TDMS Study 96022-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) DATE: 05/06/04
EXPERIMENT: 96022 TEST: 02 TIME: 10:07:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96022
PATHOLOGIST: MISSING CAS: TEFPCBMIX
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1 RATS CTRL. VS. HIGH
REASONS FOR REMOVAL: 25018 Dosing Accident
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 NG / 0 UG
INCLUDE 006 4000 NG/500 UG
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) DATE: 05/06/04
EXPERIMENT: 96022 TEST: 02 TIME: 10:07:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96022
PATHOLOGIST: MISSING CAS: TEFPCBMIX
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF TEF EVALUATION (PCB MIXTURE;PCB 126/P
===============================================================
Female Rats
------------
Organ Morphology
----- ----------
Adrenal Cortex Angiectasis
Atrophy
Degeneration Cystic
Hyperplasia
Hypertrophy
Necrosis
Vacuolization Cytoplasmic
Adrenal Medulla Hyperplasia
Blood Vessel: Aorta, Adventitia Inflammation
Bone Marrow Atrophy
Hyperplasia
Brain Hemorrhage
Clitoral Gland Inflammation
Clitoral Gland: Duct Cyst
Esophagus: Muscularis Inflammation
Harderian Gland Inflammation
Heart Cardiomyopathy
Heart: Coronary Artery Inflammation Chronic
Heart: Epicardium Inflammation
Heart: Myocardium Hemorrhage
Necrosis
Intestine Large, Cecum Edema
Inflammation
Intestine Large, Colon Parasite Metazoan
Intestine Large, Rectum Parasite Metazoan
Kidney Calculus Micro Observation Only
Infarct
Mineralization
Nephropathy
Kidney: Pelvis Inflammation
Kidney: Renal Tubule Hyperplasia
Kidney: Transitional Epithelium Hyperplasia
Liver Angiectasis
Basophilic Focus
Cholangiofibrosis
Clear Cell Focus
Eosinophilic Focus
Fatty Change Diffuse
Fatty Change Focal
Hematopoietic Cell Proliferation
Hepatodiaphragmatic Nodule
Hyperplasia
Inflammation
Metaplasia
Mixed Cell Focus
Necrosis
Pigmentation
Toxic Hepatopathy
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) DATE: 05/06/04
EXPERIMENT: 96022 TEST: 02 TIME: 10:07:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96022
PATHOLOGIST: MISSING CAS: TEFPCBMIX
Liver: Bile Duct Cyst
Fibrosis
Hyperplasia
Liver: Centrilobular Degeneration
Fibrosis
Liver: Hepatocyte Glandular Structures
Hypertrophy
Multinucleated
Liver: Oval Cell Hyperplasia
Liver: Portal Fibrosis
Lung Hemorrhage
Infiltration Cellular Histiocyte
Inflammation
Metaplasia
Lung: Alveolar Epithelium Hyperplasia
Metaplasia Bronchiolar
Lung: Serosa Fibrosis
Lymph Node, Mandibular Ectasia
Hemorrhage
Hyperplasia
Lymph Node, Mesenteric Ectasia
Hemorrhage
Hyperplasia
Lymph Node: Mediastinal Ectasia
Hemorrhage
Hyperplasia
Pigmentation
Lymph Node: Pancreatic Hemorrhage
Hyperplasia
Lymph Node: Renal Hyperplasia
Mammary Gland Hyperplasia
Inflammation Granulomatous
Mesentery: Artery Inflammation Chronic
Mesentery: Fat Necrosis
Nose Inflammation
Nose: Respiratory Epithelium Hyperplasia
Oral Mucosa: Gingival Hyperplasia
Ovary Atrophy
Cyst
Pancreas Edema
Hemorrhage
Inflammation Chronic
Pancreas: Acinus Atrophy
Hyperplasia
Vacuolization Cytoplasmic
Pancreas: Artery Inflammation Chronic
Pituitary Gland Angiectasis
Vacuolization Cytoplasmic
Pituitary Gland: Pars Distalis Hyperplasia
Spleen Hematopoietic Cell Proliferation
Pigmentation
Spleen: Lymphoid Follicle Atrophy
Spleen: Red Pulp Atrophy
Stomach, Forestomach Hyperplasia
Inflammation
Mineralization
Ulcer
Stomach, Glandular Erosion
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) DATE: 05/06/04
EXPERIMENT: 96022 TEST: 02 TIME: 10:07:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96022
PATHOLOGIST: MISSING CAS: TEFPCBMIX
Hemorrhage
Mineralization
Thymus Atrophy
Thyroid Gland: C-Cell Hyperplasia
Thyroid Gland: Follicular Cell Hypertrophy
Urinary Bladder Inflammation
Urinary Bladder: Transitional Epithelium
Hyperplasia
Uterus Inflammation
Inflammation Chronic
Metaplasia
Uterus: Endometrium Hyperplasia Cystic
===============================================================
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 1
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 42/53 (79%) 6/65 (9%) |
|POLY-3 RATE (b) | 42/48.03 6/14.36 |
|POLY-3 PERCENT (g) | 87.4% 41.8% |
|TERMINAL (d) | 26/27 (96%) 0/0 (0%) |
|FIRST INCIDENCE | 482 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008 ** |
|POLY 3 | P=0.007N** |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=0.881N |
|LOGISTIC REGRESSION| P=0.007N** |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 40/65 (62%) |
|POLY-3 RATE (b) | 2/42.18 40/41.82 |
|POLY-3 PERCENT (g) | 4.7% 95.7% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 649 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 2
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 12/53 (23%) 2/65 (3%) |
|POLY-3 RATE (b) | 12/43.80 2/10.85 |
|POLY-3 PERCENT (g) | 27.4% 18.4% |
|TERMINAL (d) | 6/27 (22%) 0/0 (0%) |
|FIRST INCIDENCE | 482 336 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.152 |
|POLY 3 | P=0.716N |
|POLY 1.5 | P=0.166N |
|POLY 6 | P=0.973 |
|LOGISTIC REGRESSION| P=0.396N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 13/53 (25%) 5/65 (8%) |
|POLY-3 RATE (b) | 13/44.54 5/13.17 |
|POLY-3 PERCENT (g) | 29.2% 38.0% |
|TERMINAL (d) | 5/27 (19%) 0/0 (0%) |
|FIRST INCIDENCE | 362 321 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** |
|POLY 3 | P=0.626 |
|POLY 1.5 | P=0.438N |
|POLY 6 | P=0.580 |
|LOGISTIC REGRESSION| P=0.532N |
|COCH-ARM / FISHERS | P=0.011N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 3
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 45/53 (85%) 27/65 (42%) |
|POLY-3 RATE (b) | 45/48.89 27/31.15 |
|POLY-3 PERCENT (g) | 92.1% 86.7% |
|TERMINAL (d) | 26/27 (96%) 0/0 (0%) |
|FIRST INCIDENCE | 275 174 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.377N |
|POLY 1.5 | P=0.008N** |
|POLY 6 | P=0.757 |
|LOGISTIC REGRESSION| P=0.527 |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 4/65 (6%) |
|POLY-3 RATE (b) | 1/42.24 4/13.13 |
|POLY-3 PERCENT (g) | 2.4% 30.5% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 628 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.077 |
|POLY 3 | P=0.132 |
|POLY 1.5 | P=0.105 |
|POLY 6 | P=0.352 |
|LOGISTIC REGRESSION| P=0.627N |
|COCH-ARM / FISHERS | P=0.252 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 4
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 14/53 (26%) 12/65 (18%) |
