POLY 3             |        P=0.323          P=0.616N         P=0.425N         P=0.500          P=0.457                          | 
|POLY 1.5           |        P=0.311          P=0.575N         P=0.390N         P=0.500          P=0.471                          | 
|POLY 6             |        P=0.330          P=0.638N         P=0.446N         P=0.500          P=0.448                          | 
|LOGISTIC REGRESSION|        P=0.286          P=0.500N         P=0.322N         P=0.500          P=0.500                          | 
|COCH-ARM / FISHERS |        P=0.289          P=0.500N         P=0.331N         P=0.500          P=0.500                          | 
|ORDER RESTRICTED   |        P=0.375          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).