TDMS Study 89010-02 Pathology Tables
NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:36:24
Facility: Southern Research Institute
Chemical CAS #: PESTFERTMIX3
Lock Date: 09/08/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:36:24
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 30 30 30 30 30
Scheduled Sacrifice 9 8 10 9 10
Early Deaths
Natural Death 1 1 1
Accidently Killed 2 1
Survivors
Terminal Sacrifice 19 20 20 19 19
Animals Examined Microscopically 20 20 20 20 20
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ALIMENTARY SYSTEM
Liver (20) (20) (20) (20) (20)
Inflammation, Focal 2 (10%)
Pancreas (20) (20) (20) (20) (20)
Accessory Spleen 1 (5%)
Acinar Cell, Focal Cellular Change 1 (5%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (20) (20) (20) (20) (20)
Accessory Adrenal Cortical Nodule 1 (5%) 1 (5%)
Parathyroid Gland (19) (18) (19) (19) (19)
Cyst 1 (6%) 1 (5%)
Thyroid Gland (20) (20) (20) (19) (20)
Degeneration, Cystic 2 (10%) 1 (5%)
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GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:36:24
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (20) (20) (20) (20) (20)
Cyst 1 (5%)
Uterus (20) (20) (20) (20) (20)
Endometrium, Edema 1 (5%) 1 (5%)
Endometrium, Hyperplasia, Cystic 10 (50%) 9 (45%) 8 (40%) 10 (50%) 9 (45%)
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HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (20) (20) (20) (20) (20)
Cyst Epithelial Inclusion 1 (5%)
Inflammation, Chronic, Focal 1 (5%) 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (20) (20) (20) (20)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:36:24
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hydronephrosis 1 (5%) 1 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:36:24
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 30 30 30 30 30
Scheduled Sacrifice 10 9 10 9 10
Early Deaths
Accidently Killed 1 1
Survivors
Terminal Sacrifice 20 20 20 20 20
Animals Examined Microscopically 20 20 20 20 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (20) (20) (20) (20) (20)
Mucosa, Cyst 1 (5%)
Liver (20) (20) (20) (20) (20)
Hemorrhage 1 (5%)
Hepatocyte, Vacuolization Cytoplasmic 6 (30%) 6 (30%)
Pancreas (20) (20) (20) (20) (20)
Atrophy, Focal 1 (5%)
Salivary Glands (20) (20) (20) (20) (20)
Duct, Hyperplasia 1 (5%)
Duct, Metaplasia, Squamous 1 (5%)
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CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (20) (20) (20) (20) (20)
Accessory Adrenal Cortical Nodule 1 (5%)
Parathyroid Gland (19) (18) (19) (19) (19)
Cyst 2 (11%) 1 (5%)
Thyroid Gland (20) (20) (20) (20) (20)
Degeneration, Cystic 1 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:36:24
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Seminal Vesicle (20) (20) (20) (20) (20)
Developmental Malformation 1 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Thymus (19) (20) (20) (20) (18)
Cyst 1 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (20) (20) (20) (20)
Pelvis, Dilatation 1 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04
Route: DOSED WATER Time: 10:36:24
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 0.1X 1X 10X 100X
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Ureter (1)
Developmental Malformation 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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