|POLY-3 RATE (b) | 14/44.09 12/18.81 |
|POLY-3 PERCENT (g) | 31.8% 63.8% |
|TERMINAL (d) | 6/27 (22%) 0/0 (0%) |
|FIRST INCIDENCE | 564 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.059 |
|POLY 1.5 | P=0.257 |
|POLY 6 | P=0.020 * |
|LOGISTIC REGRESSION| P=0.266 |
|COCH-ARM / FISHERS | P=0.208N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 13/53 (25%) 0/64 (0%) |
|POLY-3 RATE (b) | 13/42.77 0/9.22 |
|POLY-3 PERCENT (g) | 30.4% 0.0% |
|TERMINAL (d) | 10/27 (37%) 0/0 (0%) |
|FIRST INCIDENCE | 628 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.999N |
|POLY 3 | P=0.470N |
|POLY 1.5 | P=0.028N* |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.612N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 5
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Blood Vessel: Aorta, Adventitia |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/66 (3%) |
|POLY-3 RATE (b) | 0/41.89 2/11.08 |
|POLY-3 PERCENT (g) | 0.0% 18.1% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 294 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.123 |
|POLY 3 | P=0.582 |
|POLY 1.5 | P=0.271 |
|POLY 6 | P=0.995 |
|LOGISTIC REGRESSION| P=0.609 |
|COCH-ARM / FISHERS | P=0.306 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Bone Marrow |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 12/66 (18%) |
|POLY-3 RATE (b) | 0/41.89 12/20.74 |
|POLY-3 PERCENT (g) | 0.0% 57.9% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.387 |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 6
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 37/53 (70%) 49/66 (74%) |
|POLY-3 RATE (b) | 37/51.61 49/50.11 |
|POLY-3 PERCENT (g) | 71.7% 97.8% |
|TERMINAL (d) | 14/27 (52%) 0/0 (0%) |
|FIRST INCIDENCE | 275 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P=0.002 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.298 |
|COCH-ARM / FISHERS | P=0.369 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Brain |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 14/66 (21%) |
|POLY-3 RATE (b) | 0/41.89 14/22.64 |
|POLY-3 PERCENT (g) | 0.0% 61.8% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.402 |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 7
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 49/53 (92%) 31/66 (47%) |
|POLY-3 RATE (b) | 49/52.29 31/35.89 |
|POLY-3 PERCENT (g) | 93.7% 86.4% |
|TERMINAL (d) | 24/27 (89%) 0/0 (0%) |
|FIRST INCIDENCE | 275 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.199N |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=0.626 |
|LOGISTIC REGRESSION| P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Clitoral Gland: Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 40/53 (75%) 61/66 (92%) |
|POLY-3 RATE (b) | 40/50.23 61/61.31 |
|POLY-3 PERCENT (g) | 79.6% 99.5% |
|TERMINAL (d) | 20/27 (74%) 0/0 (0%) |
|FIRST INCIDENCE | 313 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.017 * |
|COCH-ARM / FISHERS | P=0.010 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 8
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Esophagus: Muscularis |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 2/66 (3%) |
|POLY-3 RATE (b) | 3/42.85 2/10.61 |
|POLY-3 PERCENT (g) | 7.0% 18.9% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 534 254 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.066 |
|POLY 3 | P=0.751 |
|POLY 1.5 | P=0.682 |
|POLY 6 | P=0.989 |
|LOGISTIC REGRESSION| P=0.783 |
|COCH-ARM / FISHERS | P=0.397N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Harderian Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 24/53 (45%) 9/66 (14%) |
|POLY-3 RATE (b) | 24/45.26 9/16.65 |
|POLY-3 PERCENT (g) | 53.0% 54.1% |
|TERMINAL (d) | 15/27 (56%) 0/0 (0%) |
|FIRST INCIDENCE | 313 217 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.701 |
|POLY 1.5 | P=0.137N |
|POLY 6 | P=0.416 |
|LOGISTIC REGRESSION| P=0.329N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 9
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 20/53 (38%) 19/65 (29%) |
|POLY-3 RATE (b) | 20/45.03 19/24.56 |
|POLY-3 PERCENT (g) | 44.4% 77.4% |
|TERMINAL (d) | 11/27 (41%) 0/0 (0%) |
|FIRST INCIDENCE | 534 237 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.014 * |
|POLY 1.5 | P=0.140 |
|POLY 6 | P=0.002 ** |
|LOGISTIC REGRESSION| P=0.117 |
|COCH-ARM / FISHERS | P=0.217N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Heart: Coronary Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 9/65 (14%) |
|POLY-3 RATE (b) | 1/41.89 9/16.16 |
|POLY-3 PERCENT (g) | 2.4% 55.7% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.007 ** |
|COCH-ARM / FISHERS | P=0.019 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 10
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Heart: Epicardium |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 6/65 (9%) |
|POLY-3 RATE (b) | 1/42.60 6/13.78 |
|POLY-3 PERCENT (g) | 2.4% 43.5% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 482 362 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.017 * |
|POLY 1.5 | P=0.018 * |
|POLY 6 | P=0.036 * |
|LOGISTIC REGRESSION| P=0.087 |
|COCH-ARM / FISHERS | P=0.096 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Heart: Myocardium |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 3/65 (5%) |
|POLY-3 RATE (b) | 0/41.89 3/12.08 |
|POLY-3 PERCENT (g) | 0.0% 24.8% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 267 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.084 |
|POLY 3 | P=0.221 |
|POLY 1.5 | P=0.104 |
|POLY 6 | P=0.737 |
|LOGISTIC REGRESSION| P=0.655 |
|COCH-ARM / FISHERS | P=0.164 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 11
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Heart: Myocardium |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/65 (3%) |
|POLY-3 RATE (b) | 0/41.89 2/11.19 |
|POLY-3 PERCENT (g) | 0.0% 17.9% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.229 |
|POLY 3 | P=0.569 |
|POLY 1.5 | P=0.268 |
|POLY 6 | P=0.995 |
|LOGISTIC REGRESSION| P=0.890 |
|COCH-ARM / FISHERS | P=0.301 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Intestine Large, Cecum |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/65 (3%) |
|POLY-3 RATE (b) | 0/41.89 2/11.19 |
|POLY-3 PERCENT (g) | 0.0% 17.9% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 254 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.229 |
|POLY 3 | P=0.570 |
|POLY 1.5 | P=0.269 |
|POLY 6 | P=0.994 |
