https://ntp.niehs.nih.gov/go/20253

TDMS Study 99022-02 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                       DATE: 10/08/03       
EXPERIMENT: 99022 TEST: 02                                                                                     TIME: 15:46:56       
TEST TYPE:  PERINATAL EXPOS                     CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-15328                              ROUTE: IN-UTERO                                                NTP C#: C99022       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 30516-87-1      
------------------------------------------------------------------------------------------------------------------------------------
                                                             FINAL/MICE                                                             
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       MERGE   001   001,011                    0       MG/KG/DY                                    
                                       MERGE   002   002,012                    50      MG/KG/DY                                    
                                       MERGE   003   003,013                    100     MG/KG/DY                                    
                                       MERGE   004   004,014                    200     MG/KG/DY                                    
                                       MERGE   005   005,015                    300     MG/KG/DY                                    
                                       MERGE   006   006,016                    0       MG/KG/DY                                    
                                       MERGE   007   007,017                    50      MG/KG/DY                                    
                                       MERGE   008   008,018                    100     MG/KG/DY                                    
                                       MERGE   009   009,019                    200     MG/KG/DY                                    
                                       MERGE   010   010,020                    300     MG/KG/DY                                    
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                       DATE: 10/08/03       
EXPERIMENT: 99022 TEST: 02                                                                                     TIME: 15:46:56       
TEST TYPE:  PERINATAL EXPOS                     CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-15328                              ROUTE: IN-UTERO                                                NTP C#: C99022       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 30516-87-1      
Mice(SWISS)                                                                                                                         
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Brain                                                                              
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Parathyroid Gland                                                                  
                                                 Pituitary Gland                                                                    
                                                 Salivary Glands                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                       DATE: 10/08/03       
EXPERIMENT: 99022 TEST: 02                                                                                     TIME: 15:46:56       
TEST TYPE:  PERINATAL EXPOS                     CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-15328                              ROUTE: IN-UTERO                                                NTP C#: C99022       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 30516-87-1      
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF         AZT TRANSPLACENTAL CARCINOGENESIS                                                                        
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma                                                               
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
All Organs                             Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Islets, Pancreatic                     Adenoma                                                                                      
===============================================================                                                                     
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(SWISS)        -          AZT TRANSPLACENTAL CARCINOGENESIS      
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        1/50 (2%)        3/37 (8%)        0/32 (0%)                        | 
|POLY-3 RATE (b)    |        2/33.13          0/30.37          1/29.40          3/20.93          0/19.14                          | 
|POLY-3 PERCENT (g) |        6.0%             0.0%             3.4%             14.3%            0.0%                             | 
|TERMINAL (d)       |        2/19 (11%)       0/21 (0%)        0/13 (0%)        3/7 (43%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        668 (T)          ---              608              668 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.349          P=0.215N         P=0.623N         P=0.102          P=0.442N                         | 
|POLY 3             |        P=0.528          P=0.256N         P=0.542N         P=0.296          P=0.366N                         | 
|POLY 1.5           |        P=0.523          P=0.254N         P=0.526N         P=0.320          P=0.362N                         | 
|POLY 6             |        P=0.528          P=0.251N         P=0.562N         P=0.265          P=0.371N                         | 
|LOGISTIC REGRESSION|        P=0.438          (e)              P=0.585N         P=0.102          (e)                              | 
|COCH-ARM / FISHERS |        P=0.535          P=0.247N         P=0.500N         P=0.359          P=0.369N                         | 
|ORDER RESTRICTED   |        P=0.297N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        1/49 (2%)        0/50 (0%)        0/38 (0%)        0/42 (0%)                        | 
|POLY-3 RATE (b)    |        1/35.30          1/30.04          0/36.65          0/29.97          0/28.81                          | 
|POLY-3 PERCENT (g) |        2.8%             3.3%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/20 (0%)        1/17 (6%)        0/24 (0%)        0/18 (0%)        0/19 (0%)                        | 
|FIRST INCIDENCE    |        581              668 (T)          ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.156N         P=0.691          P=0.494N         P=0.540N         P=0.555N                         | 
|POLY 3             |        P=0.178N         P=0.725          P=0.493N         P=0.533N         P=0.541N                         | 
|POLY 1.5           |        P=0.176N         P=0.741          P=0.495N         P=0.537N         P=0.539N                         | 
|POLY 6             |        P=0.182N         P=0.705          P=0.487N         P=0.532N         P=0.543N                         | 
|LOGISTIC REGRESSION|        P=0.162N         P=0.726          P=0.498N         P=0.556N         P=0.537N                         | 
|COCH-ARM / FISHERS |        P=0.172N         P=0.747          P=0.500N         P=0.568N         P=0.543N                         | 
|ORDER RESTRICTED   |        P=0.235N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/37 (0%)        0/32 (0%)                        | 
|POLY-3 RATE (b)    |        0/33.13          0/30.37          0/29.15          0/20.93          0/19.14                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/19 (0%)        0/21 (0%)        0/13 (0%)        0/7 (0%)         0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)        1/40 (3%)        0/42 (0%)                        | 
|POLY-3 RATE (b)    |        0/34.96          2/31.79          0/36.65          1/31.97          0/28.81                          | 
|POLY-3 PERCENT (g) |        0.0%             6.3%             0.0%             3.1%             0.0%                             | 
|TERMINAL (d)       |        0/20 (0%)        0/18 (0%)        0/24 (0%)        1/20 (5%)        0/19 (0%)                        | 
|FIRST INCIDENCE    |        ---              565              ---              668 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.444N         P=0.160          (e)              P=0.500          (e)                              | 
|POLY 3             |        P=0.504N         P=0.215          (e)              P=0.482          (e)                              | 
|POLY 1.5           |        P=0.493N         P=0.226          (e)              P=0.476          (e)                              | 
|POLY 6             |        P=0.516N         P=0.206          (e)              P=0.487          (e)                              | 
|LOGISTIC REGRESSION|        P=0.461N         P=0.231          (e)              P=0.500          (e)                              | 
|COCH-ARM / FISHERS |        P=0.471N         P=0.247          (e)              P=0.444          (e)                              | 
|ORDER RESTRICTED   |        P=0.334N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        11/50 (22%)      8/50 (16%)       9/50 (18%)       3/37 (8%)        4/32 (13%)                       | 
|POLY-3 RATE (b)    |        11/35.25         8/31.68          9/31.45          3/21.67          4/19.78                          | 
|POLY-3 PERCENT (g) |        31.2%            25.3%            28.6%            13.9%            20.2%                            | 
|TERMINAL (d)       |        5/19 (26%)       4/21 (19%)       3/13 (23%)       1/7 (14%)        2/8 (25%)                        | 
