TDMS Study 96022-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) DATE: 06/10/04
EXPERIMENT: 96022 TEST: 02 TIME: 10:02:55
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96022
PATHOLOGIST: MISSING CAS: TEFPCBMIX
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF TEF EVALUATION (PCB MIXTURE;PCB 126/P
===============================================================
Female Rats
------------
Organ Morphology
----- ----------
Adrenal Cortex Angiectasis
Atrophy
Degeneration Cystic
Hyperplasia
Hypertrophy
Inflammation
Necrosis
Vacuolization Cytoplasmic
Adrenal Medulla Hyperplasia
Blood Vessel: Aorta, Adventitia Hemorrhage
Inflammation
Bone Marrow Atrophy
Hyperplasia
Brain Hemorrhage
Clitoral Gland Inflammation
Clitoral Gland: Duct Cyst
Esophagus: Muscularis Inflammation
Harderian Gland Inflammation
Heart Cardiomyopathy
Heart: Coronary Artery Inflammation Chronic
Heart: Epicardium Inflammation
Heart: Myocardium Hemorrhage
Necrosis
Intestine Large, Cecum Edema
Inflammation
Intestine Large, Colon Parasite Metazoan
Intestine Large, Rectum: Artery Inflammation Chronic
Kidney Mineralization
Nephropathy
Liver Angiectasis
Basophilic Focus
Cholangiofibrosis
Eosinophilic Focus
Fatty Change Diffuse
Fatty Change Focal
Hematopoietic Cell Proliferation
Hyperplasia
Inflammation
Metaplasia
Mixed Cell Focus
Necrosis
Pigmentation
Toxic Hepatopathy
Liver: Bile Duct Cyst
Fibrosis
Hyperplasia
Liver: Centrilobular Degeneration
Fibrosis
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) DATE: 06/10/04
EXPERIMENT: 96022 TEST: 02 TIME: 10:02:55
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96022
PATHOLOGIST: MISSING CAS: TEFPCBMIX
Liver: Hepatocyte Glandular Structures
Hypertrophy
Multinucleated
Liver: Oval Cell Hyperplasia
Liver: Portal Fibrosis
Lung Hemorrhage
Infiltration Cellular Histiocyte
Inflammation
Inflammation Granulomatous
Keratin Cyst
Metaplasia
Lung: Alveolar Epithelium Hyperplasia
Metaplasia Bronchiolar
Lung: Serosa Fibrosis
Lymph Node, Mandibular Ectasia
Hemorrhage
Hyperplasia
Lymph Node, Mesenteric Ectasia
Hemorrhage
Hyperplasia
Lymph Node: Mediastinal Ectasia
Hemorrhage
Hyperplasia
Pigmentation
Lymph Node: Pancreatic Hemorrhage
Hyperplasia
Lymph Node: Renal Hemorrhage
Hyperplasia
Mammary Gland Hyperplasia
Mesentery: Artery Inflammation Chronic
Mesentery: Fat Necrosis
Nose Inflammation
Nose: Olfactory Epithelium Metaplasia
Nose: Respiratory Epithelium Hyperplasia
Oral Mucosa: Gingival Hyperplasia
Ovary Atrophy
Cyst
Pancreas Edema
Hemorrhage
Inflammation Chronic
Pancreas: Acinus Atrophy
Vacuolization Cytoplasmic
Pancreas: Artery Inflammation Chronic
Pituitary Gland Angiectasis
Cyst
Cytoplasmic Alteration
Pituitary Gland: Pars Distalis Hyperplasia
Spleen Hematopoietic Cell Proliferation
Pigmentation
Spleen: Lymphoid Follicle Atrophy
Spleen: Red Pulp Atrophy
Stomach, Forestomach Hyperplasia
Inflammation
Mineralization
Ulcer
Stomach, Glandular Erosion
Hemorrhage
Mineralization
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) DATE: 06/10/04
EXPERIMENT: 96022 TEST: 02 TIME: 10:02:55
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96022
PATHOLOGIST: MISSING CAS: TEFPCBMIX
Thymus Atrophy
Thyroid Gland Infiltration Cellular Lymphoid
Thyroid Gland: C-Cell Hyperplasia
Thyroid Gland: Follicular Cell Hypertrophy
Uterus Inflammation
Metaplasia
Uterus: Endometrium Hyperplasia Cystic
===============================================================
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 1
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 21/50 (42%) 6/65 (9%) |
|POLY-3 RATE (b) | 21/28.18 6/14.36 |
|POLY-3 PERCENT (g) | 74.5% 41.8% |
|TERMINAL (d) | 9/10 (90%) 0/0 (0%) |
|FIRST INCIDENCE | 232 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.485 |
|POLY 3 | P=0.048N* |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=0.754N |
|LOGISTIC REGRESSION| P=0.012N* |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 12/50 (24%) 40/65 (62%) |
|POLY-3 RATE (b) | 12/30.21 40/41.82 |
|POLY-3 PERCENT (g) | 39.7% 95.7% |
|TERMINAL (d) | 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | 226 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 2
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 9/50 (18%) 2/65 (3%) |
|POLY-3 RATE (b) | 9/22.95 2/10.85 |
|POLY-3 PERCENT (g) | 39.2% 18.4% |
|TERMINAL (d) | 4/10 (40%) 0/0 (0%) |
|FIRST INCIDENCE | 504 336 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.338 |
|POLY 3 | P=0.339N |
|POLY 1.5 | P=0.053N |
|POLY 6 | P=0.924N |
|LOGISTIC REGRESSION| P=0.478N |
|COCH-ARM / FISHERS | P=0.008N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/50 (20%) 5/65 (8%) |
|POLY-3 RATE (b) | 10/25.67 5/13.17 |
|POLY-3 PERCENT (g) | 39.0% 38.0% |
|TERMINAL (d) | 4/10 (40%) 0/0 (0%) |
|FIRST INCIDENCE | 258 321 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.334 |
|POLY 3 | P=0.697N |
|POLY 1.5 | P=0.260N |
|POLY 6 | P=0.537 |
|LOGISTIC REGRESSION| P=0.258N |
|COCH-ARM / FISHERS | P=0.048N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 3
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 29/50 (58%) 27/65 (42%) |
|POLY-3 RATE (b) | 29/31.75 27/31.15 |
|POLY-3 PERCENT (g) | 91.3% 86.7% |
|TERMINAL (d) | 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 230 174 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.390N |
|POLY 1.5 | P=0.121N |
|POLY 6 | P=0.824 |
|LOGISTIC REGRESSION| P=0.465 |
|COCH-ARM / FISHERS | P=0.059N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/65 (0%) |
|POLY-3 RATE (b) | 2/22.11 0/9.28 |
|POLY-3 PERCENT (g) | 9.1% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 279 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.443N |
|POLY 3 | P=0.737N |
|POLY 1.5 | P=0.356N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.250N |
|COCH-ARM / FISHERS | P=0.187N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 4
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 4/65 (6%) |
|POLY-3 RATE (b) | 2/22.01 4/13.13 |
|POLY-3 PERCENT (g) | 9.1% 30.5% |
|TERMINAL (d) | 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | 267 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.274 |
|POLY 3 | P=0.190 |
|POLY 1.5 | P=0.286 |
|POLY 6 | P=0.159 |
|LOGISTIC REGRESSION| P=0.603 |
|COCH-ARM / FISHERS | P=0.471 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 16/50 (32%) 12/65 (18%) |
|POLY-3 RATE (b) | 16/26.74 12/18.81 |
|POLY-3 PERCENT (g) | 59.9% 63.8% |
|TERMINAL (d) | 5/10 (50%) 0/0 (0%) |
|FIRST INCIDENCE | 201 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.006 ** |
|POLY 3 | P=0.558 |
|POLY 1.5 | P=0.316N |
|POLY 6 | P=0.216 |
|LOGISTIC REGRESSION| P=0.572N |
|COCH-ARM / FISHERS | P=0.073N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 5
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/49 (16%) 0/64 (0%) |
|POLY-3 RATE (b) | 8/23.03 0/9.22 |