|LOGISTIC REGRESSION| P=0.865 |
|COCH-ARM / FISHERS | P=0.301 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 12
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Intestine Large, Cecum |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/65 (3%) |
|POLY-3 RATE (b) | 0/41.89 2/11.20 |
|POLY-3 PERCENT (g) | 0.0% 17.9% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.243 |
|POLY 3 | P=0.569 |
|POLY 1.5 | P=0.268 |
|POLY 6 | P=0.994 |
|LOGISTIC REGRESSION| P=0.887 |
|COCH-ARM / FISHERS | P=0.301 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Intestine Large, Colon |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 2/65 (3%) |
|POLY-3 RATE (b) | 2/41.97 2/11.13 |
|POLY-3 PERCENT (g) | 4.8% 18.0% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 707 236 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.175 |
|POLY 3 | P=0.691 |
|POLY 1.5 | P=0.582 |
|POLY 6 | P=0.978 |
|LOGISTIC REGRESSION| P=0.807N |
|COCH-ARM / FISHERS | P=0.610N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 13
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Intestine Large, Rectum |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/52 (6%) 0/66 (0%) |
|POLY-3 RATE (b) | 3/41.84 0/9.33 |
|POLY-3 PERCENT (g) | 7.2% 0.0% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 567 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.987N |
|POLY 3 | P=0.935N |
|POLY 1.5 | P=0.469N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.613N |
|COCH-ARM / FISHERS | P=0.083N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Kidney |
| Calculus Micro Observation Only |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/53 (11%) 0/65 (0%) |
|POLY-3 RATE (b) | 6/42.65 0/9.28 |
|POLY-3 PERCENT (g) | 14.1% 0.0% |
|TERMINAL (d) | 4/27 (15%) 0/0 (0%) |
|FIRST INCIDENCE | 586 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.985N |
|POLY 3 | P=0.778N |
|POLY 1.5 | P=0.214N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.561N |
|COCH-ARM / FISHERS | P=0.007N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 14
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Kidney |
| Infarct |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 1/65 (2%) |
|POLY-3 RATE (b) | 2/41.89 1/10.26 |
|POLY-3 PERCENT (g) | 4.8% 9.8% |
|TERMINAL (d) | 2/27 (7%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.534 |
|POLY 3 | P=0.926 |
|POLY 1.5 | P=0.831 |
|POLY 6 | P=1.000 |
|LOGISTIC REGRESSION| P=0.732N |
|COCH-ARM / FISHERS | P=0.423N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Kidney |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 46/53 (87%) 37/65 (57%) |
|POLY-3 RATE (b) | 46/51.13 37/39.76 |
|POLY-3 PERCENT (g) | 90.0% 93.1% |
|TERMINAL (d) | 23/27 (85%) 0/0 (0%) |
|FIRST INCIDENCE | 313 217 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.467 |
|POLY 1.5 | P=0.230N |
|POLY 6 | P=0.153 |
|LOGISTIC REGRESSION| P=0.551N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 15
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 41/53 (77%) 43/65 (66%) |
|POLY-3 RATE (b) | 41/49.70 43/44.50 |
|POLY-3 PERCENT (g) | 82.5% 96.6% |
|TERMINAL (d) | 24/27 (89%) 0/0 (0%) |
|FIRST INCIDENCE | 275 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.014 * |
|POLY 1.5 | P=0.146 |
|POLY 6 | P=0.007 ** |
|LOGISTIC REGRESSION| P=0.133 |
|COCH-ARM / FISHERS | P=0.128N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Kidney: Pelvis |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 0/65 (0%) |
|POLY-3 RATE (b) | 4/42.25 0/9.28 |
|POLY-3 PERCENT (g) | 9.5% 0.0% |
|TERMINAL (d) | 2/27 (7%) 0/0 (0%) |
|FIRST INCIDENCE | 672 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=1.000 |
|POLY 3 | P=0.883N |
|POLY 1.5 | P=0.364N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.876N |
|COCH-ARM / FISHERS | P=0.038N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 16
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/65 (0%) |
|POLY-3 RATE (b) | 2/42.10 0/9.28 |
|POLY-3 PERCENT (g) | 4.8% 0.0% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 672 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=1.000N |
|POLY 3 | P=0.980N |
|POLY 1.5 | P=0.642N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.966N |
|COCH-ARM / FISHERS | P=0.200N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Kidney: Transitional Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 0/65 (0%) |
|POLY-3 RATE (b) | 4/42.25 0/9.28 |
|POLY-3 PERCENT (g) | 9.5% 0.0% |
|TERMINAL (d) | 2/27 (7%) 0/0 (0%) |
|FIRST INCIDENCE | 672 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=1.000N |
|POLY 3 | P=0.883N |
|POLY 1.5 | P=0.364N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.876N |
|COCH-ARM / FISHERS | P=0.038N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 17
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/65 (3%) |
|POLY-3 RATE (b) | 0/41.89 2/10.57 |
|POLY-3 PERCENT (g) | 0.0% 18.9% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 243 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.033 * |
|POLY 3 | P=0.613 |
|POLY 1.5 | P=0.274 |
|POLY 6 | P=0.999 |
|LOGISTIC REGRESSION| P=0.300 |
|COCH-ARM / FISHERS | P=0.301 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 27/53 (51%) 0/65 (0%) |
|POLY-3 RATE (b) | 27/45.63 0/9.28 |
|POLY-3 PERCENT (g) | 59.2% 0.0% |
|TERMINAL (d) | 16/27 (59%) 0/0 (0%) |
|FIRST INCIDENCE | 534 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.681N |
|POLY 3 | P=0.140N |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.029N* |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 18
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Cholangiofibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 29/65 (45%) |
|POLY-3 RATE (b) | 1/41.89 29/31.95 |
|POLY-3 PERCENT (g) | 2.4% 90.8% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 0/65 (0%) |
|POLY-3 RATE (b) | 5/42.17 0/9.28 |
|POLY-3 PERCENT (g) | 11.9% 0.0% |
|TERMINAL (d) | 4/27 (15%) 0/0 (0%) |
|FIRST INCIDENCE | 651 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=1.000N |
|POLY 3 | P=0.826N |
|POLY 1.5 | P=0.277N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.931N |
|COCH-ARM / FISHERS | P=0.016N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 19
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/53 (19%) 10/65 (15%) |
|POLY-3 RATE (b) | 10/43.62 10/18.34 |
|POLY-3 PERCENT (g) | 22.9% 54.5% |
|TERMINAL (d) | 6/27 (22%) 0/0 (0%) |