|FIRST INCIDENCE    |        453              523              413              501              488                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.283N         P=0.302N         P=0.521          P=0.291N         P=0.418N                         | 
|POLY 3             |        P=0.119N         P=0.393N         P=0.515N         P=0.122N         P=0.287N                         | 
|POLY 1.5           |        P=0.103N         P=0.381N         P=0.472N         P=0.101N         P=0.270N                         | 
|POLY 6             |        P=0.151N         P=0.377N         P=0.563N         P=0.155N         P=0.310N                         | 
|LOGISTIC REGRESSION|        P=0.114N         P=0.371N         P=0.507N         P=0.112N         P=0.267N                         | 
|COCH-ARM / FISHERS |        P=0.082N         P=0.306N         P=0.402N         P=0.071N         P=0.216N                         | 
|ORDER RESTRICTED   |        P=0.228N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/50 (8%)        6/50 (12%)       9/50 (18%)       4/40 (10%)       7/42 (17%)                       | 
|POLY-3 RATE (b)    |        4/35.91          6/31.40          9/37.13          4/32.36          7/30.54                          | 
|POLY-3 PERCENT (g) |        11.1%            19.1%            24.2%            12.4%            22.9%                            | 
|TERMINAL (d)       |        1/20 (5%)        5/18 (28%)       8/24 (33%)       3/20 (15%)       3/19 (16%)                       | 
|FIRST INCIDENCE    |        558              577              537              565              453                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.335          P=0.260          P=0.182          P=0.608          P=0.190                          | 
|POLY 3             |        P=0.294          P=0.283          P=0.121          P=0.587          P=0.167                          | 
|POLY 1.5           |        P=0.266          P=0.325          P=0.119          P=0.573          P=0.165                          | 
|POLY 6             |        P=0.318          P=0.237          P=0.126          P=0.593          P=0.172                          | 
|LOGISTIC REGRESSION|        P=0.268          P=0.267          P=0.137          P=0.584          P=0.162                          | 
|COCH-ARM / FISHERS |        P=0.221          P=0.370          P=0.117          P=0.512          P=0.170                          | 
|ORDER RESTRICTED   |        P=0.175          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        11/50 (22%)      8/50 (16%)       10/50 (20%)      3/37 (8%)        5/32 (16%)                       | 
|POLY-3 RATE (b)    |        11/35.25         8/31.68          10/31.45         3/21.67          5/20.60                          | 
|POLY-3 PERCENT (g) |        31.2%            25.3%            31.8%            13.9%            24.3%                            | 
|TERMINAL (d)       |        5/19 (26%)       4/21 (19%)       4/13 (31%)       1/7 (14%)        2/8 (25%)                        | 
|FIRST INCIDENCE    |        453              523              413              501              376                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.416N         P=0.302N         P=0.411          P=0.291N         P=0.563N                         | 
|POLY 3             |        P=0.196N         P=0.393N         P=0.586          P=0.122N         P=0.402N                         | 
|POLY 1.5           |        P=0.176N         P=0.381N         P=0.579N         P=0.101N         P=0.392N                         | 
|POLY 6             |        P=0.236N         P=0.377N         P=0.540          P=0.155N         P=0.420N                         | 
|LOGISTIC REGRESSION|        P=0.195N         P=0.371N         P=0.583          P=0.112N         P=0.398N                         | 
|COCH-ARM / FISHERS |        P=0.147N         P=0.306N         P=0.500N         P=0.071N         P=0.340N                         | 
|ORDER RESTRICTED   |        P=0.291N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/50 (8%)        6/50 (12%)       10/50 (20%)      4/40 (10%)       8/42 (19%)                       | 
|POLY-3 RATE (b)    |        4/35.91          6/31.40          10/37.49         4/32.36          8/30.54                          | 
|POLY-3 PERCENT (g) |        11.1%            19.1%            26.7%            12.4%            26.2%                            | 
|TERMINAL (d)       |        1/20 (5%)        5/18 (28%)       8/24 (33%)       3/20 (15%)       4/19 (21%)                       | 
|FIRST INCIDENCE    |        558              577              537              565              453                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.248          P=0.260          P=0.125          P=0.608          P=0.125                          | 
|POLY 3             |        P=0.211          P=0.283          P=0.078          P=0.587          P=0.098                          | 
|POLY 1.5           |        P=0.188          P=0.325          P=0.075          P=0.573          P=0.098                          | 
|POLY 6             |        P=0.231          P=0.237          P=0.084          P=0.593          P=0.101                          | 
|LOGISTIC REGRESSION|        P=0.187          P=0.267          P=0.087          P=0.584          P=0.097                          | 
|COCH-ARM / FISHERS |        P=0.151          P=0.370          P=0.074          P=0.512          P=0.105                          | 
|ORDER RESTRICTED   |        P=0.091          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/36 (0%)        0/31 (0%)                        | 
|POLY-3 RATE (b)    |        1/33.89          0/30.37          0/29.15          0/19.93          0/18.96                          | 
|POLY-3 PERCENT (g) |        3.0%             0.0%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/19 (0%)        0/21 (0%)        0/13 (0%)        0/6 (0%)         0/8 (0%)                         | 
|FIRST INCIDENCE    |        413              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.284N         P=0.525N         P=0.515N         P=0.588N         P=0.620N                         | 
|POLY 3             |        P=0.282N         P=0.522N         P=0.530N         P=0.603N         P=0.614N                         | 
|POLY 1.5           |        P=0.272N         P=0.518N         P=0.518N         P=0.590N         P=0.611N                         | 
|POLY 6             |        P=0.300N         P=0.521N         P=0.545N         P=0.621N         P=0.619N                         | 
|LOGISTIC REGRESSION|        P=0.257N         P=0.462N         P=0.477N         P=0.528N         P=0.555N                         | 
|COCH-ARM / FISHERS |        P=0.273N         P=0.500N         P=0.500N         P=0.581N         P=0.617N                         | 
|ORDER RESTRICTED   |        P=0.230N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        0/49 (0%)        0/49 (0%)        1/40 (3%)        2/41 (5%)                        | 
|POLY-3 RATE (b)    |        0/34.96          0/30.96          0/36.54          1/31.97          2/29.09                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             3.1%             6.9%                             | 
|TERMINAL (d)       |        0/20 (0%)        0/18 (0%)        0/24 (0%)        1/20 (5%)        1/19 (5%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              668 (T)          565                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.022 *        (e)              (e)              P=0.500          P=0.206                          | 
|POLY 3             |        P=0.020 *        (e)              (e)              P=0.482          P=0.195                          | 
|POLY 1.5           |        P=0.019 *        (e)              (e)              P=0.476          P=0.194                          | 
|POLY 6             |        P=0.021 *        (e)              (e)              P=0.487          P=0.197                          | 
|LOGISTIC REGRESSION|        P=0.018 *        (e)              (e)              P=0.500          P=0.194                          | 
|COCH-ARM / FISHERS |        P=0.017 *        (e)              (e)              P=0.444          P=0.200                          | 
|ORDER RESTRICTED   |        P=0.030 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/50 (14%)       4/50 (8%)        3/50 (6%)        1/37 (3%)        3/32 (9%)                        | 
|POLY-3 RATE (b)    |        7/36.30          4/31.83          3/30.02          1/21.18          3/20.40                          | 
|POLY-3 PERCENT (g) |        19.3%            12.6%            10.0%            4.7%             14.7%                            | 
|TERMINAL (d)       |        1/19 (5%)        1/21 (5%)        1/13 (8%)        0/7 (0%)         1/8 (13%)                        | 
|FIRST INCIDENCE    |        373              385              482              607              404                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.293N         P=0.316N         P=0.261N         P=0.148N         P=0.494N                         | 
|POLY 3             |        P=0.241N         P=0.337N         P=0.240N         P=0.131N         P=0.472N                         | 
|POLY 1.5           |        P=0.217N         P=0.321N         P=0.204N         P=0.107N         P=0.454N                         | 
|POLY 6             |        P=0.281N         P=0.339N         P=0.290N         P=0.166N         P=0.496N                         | 
|LOGISTIC REGRESSION|        P=0.200N         P=0.263N         P=0.162N         P=0.076N         P=0.384N                         | 
|COCH-ARM / FISHERS |        P=0.188N         P=0.262N         P=0.159N         P=0.072N         P=0.398N                         | 
|ORDER RESTRICTED   |        P=0.282N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        1/50 (2%)        0/40 (0%)        0/42 (0%)                        | 