|POLY-3 PERCENT (g) | 34.7% 0.0% |
|TERMINAL (d) | 3/9 (33%) 0/0 (0%) |
|FIRST INCIDENCE | 226 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.247N |
|POLY 3 | P=0.188N |
|POLY 1.5 | P=0.012N* |
|POLY 6 | P=0.979N |
|LOGISTIC REGRESSION| P=0.026N* |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Blood Vessel: Aorta, Adventitia |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/66 (2%) |
|POLY-3 RATE (b) | 2/22.98 1/10.26 |
|POLY-3 PERCENT (g) | 8.7% 9.8% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 240 294 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.412N |
|POLY 3 | P=0.848 |
|POLY 1.5 | P=0.631N |
|POLY 6 | P=0.976 |
|LOGISTIC REGRESSION| P=0.264N |
|COCH-ARM / FISHERS | P=0.396N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 6
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Blood Vessel: Aorta, Adventitia |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 2/66 (3%) |
|POLY-3 RATE (b) | 2/22.99 2/11.08 |
|POLY-3 PERCENT (g) | 8.7% 18.1% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 240 294 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.654N |
|POLY 3 | P=0.592 |
|POLY 1.5 | P=0.645 |
|POLY 6 | P=0.745 |
|LOGISTIC REGRESSION| P=0.452N |
|COCH-ARM / FISHERS | P=0.580N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Bone Marrow |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/50 (8%) 12/66 (18%) |
|POLY-3 RATE (b) | 4/24.94 12/20.74 |
|POLY-3 PERCENT (g) | 16.0% 57.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 201 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.102 |
|POLY 3 | P=0.002 ** |
|POLY 1.5 | P=0.016 * |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.275 |
|COCH-ARM / FISHERS | P=0.095 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 7
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 40/50 (80%) 49/66 (74%) |
|POLY-3 RATE (b) | 40/46.05 49/50.11 |
|POLY-3 PERCENT (g) | 86.9% 97.8% |
|TERMINAL (d) | 5/10 (50%) 0/0 (0%) |
|FIRST INCIDENCE | 209 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.032 * |
|POLY 1.5 | P=0.179 |
|POLY 6 | P=0.014 * |
|LOGISTIC REGRESSION| P=0.432N |
|COCH-ARM / FISHERS | P=0.309N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Brain |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/50 (16%) 14/66 (21%) |
|POLY-3 RATE (b) | 8/28.75 14/22.64 |
|POLY-3 PERCENT (g) | 27.8% 61.8% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 201 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.307 |
|POLY 3 | P=0.011 * |
|POLY 1.5 | P=0.070 |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.547N |
|COCH-ARM / FISHERS | P=0.322 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 8
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 30/50 (60%) 31/66 (47%) |
|POLY-3 RATE (b) | 30/33.33 31/35.89 |
|POLY-3 PERCENT (g) | 90.0% 86.4% |
|TERMINAL (d) | 9/10 (90%) 0/0 (0%) |
|FIRST INCIDENCE | 226 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.435N |
|POLY 1.5 | P=0.144N |
|POLY 6 | P=0.592 |
|LOGISTIC REGRESSION| P=0.517N |
|COCH-ARM / FISHERS | P=0.114N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Clitoral Gland: Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 40/50 (80%) 61/66 (92%) |
|POLY-3 RATE (b) | 40/43.50 61/61.31 |
|POLY-3 PERCENT (g) | 92.0% 99.5% |
|TERMINAL (d) | 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 226 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.019 * |
|POLY 1.5 | P=0.013 * |
|POLY 6 | P=0.053 |
|LOGISTIC REGRESSION| P=0.023 * |
|COCH-ARM / FISHERS | P=0.045 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 9
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Esophagus: Muscularis |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/66 (3%) |
|POLY-3 RATE (b) | 0/21.06 2/10.61 |
|POLY-3 PERCENT (g) | 0.0% 18.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 254 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.055 |
|POLY 3 | P=0.277 |
|POLY 1.5 | P=0.227 |
|POLY 6 | P=0.642 |
|LOGISTIC REGRESSION| P=0.221 |
|COCH-ARM / FISHERS | P=0.322 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Harderian Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 12/50 (24%) 9/66 (14%) |
|POLY-3 RATE (b) | 12/26.40 9/16.65 |
|POLY-3 PERCENT (g) | 45.5% 54.1% |
|TERMINAL (d) | 5/10 (50%) 0/0 (0%) |
|FIRST INCIDENCE | 209 217 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.121 |
|POLY 3 | P=0.459 |
|POLY 1.5 | P=0.452N |
|POLY 6 | P=0.184 |
|LOGISTIC REGRESSION| P=0.322N |
|COCH-ARM / FISHERS | P=0.117N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 10
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 15/50 (30%) 19/65 (29%) |
|POLY-3 RATE (b) | 15/28.08 19/24.56 |
|POLY-3 PERCENT (g) | 53.4% 77.4% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 209 237 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.042 * |
|POLY 1.5 | P=0.211 |
|POLY 6 | P=0.007 ** |
|LOGISTIC REGRESSION| P=0.254 |
|COCH-ARM / FISHERS | P=0.545N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Heart: Coronary Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/50 (12%) 9/65 (14%) |
|POLY-3 RATE (b) | 6/24.90 9/16.16 |
|POLY-3 PERCENT (g) | 24.1% 55.7% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 273 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.015 * |
|POLY 3 | P=0.054 |
|POLY 1.5 | P=0.185 |
|POLY 6 | P=0.015 * |
|LOGISTIC REGRESSION| P=0.333 |
|COCH-ARM / FISHERS | P=0.499 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 11
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Heart: Epicardium |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 6/65 (9%) |
|POLY-3 RATE (b) | 1/21.78 6/13.78 |
|POLY-3 PERCENT (g) | 4.6% 43.5% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 474 362 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.005 ** |
|POLY 3 | P=0.014 * |
|POLY 1.5 | P=0.035 * |
|POLY 6 | P=0.007 ** |
|LOGISTIC REGRESSION| P=0.050 |
|COCH-ARM / FISHERS | P=0.110 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Heart: Myocardium |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 3/65 (5%) |
|POLY-3 RATE (b) | 1/22.01 3/12.08 |
|POLY-3 PERCENT (g) | 4.5% 24.8% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 258 267 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.393 |
|POLY 3 | P=0.219 |
|POLY 1.5 | P=0.264 |
|POLY 6 | P=0.284 |
|LOGISTIC REGRESSION| P=0.550 |
|COCH-ARM / FISHERS | P=0.414 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 12
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Heart: Myocardium |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/65 (3%) |
|POLY-3 RATE (b) | 0/21.06 2/11.19 |
|POLY-3 PERCENT (g) | 0.0% 17.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.297 |
|POLY 3 | P=0.263 |
|POLY 1.5 | P=0.227 |
|POLY 6 | P=0.556 |
|LOGISTIC REGRESSION| P=0.403 |