|FIRST INCIDENCE | 534 174 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.060 |
|POLY 1.5 | P=0.206 |
|POLY 6 | P=0.024 * |
|LOGISTIC REGRESSION| P=0.333N |
|COCH-ARM / FISHERS | P=0.398N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Fatty Change Diffuse |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 56/65 (86%) |
|POLY-3 RATE (b) | 3/42.21 56/57.00 |
|POLY-3 PERCENT (g) | 7.1% 98.3% |
|TERMINAL (d) | 2/27 (7%) 0/0 (0%) |
|FIRST INCIDENCE | 639 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 20
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Fatty Change Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/53 (19%) 6/65 (9%) |
|POLY-3 RATE (b) | 10/43.19 6/13.82 |
|POLY-3 PERCENT (g) | 23.2% 43.4% |
|TERMINAL (d) | 5/27 (19%) 0/0 (0%) |
|FIRST INCIDENCE | 586 329 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.356 |
|POLY 1.5 | P=0.590 |
|POLY 6 | P=0.309 |
|LOGISTIC REGRESSION| P=0.228 |
|COCH-ARM / FISHERS | P=0.106N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 27/53 (51%) 11/65 (17%) |
|POLY-3 RATE (b) | 27/48.61 11/17.99 |
|POLY-3 PERCENT (g) | 55.6% 61.1% |
|TERMINAL (d) | 11/27 (41%) 0/0 (0%) |
|FIRST INCIDENCE | 275 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.587 |
|POLY 1.5 | P=0.173N |
|POLY 6 | P=0.278 |
|LOGISTIC REGRESSION| P=0.014N* |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 21
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/65 (0%) |
|POLY-3 RATE (b) | 2/41.89 0/9.28 |
|POLY-3 PERCENT (g) | 4.8% 0.0% |
|TERMINAL (d) | 2/27 (7%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=1.000N |
|POLY 3 | P=0.979N |
|POLY 1.5 | P=0.641N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| (e) |
|COCH-ARM / FISHERS | P=0.200N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 61/65 (94%) |
|POLY-3 RATE (b) | 0/41.89 61/61.04 |
|POLY-3 PERCENT (g) | 0.0% 99.9% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 22
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 49/53 (92%) 64/65 (98%) |
|POLY-3 RATE (b) | 49/51.05 64/64.15 |
|POLY-3 PERCENT (g) | 96.0% 99.8% |
|TERMINAL (d) | 26/27 (96%) 0/0 (0%) |
|FIRST INCIDENCE | 313 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.149 |
|POLY 1.5 | P=0.121 |
|POLY 6 | P=0.231 |
|LOGISTIC REGRESSION| P=0.054 |
|COCH-ARM / FISHERS | P=0.125 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 4/65 (6%) |
|POLY-3 RATE (b) | 0/41.89 4/11.99 |
|POLY-3 PERCENT (g) | 0.0% 33.4% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 338 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.083 |
|POLY 1.5 | P=0.040 * |
|POLY 6 | P=0.350 |
|LOGISTIC REGRESSION| P=0.014 * |
|COCH-ARM / FISHERS | P=0.088 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 23
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 38/53 (72%) 3/65 (5%) |
|POLY-3 RATE (b) | 38/45.68 3/11.13 |
|POLY-3 PERCENT (g) | 83.2% 27.0% |
|TERMINAL (d) | 26/27 (96%) 0/0 (0%) |
|FIRST INCIDENCE | 534 429 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.005 ** |
|POLY 3 | P=0.019N* |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=0.994N |
|LOGISTIC REGRESSION| P=0.587N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 27/65 (42%) |
|POLY-3 RATE (b) | 3/42.94 27/31.21 |
|POLY-3 PERCENT (g) | 7.0% 86.5% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 564 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 24
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 60/65 (92%) |
|POLY-3 RATE (b) | 5/43.23 60/60.56 |
|POLY-3 PERCENT (g) | 11.6% 99.1% |
|TERMINAL (d) | 2/27 (7%) 0/0 (0%) |
|FIRST INCIDENCE | 534 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Toxic Hepatopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 64/65 (98%) |
|POLY-3 RATE (b) | 0/41.89 64/64.00 |
|POLY-3 PERCENT (g) | 0.0% 100.0% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 25
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 14/65 (22%) |
|POLY-3 RATE (b) | 4/42.10 14/19.17 |
|POLY-3 PERCENT (g) | 9.5% 73.0% |
|TERMINAL (d) | 3/27 (11%) 0/0 (0%) |
|FIRST INCIDENCE | 672 289 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P=0.030 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/53 (11%) 4/65 (6%) |
|POLY-3 RATE (b) | 6/42.12 4/12.37 |
|POLY-3 PERCENT (g) | 14.2% 32.3% |
|TERMINAL (d) | 5/27 (19%) 0/0 (0%) |
|FIRST INCIDENCE | 665 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** |
|POLY 3 | P=0.457 |
|POLY 1.5 | P=0.575 |
|POLY 6 | P=0.582 |
|LOGISTIC REGRESSION| P=0.362 |
|COCH-ARM / FISHERS | P=0.251N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 26
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 60/65 (92%) |
|POLY-3 RATE (b) | 5/42.04 60/60.13 |
|POLY-3 PERCENT (g) | 11.9% 99.8% |
|TERMINAL (d) | 4/27 (15%) 0/0 (0%) |
|FIRST INCIDENCE | 687 174 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver: Centrilobular |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 8/65 (12%) |
|POLY-3 RATE (b) | 2/42.71 8/16.92 |
|POLY-3 PERCENT (g) | 4.7% 47.3% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 564 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.006 ** |
|POLY 3 | P=0.004 ** |
|POLY 1.5 | P=0.009 ** |
|POLY 6 | P=0.003 ** |
|LOGISTIC REGRESSION| P=0.493N |
|COCH-ARM / FISHERS | P=0.091 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 27
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver: Centrilobular |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 57/65 (88%) |
|POLY-3 RATE (b) | 0/41.89 57/59.02 |
|POLY-3 PERCENT (g) | 0.0% 96.6% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 174 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Glandular Structures |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 25/65 (38%) |
|POLY-3 RATE (b) | 0/41.89 25/31.26 |
|POLY-3 PERCENT (g) | 0.0% 80.0% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.007 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 28
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 65/65 (100%) |
|POLY-3 RATE (b) | 0/41.89 65/65.00 |
|POLY-3 PERCENT (g) | 0.0% 100.0% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Multinucleated |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 48/65 (74%) |
|POLY-3 RATE (b) | 0/41.89 48/50.32 |
|POLY-3 PERCENT (g) | 0.0% 95.4% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 29
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver: Oval Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 62/65 (95%) |