|POLY-3 RATE (b)    |        1/34.96          0/31.04          1/36.65          0/31.97          0/28.81                          | 
|POLY-3 PERCENT (g) |        2.9%             0.0%             2.7%             0.0%             0.0%                             | 
|TERMINAL (d)       |        1/20 (5%)        0/18 (0%)        1/24 (4%)        0/20 (0%)        0/19 (0%)                        | 
|FIRST INCIDENCE    |        668 (T)          ---              668 (T)          ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.234N         P=0.521N         P=0.722N         P=0.500N         P=0.510N                         | 
|POLY 3             |        P=0.253N         P=0.524N         P=0.751N         P=0.518N         P=0.539N                         | 
|POLY 1.5           |        P=0.261N         P=0.512N         P=0.755N         P=0.524N         P=0.538N                         | 
|POLY 6             |        P=0.245N         P=0.536N         P=0.743N         P=0.513N         P=0.539N                         | 
|LOGISTIC REGRESSION|        P=0.234N         (e)              P=0.722N         (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.268N         P=0.500N         P=0.753N         P=0.556N         P=0.543N                         | 
|ORDER RESTRICTED   |        P=0.269N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatoblastoma                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        2/50 (4%)        0/37 (0%)        0/32 (0%)                        | 
|POLY-3 RATE (b)    |        1/33.74          0/30.37          2/30.16          0/20.93          0/19.14                          | 
|POLY-3 PERCENT (g) |        3.0%             0.0%             6.6%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/19 (0%)        0/21 (0%)        0/13 (0%)        0/7 (0%)         0/8 (0%)                         | 
|FIRST INCIDENCE    |        488              ---              413              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.330N         P=0.524N         P=0.458          P=0.575N         P=0.593N                         | 
|POLY 3             |        P=0.346N         P=0.521N         P=0.461          P=0.594N         P=0.611N                         | 
|POLY 1.5           |        P=0.330N         P=0.518N         P=0.476          P=0.581N         P=0.607N                         | 
|POLY 6             |        P=0.372N         P=0.520N         P=0.441          P=0.609N         P=0.617N                         | 
|LOGISTIC REGRESSION|        P=0.306N         P=0.487N         P=0.514          P=0.546N         P=0.575N                         | 
|COCH-ARM / FISHERS |        P=0.311N         P=0.500N         P=0.500          P=0.575N         P=0.610N                         | 
|ORDER RESTRICTED   |        P=0.425N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatoblastoma                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/40 (0%)        0/42 (0%)                        | 
|POLY-3 RATE (b)    |        0/34.96          0/31.04          0/36.65          0/31.97          0/28.81                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/20 (0%)        0/18 (0%)        0/24 (0%)        0/20 (0%)        0/19 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        14/50 (28%)      11/50 (22%)      10/50 (20%)      8/37 (22%)       4/32 (13%)                       | 
|POLY-3 RATE (b)    |        14/35.88         11/30.85         10/31.07         8/22.35          4/19.37                          | 
|POLY-3 PERCENT (g) |        39.0%            35.7%            32.2%            35.8%            20.7%                            | 
|TERMINAL (d)       |        8/19 (42%)       9/21 (43%)       4/13 (31%)       3/7 (43%)        2/8 (25%)                        | 
|FIRST INCIDENCE    |        446              595              505              483              627                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.377N         P=0.284N         P=0.530N         P=0.406          P=0.214N                         | 
|POLY 3             |        P=0.124N         P=0.488N         P=0.369N         P=0.512N         P=0.137N                         | 
|POLY 1.5           |        P=0.107N         P=0.442N         P=0.314N         P=0.445N         P=0.119N                         | 
|POLY 6             |        P=0.159N         P=0.515N         P=0.440N         P=0.593N         P=0.164N                         | 
|LOGISTIC REGRESSION|        P=0.127N         P=0.403N         P=0.355N         P=0.490N         P=0.111N                         | 
|COCH-ARM / FISHERS |        P=0.082N         P=0.322N         P=0.241N         P=0.337N         P=0.081N                         | 
|ORDER RESTRICTED   |        P=0.160N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/50 (6%)        4/50 (8%)        5/50 (10%)       2/40 (5%)        4/42 (10%)                       | 
|POLY-3 RATE (b)    |        3/35.01          4/31.04          5/37.87          2/32.58          4/29.20                          | 
|POLY-3 PERCENT (g) |        8.6%             12.9%            13.2%            6.1%             13.7%                            | 
|TERMINAL (d)       |        2/20 (10%)       4/18 (22%)       2/24 (8%)        1/20 (5%)        3/19 (16%)                       | 
|FIRST INCIDENCE    |        658              668 (T)          514              488              565                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.539          P=0.437          P=0.439          P=0.498N         P=0.452                          | 
|POLY 3             |        P=0.511          P=0.433          P=0.399          P=0.533N         P=0.400                          | 
|POLY 1.5           |        P=0.485          P=0.467          P=0.380          P=0.551N         P=0.399                          | 
|POLY 6             |        P=0.534          P=0.397          P=0.432          P=0.519N         P=0.403                          | 
|LOGISTIC REGRESSION|        P=0.486          P=0.415          P=0.379          P=0.545N         P=0.396                          | 
|COCH-ARM / FISHERS |        P=0.436          P=0.500          P=0.357          P=0.606N         P=0.402                          | 
|ORDER RESTRICTED   |        P=0.452          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/50 (12%)       6/50 (12%)       6/50 (12%)       4/37 (11%)       2/32 (6%)                        | 
|POLY-3 RATE (b)    |        6/35.11          6/31.38          6/31.52          4/22.29          2/20.40                          | 
|POLY-3 PERCENT (g) |        17.1%            19.1%            19.0%            17.9%            9.8%                             | 
|TERMINAL (d)       |        2/19 (11%)       4/21 (19%)       1/13 (8%)        0/7 (0%)         0/8 (0%)                         | 
|FIRST INCIDENCE    |        392              444              413              483              473                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.387N         P=0.615          P=0.474          P=0.514          P=0.402N                         | 
|POLY 3             |        P=0.287N         P=0.542          P=0.545          P=0.607          P=0.365N                         | 
|POLY 1.5           |        P=0.275N         P=0.556          P=0.573          P=0.635N         P=0.359N                         | 
|POLY 6             |        P=0.307N         P=0.543          P=0.513          P=0.573          P=0.374N                         | 
|LOGISTIC REGRESSION|        P=0.267N         P=0.575          P=0.596          P=0.612N         P=0.325N                         | 
|COCH-ARM / FISHERS |        P=0.237N         P=0.620N         P=0.620N         P=0.571N         P=0.326N                         | 
|ORDER RESTRICTED   |        P=0.390N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)        0/40 (0%)        2/42 (5%)                        | 
|POLY-3 RATE (b)    |        2/34.96          1/31.04          0/36.65          0/31.97          2/29.43                          | 
|POLY-3 PERCENT (g) |        5.7%             3.2%             0.0%             0.0%             6.8%                             | 
|TERMINAL (d)       |        2/20 (10%)       1/18 (6%)        0/24 (0%)        0/20 (0%)        1/19 (5%)                        | 
|FIRST INCIDENCE    |        668 (T)          668 (T)          ---              ---              482                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.567          P=0.537N         P=0.198N         P=0.237N         P=0.660                          | 
|POLY 3             |        P=0.562          P=0.542N         P=0.226N         P=0.255N         P=0.632                          | 
|POLY 1.5           |        P=0.548          P=0.521N         P=0.230N         P=0.263N         P=0.629                          | 
|POLY 6             |        P=0.571          P=0.564N         P=0.218N         P=0.250N         P=0.637                          | 
|LOGISTIC REGRESSION|        P=0.535          P=0.537N         (e)              (e)              P=0.625                          | 
|COCH-ARM / FISHERS |        P=0.510          P=0.500N         P=0.247N         P=0.306N         P=0.623                          | 
|ORDER RESTRICTED   |        P=0.251          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/50 (14%)       6/50 (12%)       6/50 (12%)       4/37 (11%)       2/32 (6%)                        | 
|POLY-3 RATE (b)    |        7/35.72          6/31.38          6/31.52          4/22.29          2/20.40                          | 
|POLY-3 PERCENT (g) |        19.6%            19.1%            19.0%            17.9%            9.8%                             | 
|TERMINAL (d)       |        2/19 (11%)       4/21 (19%)       1/13 (8%)        0/7 (0%)         0/8 (0%)                         | 