|COCH-ARM / FISHERS | P=0.317 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Intestine Large, Cecum |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/65 (3%) |
|POLY-3 RATE (b) | 1/22.03 2/11.19 |
|POLY-3 PERCENT (g) | 4.5% 17.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 232 254 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.596 |
|POLY 3 | P=0.453 |
|POLY 1.5 | P=0.466 |
|POLY 6 | P=0.667 |
|LOGISTIC REGRESSION| P=0.735N |
|COCH-ARM / FISHERS | P=0.598 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 13
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Intestine Large, Cecum |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/65 (3%) |
|POLY-3 RATE (b) | 1/22.03 2/11.20 |
|POLY-3 PERCENT (g) | 4.5% 17.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 232 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.600 |
|POLY 3 | P=0.453 |
|POLY 1.5 | P=0.466 |
|POLY 6 | P=0.667 |
|LOGISTIC REGRESSION| P=0.732N |
|COCH-ARM / FISHERS | P=0.598 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Intestine Large, Colon |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/65 (3%) |
|POLY-3 RATE (b) | 1/21.06 2/11.13 |
|POLY-3 PERCENT (g) | 4.8% 18.0% |
|TERMINAL (d) | 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) 236 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.254 |
|POLY 3 | P=0.449 |
|POLY 1.5 | P=0.469 |
|POLY 6 | P=0.638 |
|LOGISTIC REGRESSION| P=0.528 |
|COCH-ARM / FISHERS | P=0.598 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 14
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Intestine Large, Rectum: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/50 (8%) 0/66 (0%) |
|POLY-3 RATE (b) | 4/21.71 0/9.33 |
|POLY-3 PERCENT (g) | 18.4% 0.0% |
|TERMINAL (d) | 2/10 (20%) 0/0 (0%) |
|FIRST INCIDENCE | 607 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.901N |
|POLY 3 | P=0.443N |
|POLY 1.5 | P=0.112N |
|POLY 6 | P=0.994N |
|LOGISTIC REGRESSION| P=0.604N |
|COCH-ARM / FISHERS | P=0.032N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Kidney |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 32/50 (64%) 37/65 (57%) |
|POLY-3 RATE (b) | 32/39.76 37/39.76 |
|POLY-3 PERCENT (g) | 80.5% 93.1% |
|TERMINAL (d) | 7/10 (70%) 0/0 (0%) |
|FIRST INCIDENCE | 201 217 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.050 |
|POLY 1.5 | P=0.266 |
|POLY 6 | P=0.016 * |
|LOGISTIC REGRESSION| P=0.484N |
|COCH-ARM / FISHERS | P=0.283N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 15
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 34/50 (68%) 43/65 (66%) |
|POLY-3 RATE (b) | 34/34.66 43/44.50 |
|POLY-3 PERCENT (g) | 98.1% 96.6% |
|TERMINAL (d) | 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 209 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.742N |
|POLY 1.5 | P=0.456N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.123 |
|COCH-ARM / FISHERS | P=0.498N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/50 (8%) 2/65 (3%) |
|POLY-3 RATE (b) | 4/21.49 2/10.57 |
|POLY-3 PERCENT (g) | 18.6% 18.9% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 601 243 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.107 |
|POLY 3 | P=0.776 |
|POLY 1.5 | P=0.459N |
|POLY 6 | P=0.822 |
|LOGISTIC REGRESSION| P=0.493 |
|COCH-ARM / FISHERS | P=0.225N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 16
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/50 (10%) 0/65 (0%) |
|POLY-3 RATE (b) | 5/21.73 0/9.28 |
|POLY-3 PERCENT (g) | 23.0% 0.0% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 601 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.916N |
|POLY 3 | P=0.346N |
|POLY 1.5 | P=0.065N |
|POLY 6 | P=0.988N |
|LOGISTIC REGRESSION| P=0.599N |
|COCH-ARM / FISHERS | P=0.014N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Cholangiofibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 27/50 (54%) 29/65 (45%) |
|POLY-3 RATE (b) | 27/33.72 29/31.95 |
|POLY-3 PERCENT (g) | 80.1% 90.8% |
|TERMINAL (d) | 8/10 (80%) 0/0 (0%) |
|FIRST INCIDENCE | 201 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.133 |
|POLY 1.5 | P=0.483 |
|POLY 6 | P=0.043 * |
|LOGISTIC REGRESSION| P=0.328 |
|COCH-ARM / FISHERS | P=0.209N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 17
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 15/50 (30%) 10/65 (15%) |
|POLY-3 RATE (b) | 15/28.06 10/18.34 |
|POLY-3 PERCENT (g) | 53.5% 54.5% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 209 174 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.186 |
|POLY 3 | P=0.642 |
|POLY 1.5 | P=0.243N |
|POLY 6 | P=0.276 |
|LOGISTIC REGRESSION| P=0.114N |
|COCH-ARM / FISHERS | P=0.049N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Fatty Change Diffuse |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 35/50 (70%) 56/65 (86%) |
|POLY-3 RATE (b) | 35/43.37 56/57.00 |
|POLY-3 PERCENT (g) | 80.7% 98.3% |
|TERMINAL (d) | 7/10 (70%) 0/0 (0%) |
|FIRST INCIDENCE | 201 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.106 |
|COCH-ARM / FISHERS | P=0.030 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 18
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Fatty Change Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 14/50 (28%) 6/65 (9%) |
|POLY-3 RATE (b) | 14/24.02 6/13.82 |
|POLY-3 PERCENT (g) | 58.3% 43.4% |
|TERMINAL (d) | 7/10 (70%) 0/0 (0%) |
|FIRST INCIDENCE | 282 329 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.034 * |
|POLY 3 | P=0.354N |
|POLY 1.5 | P=0.057N |
|POLY 6 | P=0.770 |
|LOGISTIC REGRESSION| P=0.627 |
|COCH-ARM / FISHERS | P=0.009N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 22/50 (44%) 11/65 (17%) |
|POLY-3 RATE (b) | 22/29.47 11/17.99 |
|POLY-3 PERCENT (g) | 74.6% 61.1% |
|TERMINAL (d) | 8/10 (80%) 0/0 (0%) |
|FIRST INCIDENCE | 209 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.071 |
|POLY 3 | P=0.281N |
|POLY 1.5 | P=0.015N* |
|POLY 6 | P=0.656 |
|LOGISTIC REGRESSION| P=0.080N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 19
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 34/50 (68%) 61/65 (94%) |
|POLY-3 RATE (b) | 34/44.64 61/61.04 |
|POLY-3 PERCENT (g) | 76.2% 99.9% |
|TERMINAL (d) | 4/10 (40%) 0/0 (0%) |
|FIRST INCIDENCE | 201 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.008 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 48/50 (96%) 64/65 (98%) |
|POLY-3 RATE (b) | 48/48.82 64/64.15 |
|POLY-3 PERCENT (g) | 98.3% 99.8% |
|TERMINAL (d) | 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 201 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.532 |
|POLY 1.5 | P=0.464 |
|POLY 6 | P=0.667 |
|LOGISTIC REGRESSION| P=0.490 |
|COCH-ARM / FISHERS | P=0.402 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 20
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 4/65 (6%) |
|POLY-3 RATE (b) | 2/22.97 4/11.99 |
