TDMS Study 99022-02 Pathology Tables
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
FINAL/MICE
Facility: Southern Research Institute
Chemical CAS #: 30516-87-1
Lock Date: 06/20/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Merge 001 001,011
Merge 002 002,012
Merge 003 003,013
Merge 004 004,014
Merge 005 005,015
Merge 006 006,016
Merge 007 007,017
Merge 008 008,018
Merge 009 009,019
Merge 010 010,020
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|
| 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/KG/DY | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + A + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + I + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + M +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|
| 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/KG/DY | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Subcapsular, Adenoma | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + M + M + + + + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|
| 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/KG/DY | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cystadenoma | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X |
Polyp Stromal | X |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Lymph Node | + + + + + + + |
Lymphoma Malignant | X X |
Bronchial, Lymphoma Malignant | |
Iliac, Lymphoma Malignant | X X |
Inguinal, Lymphoma Malignant | X |
Mediastinal, Lymphoma Malignant | X X X |
Pancreatic, Lymphoma Malignant | X |
Renal, Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant | X X X X |
Sarcoma, Metastatic, Skeletal Muscle | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|
| 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/KG/DY | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant | X X X X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + |
Lymphoma Malignant | X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Peripheral Nerve | + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|
| 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/KG/DY | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Lymphoma Malignant | X X X |
Sarcoma, Metastatic, Skeletal Muscle | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X X X|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6| |
DAY ON TEST | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7| |
| 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7| A |
0 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2| L |
MG/KG/DY | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + + + + + A + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + A + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + M + + + + + + + + + + A + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Adenoma | X | 2 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant | X X | 4 |
|__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X | 7 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X | 5 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6| |
DAY ON TEST | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7| |
| 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7| A |
0 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2| L |
MG/KG/DY | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X | 2 |
Squamous Cell Papilloma | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + | 3 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 2 |
Subcapsular, Adenoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6| |
DAY ON TEST | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7| |
| 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7| A |
0 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2| L |
MG/KG/DY | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cystadenoma | X | 2 |
Lymphoma Malignant | X X | 3 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 4 |
Polyp Stromal | | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + I + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X | 6 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 14 |
Lymphoma Malignant | X | 3 |
Bronchial, Lymphoma Malignant | X | 1 |
Iliac, Lymphoma Malignant | X X | 4 |
Inguinal, Lymphoma Malignant | X | 2 |
Mediastinal, Lymphoma Malignant | X X | 5 |
Pancreatic, Lymphoma Malignant | X X | 3 |
Renal, Lymphoma Malignant | X X | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X X | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6| |
DAY ON TEST | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7| |
| 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7| A |
0 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2| L |
MG/KG/DY | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant | X X X X X | 9 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant | X X X | 7 |
Sarcoma, Metastatic, Skeletal Muscle | X | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X X X X X X X | 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X | 2 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | X| 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 5 |
Lymphoma Malignant | X | 2 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6| |
DAY ON TEST | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7| |
| 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7| A |
0 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2| L |
MG/KG/DY | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + | 7 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X| 7 |
Alveolar/Bronchiolar Carcinoma | X X X| 4 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Lymphoma Malignant | X X X X | 7 |
Sarcoma, Metastatic, Skeletal Muscle | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X X X | 4 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X | 6 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6| |
DAY ON TEST | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7| |
| 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7| A |
0 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2| L |
MG/KG/DY | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X X X X X X X X X | 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|
DAY ON TEST | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|
| 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X |
Osteosarcoma, Metastatic, Bone | X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Mesentery | + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X|
Lymphoma Malignant | X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|
DAY ON TEST | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|
| 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Plasma Cell Tumor Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Plasma Cell Tumor Malignant | X |
Subcapsular, Adenoma | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
Pars Intermedia, Adenoma | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|
DAY ON TEST | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|
| 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Luteoma | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Leiomyoma | |
Lymphoma Malignant | |
Polyp Stromal | |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + M + + + + + + +|
Lymphoma Malignant | |
Plasma Cell Tumor Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|
DAY ON TEST | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|
| 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Bronchial, Lymphoma Malignant | |
Iliac, Histiocytic Sarcoma | X |
Iliac, Lymphoma Malignant | X X |
Inguinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant | X X X |