|FIRST INCIDENCE    |        392              444              413              483              473                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.306N         P=0.509N         P=0.585          P=0.614          P=0.307N                         | 
|POLY 3             |        P=0.219N         P=0.603N         P=0.599N         P=0.573N         P=0.282N                         | 
|POLY 1.5           |        P=0.206N         P=0.580N         P=0.562N         P=0.532N         P=0.273N                         | 
|POLY 6             |        P=0.241N         P=0.611N         P=0.606          P=0.618N         P=0.294N                         | 
|LOGISTIC REGRESSION|        P=0.197N         P=0.545N         P=0.522N         P=0.491N         P=0.234N                         | 
|COCH-ARM / FISHERS |        P=0.174N         P=0.500N         P=0.500N         P=0.459N         P=0.236N                         | 
|ORDER RESTRICTED   |        P=0.337N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)        0/40 (0%)        2/42 (5%)                        | 
|POLY-3 RATE (b)    |        2/34.96          1/31.04          0/36.65          0/31.97          2/29.43                          | 
|POLY-3 PERCENT (g) |        5.7%             3.2%             0.0%             0.0%             6.8%                             | 
|TERMINAL (d)       |        2/20 (10%)       1/18 (6%)        0/24 (0%)        0/20 (0%)        1/19 (5%)                        | 
|FIRST INCIDENCE    |        668 (T)          668 (T)          ---              ---              482                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.567          P=0.537N         P=0.198N         P=0.237N         P=0.660                          | 
|POLY 3             |        P=0.562          P=0.542N         P=0.226N         P=0.255N         P=0.632                          | 
|POLY 1.5           |        P=0.548          P=0.521N         P=0.230N         P=0.263N         P=0.629                          | 
|POLY 6             |        P=0.571          P=0.564N         P=0.218N         P=0.250N         P=0.637                          | 
|LOGISTIC REGRESSION|        P=0.535          P=0.537N         (e)              (e)              P=0.625                          | 
|COCH-ARM / FISHERS |        P=0.510          P=0.500N         P=0.247N         P=0.306N         P=0.623                          | 
|ORDER RESTRICTED   |        P=0.251          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        18/50 (36%)      16/50 (32%)      16/50 (32%)      10/37 (27%)      6/32 (19%)                       | 
|POLY-3 RATE (b)    |        18/37.65         16/31.86         16/33.44         10/22.91         6/20.63                          | 
|POLY-3 PERCENT (g) |        47.8%            50.2%            47.9%            43.7%            29.1%                            | 
|TERMINAL (d)       |        9/19 (47%)       12/21 (57%)      5/13 (39%)       3/7 (43%)        2/8 (25%)                        | 
|FIRST INCIDENCE    |        392              444              413              483              473                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.328N         P=0.390N         P=0.410          P=0.451          P=0.225N                         | 
|POLY 3             |        P=0.083N         P=0.517          P=0.596          P=0.480N         P=0.130N                         | 
|POLY 1.5           |        P=0.069N         P=0.584          P=0.532N         P=0.392N         P=0.114N                         | 
|POLY 6             |        P=0.110N         P=0.472          P=0.542          P=0.578N         P=0.154N                         | 
|LOGISTIC REGRESSION|        P=0.076N         P=0.538N         P=0.540N         P=0.388N         P=0.104N                         | 
|COCH-ARM / FISHERS |        P=0.050N         P=0.417N         P=0.417N         P=0.258N         P=0.075N                         | 
|ORDER RESTRICTED   |        P=0.133N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/50 (10%)       5/50 (10%)       5/50 (10%)       2/40 (5%)        6/42 (14%)                       | 
|POLY-3 RATE (b)    |        5/35.01          5/31.04          5/37.87          2/32.58          6/29.83                          | 
|POLY-3 PERCENT (g) |        14.3%            16.1%            13.2%            6.1%             20.1%                            | 
|TERMINAL (d)       |        4/20 (20%)       5/18 (28%)       2/24 (8%)        1/20 (5%)        4/19 (21%)                       | 
|FIRST INCIDENCE    |        658              668 (T)          514              488              482                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.526          P=0.563          P=0.532N         P=0.215N         P=0.436                          | 
|POLY 3             |        P=0.501          P=0.555          P=0.582N         P=0.241N         P=0.385                          | 
|POLY 1.5           |        P=0.469          P=0.594          P=0.603N         P=0.260N         P=0.377                          | 
|POLY 6             |        P=0.527          P=0.510          P=0.544N         P=0.225N         P=0.398                          | 
|LOGISTIC REGRESSION|        P=0.462          P=0.544          P=0.598N         P=0.245N         P=0.362                          | 
|COCH-ARM / FISHERS |        P=0.406          P=0.630N         P=0.630N         P=0.320N         P=0.377                          | 
|ORDER RESTRICTED   |        P=0.329          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        18/50 (36%)      16/50 (32%)      16/50 (32%)      10/37 (27%)      6/32 (19%)                       | 
|POLY-3 RATE (b)    |        18/37.65         16/31.86         16/33.44         10/22.91         6/20.63                          | 
|POLY-3 PERCENT (g) |        47.8%            50.2%            47.9%            43.7%            29.1%                            | 
|TERMINAL (d)       |        9/19 (47%)       12/21 (57%)      5/13 (39%)       3/7 (43%)        2/8 (25%)                        | 
|FIRST INCIDENCE    |        392              444              413              483              473                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.328N         P=0.390N         P=0.410          P=0.451          P=0.225N                         | 
|POLY 3             |        P=0.083N         P=0.517          P=0.596          P=0.480N         P=0.130N                         | 
|POLY 1.5           |        P=0.069N         P=0.584          P=0.532N         P=0.392N         P=0.114N                         | 
|POLY 6             |        P=0.110N         P=0.472          P=0.542          P=0.578N         P=0.154N                         | 
|LOGISTIC REGRESSION|        P=0.076N         P=0.538N         P=0.540N         P=0.388N         P=0.104N                         | 
|COCH-ARM / FISHERS |        P=0.050N         P=0.417N         P=0.417N         P=0.258N         P=0.075N                         | 
|ORDER RESTRICTED   |        P=0.133N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/50 (10%)       5/50 (10%)       5/50 (10%)       2/40 (5%)        6/42 (14%)                       | 
|POLY-3 RATE (b)    |        5/35.01          5/31.04          5/37.87          2/32.58          6/29.83                          | 
|POLY-3 PERCENT (g) |        14.3%            16.1%            13.2%            6.1%             20.1%                            | 
|TERMINAL (d)       |        4/20 (20%)       5/18 (28%)       2/24 (8%)        1/20 (5%)        4/19 (21%)                       | 
|FIRST INCIDENCE    |        658              668 (T)          514              488              482                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.526          P=0.563          P=0.532N         P=0.215N         P=0.436                          | 
|POLY 3             |        P=0.501          P=0.555          P=0.582N         P=0.241N         P=0.385                          | 
|POLY 1.5           |        P=0.469          P=0.594          P=0.603N         P=0.260N         P=0.377                          | 
|POLY 6             |        P=0.527          P=0.510          P=0.544N         P=0.225N         P=0.398                          | 
|LOGISTIC REGRESSION|        P=0.462          P=0.544          P=0.598N         P=0.245N         P=0.362                          | 
|COCH-ARM / FISHERS |        P=0.406          P=0.630N         P=0.630N         P=0.320N         P=0.377                          | 
|ORDER RESTRICTED   |        P=0.329          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/50 (20%)      13/50 (26%)      8/50 (16%)       9/37 (24%)       11/32 (34%)                      | 
|POLY-3 RATE (b)    |        10/34.53         13/34.83         8/31.51          9/24.48          11/23.96                         | 
|POLY-3 PERCENT (g) |        29.0%            37.3%            25.4%            36.8%            45.9%                            | 
|TERMINAL (d)       |        5/19 (26%)       5/21 (24%)       3/13 (23%)       2/7 (29%)        3/8 (38%)                        | 
|FIRST INCIDENCE    |        560              229              322              167              229                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.028 *        P=0.332          P=0.540          P=0.138          P=0.053                          | 
|POLY 3             |        P=0.109          P=0.311          P=0.480N         P=0.361          P=0.137                          | 
|POLY 1.5           |        P=0.102          P=0.288          P=0.446N         P=0.377          P=0.118                          | 
|POLY 6             |        P=0.105          P=0.356          P=0.532N         P=0.336          P=0.149                          | 
|LOGISTIC REGRESSION|        P=0.084          P=0.255          P=0.502N         P=0.327          P=0.092                          | 