|POLY-3 PERCENT (g) | 8.7% 33.4% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 232 338 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.130 |
|POLY 3 | P=0.177 |
|POLY 1.5 | P=0.261 |
|POLY 6 | P=0.174 |
|LOGISTIC REGRESSION| P=0.451 |
|COCH-ARM / FISHERS | P=0.471 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 20/50 (40%) 3/65 (5%) |
|POLY-3 RATE (b) | 20/26.46 3/11.13 |
|POLY-3 PERCENT (g) | 75.6% 27.0% |
|TERMINAL (d) | 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 282 429 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.523 |
|POLY 3 | P=0.016N* |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=0.903N |
|LOGISTIC REGRESSION| P=0.046N* |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 21
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/50 (12%) 27/65 (42%) |
|POLY-3 RATE (b) | 6/25.40 27/31.21 |
|POLY-3 PERCENT (g) | 23.6% 86.5% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 201 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 50/50 (100%) 60/65 (92%) |
|POLY-3 RATE (b) | 50/50.00 60/60.56 |
|POLY-3 PERCENT (g) | 100.0% 99.1% |
|TERMINAL (d) | 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 201 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.890N |
|POLY 1.5 | P=0.293N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.109N |
|COCH-ARM / FISHERS | P=0.054N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 22
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver |
| Toxic Hepatopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 50/50 (100%) 64/65 (98%) |
|POLY-3 RATE (b) | 50/50.00 64/64.00 |
|POLY-3 PERCENT (g) | 100.0% 100.0% |
|TERMINAL (d) | 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 201 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=1.000N |
|POLY 1.5 | P=1.000N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| (e) |
|COCH-ARM / FISHERS | P=0.565N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 21/50 (42%) 14/65 (22%) |
|POLY-3 RATE (b) | 21/25.42 14/19.17 |
|POLY-3 PERCENT (g) | 82.6% 73.0% |
|TERMINAL (d) | 9/10 (90%) 0/0 (0%) |
|FIRST INCIDENCE | 474 289 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.325N |
|POLY 1.5 | P=0.050N |
|POLY 6 | P=0.780 |
|LOGISTIC REGRESSION| P=0.091 |
|COCH-ARM / FISHERS | P=0.016N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 23
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 12/50 (24%) 4/65 (6%) |
|POLY-3 RATE (b) | 12/24.42 4/12.37 |
|POLY-3 PERCENT (g) | 49.2% 32.3% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 383 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.159 |
|POLY 3 | P=0.369N |
|POLY 1.5 | P=0.050N |
|POLY 6 | P=0.800 |
|LOGISTIC REGRESSION| P=0.346N |
|COCH-ARM / FISHERS | P=0.007N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 37/50 (74%) 60/65 (92%) |
|POLY-3 RATE (b) | 37/44.10 60/60.13 |
|POLY-3 PERCENT (g) | 83.9% 99.8% |
|TERMINAL (d) | 5/10 (50%) 0/0 (0%) |
|FIRST INCIDENCE | 209 174 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P=0.002 ** |
|LOGISTIC REGRESSION| P=0.013 * |
|COCH-ARM / FISHERS | P=0.008 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 24
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver: Centrilobular |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/50 (12%) 8/65 (12%) |
|POLY-3 RATE (b) | 6/25.86 8/16.92 |
|POLY-3 PERCENT (g) | 23.2% 47.3% |
|TERMINAL (d) | 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | 201 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.462 |
|POLY 3 | P=0.119 |
|POLY 1.5 | P=0.291 |
|POLY 6 | P=0.040 * |
|LOGISTIC REGRESSION| P=0.345N |
|COCH-ARM / FISHERS | P=0.628N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver: Centrilobular |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 43/50 (86%) 57/65 (88%) |
|POLY-3 RATE (b) | 43/50.00 57/59.02 |
|POLY-3 PERCENT (g) | 86.0% 96.6% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 201 174 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.034 * |
|POLY 1.5 | P=0.103 |
|POLY 6 | P=0.010 * |
|LOGISTIC REGRESSION| P=0.070N |
|COCH-ARM / FISHERS | P=0.501 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 25
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Glandular Structures |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 9/50 (18%) 25/65 (38%) |
|POLY-3 RATE (b) | 9/29.71 25/31.26 |
|POLY-3 PERCENT (g) | 30.3% 80.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 226 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.005 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.129 |
|COCH-ARM / FISHERS | P=0.014 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 36/50 (72%) 65/65 (100%) |
|POLY-3 RATE (b) | 36/45.73 65/65.00 |
|POLY-3 PERCENT (g) | 78.7% 100.0% |
|TERMINAL (d) | 5/10 (50%) 0/0 (0%) |
|FIRST INCIDENCE | 201 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.005 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 26
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Multinucleated |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 38/50 (76%) 48/65 (74%) |
|POLY-3 RATE (b) | 38/44.81 48/50.32 |
|POLY-3 PERCENT (g) | 84.8% 95.4% |
|TERMINAL (d) | 5/10 (50%) 0/0 (0%) |
|FIRST INCIDENCE | 201 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.046 * |
|POLY 1.5 | P=0.194 |
|POLY 6 | P=0.014 * |
|LOGISTIC REGRESSION| P=0.356N |
|COCH-ARM / FISHERS | P=0.483N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver: Oval Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 43/50 (86%) 62/65 (95%) |
|POLY-3 RATE (b) | 43/48.43 62/62.03 |
|POLY-3 PERCENT (g) | 88.8% 100.0% |
|TERMINAL (d) | 5/10 (50%) 0/0 (0%) |
|FIRST INCIDENCE | 201 174 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.008 ** |
|POLY 1.5 | P=0.006 ** |
|POLY 6 | P=0.010 * |
|LOGISTIC REGRESSION| P=0.183 |
|COCH-ARM / FISHERS | P=0.076 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 27
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Liver: Portal |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 42/50 (84%) 58/65 (89%) |
|POLY-3 RATE (b) | 42/48.26 58/58.27 |
|POLY-3 PERCENT (g) | 87.0% 99.5% |
|TERMINAL (d) | 5/10 (50%) 0/0 (0%) |
|FIRST INCIDENCE | 201 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.005 ** |
|POLY 1.5 | P=0.010 * |
|POLY 6 | P=0.007 ** |
|LOGISTIC REGRESSION| P=0.443 |
|COCH-ARM / FISHERS | P=0.291 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lung |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 4/66 (6%) |
|POLY-3 RATE (b) | 3/23.69 4/12.86 |
|POLY-3 PERCENT (g) | 12.7% 31.1% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 226 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.440 |
|POLY 3 | P=0.285 |
|POLY 1.5 | P=0.419 |
|POLY 6 | P=0.247 |
|LOGISTIC REGRESSION| P=0.524N |
|COCH-ARM / FISHERS | P=0.651N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 28