Mediastinal, Plasma Cell Tumor | |
Malignant | X X |
Pancreatic, Lymphoma Malignant | |
Renal, Histiocytic Sarcoma | X |
Renal, Lymphoma Malignant | X X |
Renal, Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + I + + + + + + + + + + + + + + + + + I + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X |
Osteosarcoma, Metastatic, Bone | X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Thymus | + + + + + + + I + + + + + + + + M + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X X X |
Plasma Cell Tumor Malignant | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|
DAY ON TEST | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|
| 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Carcinoma | X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibrosarcoma | X|
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteoma | X |
Osteosarcoma | X |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Peripheral Nerve | + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X|
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X X |
Alveolar/Bronchiolar Carcinoma | X X X X X |
Lymphoma Malignant | X X X X X |
Osteosarcoma, Metastatic, Bone | X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|
DAY ON TEST | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|
| 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + A + + + + + + + + +| 48 |
Lymphoma Malignant | X X | 3 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + A + + + + + + + + +| 48 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | X X | 3 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X X X X| 10 |
Osteosarcoma, Metastatic, Bone | | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + | 8 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant | | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Lymphoma Malignant | X X X X | 7 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Lymphoma Malignant | X X X X| 6 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X| 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X| 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Lymphoma Malignant | X | 1 |
Plasma Cell Tumor Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Lymphoma Malignant | X | 2 |
Plasma Cell Tumor Malignant | | 1 |
Subcapsular, Adenoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + M M + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Pars Distalis, Adenoma | | 1 |
Pars Intermedia, Adenoma | X| 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 2 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cystadenoma | | 1 |
Luteoma | X | 1 |
Lymphoma Malignant | X X| 3 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | X | 1 |
Leiomyoma | X | 1 |
Lymphoma Malignant | X| 1 |
Polyp Stromal | X | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X X X| 3 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Plasma Cell Tumor Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X | 5 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + +| 23 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X | 3 |
Bronchial, Lymphoma Malignant | X | 1 |
Iliac, Histiocytic Sarcoma | | 1 |
Iliac, Lymphoma Malignant | X X | 4 |
Inguinal, Lymphoma Malignant | X X X| 3 |
Mediastinal, Lymphoma Malignant | X X X X X| 8 |
Mediastinal, Plasma Cell Tumor | | |
Malignant | | 2 |
Pancreatic, Lymphoma Malignant | X X | 2 |
Renal, Histiocytic Sarcoma | | 1 |
Renal, Lymphoma Malignant | X X X X| 6 |
Renal, Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| 47 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X X X X X X| 14 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + M + + + + + + + + +| 48 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X X X X | 12 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X X X X X | 12 |
Osteosarcoma, Metastatic, Bone | | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + M M + + + + + + + + + + + M M + + + + + + + +| 44 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X X X X X| 15 |
Plasma Cell Tumor Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteoma | | 1 |
Osteosarcoma | | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 3 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 5 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 3 |
Alveolar/Bronchiolar Carcinoma | X | 6 |
Lymphoma Malignant | X X X X X| 10 |
Osteosarcoma, Metastatic, Bone | | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X| 3 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Adenoma | X | 6 |
Lymphoma Malignant | X X | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X X X| 10 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X| 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X X X X X X X X| 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|
| 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + A A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A A + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Hemangiosarcoma | X|
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X X|
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Mesentery | + + |
Hemangioma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|
| 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Plasma Cell Tumor Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + M + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|
| 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Leukemia Granulocytic | |
Lymphoma Malignant | |
Plasma Cell Tumor Malignant | X |
Sertoli Cell Tumor Benign | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
Leiomyosarcoma | |
Polyp Stromal | X |
|__________________________________________________________________________|
Vagina | + + M + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X|
|__________________________________________________________________________|
Lymph Node | + + + + + + +|
Lymphoma Malignant | |
Plasma Cell Tumor Malignant | X |
Deep Cervical, Plasma Cell Tumor | |
Malignant | X |
Iliac, Lymphoma Malignant | X|
Iliac, Plasma Cell Tumor Malignant | X |
Inguinal, Lymphoma Malignant | |
Inguinal, Plasma Cell Tumor Malignant| X |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Lymphoma Malignant | X X|
Mediastinal, Plasma Cell Tumor | |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|
| 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Malignant | X |
Pancreatic, Hemangioma | |
Pancreatic, Lymphoma Malignant | X|
Pancreatic, Plasma Cell Tumor | |
Malignant | X |
Popliteal, Plasma Cell Tumor | |
Malignant | X |
Renal, Lymphoma Malignant | X X|
Renal, Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X X X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X X X X|
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X X X X X X|
Plasma Cell Tumor Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|
| 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
|__________________________________________________________________________|
Peripheral Nerve | + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X|
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X |
Carcinoma, Metastatic, Harderian | |
Gland | X |
Carcinoma, Metastatic, Mammary Gland | |
Histiocytic Sarcoma | |
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|
| 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant | X X X|
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X|
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | X X X|
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X X X X X X X X X|