|COCH-ARM / FISHERS |        P=0.105          P=0.318          P=0.398N         P=0.410          P=0.116                          | 
|ORDER RESTRICTED   |        P=0.150          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/50 (14%)       6/49 (12%)       8/50 (16%)       4/40 (10%)       7/42 (17%)                       | 
|POLY-3 RATE (b)    |        7/35.71          6/31.12          8/37.89          4/33.04          7/30.14                          | 
|POLY-3 PERCENT (g) |        19.6%            19.3%            21.1%            12.1%            23.2%                            | 
|TERMINAL (d)       |        4/20 (20%)       4/18 (22%)       4/24 (17%)       2/20 (10%)       5/19 (26%)                       | 
|FIRST INCIDENCE    |        573              644              432              359              453                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.480N         P=0.614          P=0.586N         P=0.288N         P=0.535                          | 
|POLY 3             |        P=0.522N         P=0.609N         P=0.551          P=0.301N         P=0.478                          | 
|POLY 1.5           |        P=0.523          P=0.559N         P=0.530          P=0.324N         P=0.473                          | 
|POLY 6             |        P=0.498N         P=0.579          P=0.585          P=0.287N         P=0.480                          | 
|LOGISTIC REGRESSION|        P=0.508          P=0.587          P=0.543          P=0.334N         P=0.458                          | 
|COCH-ARM / FISHERS |        P=0.454          P=0.516N         P=0.500          P=0.405N         P=0.472                          | 
|ORDER RESTRICTED   |        P=0.523          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/50 (10%)       11/50 (22%)      6/50 (12%)       11/37 (30%)      8/32 (25%)                       | 
|POLY-3 RATE (b)    |        5/33.64          11/33.29         6/30.23          11/24.41         8/20.69                          | 
|POLY-3 PERCENT (g) |        14.9%            33.0%            19.9%            45.1%            38.7%                            | 
|TERMINAL (d)       |        2/19 (11%)       5/21 (24%)       4/13 (31%)       3/7 (43%)        3/8 (38%)                        | 
|FIRST INCIDENCE    |        619              363              482              341              376                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.004 **       P=0.100          P=0.291          P=0.003 **       P=0.028 *                        | 
|POLY 3             |        P=0.014 *        P=0.068          P=0.422          P=0.009 **       P=0.043 *                        | 
|POLY 1.5           |        P=0.016 *        P=0.064          P=0.452          P=0.010 *        P=0.045 *                        | 
|POLY 6             |        P=0.012 *        P=0.082          P=0.380          P=0.008 **       P=0.041 *                        | 
|LOGISTIC REGRESSION|        P=0.015 *        P=0.060          P=0.381          P=0.008 **       P=0.038 *                        | 
|COCH-ARM / FISHERS |        P=0.028 *        P=0.086          P=0.500          P=0.020 *        P=0.068                          | 
|ORDER RESTRICTED   |        P=0.026 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/50 (10%)       6/49 (12%)       8/50 (16%)       8/40 (20%)       5/42 (12%)                       | 
|POLY-3 RATE (b)    |        5/35.35          6/32.12          8/37.19          8/33.10          5/29.11                          | 
|POLY-3 PERCENT (g) |        14.2%            18.7%            21.5%            24.2%            17.2%                            | 
|TERMINAL (d)       |        3/20 (15%)       3/18 (17%)       7/24 (29%)       5/20 (25%)       4/19 (21%)                       | 
|FIRST INCIDENCE    |        599              560              514              539              593                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.445          P=0.369          P=0.388          P=0.263          P=0.566                          | 
|POLY 3             |        P=0.356          P=0.431          P=0.304          P=0.225          P=0.504                          | 
|POLY 1.5           |        P=0.337          P=0.461          P=0.292          P=0.203          P=0.506                          | 
|POLY 6             |        P=0.372          P=0.403          P=0.325          P=0.246          P=0.503                          | 
|LOGISTIC REGRESSION|        P=0.378          P=0.389          P=0.329          P=0.218          P=0.509                          | 
|COCH-ARM / FISHERS |        P=0.317          P=0.486          P=0.277          P=0.149          P=0.514                          | 
|ORDER RESTRICTED   |        P=0.424          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        14/50 (28%)      20/50 (40%)      13/50 (26%)      18/37 (49%)      18/32 (56%)                      | 
|POLY-3 RATE (b)    |        14/34.86         20/36.71         13/32.14         18/27.17         18/24.68                         | 
|POLY-3 PERCENT (g) |        40.2%            54.5%            40.5%            66.3%            72.9%                            | 
|TERMINAL (d)       |        7/19 (37%)       9/21 (43%)       7/13 (54%)       5/7 (71%)        6/8 (75%)                        | 
|FIRST INCIDENCE    |        560              229              322              167              229                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.178          P=0.323          P=0.002 **       P=0.003 **                       | 
|POLY 3             |        P=0.002 **       P=0.156          P=0.592          P=0.027 *        P=0.007 **                       | 
|POLY 1.5           |        P=0.002 **       P=0.127          P=0.565N         P=0.028 *        P=0.005 **                       | 
|POLY 6             |        P=0.002 **       P=0.212          P=0.528          P=0.027 *        P=0.009 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.087          P=0.521          P=0.014 *        P=0.003 **                       | 
|COCH-ARM / FISHERS |        P=0.003 **       P=0.146          P=0.500N         P=0.040 *        P=0.010 *                        | 
|ORDER RESTRICTED   |        P=0.008 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/50 (20%)      11/49 (22%)      14/50 (28%)      12/40 (30%)      11/42 (26%)                      | 
|POLY-3 RATE (b)    |        10/36.09         11/32.28         14/38.44         12/34.17         11/30.44                         | 
|POLY-3 PERCENT (g) |        27.7%            34.1%            36.4%            35.1%            36.1%                            | 
|TERMINAL (d)       |        5/20 (25%)       6/18 (33%)       9/24 (38%)       7/20 (35%)       8/19 (42%)                       | 
|FIRST INCIDENCE    |        573              560              432              359              453                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.379          P=0.324          P=0.402          P=0.376          P=0.391                          | 
|POLY 3             |        P=0.296          P=0.377          P=0.286          P=0.338          P=0.315                          | 
|POLY 1.5           |        P=0.260          P=0.432          P=0.266          P=0.298          P=0.315                          | 
|POLY 6             |        P=0.323          P=0.319          P=0.319          P=0.370          P=0.311                          | 
|LOGISTIC REGRESSION|        P=0.268          P=0.313          P=0.281          P=0.292          P=0.297                          | 
|COCH-ARM / FISHERS |        P=0.213          P=0.479          P=0.241          P=0.197          P=0.324                          | 
|ORDER RESTRICTED   |        P=0.410          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node                                                                                                                       | 
|     Plasma Cell Tumor Malignant                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/37 (0%)        0/32 (0%)                        | 
|POLY-3 RATE (b)    |        0/33.13          0/30.37          0/29.15          0/20.93          0/19.14                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/19 (0%)        0/21 (0%)        0/13 (0%)        0/7 (0%)         0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node                                                                                                                       | 
|     Plasma Cell Tumor Malignant                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        1/50 (2%)        0/40 (0%)        0/42 (0%)                        | 
|POLY-3 RATE (b)    |        0/34.96          2/32.17          1/37.63          0/31.97          0/28.81                          | 
|POLY-3 PERCENT (g) |        0.0%             6.2%             2.7%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/20 (0%)        0/18 (0%)        0/24 (0%)        0/20 (0%)        0/19 (0%)                        | 
|FIRST INCIDENCE    |        ---              441              182              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.259N         P=0.204          P=0.504          (e)              (e)                              | 
|POLY 3             |        P=0.272N         P=0.218          P=0.515          (e)              (e)                              | 
|POLY 1.5           |        P=0.269N         P=0.227          P=0.510          (e)              (e)                              | 
|POLY 6             |        P=0.275N         P=0.209          P=0.523          (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.264N         P=0.244          P=0.381          (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.267N         P=0.247          P=0.500          (e)              (e)                              | 