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 24/50 (48%) 33/66 (50%) |
|POLY-3 RATE (b) | 24/32.50 33/37.16 |
|POLY-3 PERCENT (g) | 73.8% 88.8% |
|TERMINAL (d) | 6/10 (60%) 0/0 (0%) |
|FIRST INCIDENCE | 226 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.054 |
|POLY 1.5 | P=0.181 |
|POLY 6 | P=0.016 * |
|LOGISTIC REGRESSION| P=0.134 |
|COCH-ARM / FISHERS | P=0.490 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lung |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/50 (12%) 2/66 (3%) |
|POLY-3 RATE (b) | 6/23.16 2/11.03 |
|POLY-3 PERCENT (g) | 25.9% 18.1% |
|TERMINAL (d) | 2/10 (20%) 0/0 (0%) |
|FIRST INCIDENCE | 267 243 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.601 |
|POLY 3 | P=0.610N |
|POLY 1.5 | P=0.226N |
|POLY 6 | P=0.873 |
|LOGISTIC REGRESSION| P=0.282N |
|COCH-ARM / FISHERS | P=0.065N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 29
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Granulomatous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/50 (8%) 0/66 (0%) |
|POLY-3 RATE (b) | 4/22.05 0/9.33 |
|POLY-3 PERCENT (g) | 18.1% 0.0% |
|TERMINAL (d) | 2/10 (20%) 0/0 (0%) |
|FIRST INCIDENCE | 561 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.793N |
|POLY 3 | P=0.455N |
|POLY 1.5 | P=0.115N |
|POLY 6 | P=0.995N |
|LOGISTIC REGRESSION| P=0.396N |
|COCH-ARM / FISHERS | P=0.032N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lung |
| Keratin Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 9/50 (18%) 0/66 (0%) |
|POLY-3 RATE (b) | 9/23.33 0/9.33 |
|POLY-3 PERCENT (g) | 38.6% 0.0% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 525 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.664N |
|POLY 3 | P=0.145N |
|POLY 1.5 | P=0.006N** |
|POLY 6 | P=0.977N |
|LOGISTIC REGRESSION| P=0.110N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 30
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lung |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/50 (16%) 7/66 (11%) |
|POLY-3 RATE (b) | 8/22.72 7/14.88 |
|POLY-3 PERCENT (g) | 35.2% 47.1% |
|TERMINAL (d) | 4/10 (40%) 0/0 (0%) |
|FIRST INCIDENCE | 541 289 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.006 ** |
|POLY 3 | P=0.399 |
|POLY 1.5 | P=0.599N |
|POLY 6 | P=0.184 |
|LOGISTIC REGRESSION| P=0.251 |
|COCH-ARM / FISHERS | P=0.280N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/50 (10%) 4/66 (6%) |
|POLY-3 RATE (b) | 5/22.02 4/12.41 |
|POLY-3 PERCENT (g) | 22.7% 32.2% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 383 303 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.054 |
|POLY 3 | P=0.514 |
|POLY 1.5 | P=0.622N |
|POLY 6 | P=0.396 |
|LOGISTIC REGRESSION| P=0.377 |
|COCH-ARM / FISHERS | P=0.329N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 31
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Metaplasia Bronchiolar |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 15/50 (30%) 8/66 (12%) |
|POLY-3 RATE (b) | 15/27.99 8/16.09 |
|POLY-3 PERCENT (g) | 53.6% 49.7% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 226 267 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.194 |
|POLY 3 | P=0.597N |
|POLY 1.5 | P=0.137N |
|POLY 6 | P=0.430 |
|LOGISTIC REGRESSION| P=0.160N |
|COCH-ARM / FISHERS | P=0.016N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lung: Serosa |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 8/66 (12%) |
|POLY-3 RATE (b) | 1/22.01 8/15.93 |
|POLY-3 PERCENT (g) | 4.5% 50.2% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 273 294 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.006 ** |
|POLY 3 | P=0.002 ** |
|POLY 1.5 | P=0.008 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.050 |
|COCH-ARM / FISHERS | P=0.043 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 32
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/49 (22%) 1/66 (2%) |
|POLY-3 RATE (b) | 11/24.51 1/10.25 |
|POLY-3 PERCENT (g) | 44.9% 9.8% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 247 313 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.513N |
|POLY 3 | P=0.160N |
|POLY 1.5 | P=0.006N** |
|POLY 6 | P=0.935N |
|LOGISTIC REGRESSION| P=0.041N* |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/49 (8%) 7/66 (11%) |
|POLY-3 RATE (b) | 4/24.84 7/15.76 |
|POLY-3 PERCENT (g) | 16.1% 44.4% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 230 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.365 |
|POLY 3 | P=0.076 |
|POLY 1.5 | P=0.188 |
|POLY 6 | P=0.031 * |
|LOGISTIC REGRESSION| P=0.540N |
|COCH-ARM / FISHERS | P=0.458 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 33
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 28/49 (57%) 20/66 (30%) |
|POLY-3 RATE (b) | 28/32.76 20/26.79 |
|POLY-3 PERCENT (g) | 85.5% 74.7% |
|TERMINAL (d) | 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 209 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.038 * |
|POLY 3 | P=0.176N |
|POLY 1.5 | P=0.022N* |
|POLY 6 | P=0.770N |
|LOGISTIC REGRESSION| P=0.058N |
|COCH-ARM / FISHERS | P=0.003N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/65 (3%) |
|POLY-3 RATE (b) | 1/21.31 2/11.14 |
|POLY-3 PERCENT (g) | 4.7% 18.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 659 245 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.268 |
|POLY 3 | P=0.450 |
|POLY 1.5 | P=0.468 |
|POLY 6 | P=0.651 |
|LOGISTIC REGRESSION| P=0.575 |
|COCH-ARM / FISHERS | P=0.598 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 34
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/50 (20%) 14/65 (22%) |
|POLY-3 RATE (b) | 10/28.48 14/22.13 |
|POLY-3 PERCENT (g) | 35.1% 63.3% |
|TERMINAL (d) | 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | 226 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.176 |
|POLY 3 | P=0.037 * |
|POLY 1.5 | P=0.164 |
|POLY 6 | P=0.006 ** |
|LOGISTIC REGRESSION| P=0.373N |
|COCH-ARM / FISHERS | P=0.514 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/65 (0%) |
|POLY-3 RATE (b) | 2/22.10 0/9.28 |
|POLY-3 PERCENT (g) | 9.1% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 541 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.753N |
|POLY 3 | P=0.736N |
|POLY 1.5 | P=0.352N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.388N |
|COCH-ARM / FISHERS | P=0.187N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 35
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/22 (14%) 27/45 (60%) |
|POLY-3 RATE (b) | 3/10.39 27/29.76 |
|POLY-3 PERCENT (g) | 28.9% 90.7% |
|TERMINAL (d) | 0/2 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 254 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/22 (50%) 25/45 (56%) |
|POLY-3 RATE (b) | 11/16.43 25/28.50 |
|POLY-3 PERCENT (g) | 67.0% 87.7% |
|TERMINAL (d) | 0/2 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 226 174 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.034 * |
|POLY 1.5 | P=0.126 |
|POLY 6 | P=0.009 ** |