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + A A A + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + A A A + + + + + +| 45 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Leukemia Granulocytic | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A A + + + + + + +| 46 |
Lymphoma Malignant | X | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + A M M + + + + + +| 45 |
Lymphoma Malignant | | 2 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Hemangiosarcoma | | 1 |
Hepatocellular Adenoma | X | 4 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | X X X | 5 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + + + +| 7 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Hemangioma | X | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Lymphoma Malignant | X X| 5 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X X | 2 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Squamous Cell Papilloma | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Leukemia Granulocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Plasma Cell Tumor Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X | 2 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Adenoma | | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Cystadenoma | X | 2 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Plasma Cell Tumor Malignant | | 1 |
Sertoli Cell Tumor Benign | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Leiomyoma | | 1 |
Leiomyosarcoma | X | 1 |
Polyp Stromal | | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | X X X | 4 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 16 |
Lymphoma Malignant | X X | 2 |
Plasma Cell Tumor Malignant | | 1 |
Deep Cervical, Plasma Cell Tumor | | |
Malignant | | 1 |
Iliac, Lymphoma Malignant | | 1 |
Iliac, Plasma Cell Tumor Malignant | | 1 |
Inguinal, Lymphoma Malignant | X X X | 3 |
Inguinal, Plasma Cell Tumor Malignant| | 1 |
Mediastinal, Histiocytic Sarcoma | X | 1 |
Mediastinal, Lymphoma Malignant | X X X | 5 |
Mediastinal, Plasma Cell Tumor | | |
Malignant | | 1 |
Pancreatic, Hemangioma | X | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
Pancreatic, Plasma Cell Tumor | | |
Malignant | | 1 |
Popliteal, Plasma Cell Tumor | | |
Malignant | | 1 |
Renal, Lymphoma Malignant | | 2 |
Renal, Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | X X X X X | 7 |
Plasma Cell Tumor Malignant | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M M + + A + + + + + + + +| 46 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | X X X X X X X| 10 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | X X X X X X X X X| 13 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + M M + + + + + + + + + + + + + + + + + + M + +| 46 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X X X X X X X X X| 19 |
Plasma Cell Tumor Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Carcinoma | X X | 2 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X | 7 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Alveolar/Bronchiolar Carcinoma | X X X X X | 6 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 2 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Carcinoma, Metastatic, Mammary Gland | X | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X X| 6 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 2 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X X X X | 9 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | X X | 5 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | X X X X X X X X X X X| 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|
DAY ON TEST | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|
| 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
|__________________________________________________________________________|
Mesentery | + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|
DAY ON TEST | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|
| 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + M + + + + + + M + + + + + + + + + + + + + + +|
Carcinoma | |
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Pars Distalis, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X |
Hemangioma | |
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|
DAY ON TEST | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|
| 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
Polyp Stromal | |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Lymphoma Malignant | X X X |
Deep Cervical, Lymphoma Malignant | |
Iliac, Lymphoma Malignant | X X X X |
Inguinal, Lymphoma Malignant | X X |
Mediastinal, Lymphoma Malignant | X X |
Pancreatic, Lymphoma Malignant | |
Popliteal, Lymphoma Malignant | X |
Renal, Lymphoma Malignant | X X X X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + M + M + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|
DAY ON TEST | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|
| 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteoma | X|
|__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Peripheral Nerve | + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X X |
Granulosa Cell Tumor Malignant, | |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|
DAY ON TEST | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|
| 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Metastatic, Lung | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6| | |
DAY ON TEST | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7| | |
| 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 38 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
Hepatocellular Adenoma | | 2 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X | 6 |
|__________________________________________________________________________|____________|
Mesentery | | 3 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | X X X | 8 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | X X X | 8 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6| | |
DAY ON TEST | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7| | |
| 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant | X X | 3 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | X | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 38 |
Carcinoma | X | 1 |
Lymphoma Malignant | X | 3 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 38 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + | 37 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | | 1 |
Pars Distalis, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6| | |
DAY ON TEST | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7| | |
| 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | X X | 3 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 40 |
Granulosa Cell Tumor Malignant | X | 2 |
Hemangioma | X | 1 |
Lymphoma Malignant | X | 4 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 40 |
Hemangioma | X | 1 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant | | 2 |
Polyp Stromal | X | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | X X X | 6 |
|__________________________________________________________________________|____________|
Lymph Node | + + + | 12 |
Lymphoma Malignant | X X | 5 |
Deep Cervical, Lymphoma Malignant | X | 1 |
Iliac, Lymphoma Malignant | X X | 6 |
Inguinal, Lymphoma Malignant | X | 3 |
Mediastinal, Lymphoma Malignant | | 2 |
Pancreatic, Lymphoma Malignant | X | 1 |
Popliteal, Lymphoma Malignant | X | 2 |
Renal, Lymphoma Malignant | X X | 6 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6| | |
DAY ON TEST | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7| | |