|ORDER RESTRICTED   |        P=0.336N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/37 (0%)        0/32 (0%)                        | 
|POLY-3 RATE (b)    |        0/33.13          0/30.37          0/29.15          0/20.93          0/19.14                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/19 (0%)        0/21 (0%)        0/13 (0%)        0/7 (0%)         0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        2/50 (4%)        1/40 (3%)        1/42 (2%)                        | 
|POLY-3 RATE (b)    |        2/35.44          2/31.04          2/37.47          1/32.07          1/29.15                          | 
|POLY-3 PERCENT (g) |        5.6%             6.4%             5.3%             3.1%             3.4%                             | 
|TERMINAL (d)       |        0/20 (0%)        2/18 (11%)       0/24 (0%)        0/20 (0%)        0/19 (0%)                        | 
|FIRST INCIDENCE    |        573              668 (T)          425              646              580                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.299N         P=0.619          P=0.661N         P=0.535N         P=0.582N                         | 
|POLY 3             |        P=0.322N         P=0.647          P=0.675N         P=0.535N         P=0.568N                         | 
|POLY 1.5           |        P=0.330N         P=0.671          P=0.682N         P=0.544N         P=0.567N                         | 
|POLY 6             |        P=0.316N         P=0.618          P=0.663N         P=0.530N         P=0.570N                         | 
|LOGISTIC REGRESSION|        P=0.325N         P=0.634          P=0.694N         P=0.542N         P=0.566N                         | 
|COCH-ARM / FISHERS |        P=0.343N         P=0.691N         P=0.691N         P=0.584N         P=0.566N                         | 
|ORDER RESTRICTED   |        P=0.534N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        2/49 (4%)        0/40 (0%)        1/42 (2%)                        | 
|POLY-3 RATE (b)    |        2/35.80          1/31.04          2/36.60          0/31.97          1/28.91                          | 
|POLY-3 PERCENT (g) |        5.6%             3.2%             5.5%             0.0%             3.5%                             | 
|TERMINAL (d)       |        0/20 (0%)        1/18 (6%)        1/24 (4%)        0/20 (0%)        0/19 (0%)                        | 
|FIRST INCIDENCE    |        510              668 (T)          654              ---              645                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.267N         P=0.569N         P=0.647N         P=0.254N         P=0.579N                         | 
|POLY 3             |        P=0.278N         P=0.550N         P=0.687N         P=0.261N         P=0.575N                         | 
|POLY 1.5           |        P=0.290N         P=0.525N         P=0.692N         P=0.266N         P=0.570N                         | 
|POLY 6             |        P=0.271N         P=0.578N         P=0.680N         P=0.259N         P=0.580N                         | 
|LOGISTIC REGRESSION|        P=0.288N         P=0.521N         P=0.690N         P=0.305N         P=0.564N                         | 
|COCH-ARM / FISHERS |        P=0.310N         P=0.500N         P=0.684          P=0.306N         P=0.566N                         | 
|ORDER RESTRICTED   |        P=0.357N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Granulosa Cell Tumor Malignant                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Granulosa Cell Tumor Malignant                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/49 (0%)        2/40 (5%)        1/42 (2%)                        | 
|POLY-3 RATE (b)    |        0/34.96          0/31.04          0/36.54          2/32.46          1/28.81                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             6.2%             3.5%                             | 
|TERMINAL (d)       |        0/20 (0%)        0/18 (0%)        0/24 (0%)        0/20 (0%)        1/19 (5%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              565              668 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.068          (e)              (e)              P=0.219          P=0.490                          | 
|POLY 3             |        P=0.059          (e)              (e)              P=0.219          P=0.461                          | 
|POLY 1.5           |        P=0.058          (e)              (e)              P=0.211          P=0.462                          | 
|POLY 6             |        P=0.061          (e)              (e)              P=0.226          P=0.461                          | 
|LOGISTIC REGRESSION|        P=0.061          (e)              (e)              P=0.201          P=0.490                          | 
|COCH-ARM / FISHERS |        P=0.058          (e)              (e)              P=0.195          P=0.457                          | 
|ORDER RESTRICTED   |        P=0.125          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 20      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)        1/37 (3%)        0/32 (0%)                        | 
|POLY-3 RATE (b)    |        0/33.13          1/31.33          0/29.15          1/20.93          0/19.14                          | 
|POLY-3 PERCENT (g) |        0.0%             3.2%             0.0%             4.8%             0.0%                             | 
|TERMINAL (d)       |        0/19 (0%)        0/21 (0%)        0/13 (0%)        1/7 (14%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              229              ---              668 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.502          P=0.492          (e)              P=0.301          (e)                              | 
|POLY 3             |        P=0.548          P=0.489          (e)              P=0.409          (e)                              | 
|POLY 1.5           |        P=0.544          P=0.489          (e)              P=0.420          (e)                              | 
|POLY 6             |        P=0.555          P=0.494          (e)              P=0.395          (e)                              | 
|LOGISTIC REGRESSION|        P=0.584          P=0.607          (e)              P=0.301          (e)                              | 
|COCH-ARM / FISHERS |        P=0.566          P=0.500          (e)              P=0.425          (e)                              | 
|ORDER RESTRICTED   |        P=0.444          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)        1/40 (3%)        0/42 (0%)                        | 
|POLY-3 RATE (b)    |        2/35.19          1/31.15          0/36.65          1/32.49          0/28.81                          | 
|POLY-3 PERCENT (g) |        5.7%             3.2%             0.0%             3.1%             0.0%                             | 
|TERMINAL (d)       |        1/20 (5%)        0/18 (0%)        0/24 (0%)        0/20 (0%)        0/19 (0%)                        | 
|FIRST INCIDENCE    |        612              644              ---              523              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.165N         P=0.559N         P=0.194N         P=0.510N         P=0.265N                         | 
|POLY 3             |        P=0.192N         P=0.543N         P=0.227N         P=0.528N         P=0.282N                         | 
|POLY 1.5           |        P=0.194N         P=0.522N         P=0.231N         P=0.540N         P=0.281N                         | 
|POLY 6             |        P=0.192N         P=0.566N         P=0.221N         P=0.519N         P=0.283N                         | 
|LOGISTIC REGRESSION|        P=0.178N         P=0.562N         P=0.222N         P=0.560N         P=0.280N                         | 
|COCH-ARM / FISHERS |        P=0.190N         P=0.500N         P=0.247N         P=0.584N         P=0.293N                         | 
|ORDER RESTRICTED   |        P=0.122N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 21      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)        1/37 (3%)        0/32 (0%)                        | 
|POLY-3 RATE (b)    |        0/33.13          1/31.33          0/29.15          1/20.93          0/19.14                          | 
|POLY-3 PERCENT (g) |        0.0%             3.2%             0.0%             4.8%             0.0%                             | 
|TERMINAL (d)       |        0/19 (0%)        0/21 (0%)        0/13 (0%)        1/7 (14%)        0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              229              ---              668 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.502          P=0.492          (e)              P=0.301          (e)                              | 
|POLY 3             |        P=0.548          P=0.489          (e)              P=0.409          (e)                              | 
|POLY 1.5           |        P=0.544          P=0.489          (e)              P=0.420          (e)                              | 
|POLY 6             |        P=0.555          P=0.494          (e)              P=0.395          (e)                              | 
|LOGISTIC REGRESSION|        P=0.584          P=0.607          (e)              P=0.301          (e)                              | 
|COCH-ARM / FISHERS |        P=0.566          P=0.500          (e)              P=0.425          (e)                              | 
|ORDER RESTRICTED   |        P=0.444          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)        1/40 (3%)        0/42 (0%)                        | 
|POLY-3 RATE (b)    |        2/35.19          1/31.15          0/36.65          1/32.49          0/28.81                          | 
|POLY-3 PERCENT (g) |        5.7%             3.2%             0.0%             3.1%             0.0%                             | 
|TERMINAL (d)       |        1/20 (5%)        0/18 (0%)        0/24 (0%)        0/20 (0%)        0/19 (0%)                        | 