|POLY-3 RATE (b) | 4/41.89 62/62.03 |
|POLY-3 PERCENT (g) | 9.6% 100.0% |
|TERMINAL (d) | 4/27 (15%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) 174 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Liver: Portal |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 58/65 (89%) |
|POLY-3 RATE (b) | 0/41.89 58/58.27 |
|POLY-3 PERCENT (g) | 0.0% 99.5% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 30
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lung |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 4/66 (6%) |
|POLY-3 RATE (b) | 0/41.89 4/12.86 |
|POLY-3 PERCENT (g) | 0.0% 31.1% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.016 * |
|POLY 3 | P=0.074 |
|POLY 1.5 | P=0.040 * |
|POLY 6 | P=0.293 |
|LOGISTIC REGRESSION| P=0.397 |
|COCH-ARM / FISHERS | P=0.091 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 40/53 (75%) 33/66 (50%) |
|POLY-3 RATE (b) | 40/49.03 33/37.16 |
|POLY-3 PERCENT (g) | 81.6% 88.8% |
|TERMINAL (d) | 21/27 (78%) 0/0 (0%) |
|FIRST INCIDENCE | 362 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.268 |
|POLY 1.5 | P=0.469N |
|POLY 6 | P=0.078 |
|LOGISTIC REGRESSION| P=0.519 |
|COCH-ARM / FISHERS | P=0.004N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 31
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lung |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 2/66 (3%) |
|POLY-3 RATE (b) | 5/43.02 2/11.03 |
|POLY-3 PERCENT (g) | 11.6% 18.1% |
|TERMINAL (d) | 3/27 (11%) 0/0 (0%) |
|FIRST INCIDENCE | 534 243 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.162 |
|POLY 3 | P=0.798 |
|POLY 1.5 | P=0.653N |
|POLY 6 | P=0.972 |
|LOGISTIC REGRESSION| P=0.471N |
|COCH-ARM / FISHERS | P=0.140N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lung |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 7/66 (11%) |
|POLY-3 RATE (b) | 0/41.89 7/14.88 |
|POLY-3 PERCENT (g) | 0.0% 47.1% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 289 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P=0.002 ** |
|POLY 6 | P=0.003 ** |
|LOGISTIC REGRESSION| P=0.019 * |
|COCH-ARM / FISHERS | P=0.014 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 32
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 18/53 (34%) 4/66 (6%) |
|POLY-3 RATE (b) | 18/43.48 4/12.41 |
|POLY-3 PERCENT (g) | 41.4% 32.2% |
|TERMINAL (d) | 13/27 (48%) 0/0 (0%) |
|FIRST INCIDENCE | 534 303 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002 ** |
|POLY 3 | P=0.637N |
|POLY 1.5 | P=0.089N |
|POLY 6 | P=0.841 |
|LOGISTIC REGRESSION| P=0.586 |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Metaplasia Bronchiolar |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 8/66 (12%) |
|POLY-3 RATE (b) | 1/41.89 8/16.09 |
|POLY-3 PERCENT (g) | 2.4% 49.7% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) 267 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P=0.003 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.066 |
|COCH-ARM / FISHERS | P=0.035 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 33
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lung: Serosa |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 8/66 (12%) |
|POLY-3 RATE (b) | 3/42.18 8/15.93 |
|POLY-3 PERCENT (g) | 7.1% 50.2% |
|TERMINAL (d) | 2/27 (7%) 0/0 (0%) |
|FIRST INCIDENCE | 649 294 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.009 ** |
|POLY 1.5 | P=0.021 * |
|POLY 6 | P=0.007 ** |
|LOGISTIC REGRESSION| P=0.084 |
|COCH-ARM / FISHERS | P=0.188 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 1/66 (2%) |
|POLY-3 RATE (b) | 3/42.29 1/10.25 |
|POLY-3 PERCENT (g) | 7.1% 9.8% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 639 313 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.427 |
|POLY 3 | P=0.927 |
|POLY 1.5 | P=0.703N |
|POLY 6 | P=1.000 |
|LOGISTIC REGRESSION| P=0.723N |
|COCH-ARM / FISHERS | P=0.232N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 34
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 7/66 (11%) |
|POLY-3 RATE (b) | 0/41.89 7/15.76 |
|POLY-3 PERCENT (g) | 0.0% 44.4% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P=0.002 ** |
|POLY 6 | P=0.002 ** |
|LOGISTIC REGRESSION| P=0.363 |
|COCH-ARM / FISHERS | P=0.014 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 45/53 (85%) 20/66 (30%) |
|POLY-3 RATE (b) | 45/51.67 20/26.79 |
|POLY-3 PERCENT (g) | 87.1% 74.7% |
|TERMINAL (d) | 24/27 (89%) 0/0 (0%) |
|FIRST INCIDENCE | 275 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.179N |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=0.705 |
|LOGISTIC REGRESSION| P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 35
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 2/65 (3%) |
|POLY-3 RATE (b) | 1/41.89 2/11.14 |
|POLY-3 PERCENT (g) | 2.4% 18.0% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) 245 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.183 |
|POLY 3 | P=0.640 |
|POLY 1.5 | P=0.448 |
|POLY 6 | P=0.986 |
|LOGISTIC REGRESSION| P=0.813 |
|COCH-ARM / FISHERS | P=0.577 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 14/65 (22%) |
|POLY-3 RATE (b) | 0/41.89 14/22.13 |
|POLY-3 PERCENT (g) | 0.0% 63.3% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.136 |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 36
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 0/65 (0%) |
|POLY-3 RATE (b) | 3/42.49 0/9.28 |
|POLY-3 PERCENT (g) | 7.1% 0.0% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 639 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=1.000N |
|POLY 3 | P=0.939N |
|POLY 1.5 | P=0.484N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.661N |
|COCH-ARM / FISHERS | P=0.088N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/28 (25%) 27/45 (60%) |
|POLY-3 RATE (b) | 7/23.39 27/29.76 |
|POLY-3 PERCENT (g) | 29.9% 90.7% |
|TERMINAL (d) | 2/12 (17%) 0/0 (0%) |
|FIRST INCIDENCE | 275 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.140 |
|COCH-ARM / FISHERS | P=0.003 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 37
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/28 (7%) 25/45 (56%) |
|POLY-3 RATE (b) | 2/21.96 25/28.50 |
|POLY-3 PERCENT (g) | 9.1% 87.7% |
|TERMINAL (d) | 0/12 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 586 174 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.042 * |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/28 (0%) 2/45 (4%) |
|POLY-3 RATE (b) | 0/21.26 2/7.29 |