|LOGISTIC REGRESSION| P=0.473N |
|COCH-ARM / FISHERS | P=0.433 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 36
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/22 (18%) 2/45 (4%) |
|POLY-3 RATE (b) | 4/10.38 2/7.29 |
|POLY-3 PERCENT (g) | 38.5% 27.4% |
|TERMINAL (d) | 0/2 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 594 611 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.039 * |
|POLY 3 | P=0.590N |
|POLY 1.5 | P=0.212N |
|POLY 6 | P=0.866 |
|LOGISTIC REGRESSION| P=0.529 |
|COCH-ARM / FISHERS | P=0.085N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/22 (0%) 2/45 (4%) |
|POLY-3 RATE (b) | 0/8.85 2/8.07 |
|POLY-3 PERCENT (g) | 0.0% 24.8% |
|TERMINAL (d) | 0/2 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 289 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.087 |
|POLY 3 | P=0.219 |
|POLY 1.5 | P=0.240 |
|POLY 6 | P=0.236 |
|LOGISTIC REGRESSION| P=0.346 |
|COCH-ARM / FISHERS | P=0.448 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 37
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Pancreatic |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/22 (14%) 4/45 (9%) |
|POLY-3 RATE (b) | 3/11.01 4/10.12 |
|POLY-3 PERCENT (g) | 27.3% 39.5% |
|TERMINAL (d) | 0/2 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 230 243 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.375 |
|POLY 3 | P=0.457 |
|POLY 1.5 | P=0.621 |
|POLY 6 | P=0.326 |
|LOGISTIC REGRESSION| P=0.329N |
|COCH-ARM / FISHERS | P=0.417N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/22 (14%) 3/45 (7%) |
|POLY-3 RATE (b) | 3/11.01 3/8.86 |
|POLY-3 PERCENT (g) | 27.3% 33.9% |
|TERMINAL (d) | 0/2 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 230 342 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.354 |
|POLY 3 | P=0.612 |
|POLY 1.5 | P=0.567N |
|POLY 6 | P=0.526 |
|LOGISTIC REGRESSION| P=0.363N |
|COCH-ARM / FISHERS | P=0.304N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 38
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Renal |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/22 (9%) 0/45 (0%) |
|POLY-3 RATE (b) | 2/9.18 0/6.56 |
|POLY-3 PERCENT (g) | 21.8% 0.0% |
|TERMINAL (d) | 1/2 (50%) 0/0 (0%) |
|FIRST INCIDENCE | 636 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.970N |
|POLY 3 | P=0.414N |
|POLY 1.5 | P=0.151N |
|POLY 6 | P=0.952N |
|LOGISTIC REGRESSION| P=0.808N |
|COCH-ARM / FISHERS | P=0.104N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Lymph Node: Renal |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/22 (14%) 2/45 (4%) |
|POLY-3 RATE (b) | 3/9.93 2/7.54 |
|POLY-3 PERCENT (g) | 30.2% 26.5% |
|TERMINAL (d) | 0/2 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 601 545 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.030 * |
|POLY 3 | P=0.699N |
|POLY 1.5 | P=0.371N |
|POLY 6 | P=0.780 |
|LOGISTIC REGRESSION| P=0.479 |
|COCH-ARM / FISHERS | P=0.195N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 39
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/50 (22%) 0/66 (0%) |
|POLY-3 RATE (b) | 11/23.96 0/9.33 |
|POLY-3 PERCENT (g) | 45.9% 0.0% |
|TERMINAL (d) | 4/10 (40%) 0/0 (0%) |
|FIRST INCIDENCE | 282 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.276N |
|POLY 3 | P=0.087N |
|POLY 1.5 | P=0.002N** |
|POLY 6 | P=0.973N |
|LOGISTIC REGRESSION| P=0.032N* |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Mesentery: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/43 (16%) 3/63 (5%) |
|POLY-3 RATE (b) | 7/21.52 3/11.22 |
|POLY-3 PERCENT (g) | 32.5% 26.7% |
|TERMINAL (d) | 1/9 (11%) 0/0 (0%) |
|FIRST INCIDENCE | 451 267 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.270 |
|POLY 3 | P=0.631N |
|POLY 1.5 | P=0.207N |
|POLY 6 | P=0.746 |
|LOGISTIC REGRESSION| P=0.383N |
|COCH-ARM / FISHERS | P=0.050N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 40
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/43 (0%) 3/63 (5%) |
|POLY-3 RATE (b) | 0/18.60 3/11.49 |
|POLY-3 PERCENT (g) | 0.0% 26.1% |
|TERMINAL (d) | 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.036 * |
|POLY 3 | P=0.096 |
|POLY 1.5 | P=0.108 |
|POLY 6 | P=0.157 |
|LOGISTIC REGRESSION| P=0.175 |
|COCH-ARM / FISHERS | P=0.206 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Nose |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/50 (22%) 11/66 (17%) |
|POLY-3 RATE (b) | 11/25.60 11/17.92 |
|POLY-3 PERCENT (g) | 43.0% 61.4% |
|TERMINAL (d) | 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | 209 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002 ** |
|POLY 3 | P=0.203 |
|POLY 1.5 | P=0.511 |
|POLY 6 | P=0.059 |
|LOGISTIC REGRESSION| P=0.318 |
|COCH-ARM / FISHERS | P=0.312N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 41
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Nose: Olfactory Epithelium |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/50 (10%) 1/66 (2%) |
|POLY-3 RATE (b) | 5/22.14 1/10.02 |
|POLY-3 PERCENT (g) | 22.6% 10.0% |
|TERMINAL (d) | 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | 593 491 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.448 |
|POLY 3 | P=0.544N |
|POLY 1.5 | P=0.176N |
|POLY 6 | P=0.975 |
|LOGISTIC REGRESSION| P=0.680N |
|COCH-ARM / FISHERS | P=0.052N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/50 (20%) 9/66 (14%) |
|POLY-3 RATE (b) | 10/24.54 9/16.16 |
|POLY-3 PERCENT (g) | 40.7% 55.7% |
|TERMINAL (d) | 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | 474 289 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002 ** |
|POLY 3 | P=0.307 |
|POLY 1.5 | P=0.623 |
|POLY 6 | P=0.114 |
|LOGISTIC REGRESSION| P=0.230 |
|COCH-ARM / FISHERS | P=0.252N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 42
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Oral Mucosa: Gingival |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 18/50 (36%) 18/66 (27%) |
|POLY-3 RATE (b) | 18/29.52 18/22.91 |
|POLY-3 PERCENT (g) | 61.0% 78.6% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 209 222 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.131 |
|POLY 1.5 | P=0.506 |
|POLY 6 | P=0.024 * |
|LOGISTIC REGRESSION| P=0.301 |
|COCH-ARM / FISHERS | P=0.211N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Ovary |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 15/50 (30%) 9/65 (14%) |
|POLY-3 RATE (b) | 15/27.64 9/17.30 |
|POLY-3 PERCENT (g) | 54.3% 52.0% |
|TERMINAL (d) | 6/10 (60%) 0/0 (0%) |
|FIRST INCIDENCE | 226 217 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.328 |
|POLY 3 | P=0.623N |
|POLY 1.5 | P=0.198N |
|POLY 6 | P=0.408 |
|LOGISTIC REGRESSION| P=0.110N |
|COCH-ARM / FISHERS | P=0.030N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 43
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/50 (14%) 13/65 (20%) |
|POLY-3 RATE (b) | 7/22.45 13/19.19 |
|POLY-3 PERCENT (g) | 31.2% 67.7% |