|FIRST INCIDENCE    |        612              644              ---              523              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.165N         P=0.559N         P=0.194N         P=0.510N         P=0.265N                         | 
|POLY 3             |        P=0.192N         P=0.543N         P=0.227N         P=0.528N         P=0.282N                         | 
|POLY 1.5           |        P=0.194N         P=0.522N         P=0.231N         P=0.540N         P=0.281N                         | 
|POLY 6             |        P=0.192N         P=0.566N         P=0.221N         P=0.519N         P=0.283N                         | 
|LOGISTIC REGRESSION|        P=0.178N         P=0.562N         P=0.222N         P=0.560N         P=0.280N                         | 
|COCH-ARM / FISHERS |        P=0.190N         P=0.500N         P=0.247N         P=0.584N         P=0.293N                         | 
|ORDER RESTRICTED   |        P=0.122N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 22      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/49 (6%)        2/50 (4%)        1/50 (2%)        0/37 (0%)        1/32 (3%)                        | 
|POLY-3 RATE (b)    |        3/34.14          2/30.72          1/29.15          0/20.93          1/19.92                          | 
|POLY-3 PERCENT (g) |        8.8%             6.5%             3.4%             0.0%             5.0%                             | 
|TERMINAL (d)       |        0/18 (0%)        1/21 (5%)        1/13 (8%)        0/7 (0%)         0/8 (0%)                         | 
|FIRST INCIDENCE    |        373              580              668 (T)          ---              404                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.253N         P=0.519N         P=0.366N         P=0.214N         P=0.519N                         | 
|POLY 3             |        P=0.215N         P=0.549N         P=0.362N         P=0.222N         P=0.511N                         | 
|POLY 1.5           |        P=0.201N         P=0.538N         P=0.336N         P=0.203N         P=0.502N                         | 
|POLY 6             |        P=0.239N         P=0.547N         P=0.398N         P=0.247N         P=0.522N                         | 
|LOGISTIC REGRESSION|        P=0.184N         P=0.482N         P=0.283N         P=0.145N         P=0.400N                         | 
|COCH-ARM / FISHERS |        P=0.184N         P=0.490N         P=0.301N         P=0.180N         P=0.482N                         | 
|ORDER RESTRICTED   |        P=0.295N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/49 (0%)        0/40 (0%)        0/42 (0%)                        | 
|POLY-3 RATE (b)    |        1/35.24          0/31.04          0/36.54          0/31.97          0/28.81                          | 
|POLY-3 PERCENT (g) |        2.8%             0.0%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/20 (0%)        0/18 (0%)        0/24 (0%)        0/20 (0%)        0/19 (0%)                        | 
|FIRST INCIDENCE    |        599              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.234N         P=0.550N         P=0.466N         P=0.500N         P=0.550N                         | 
|POLY 3             |        P=0.251N         P=0.525N         P=0.493N         P=0.520N         P=0.540N                         | 
|POLY 1.5           |        P=0.254N         P=0.513N         P=0.497N         P=0.525N         P=0.539N                         | 
|POLY 6             |        P=0.248N         P=0.539N         P=0.487N         P=0.517N         P=0.542N                         | 
|LOGISTIC REGRESSION|        P=0.246N         P=0.515N         P=0.499N         P=0.536N         P=0.538N                         | 
|COCH-ARM / FISHERS |        P=0.251N         P=0.500N         P=0.505N         P=0.556N         P=0.543N                         | 
|ORDER RESTRICTED   |        P=0.126N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 23      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Plasma Cell Tumor Malignant                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/48 (0%)        0/45 (0%)        0/47 (0%)        0/33 (0%)        0/32 (0%)                        | 
|POLY-3 RATE (b)    |        0/31.39          0/26.53          0/27.78          0/19.03          0/19.14                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/19 (0%)        0/18 (0%)        0/12 (0%)        0/7 (0%)         0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Plasma Cell Tumor Malignant                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/49 (0%)        2/44 (5%)        1/46 (2%)        0/36 (0%)        0/42 (0%)                        | 
|POLY-3 RATE (b)    |        0/34.91          2/29.92          1/35.73          0/29.65          0/28.81                          | 
|POLY-3 PERCENT (g) |        0.0%             6.7%             2.8%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/20 (0%)        0/17 (0%)        0/23 (0%)        0/19 (0%)        0/19 (0%)                        | 
|FIRST INCIDENCE    |        ---              441              182              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.259N         P=0.204          P=0.504          (e)              (e)                              | 
|POLY 3             |        P=0.270N         P=0.202          P=0.505          (e)              (e)                              | 
|POLY 1.5           |        P=0.267N         P=0.210          P=0.498          (e)              (e)                              | 
|POLY 6             |        P=0.273N         P=0.195          P=0.514          (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.231N         P=0.207          P=0.397          (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.263N         P=0.221          P=0.484          (e)              (e)                              | 
|ORDER RESTRICTED   |        P=0.320N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 24      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        1/50 (2%)        0/37 (0%)        0/32 (0%)                        | 
|POLY-3 RATE (b)    |        0/33.13          1/30.37          1/29.15          0/20.93          0/19.14                          | 
|POLY-3 PERCENT (g) |        0.0%             3.3%             3.4%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/19 (0%)        1/21 (5%)        1/13 (8%)        0/7 (0%)         0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              668 (T)          668 (T)          ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.556N         P=0.520          P=0.424          (e)              (e)                              | 
|POLY 3             |        P=0.481N         P=0.483          P=0.474          (e)              (e)                              | 
|POLY 1.5           |        P=0.465N         P=0.484          P=0.485          (e)              (e)                              | 
|POLY 6             |        P=0.502N         P=0.486          P=0.461          (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              P=0.520          P=0.424          (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.434N         P=0.500          P=0.500          (e)              (e)                              | 
|ORDER RESTRICTED   |        P=0.495N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        2/50 (4%)        2/40 (5%)        0/42 (0%)                        | 
|POLY-3 RATE (b)    |        0/34.96          1/31.45          2/36.80          2/32.09          0/28.81                          | 
|POLY-3 PERCENT (g) |        0.0%             3.2%             5.4%             6.2%             0.0%                             | 
|TERMINAL (d)       |        0/20 (0%)        0/18 (0%)        1/24 (4%)        0/20 (0%)        0/19 (0%)                        | 
|FIRST INCIDENCE    |        ---              560              631              646              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.559          P=0.441          P=0.281          P=0.250          (e)                              | 
|POLY 3             |        P=0.520          P=0.479          P=0.248          P=0.216          (e)                              | 
|POLY 1.5           |        P=0.513          P=0.489          P=0.243          P=0.209          (e)                              | 
|POLY 6             |        P=0.528          P=0.469          P=0.257          P=0.222          (e)                              | 
|LOGISTIC REGRESSION|        P=0.536          P=0.498          P=0.256          P=0.225          (e)                              | 
|COCH-ARM / FISHERS |        P=0.510          P=0.500          P=0.247          P=0.195          (e)                              | 
|ORDER RESTRICTED   |        P=0.306          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 25      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/50 (14%)       6/50 (12%)       4/50 (8%)        2/37 (5%)        3/32 (9%)                        | 
|POLY-3 RATE (b)    |        7/36.30          6/31.83          4/30.11          2/21.18          3/20.40                          | 
|POLY-3 PERCENT (g) |        19.3%            18.9%            13.3%            9.4%             14.7%                            | 
|TERMINAL (d)       |        1/19 (5%)        3/21 (14%)       1/13 (8%)        1/7 (14%)        1/8 (13%)                        | 
|FIRST INCIDENCE    |        373              385              482              607              404                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.334N         P=0.536N         P=0.399N         P=0.315N         P=0.494N                         | 
|POLY 3             |        P=0.247N         P=0.604N         P=0.374N         P=0.274N         P=0.472N                         | 
|POLY 1.5           |        P=0.220N         P=0.582N         P=0.326N         P=0.232N         P=0.454N                         | 