| 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | X X X | 9 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | X X X X X | 12 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | X X X | 9 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + | 36 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Lymphoma Malignant | X X X X X | 14 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 40 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 40 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 40 |
Osteoma | | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6| | |
DAY ON TEST | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7| | |
| 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | | 3 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 5 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Alveolar/Bronchiolar Adenoma | X | 4 |
Alveolar/Bronchiolar Carcinoma | X | 4 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 4 |
Granulosa Cell Tumor Malignant, | | |
Metastatic, Lung | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X | 5 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 2 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 40 |
Adenoma | | 4 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6| | |
DAY ON TEST | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7| | |
| 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 40 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X | 8 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 40 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant | X X X X X X X | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|
DAY ON TEST | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|
| 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + A + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + I + + + + + I + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + M + + + + + + + + + + + +|
Leiomyosarcoma | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + A + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X |
Leukemia Granulocytic | X |
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Mesentery | + + + |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|
DAY ON TEST | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|
| 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Histiocytic Sarcoma | |
Leukemia Granulocytic | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoid Tumor Malignant | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M + + + I + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Pars Distalis, Adenoma | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|
DAY ON TEST | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|
| 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Malignant | |
Hemangiosarcoma | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
Polyp Stromal | X |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + M + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | X |
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | |
Iliac, Lymphoma Malignant | X |
Inguinal, Lymphoma Malignant | X X X |
Mediastinal, Histiocytic Sarcoma | |
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|
DAY ON TEST | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|
| 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Lymphoma Malignant | X X |
Pancreatic, Lymphoma Malignant | X |
Popliteal, Lymphoma Malignant | |
Renal, Leukemia Granulocytic | X |
Renal, Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | X X X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Granulocytic | X |
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | X |
Lymphoma Malignant | X X X X X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Granulocytic | X |
Lymphoma Malignant | X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|
DAY ON TEST | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|
| 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Skeletal Muscle | + + + |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + M + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Hemangiosarcoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Leukemia Granulocytic | X |
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X |
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|
DAY ON TEST | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|
| 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Granulocytic | X |
Lymphoma Malignant | X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + | 40 |
Leiomyosarcoma | | 1 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + | 42 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + | 40 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X | 3 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | X X X X | 4 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 42 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Adenoma | X X | 2 |
Hepatocellular Adenoma, Multiple | X X | 2 |
Histiocytic Sarcoma | X | 2 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X X X | 7 |
|__________________________________________________________________________|____________|
Mesentery | + + | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + A + + + + | 41 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X X X | 5 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 42 |
Lymphoma Malignant | X X | 4 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 42 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 42 |
Carcinoid Tumor Malignant | | 1 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 42 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + | 42 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + | 41 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | X X | 2 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + + + M + + + + + + + | 36 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 42 |
Lymphoma Malignant | X X | 2 |
Pars Distalis, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + | 42 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + | 42 |
Cystadenoma | | 1 |
Granulosa Cell Tumor Malignant | X | 1 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant | X X X | 3 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + | 42 |
Lymphoma Malignant | X | 3 |
Polyp Stromal | | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + | 41 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 42 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X | 4 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 16 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X X | 3 |
Iliac, Lymphoma Malignant | X X X X | 5 |
Inguinal, Lymphoma Malignant | X X | 5 |
Mediastinal, Histiocytic Sarcoma | X | 1 |
Mediastinal, Lymphoma Malignant | X X X X | 6 |
Pancreatic, Lymphoma Malignant | | 1 |
Popliteal, Lymphoma Malignant | X | 1 |
Renal, Leukemia Granulocytic | | 1 |
Renal, Lymphoma Malignant | X X X X | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + | 42 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X X X X | 9 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + | 42 |
Histiocytic Sarcoma | X | 2 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X X X X X | 9 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 42 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X X X X X | 11 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Thymus | + + + + + + + + + + + + + + + + + | 42 |
Histiocytic Sarcoma | X | 2 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X X X X X X X X X | 17 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + | 42 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 4 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 6 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 42 |