|TERMINAL (d) | 2/10 (20%) 0/0 (0%) |
|FIRST INCIDENCE | 525 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.012 * |
|POLY 1.5 | P=0.070 |
|POLY 6 | P=0.002 ** |
|LOGISTIC REGRESSION| P=0.008 ** |
|COCH-ARM / FISHERS | P=0.278 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Pancreas |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 12/50 (24%) 19/65 (29%) |
|POLY-3 RATE (b) | 12/31.74 19/26.29 |
|POLY-3 PERCENT (g) | 37.8% 72.3% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 226 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.127 |
|POLY 3 | P=0.005 ** |
|POLY 1.5 | P=0.046 * |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.418N |
|COCH-ARM / FISHERS | P=0.341 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 44
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Pancreas |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/65 (3%) |
|POLY-3 RATE (b) | 1/22.01 2/11.15 |
|POLY-3 PERCENT (g) | 4.5% 17.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 258 294 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.587 |
|POLY 3 | P=0.453 |
|POLY 1.5 | P=0.465 |
|POLY 6 | P=0.668 |
|LOGISTIC REGRESSION| P=0.719 |
|COCH-ARM / FISHERS | P=0.598 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Pancreas |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/50 (10%) 6/65 (9%) |
|POLY-3 RATE (b) | 5/22.51 6/14.33 |
|POLY-3 PERCENT (g) | 22.2% 41.9% |
|TERMINAL (d) | 2/10 (20%) 0/0 (0%) |
|FIRST INCIDENCE | 541 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.023 * |
|POLY 3 | P=0.231 |
|POLY 1.5 | P=0.428 |
|POLY 6 | P=0.115 |
|LOGISTIC REGRESSION| P=0.336 |
|COCH-ARM / FISHERS | P=0.567N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 45
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/50 (16%) 8/65 (12%) |
|POLY-3 RATE (b) | 8/24.21 8/16.01 |
|POLY-3 PERCENT (g) | 33.0% 50.0% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 258 222 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.044 * |
|POLY 3 | P=0.264 |
|POLY 1.5 | P=0.526 |
|POLY 6 | P=0.103 |
|LOGISTIC REGRESSION| P=0.564 |
|COCH-ARM / FISHERS | P=0.381N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 41/50 (82%) 43/65 (66%) |
|POLY-3 RATE (b) | 41/41.99 43/44.52 |
|POLY-3 PERCENT (g) | 97.7% 96.6% |
|TERMINAL (d) | 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 209 203 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.754N |
|POLY 1.5 | P=0.217N |
|POLY 6 | P=1.000 |
|LOGISTIC REGRESSION| P=0.268N |
|COCH-ARM / FISHERS | P=0.045N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 46
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Pancreas: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/50 (20%) 4/65 (6%) |
|POLY-3 RATE (b) | 10/24.82 4/12.01 |
|POLY-3 PERCENT (g) | 40.3% 33.3% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 401 329 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.197 |
|POLY 3 | P=0.596N |
|POLY 1.5 | P=0.156N |
|POLY 6 | P=0.692 |
|LOGISTIC REGRESSION| P=0.438N |
|COCH-ARM / FISHERS | P=0.025N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 0/65 (0%) |
|POLY-3 RATE (b) | 3/21.06 0/9.27 |
|POLY-3 PERCENT (g) | 14.3% 0.0% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 726 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=1.000N |
|POLY 3 | P=0.547N |
|POLY 1.5 | P=0.194N |
|POLY 6 | P=0.997N |
|LOGISTIC REGRESSION| (e) |
|COCH-ARM / FISHERS | P=0.079N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 47
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 0/65 (0%) |
|POLY-3 RATE (b) | 3/23.88 0/9.27 |
|POLY-3 PERCENT (g) | 12.6% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 258 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.084N |
|POLY 3 | P=0.639N |
|POLY 1.5 | P=0.231N |
|POLY 6 | P=0.999N |
|LOGISTIC REGRESSION| P=0.034N* |
|COCH-ARM / FISHERS | P=0.079N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Cytoplasmic Alteration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/65 (0%) |
|POLY-3 RATE (b) | 2/22.03 0/9.27 |
|POLY-3 PERCENT (g) | 9.1% 0.0% |
|TERMINAL (d) | 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | 226 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.459N |
|POLY 3 | P=0.735N |
|POLY 1.5 | P=0.357N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.234N |
|COCH-ARM / FISHERS | P=0.187N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 48
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/50 (16%) 1/65 (2%) |
|POLY-3 RATE (b) | 8/22.16 1/10.02 |
|POLY-3 PERCENT (g) | 36.1% 10.0% |
|TERMINAL (d) | 5/10 (50%) 0/0 (0%) |
|FIRST INCIDENCE | 601 456 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.516 |
|POLY 3 | P=0.271N |
|POLY 1.5 | P=0.036N* |
|POLY 6 | P=0.936N |
|LOGISTIC REGRESSION| P=0.626N |
|COCH-ARM / FISHERS | P=0.005N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 45/50 (90%) 43/65 (66%) |
|POLY-3 RATE (b) | 45/46.08 43/45.37 |
|POLY-3 PERCENT (g) | 97.7% 94.8% |
|TERMINAL (d) | 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 209 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002 ** |
|POLY 3 | P=0.395N |
|POLY 1.5 | P=0.032N* |
|POLY 6 | P=0.809 |
|LOGISTIC REGRESSION| P=0.022N* |
|COCH-ARM / FISHERS | P=0.002N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 49
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Spleen |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 41/50 (82%) 59/65 (91%) |
|POLY-3 RATE (b) | 41/43.06 59/59.63 |
|POLY-3 PERCENT (g) | 95.2% 99.0% |
|TERMINAL (d) | 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 201 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.153 |
|POLY 1.5 | P=0.119 |
|POLY 6 | P=0.393 |
|LOGISTIC REGRESSION| P=0.065 |
|COCH-ARM / FISHERS | P=0.135 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Spleen: Lymphoid Follicle |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/50 (8%) 9/65 (14%) |
|POLY-3 RATE (b) | 4/23.68 9/17.28 |
|POLY-3 PERCENT (g) | 16.9% 52.1% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 201 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.040 * |
|POLY 3 | P=0.021 * |
|POLY 1.5 | P=0.076 |
|POLY 6 | P=0.005 ** |
|LOGISTIC REGRESSION| P=0.367 |
|COCH-ARM / FISHERS | P=0.249 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 50
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Spleen: Red Pulp |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/65 (3%) |
|POLY-3 RATE (b) | 0/21.06 2/11.23 |
|POLY-3 PERCENT (g) | 0.0% 17.8% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.289 |
|POLY 3 | P=0.263 |
|POLY 1.5 | P=0.227 |
|POLY 6 | P=0.555 |
|LOGISTIC REGRESSION| P=0.427 |
|COCH-ARM / FISHERS | P=0.317 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 9/65 (14%) |
|POLY-3 RATE (b) | 2/22.11 9/16.84 |
