TDMS Study 89010-02 Pathology Tables
NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:36:24 Facility: Southern Research Institute Chemical CAS #: PESTFERTMIX3 Lock Date: 09/08/92 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:36:24 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 30 30 30 30 30 Scheduled Sacrifice 9 8 10 9 10 Early Deaths Natural Death 1 1 1 Accidently Killed 2 1 Survivors Terminal Sacrifice 19 20 20 19 19 Animals Examined Microscopically 20 20 20 20 20 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (20) (20) (20) (20) (20) Inflammation, Focal 2 (10%) Pancreas (20) (20) (20) (20) (20) Accessory Spleen 1 (5%) Acinar Cell, Focal Cellular Change 1 (5%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (20) (20) (20) (20) (20) Accessory Adrenal Cortical Nodule 1 (5%) 1 (5%) Parathyroid Gland (19) (18) (19) (19) (19) Cyst 1 (6%) 1 (5%) Thyroid Gland (20) (20) (20) (19) (20) Degeneration, Cystic 2 (10%) 1 (5%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:36:24 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (20) (20) (20) (20) (20) Cyst 1 (5%) Uterus (20) (20) (20) (20) (20) Endometrium, Edema 1 (5%) 1 (5%) Endometrium, Hyperplasia, Cystic 10 (50%) 9 (45%) 8 (40%) 10 (50%) 9 (45%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (20) (20) (20) (20) (20) Cyst Epithelial Inclusion 1 (5%) Inflammation, Chronic, Focal 1 (5%) 1 (5%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (20) (20) (20) (20) (20) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:36:24 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Hydronephrosis 1 (5%) 1 (5%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:36:24 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 30 30 30 30 30 Scheduled Sacrifice 10 9 10 9 10 Early Deaths Accidently Killed 1 1 Survivors Terminal Sacrifice 20 20 20 20 20 Animals Examined Microscopically 20 20 20 20 20 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Rectum (20) (20) (20) (20) (20) Mucosa, Cyst 1 (5%) Liver (20) (20) (20) (20) (20) Hemorrhage 1 (5%) Hepatocyte, Vacuolization Cytoplasmic 6 (30%) 6 (30%) Pancreas (20) (20) (20) (20) (20) Atrophy, Focal 1 (5%) Salivary Glands (20) (20) (20) (20) (20) Duct, Hyperplasia 1 (5%) Duct, Metaplasia, Squamous 1 (5%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (20) (20) (20) (20) (20) Accessory Adrenal Cortical Nodule 1 (5%) Parathyroid Gland (19) (18) (19) (19) (19) Cyst 2 (11%) 1 (5%) Thyroid Gland (20) (20) (20) (20) (20) Degeneration, Cystic 1 (5%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:36:24 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Seminal Vesicle (20) (20) (20) (20) (20) Developmental Malformation 1 (5%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Thymus (19) (20) (20) (20) (18) Cyst 1 (5%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (20) (20) (20) (20) (20) Pelvis, Dilatation 1 (5%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 89010-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 3 Date: 10/18/04 Route: DOSED WATER Time: 10:36:24 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 0.1X 1X 10X 100X CONTROL ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Ureter (1) Developmental Malformation 1 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------