Alveolar/Bronchiolar Adenoma | X X X X X | 7 |
Alveolar/Bronchiolar Carcinoma | X | 3 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 2 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X X | 6 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + M | 2 |
|__________________________________________________________________________|____________|
Harderian Gland | M + + + + + + + + + + + + + + + + | 41 |
Adenoma | X X X X | 7 |
Carcinoma | | 1 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 42 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X X X | 7 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + | 42 |
Lymphoma Malignant | X X X | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + | 42 |
Histiocytic Sarcoma | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
_____________________________________________________________________________________________________________________ T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X X X X X X X X X | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|
DAY ON TEST | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|
| 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + I + + + + A + + + A + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant | |
Polyp Adenomatous | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hepatoblastoma | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X|
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Mesentery | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|
DAY ON TEST | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|
| 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X|
Lymphoma Malignant | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + I + + + + + + + + M + + + + + + + + + + + +|
Lymphoma Malignant | |
Schwannoma Malignant, Metastatic, | |
Brain | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|
DAY ON TEST | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|
| 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node | + + + + + + +|
Lymphoma Malignant | X|
Iliac, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
Popliteal, Lymphoma Malignant | X|
Renal, Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|
DAY ON TEST | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|
| 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Thymus | + + + + + + + + + M + + M + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranial Nerve, Schwannoma Malignant | X |
|__________________________________________________________________________|
Peripheral Nerve | + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X X |
Alveolar/Bronchiolar Carcinoma | X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|
DAY ON TEST | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|
| 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X X X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Ureter | M |
|__________________________________________________________________________|
Urethra | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X|
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4| |
DAY ON TEST | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8| |
| 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| A |
0 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1| L |
MG/KG/DY | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + M A + + + + + + + + + + + +| 45 |
Lymphoma Malignant | X| 1 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant | X| 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X| 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X X| 2 |
Polyp Adenomatous | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X X | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X X X X X | 7 |
Hepatoblastoma | X| 1 |
Hepatocellular Carcinoma | | 4 |
Hepatocellular Carcinoma, Multiple | X | 2 |
Hepatocellular Adenoma | X X X X X X| 12 |
Hepatocellular Adenoma, Multiple | X | 2 |
Lymphoma Malignant | X X X X| 4 |
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4| |
DAY ON TEST | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8| |
| 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| A |
0 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1| L |
MG/KG/DY | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X| 2 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X| 2 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 2 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4| |
DAY ON TEST | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8| |
| 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| A |
0 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1| L |
MG/KG/DY | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant | X | 1 |
Schwannoma Malignant, Metastatic, | | |
Brain | | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X| 4 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + +| 12 |
Lymphoma Malignant | X X | 3 |
Iliac, Lymphoma Malignant | X X X| 3 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4| |
DAY ON TEST | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8| |
| 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| A |
0 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1| L |
MG/KG/DY | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inguinal, Lymphoma Malignant | X | 1 |
Mediastinal, Lymphoma Malignant | X | 1 |
Pancreatic, Lymphoma Malignant | X | 1 |
Popliteal, Lymphoma Malignant | | 1 |
Renal, Lymphoma Malignant | X X| 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X| 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X X| 6 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Hemangiosarcoma | X X | 3 |
Lymphoma Malignant | X X X X X| 5 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant | X X X| 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4| |
DAY ON TEST | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8| |
| 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| A |
0 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1| L |
MG/KG/DY | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Brain | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Cranial Nerve, Schwannoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + | 7 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X | 7 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 3 |
Alveolar/Bronchiolar Carcinoma | X | 4 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | X X X | 3 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X X X| 11 |
Lymphoma Malignant | X| 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4| |
DAY ON TEST | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8| |
| 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| A |
0 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1| L |
MG/KG/DY | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X X| 5 |
|__________________________________________________________________________|____________|
Ureter | | |
|__________________________________________________________________________|____________|
Urethra | + | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X| 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X X| 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|
DAY ON TEST | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|
| 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
50 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG/DY | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|
DAY ON TEST | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|
| 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
50 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG/DY | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|