|POLY-3 PERCENT (g) | 0.0% 27.4% |
|TERMINAL (d) | 0/12 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 611 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.474 |
|POLY 1.5 | P=0.249 |
|POLY 6 | P=0.948 |
|LOGISTIC REGRESSION| P=0.004 ** |
|COCH-ARM / FISHERS | P=0.377 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 38
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/28 (0%) 2/45 (4%) |
|POLY-3 RATE (b) | 0/21.26 2/8.07 |
|POLY-3 PERCENT (g) | 0.0% 24.8% |
|TERMINAL (d) | 0/12 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 289 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.036 * |
|POLY 3 | P=0.416 |
|POLY 1.5 | P=0.244 |
|POLY 6 | P=0.854 |
|LOGISTIC REGRESSION| P=0.394 |
|COCH-ARM / FISHERS | P=0.377 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Pancreatic |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/28 (0%) 4/45 (9%) |
|POLY-3 RATE (b) | 0/21.26 4/10.12 |
|POLY-3 PERCENT (g) | 0.0% 39.5% |
|TERMINAL (d) | 0/12 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 243 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.020 * |
|POLY 3 | P=0.042 * |
|POLY 1.5 | P=0.041 * |
|POLY 6 | P=0.075 |
|LOGISTIC REGRESSION| P=0.412 |
|COCH-ARM / FISHERS | P=0.137 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 39
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/28 (0%) 3/45 (7%) |
|POLY-3 RATE (b) | 0/21.26 3/8.86 |
|POLY-3 PERCENT (g) | 0.0% 33.9% |
|TERMINAL (d) | 0/12 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 342 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** |
|POLY 3 | P=0.146 |
|POLY 1.5 | P=0.101 |
|POLY 6 | P=0.335 |
|LOGISTIC REGRESSION| P=0.158 |
|COCH-ARM / FISHERS | P=0.228 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Renal |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/28 (0%) 2/45 (4%) |
|POLY-3 RATE (b) | 0/21.26 2/7.54 |
|POLY-3 PERCENT (g) | 0.0% 26.5% |
|TERMINAL (d) | 0/12 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 545 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.454 |
|POLY 1.5 | P=0.247 |
|POLY 6 | P=0.911 |
|LOGISTIC REGRESSION| P=0.028 * |
|COCH-ARM / FISHERS | P=0.377 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 40
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 26/53 (49%) 0/66 (0%) |
|POLY-3 RATE (b) | 26/46.93 0/9.33 |
|POLY-3 PERCENT (g) | 55.4% 0.0% |
|TERMINAL (d) | 14/27 (52%) 0/0 (0%) |
|FIRST INCIDENCE | 313 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.399N |
|POLY 3 | P=0.187N |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Inflammation Granulomatous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 0/66 (0%) |
|POLY-3 RATE (b) | 3/42.81 0/9.33 |
|POLY-3 PERCENT (g) | 7.0% 0.0% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 555 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.958N |
|POLY 3 | P=0.940N |
|POLY 1.5 | P=0.482N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.377N |
|COCH-ARM / FISHERS | P=0.086N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 41
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Mesentery: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 3/63 (5%) |
|POLY-3 RATE (b) | 0/41.89 3/11.22 |
|POLY-3 PERCENT (g) | 0.0% 26.7% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 267 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.005 ** |
|POLY 3 | P=0.245 |
|POLY 1.5 | P=0.105 |
|POLY 6 | P=0.801 |
|LOGISTIC REGRESSION| P=0.113 |
|COCH-ARM / FISHERS | P=0.157 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 3/63 (5%) |
|POLY-3 RATE (b) | 1/41.89 3/11.49 |
|POLY-3 PERCENT (g) | 2.4% 26.1% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.009 ** |
|POLY 3 | P=0.332 |
|POLY 1.5 | P=0.223 |
|POLY 6 | P=0.762 |
|LOGISTIC REGRESSION| P=0.313 |
|COCH-ARM / FISHERS | P=0.377 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 42
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Nose |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 17/53 (32%) 11/66 (17%) |
|POLY-3 RATE (b) | 17/45.19 11/17.92 |
|POLY-3 PERCENT (g) | 37.6% 61.4% |
|TERMINAL (d) | 10/27 (37%) 0/0 (0%) |
|FIRST INCIDENCE | 275 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.181 |
|POLY 1.5 | P=0.525 |
|POLY 6 | P=0.077 |
|LOGISTIC REGRESSION| P=0.487 |
|COCH-ARM / FISHERS | P=0.040N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/53 (15%) 9/66 (14%) |
|POLY-3 RATE (b) | 8/43.10 9/16.16 |
|POLY-3 PERCENT (g) | 18.6% 55.7% |
|TERMINAL (d) | 5/27 (19%) 0/0 (0%) |
|FIRST INCIDENCE | 564 289 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.046 * |
|POLY 1.5 | P=0.140 |
|POLY 6 | P=0.026 * |
|LOGISTIC REGRESSION| P=0.050 |
|COCH-ARM / FISHERS | P=0.512N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 43
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Oral Mucosa: Gingival |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/53 (21%) 18/66 (27%) |
|POLY-3 RATE (b) | 11/43.10 18/22.91 |
|POLY-3 PERCENT (g) | 25.5% 78.6% |
|TERMINAL (d) | 7/27 (26%) 0/0 (0%) |
|FIRST INCIDENCE | 582 222 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P=0.003 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P=0.273 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Ovary |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 46/53 (87%) 9/65 (14%) |
|POLY-3 RATE (b) | 46/50.65 9/17.30 |
|POLY-3 PERCENT (g) | 90.8% 52.0% |
|TERMINAL (d) | 25/27 (93%) 0/0 (0%) |
|FIRST INCIDENCE | 275 217 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.014 * |
|POLY 3 | P=0.003N** |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=0.755N |
|LOGISTIC REGRESSION| P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 44
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 19/53 (36%) 13/65 (20%) |
|POLY-3 RATE (b) | 19/44.54 13/19.19 |
|POLY-3 PERCENT (g) | 42.7% 67.7% |
|TERMINAL (d) | 13/27 (48%) 0/0 (0%) |
|FIRST INCIDENCE | 313 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.128 |
|POLY 1.5 | P=0.472 |
|POLY 6 | P=0.042 * |
|LOGISTIC REGRESSION| P=0.199 |
|COCH-ARM / FISHERS | P=0.043N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Pancreas |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 19/65 (29%) |
|POLY-3 RATE (b) | 0/41.89 19/26.29 |
|POLY-3 PERCENT (g) | 0.0% 72.3% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.029 * |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 45