|POLY-3 PERCENT (g) | 9.1% 53.4% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 474 217 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** |
|POLY 3 | P=0.003 ** |
|POLY 1.5 | P=0.015 * |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.071 |
|COCH-ARM / FISHERS | P=0.069 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 51
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/65 (2%) |
|POLY-3 RATE (b) | 2/21.77 1/9.95 |
|POLY-3 PERCENT (g) | 9.2% 10.1% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 593 482 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.399 |
|POLY 3 | P=0.846 |
|POLY 1.5 | P=0.622N |
|POLY 6 | P=0.973 |
|LOGISTIC REGRESSION| P=0.751 |
|COCH-ARM / FISHERS | P=0.402N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/65 (3%) |
|POLY-3 RATE (b) | 1/21.78 2/11.13 |
|POLY-3 PERCENT (g) | 4.6% 18.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 474 267 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.465 |
|POLY 3 | P=0.452 |
|POLY 1.5 | P=0.466 |
|POLY 6 | P=0.665 |
|LOGISTIC REGRESSION| P=0.669 |
|COCH-ARM / FISHERS | P=0.598 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 52
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/65 (2%) |
|POLY-3 RATE (b) | 2/21.61 1/9.95 |
|POLY-3 PERCENT (g) | 9.3% 10.1% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 593 482 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.399 |
|POLY 3 | P=0.846 |
|POLY 1.5 | P=0.621N |
|POLY 6 | P=0.971 |
|LOGISTIC REGRESSION| P=0.715 |
|COCH-ARM / FISHERS | P=0.402N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Erosion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/65 (3%) |
|POLY-3 RATE (b) | 0/21.06 2/10.92 |
|POLY-3 PERCENT (g) | 0.0% 18.3% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 237 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.163 |
|POLY 3 | P=0.268 |
|POLY 1.5 | P=0.226 |
|POLY 6 | P=0.570 |
|LOGISTIC REGRESSION| P=0.329 |
|COCH-ARM / FISHERS | P=0.317 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 53
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 3/65 (5%) |
|POLY-3 RATE (b) | 0/21.06 3/12.13 |
|POLY-3 PERCENT (g) | 0.0% 24.7% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 233 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.180 |
|POLY 3 | P=0.094 |
|POLY 1.5 | P=0.103 |
|POLY 6 | P=0.160 |
|LOGISTIC REGRESSION| P=0.269 |
|COCH-ARM / FISHERS | P=0.177 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 5/65 (8%) |
|POLY-3 RATE (b) | 1/21.72 5/13.58 |
|POLY-3 PERCENT (g) | 4.6% 36.8% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 504 267 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.048 * |
|POLY 3 | P=0.039 * |
|POLY 1.5 | P=0.074 |
|POLY 6 | P=0.027 * |
|LOGISTIC REGRESSION| P=0.191 |
|COCH-ARM / FISHERS | P=0.176 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 54
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 45/46 (98%) 57/59 (97%) |
|POLY-3 RATE (b) | 45/45.07 57/57.15 |
|POLY-3 PERCENT (g) | 99.8% 99.7% |
|TERMINAL (d) | 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 201 91 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=1.000N |
|POLY 1.5 | P=0.960N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.725 |
|COCH-ARM / FISHERS | P=0.593N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Infiltration Cellular Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/49 (4%) 0/66 (0%) |
|POLY-3 RATE (b) | 2/21.97 0/9.33 |
|POLY-3 PERCENT (g) | 9.1% 0.0% |
|TERMINAL (d) | 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 226 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.186N |
|POLY 3 | P=0.734N |
|POLY 1.5 | P=0.348N |
|POLY 6 | P=1.000N |
|LOGISTIC REGRESSION| P=0.095N |
|COCH-ARM / FISHERS | P=0.179N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 55
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/49 (12%) 3/66 (5%) |
|POLY-3 RATE (b) | 6/21.98 3/11.81 |
|POLY-3 PERCENT (g) | 27.3% 25.4% |
|TERMINAL (d) | 2/9 (22%) 0/0 (0%) |
|FIRST INCIDENCE | 258 321 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.328 |
|POLY 3 | P=0.701N |
|POLY 1.5 | P=0.334N |
|POLY 6 | P=0.687 |
|LOGISTIC REGRESSION| P=0.489N |
|COCH-ARM / FISHERS | P=0.122N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 29/49 (59%) 37/66 (56%) |
|POLY-3 RATE (b) | 29/35.78 37/40.35 |
|POLY-3 PERCENT (g) | 81.1% 91.7% |
|TERMINAL (d) | 6/9 (67%) 0/0 (0%) |
|FIRST INCIDENCE | 209 51 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.100 |
|POLY 1.5 | P=0.328 |
|POLY 6 | P=0.033 * |
|LOGISTIC REGRESSION| P=0.393 |
|COCH-ARM / FISHERS | P=0.443N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 56
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Tooth: Peridontal Tissue |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 23/23 (100%) 25/25 (100%) |
|POLY-3 RATE (b) | 23/23.00 25/25.00 |
|POLY-3 PERCENT (g) | 100.0% 100.0% |
|TERMINAL (d) | 7/7 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 209 245 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) |
|POLY 3 | (e) |
|POLY 1.5 | (e) |
|POLY 6 | (e) |
|LOGISTIC REGRESSION| (e) |
|COCH-ARM / FISHERS | (e) |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Uterus |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/50 (8%) 2/66 (3%) |
|POLY-3 RATE (b) | 4/22.63 2/10.47 |
|POLY-3 PERCENT (g) | 17.7% 19.1% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 541 415 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.167 |
|POLY 3 | P=0.767 |
|POLY 1.5 | P=0.475N |
|POLY 6 | P=0.843 |
|LOGISTIC REGRESSION| P=0.641 |
|COCH-ARM / FISHERS | P=0.219N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 06/10/04 EXPERIMENT: 96022 TEST: 02 Page 57
Statistical Analysis of Non-neoplastic Lesions in Rats(SD) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Uterus |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/50 (16%) 0/66 (0%) |
|POLY-3 RATE (b) | 8/23.38 0/9.33 |
|POLY-3 PERCENT (g) | 34.2% 0.0% |
|TERMINAL (d) | 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 494 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.506N |
|POLY 3 | P=0.194N |
|POLY 1.5 | P=0.012N* |
|POLY 6 | P=0.982N |
|LOGISTIC REGRESSION| P=0.097N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 4000 NG/ 4000 NG/ |
| | 500UG ST 500 UG |
|=================================================================================================================================|
| |
|Uterus: Endometrium |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 17/50 (34%) 8/66 (12%) |
|POLY-3 RATE (b) | 17/24.95 8/15.68 |
|POLY-3 PERCENT (g) | 68.2% 51.0% |
|TERMINAL (d) | 8/10 (80%) 0/0 (0%) |
|FIRST INCIDENCE | 273 243 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.022 * |
|POLY 3 | P=0.241N |
|POLY 1.5 | P=0.026N* |
|POLY 6 | P=0.798 |
|LOGISTIC REGRESSION| P=0.490N |
|COCH-ARM / FISHERS | P=0.005N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).