DAY ON TEST | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|
| 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
50 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG/DY | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Penis | + |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node | + + + + + |
Lymphoma Malignant | X |
Bronchial, Lymphoma Malignant | X |
Deep Cervical, Lymphoma Malignant | |
Iliac, Lymphoma Malignant | X X X |
Inguinal, Lymphoma Malignant | X X |
Mediastinal, Lymphoma Malignant | X X |
Pancreatic, Lymphoma Malignant | X X |
Popliteal, Lymphoma Malignant | |
Renal, Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|
DAY ON TEST | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|
| 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
50 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG/DY | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Thymus | + + + + I + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Basal Cell | |
Carcinoma | X|
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Hemangioma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|
DAY ON TEST | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|
| 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
50 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG/DY | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
Renal Tubule, Adenoma | X |
|__________________________________________________________________________|
Ureter | + |
|__________________________________________________________________________|
Urethra | + + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X |
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5| |
DAY ON TEST | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6| |
| 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7| A |
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3| L |
MG/KG/DY | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + + + + + + + + M + + + + A + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X X | 4 |
Hepatocellular Carcinoma | X | 5 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X X | 5 |
Hepatocellular Adenoma, Multiple | X X X X | 6 |
Lymphoma Malignant | X X X | 4 |
|__________________________________________________________________________|____________|
Mesentery | + | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 79
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5| |
DAY ON TEST | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6| |
| 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7| A |
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3| L |
MG/KG/DY | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5| |
DAY ON TEST | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6| |
| 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7| A |
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3| L |
MG/KG/DY | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Penis | + | 2 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 2 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant | X X | 3 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + | 10 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5| |
DAY ON TEST | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6| |
| 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7| A |
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3| L |
MG/KG/DY | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Bronchial, Lymphoma Malignant | X | 2 |
Deep Cervical, Lymphoma Malignant | X | 1 |
Iliac, Lymphoma Malignant | X | 4 |
Inguinal, Lymphoma Malignant | X | 3 |
Mediastinal, Lymphoma Malignant | X | 3 |
Pancreatic, Lymphoma Malignant | X X | 4 |
Popliteal, Lymphoma Malignant | X | 1 |
Renal, Lymphoma Malignant | X | 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X | 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X X X | 6 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X X | 2 |
Lymphoma Malignant | X X X | 4 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + M + + + M + + + + +| 45 |
Lymphoma Malignant | X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Basal Cell | | |
Carcinoma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5| |
DAY ON TEST | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6| |
| 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7| A |
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3| L |
MG/KG/DY | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Hemangioma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + | 4 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X X X | 13 |
Alveolar/Bronchiolar Carcinoma | X X X X X X| 6 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X X X | 5 |
Lymphoma Malignant | X X X | 3 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 83
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5| |
DAY ON TEST | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6| |
| 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7| A |
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3| L |
MG/KG/DY | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Eye | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X X X X | 8 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 3 |
Renal Tubule, Adenoma | | 1 |
|__________________________________________________________________________|____________|
Ureter | + + | 3 |
|__________________________________________________________________________|____________|
Urethra | + +| 4 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 84
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|
DAY ON TEST | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|
| 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
100 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + M + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + M A + + M + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X |
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X X X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|
DAY ON TEST | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|
| 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
100 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Brain | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Penis | + |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|
DAY ON TEST | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|
| 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
100 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + |
Lymphoma Malignant | |
Iliac, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | |
Mediastinal, Hemangiosarcoma | X |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
Popliteal, Lymphoma Malignant | |
Renal, Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + I + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 87
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|
DAY ON TEST | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|
| 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
100 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Schwannoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Brain | |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | |
|__________________________________________________________________________|
Peripheral Nerve | + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
__________________________________________|__________________________________________________________________________|
Page 88
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|