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Pancreas |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/65 (3%) |
|POLY-3 RATE (b) | 0/41.89 2/11.15 |
|POLY-3 PERCENT (g) | 0.0% 17.9% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 294 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.183 |
|POLY 3 | P=0.572 |
|POLY 1.5 | P=0.269 |
|POLY 6 | P=0.995 |
|LOGISTIC REGRESSION| P=0.782 |
|COCH-ARM / FISHERS | P=0.301 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Pancreas |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 6/65 (9%) |
|POLY-3 RATE (b) | 1/42.38 6/14.33 |
|POLY-3 PERCENT (g) | 2.4% 41.9% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 582 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.016 * |
|POLY 1.5 | P=0.018 * |
|POLY 6 | P=0.032 * |
|LOGISTIC REGRESSION| P=0.278 |
|COCH-ARM / FISHERS | P=0.096 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 46
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 8/65 (12%) |
|POLY-3 RATE (b) | 1/41.89 8/16.01 |
|POLY-3 PERCENT (g) | 2.4% 50.0% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) 222 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P=0.003 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.099 |
|COCH-ARM / FISHERS | P=0.033 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/65 (0%) |
|POLY-3 RATE (b) | 2/42.36 0/9.28 |
|POLY-3 PERCENT (g) | 4.7% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 639 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=1.000N |
|POLY 3 | P=0.981N |
|POLY 1.5 | P=0.644N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.773N |
|COCH-ARM / FISHERS | P=0.200N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 47
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 43/65 (66%) |
|POLY-3 RATE (b) | 0/41.89 43/44.52 |
|POLY-3 PERCENT (g) | 0.0% 96.6% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Pancreas: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 4/65 (6%) |
|POLY-3 RATE (b) | 0/41.89 4/12.01 |
|POLY-3 PERCENT (g) | 0.0% 33.3% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 329 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.083 |
|POLY 1.5 | P=0.040 * |
|POLY 6 | P=0.348 |
|LOGISTIC REGRESSION| P=0.016 * |
|COCH-ARM / FISHERS | P=0.088 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 48
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 23/53 (43%) 0/65 (0%) |
|POLY-3 RATE (b) | 23/44.91 0/9.27 |
|POLY-3 PERCENT (g) | 51.2% 0.0% |
|TERMINAL (d) | 15/27 (56%) 0/0 (0%) |
|FIRST INCIDENCE | 564 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.778N |
|POLY 3 | P=0.215N |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=0.999N |
|LOGISTIC REGRESSION| P=0.067N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/65 (0%) |
|POLY-3 RATE (b) | 2/41.89 0/9.27 |
|POLY-3 PERCENT (g) | 4.8% 0.0% |
|TERMINAL (d) | 2/27 (7%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=1.000N |
|POLY 3 | P=0.979N |
|POLY 1.5 | P=0.641N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| (e) |
|COCH-ARM / FISHERS | P=0.200N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 49
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/53 (21%) 1/65 (2%) |
|POLY-3 RATE (b) | 11/43.08 1/10.02 |
|POLY-3 PERCENT (g) | 25.5% 10.0% |
|TERMINAL (d) | 6/27 (22%) 0/0 (0%) |
|FIRST INCIDENCE | 564 456 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.289 |
|POLY 3 | P=0.657N |
|POLY 1.5 | P=0.116N |
|POLY 6 | P=0.998 |
|LOGISTIC REGRESSION| P=0.625N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 49/53 (92%) 43/65 (66%) |
|POLY-3 RATE (b) | 49/51.71 43/45.37 |
|POLY-3 PERCENT (g) | 94.8% 94.8% |
|TERMINAL (d) | 26/27 (96%) 0/0 (0%) |
|FIRST INCIDENCE | 275 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.747 |
|POLY 1.5 | P=0.148N |
|POLY 6 | P=0.430 |
|LOGISTIC REGRESSION| P=0.337N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 50
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Spleen |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 52/53 (98%) 59/65 (91%) |
|POLY-3 RATE (b) | 52/53.00 59/59.63 |
|POLY-3 PERCENT (g) | 98.1% 99.0% |
|TERMINAL (d) | 26/27 (96%) 0/0 (0%) |
|FIRST INCIDENCE | 275 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.671 |
|POLY 1.5 | P=0.597N |
|POLY 6 | P=0.493 |
|LOGISTIC REGRESSION| P=0.397N |
|COCH-ARM / FISHERS | P=0.096N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Spleen: Lymphoid Follicle |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 9/65 (14%) |
|POLY-3 RATE (b) | 4/43.27 9/17.28 |
|POLY-3 PERCENT (g) | 9.3% 52.1% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 564 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.007 ** |
|POLY 1.5 | P=0.021 * |
|POLY 6 | P=0.004 ** |
|LOGISTIC REGRESSION| P=0.682 |
|COCH-ARM / FISHERS | P=0.216 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 51
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Spleen: Red Pulp |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/65 (3%) |
|POLY-3 RATE (b) | 0/41.89 2/11.23 |
|POLY-3 PERCENT (g) | 0.0% 17.8% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.269 |
|POLY 3 | P=0.567 |
|POLY 1.5 | P=0.268 |
|POLY 6 | P=0.994 |
|LOGISTIC REGRESSION| P=0.945 |
|COCH-ARM / FISHERS | P=0.301 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 9/65 (14%) |
|POLY-3 RATE (b) | 4/41.89 9/16.84 |
|POLY-3 PERCENT (g) | 9.6% 53.4% |
|TERMINAL (d) | 4/27 (15%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) 217 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.006 ** |
|POLY 1.5 | P=0.021 * |
|POLY 6 | P=0.004 ** |
|LOGISTIC REGRESSION| P=0.198 |
|COCH-ARM / FISHERS | P=0.216 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 52
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 1/65 (2%) |
|POLY-3 RATE (b) | 2/41.89 1/9.95 |
|POLY-3 PERCENT (g) | 4.8% 10.1% |
|TERMINAL (d) | 2/27 (7%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) 482 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.186 |
|POLY 3 | P=0.932 |
|POLY 1.5 | P=0.832 |
|POLY 6 | P=1.000 |
|LOGISTIC REGRESSION| P=0.554 |
|COCH-ARM / FISHERS | P=0.423N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/65 (3%) |
|POLY-3 RATE (b) | 0/41.89 2/11.13 |
|POLY-3 PERCENT (g) | 0.0% 18.0% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 267 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.205 |
|POLY 3 | P=0.573 |
|POLY 1.5 | P=0.270 |
|POLY 6 | P=0.995 |
|LOGISTIC REGRESSION| P=0.817 |