DAY ON TEST | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|
| 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
100 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X X X|
Carcinoma | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
Urethra | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________|__________________________________________________________________________|
Page 89
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4| |
DAY ON TEST | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3| |
| 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + A + + + + + + + A M| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 3 |
Hepatoblastoma | X | 2 |
Hepatocellular Carcinoma | X X X | 5 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X X X | 5 |
Hepatocellular Adenoma, Multiple | X X | 5 |
Lymphoma Malignant | X X X| 3 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X| 2 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 90
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4| |
DAY ON TEST | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3| |
| 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X| 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + I + + + + + + + + + + + + + +| 49 |
Pheochromocytoma Benign | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Schwannoma Malignant, Metastatic, | | |
Brain | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 91
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4| |
DAY ON TEST | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3| |
| 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Penis | | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | | 1 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X| 4 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + +| 15 |
Lymphoma Malignant | X | 1 |
Iliac, Lymphoma Malignant | X X| 2 |
Inguinal, Lymphoma Malignant | X X| 2 |
Mediastinal, Hemangiosarcoma | | 1 |
Mediastinal, Lymphoma Malignant | X | 1 |
Pancreatic, Lymphoma Malignant | X X| 2 |
Popliteal, Lymphoma Malignant | X | 1 |
Renal, Lymphoma Malignant | X X| 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 92
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4| |
DAY ON TEST | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3| |
| 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X X X X| 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X X X X X| 5 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant | X X X X X| 5 |
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + M + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant | X X X X| 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Schwannoma Malignant, Metastatic, | | |
Brain | X | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 93
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4| |
DAY ON TEST | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3| |
| 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Schwannoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + +| 7 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X X X | 8 |
Alveolar/Bronchiolar Carcinoma | X X | 5 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Lymphoma Malignant | X| 2 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Adenoma | X X X | 9 |
Carcinoma | X | 1 |
Lymphoma Malignant | X X| 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 94
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4| |
DAY ON TEST | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3| |
| 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
Lymphoma Malignant | X X| 2 |
|__________________________________________________________________________|____________|
Ureter | + | 1 |
|__________________________________________________________________________|____________|
Urethra | + + + + | 5 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X| 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X X| 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 95
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|
DAY ON TEST | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|
| 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
200 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + A + + + + A + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X|
Hepatocellular Adenoma, Multiple | X X X |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|
DAY ON TEST | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|
| 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
200 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Subcapsular, Adenoma | X X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + I M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Penis | + + |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 97
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|
DAY ON TEST | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|
| 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
200 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Carcinoma | |
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Renal, Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + I + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibrous | |
__________________________________________|__________________________________________________________________________|
Page 98
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|
DAY ON TEST | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|
| 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
200 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Histiocytoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X X X|
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X X X X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 99
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|
DAY ON TEST | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|
| 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
200 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Ureter | + |
|__________________________________________________________________________|
Urethra | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 100
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5| | |
DAY ON TEST | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9| | |
| 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
MG/KG/DY | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + + + + | 33 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + | 35 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + | 36 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + | 36 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + + + + | 35 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 37 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Carcinoma, Multiple | X | 2 |
Hepatocellular Adenoma | X | 5 |
Hepatocellular Adenoma, Multiple | | 3 |
|__________________________________________________________________________|____________|
Mesentery | + + | 3 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 37 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 37 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 101
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5| | |
DAY ON TEST | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9| | |
| 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
MG/KG/DY | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Squamous Cell Papilloma | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 37 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 37 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + | 37 |
Adenoma | X | 1 |
Subcapsular, Adenoma | | 2 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + | 36 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + | 35 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 36 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 37 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 102
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5| | |
DAY ON TEST | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9| | |
| 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
MG/KG/DY | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Penis | + | 3 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + | 37 |
Bilateral, Interstitial Cell, | | |
Carcinoma | X | 1 |
Interstitial Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Renal, Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + | 37 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + | 36 |
Lymphoma Malignant | X X X | 3 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 103
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5| | |
DAY ON TEST | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9| | |
| 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
MG/KG/DY | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 37 |
Lymphoma Malignant | X X | 2 |
|__________________________________________________________________________|____________|
Thymus | + + + M + M + + + + + + | 33 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 37 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 7 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + | 37 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 104
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5| | |
DAY ON TEST | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9| | |
| 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
MG/KG/DY | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 37 |
Alveolar/Bronchiolar Adenoma | X X X | 8 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Alveolar/Bronchiolar Carcinoma | X | 5 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 6 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 36 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 37 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + | 37 |
Adenoma | X X | 3 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 37 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Ureter | | 1 |
|__________________________________________________________________________|____________|
Urethra | + + | 3 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + | 37 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + | 37 |
Lymphoma Malignant | X X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 105
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|
DAY ON TEST | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|
| 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + + + A + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + A + + + + + A|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X |
Hepatocholangiocarcinoma | X |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 106
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|
DAY ON TEST | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|
| 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M I + I + + + + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Penis | + |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 107
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|
DAY ON TEST | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|
| 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Oligodendroglioma Malignant | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 108
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|
DAY ON TEST | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|
| 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Peripheral Nerve | + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
|__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urethra | + + + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 109
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________|__________________________________________________________________________
| 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|
DAY ON TEST | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|
| 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________|__________________________________________________________________________|
Page 110
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 4| 5| 2| 4| | |
DAY ON TEST | 6| 6| 2| 0| 3| 2| 8| | |
| 9| 8| 7| 4| 9| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| | A |
300 | 1| 1| 2| 2| 2| 2| 2| | L |
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Gallbladder | + + + A A + + | 27 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 31 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 30 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + | 29 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + | 30 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + | 32 |
Hemangiosarcoma | X | 3 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X | 4 |
Hepatocholangiocarcinoma | | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 31 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 111
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 4| 5| 2| 4| | |
DAY ON TEST | 6| 6| 2| 0| 3| 2| 8| | |
| 9| 8| 7| 4| 9| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| | A |
300 | 1| 1| 2| 2| 2| 2| 2| | L |
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 31 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 28 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 31 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Penis | | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 112
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 4| 5| 2| 4| | |
DAY ON TEST | 6| 6| 2| 0| 3| 2| 8| | |
| 9| 8| 7| 4| 9| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| | A |
300 | 1| 1| 2| 2| 2| 2| 2| | L |
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Lymph Node | | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 32 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + | 32 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + | 32 |
Lymphoma Malignant | | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 113
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 4| 5| 2| 4| | |
DAY ON TEST | 6| 6| 2| 0| 3| 2| 8| | |
| 9| 8| 7| 4| 9| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| | A |
300 | 1| 1| 2| 2| 2| 2| 2| | L |
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + | 32 |
Oligodendroglioma Malignant | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | | 1 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + | 32 |
Alveolar/Bronchiolar Adenoma | X X X | 10 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | | 5 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 3 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 114
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 15:46:28
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 4| 5| 2| 4| | |
DAY ON TEST | 6| 6| 2| 0| 3| 2| 8| | |
| 9| 8| 7| 4| 9| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| | A |
300 | 1| 1| 2| 2| 2| 2| 2| | L |
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + | 32 |
Adenoma | X X | 4 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Urethra | | 3 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 32 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + | 32 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 115
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