|COCH-ARM / FISHERS | P=0.301 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 53
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 1/65 (2%) |
|POLY-3 RATE (b) | 2/41.89 1/9.95 |
|POLY-3 PERCENT (g) | 4.8% 10.1% |
|TERMINAL (d) | 2/27 (7%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) 482 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.186 |
|POLY 3 | P=0.932 |
|POLY 1.5 | P=0.832 |
|POLY 6 | P=1.000 |
|LOGISTIC REGRESSION| P=0.554 |
|COCH-ARM / FISHERS | P=0.423N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Erosion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/65 (3%) |
|POLY-3 RATE (b) | 0/41.89 2/10.92 |
|POLY-3 PERCENT (g) | 0.0% 18.3% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 237 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.094 |
|POLY 3 | P=0.588 |
|POLY 1.5 | P=0.272 |
|POLY 6 | P=0.996 |
|LOGISTIC REGRESSION| P=0.580 |
|COCH-ARM / FISHERS | P=0.301 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 54
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 3/65 (5%) |
|POLY-3 RATE (b) | 0/41.89 3/12.13 |
|POLY-3 PERCENT (g) | 0.0% 24.7% |
|TERMINAL (d) | 0/27 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.129 |
|POLY 3 | P=0.220 |
|POLY 1.5 | P=0.104 |
|POLY 6 | P=0.736 |
|LOGISTIC REGRESSION| P=0.814 |
|COCH-ARM / FISHERS | P=0.164 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 12/53 (23%) 5/65 (8%) |
|POLY-3 RATE (b) | 12/45.97 5/13.58 |
|POLY-3 PERCENT (g) | 26.1% 36.8% |
|TERMINAL (d) | 3/27 (11%) 0/0 (0%) |
|FIRST INCIDENCE | 313 267 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.053 |
|POLY 3 | P=0.582 |
|POLY 1.5 | P=0.508N |
|POLY 6 | P=0.555 |
|LOGISTIC REGRESSION| P=0.033N* |
|COCH-ARM / FISHERS | P=0.021N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 55
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 40/53 (75%) 57/59 (97%) |
|POLY-3 RATE (b) | 40/48.92 57/57.15 |
|POLY-3 PERCENT (g) | 81.8% 99.7% |
|TERMINAL (d) | 23/27 (85%) 0/0 (0%) |
|FIRST INCIDENCE | 275 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.002 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/53 (13%) 3/66 (5%) |
|POLY-3 RATE (b) | 7/43.53 3/11.81 |
|POLY-3 PERCENT (g) | 16.1% 25.4% |
|TERMINAL (d) | 3/27 (11%) 0/0 (0%) |
|FIRST INCIDENCE | 555 321 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.034 * |
|POLY 3 | P=0.689 |
|POLY 1.5 | P=0.619N |
|POLY 6 | P=0.843 |
|LOGISTIC REGRESSION| P=0.512N |
|COCH-ARM / FISHERS | P=0.087N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 56
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 22/53 (42%) 37/66 (56%) |
|POLY-3 RATE (b) | 22/47.33 37/40.35 |
|POLY-3 PERCENT (g) | 46.5% 91.7% |
|TERMINAL (d) | 9/27 (33%) 0/0 (0%) |
|FIRST INCIDENCE | 275 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.137 |
|COCH-ARM / FISHERS | P=0.082 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Tooth: Peridontal Tissue |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 29/29 (100%) 25/25 (100%) |
|POLY-3 RATE (b) | 29/29.00 25/25.00 |
|POLY-3 PERCENT (g) | 100.0% 100.0% |
|TERMINAL (d) | 16/16 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 534 245 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) |
|POLY 3 | (e) |
|POLY 1.5 | (e) |
|POLY 6 | (e) |
|LOGISTIC REGRESSION| (e) |
|COCH-ARM / FISHERS | (e) |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 57
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/53 (15%) 0/66 (0%) |
|POLY-3 RATE (b) | 8/43.36 0/9.33 |
|POLY-3 PERCENT (g) | 18.5% 0.0% |
|TERMINAL (d) | 3/27 (11%) 0/0 (0%) |
|FIRST INCIDENCE | 362 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.642N |
|POLY 3 | P=0.688N |
|POLY 1.5 | P=0.126N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.136N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Urinary Bladder: Transitional Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 0/66 (0%) |
|POLY-3 RATE (b) | 4/42.40 0/9.33 |
|POLY-3 PERCENT (g) | 9.4% 0.0% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 672 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=1.000 |
|POLY 3 | P=0.884N |
|POLY 1.5 | P=0.361N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.765N |
|COCH-ARM / FISHERS | P=0.037N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 58
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Uterus |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 2/66 (3%) |
|POLY-3 RATE (b) | 4/41.89 2/10.47 |
|POLY-3 PERCENT (g) | 9.6% 19.1% |
|TERMINAL (d) | 4/27 (15%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) 415 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.006 ** |
|POLY 3 | P=0.777 |
|POLY 1.5 | P=0.758N |
|POLY 6 | P=0.983 |
|LOGISTIC REGRESSION| P=0.119 |
|COCH-ARM / FISHERS | P=0.242N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Uterus |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/66 (0%) |
|POLY-3 RATE (b) | 2/42.77 0/9.33 |
|POLY-3 PERCENT (g) | 4.7% 0.0% |
|TERMINAL (d) | 1/27 (4%) 0/0 (0%) |
|FIRST INCIDENCE | 362 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.642N |
|POLY 3 | P=0.982N |
|POLY 1.5 | P=0.645N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.191N |
|COCH-ARM / FISHERS | P=0.196N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 05/06/04 EXPERIMENT: 96022 TEST: 02 Page 59
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Uterus |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 23/53 (43%) 0/66 (0%) |
|POLY-3 RATE (b) | 23/44.48 0/9.33 |
|POLY-3 PERCENT (g) | 51.7% 0.0% |
|TERMINAL (d) | 16/27 (59%) 0/0 (0%) |
|FIRST INCIDENCE | 555 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.848N |
|POLY 3 | P=0.203N |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=0.999N |
|LOGISTIC REGRESSION| P=0.120N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500 UG |
|=================================================================================================================================|
| |
|Uterus: Endometrium |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 32/53 (60%) 8/66 (12%) |
|POLY-3 RATE (b) | 32/46.96 8/15.68 |
|POLY-3 PERCENT (g) | 68.2% 51.0% |
|TERMINAL (d) | 21/27 (78%) 0/0 (0%) |
|FIRST INCIDENCE | 275 243 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.003 ** |
|POLY 3 | P=0.367N |
|POLY 1.5 | P=0.004N** |
|POLY 6 | P=0.791 |
|LOGISTIC REGRESSION| P=0.077N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).