|POLY 6             |        P=0.290N         P=0.610N         P=0.435N         P=0.332N         P=0.496N                         | 
|LOGISTIC REGRESSION|        P=0.204N         P=0.523N         P=0.274N         P=0.182N         P=0.384N                         | 
|COCH-ARM / FISHERS |        P=0.181N         P=0.500N         P=0.262N         P=0.173N         P=0.398N                         | 
|ORDER RESTRICTED   |        P=0.434N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/50 (6%)        1/50 (2%)        2/50 (4%)        1/40 (3%)        2/42 (5%)                        | 
|POLY-3 RATE (b)    |        3/35.60          1/31.04          2/36.71          1/32.73          2/29.43                          | 
|POLY-3 PERCENT (g) |        8.4%             3.2%             5.5%             3.1%             6.8%                             | 
|TERMINAL (d)       |        1/20 (5%)        1/18 (6%)        1/24 (4%)        0/20 (0%)        1/19 (5%)                        | 
|FIRST INCIDENCE    |        577              668 (T)          654              414              482                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.450N         P=0.385N         P=0.433N         P=0.335N         P=0.576N                         | 
|POLY 3             |        P=0.460N         P=0.354N         P=0.486N         P=0.334N         P=0.587N                         | 
|POLY 1.5           |        P=0.481N         P=0.329N         P=0.491N         P=0.346N         P=0.586N                         | 
|POLY 6             |        P=0.444N         P=0.385N         P=0.476N         P=0.327N         P=0.590N                         | 
|LOGISTIC REGRESSION|        P=0.497N         P=0.355N         P=0.475N         P=0.409N         P=0.586N                         | 
|COCH-ARM / FISHERS |        P=0.513N         P=0.309N         P=0.500N         P=0.397N         P=0.583N                         | 
|ORDER RESTRICTED   |        P=0.443N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 26      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/50 (14%)       7/50 (14%)       5/50 (10%)       2/37 (5%)        3/32 (9%)                        | 
|POLY-3 RATE (b)    |        7/36.30          7/31.83          5/30.11          2/21.18          3/20.40                          | 
|POLY-3 PERCENT (g) |        19.3%            22.0%            16.6%            9.4%             14.7%                            | 
|TERMINAL (d)       |        1/19 (5%)        4/21 (19%)       2/13 (15%)       1/7 (14%)        1/8 (13%)                        | 
|FIRST INCIDENCE    |        373              385              482              607              404                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.316N         P=0.579          P=0.541N         P=0.315N         P=0.494N                         | 
|POLY 3             |        P=0.218N         P=0.510          P=0.515N         P=0.274N         P=0.472N                         | 
|POLY 1.5           |        P=0.191N         P=0.532          P=0.460N         P=0.232N         P=0.454N                         | 
|POLY 6             |        P=0.262N         P=0.505          P=0.584N         P=0.332N         P=0.496N                         | 
|LOGISTIC REGRESSION|        P=0.175N         P=0.584          P=0.405N         P=0.182N         P=0.384N                         | 
|COCH-ARM / FISHERS |        P=0.150N         P=0.613N         P=0.380N         P=0.173N         P=0.398N                         | 
|ORDER RESTRICTED   |        P=0.387N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/50 (6%)        2/50 (4%)        4/50 (8%)        3/40 (8%)        2/42 (5%)                        | 
|POLY-3 RATE (b)    |        3/35.60          2/31.45          4/36.87          3/32.85          2/29.43                          | 
|POLY-3 PERCENT (g) |        8.4%             6.4%             10.9%            9.1%             6.8%                             | 
|TERMINAL (d)       |        1/20 (5%)        1/18 (6%)        2/24 (8%)        0/20 (0%)        1/19 (5%)                        | 
|FIRST INCIDENCE    |        577              560              631              414              482                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.476N         P=0.602N         P=0.585          P=0.643          P=0.576N                         | 
|POLY 3             |        P=0.514N         P=0.557N         P=0.519          P=0.627          P=0.587N                         | 
|POLY 1.5           |        P=0.533N         P=0.529N         P=0.512          P=0.611          P=0.586N                         | 
|POLY 6             |        P=0.500N         P=0.588N         P=0.534          P=0.637          P=0.590N                         | 
|LOGISTIC REGRESSION|        P=0.529N         P=0.550N         P=0.534          P=0.574          P=0.586N                         | 
|COCH-ARM / FISHERS |        P=0.547          P=0.500N         P=0.500          P=0.550          P=0.583N                         | 
|ORDER RESTRICTED   |        P=0.658N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 27      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/37 (0%)        0/32 (0%)                        | 
|POLY-3 RATE (b)    |        0/33.13          0/30.37          0/29.15          0/20.93          0/19.14                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/19 (0%)        0/21 (0%)        0/13 (0%)        0/7 (0%)         0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        1/50 (2%)        2/40 (5%)        2/42 (5%)                        | 
|POLY-3 RATE (b)    |        1/34.96          1/31.46          1/36.80          2/32.09          2/28.81                          | 
|POLY-3 PERCENT (g) |        2.9%             3.2%             2.7%             6.2%             6.9%                             | 
|TERMINAL (d)       |        1/20 (5%)        0/18 (0%)        0/24 (0%)        1/20 (5%)        2/19 (11%)                       | 
|FIRST INCIDENCE    |        668 (T)          556              631              641              668 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.225          P=0.720          P=0.719N         P=0.500          P=0.482                          | 
|POLY 3             |        P=0.201          P=0.738          P=0.750N         P=0.470          P=0.432                          | 
|POLY 1.5           |        P=0.193          P=0.749          P=0.755N         P=0.458          P=0.433                          | 
|POLY 6             |        P=0.206          P=0.726          P=0.741N         P=0.479          P=0.431                          | 
|LOGISTIC REGRESSION|        P=0.202          P=0.741          P=0.744N         P=0.489          P=0.482                          | 
|COCH-ARM / FISHERS |        P=0.180          P=0.753N         P=0.753N         P=0.416          P=0.434                          | 
|ORDER RESTRICTED   |        P=0.379          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 28      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/50 (12%)       9/50 (18%)       7/50 (14%)       4/37 (11%)       3/32 (9%)                        | 
|POLY-3 RATE (b)    |        6/35.21          9/33.67          7/32.43          4/21.95          3/19.77                          | 
|POLY-3 PERCENT (g) |        17.0%            26.7%            21.6%            18.2%            15.2%                            | 
|TERMINAL (d)       |        1/19 (5%)        2/21 (10%)       1/13 (8%)        0/7 (0%)         1/8 (13%)                        | 
|FIRST INCIDENCE    |        413              322              187              589              495                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.405N         P=0.269          P=0.370          P=0.527          P=0.625N                         | 
|POLY 3             |        P=0.358N         P=0.246          P=0.434          P=0.595          P=0.578N                         | 
|POLY 1.5           |        P=0.321N         P=0.242          P=0.461          P=0.630          P=0.559N                         | 
|POLY 6             |        P=0.411N         P=0.271          P=0.398          P=0.557          P=0.603N                         | 
|LOGISTIC REGRESSION|        P=0.273N         P=0.263          P=0.504          P=0.624N         P=0.533N                         | 
|COCH-ARM / FISHERS |        P=0.249N         P=0.288          P=0.500          P=0.571N         P=0.505N                         | 
|ORDER RESTRICTED   |        P=0.514N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        19/50 (38%)      19/50 (38%)      20/50 (40%)      16/40 (40%)      17/42 (40%)                      | 
|POLY-3 RATE (b)    |        19/39.41         19/37.75         20/38.78         16/35.35         17/31.65                         | 
|POLY-3 PERCENT (g) |        48.2%            50.3%            51.6%            45.3%            53.7%                            | 
|TERMINAL (d)       |        8/20 (40%)       8/18 (44%)       15/24 (63%)      8/20 (40%)       11/19 (58%)                      | 
|FIRST INCIDENCE    |        352              341              425              359              325                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.395N         P=0.362          P=0.447N         P=0.415N         P=0.552                          | 
|POLY 3             |        P=0.463          P=0.517          P=0.471          P=0.491N         P=0.409                          | 
|POLY 1.5           |        P=0.446          P=0.561          P=0.487          P=0.525N         P=0.439                          | 
|POLY 6             |        P=0.458          P=0.460          P=0.454          P=0.479N         P=0.363                          | 
|LOGISTIC REGRESSION|        P=0.475          P=0.534          P=0.552          P=0.578N         P=0.464                          | 
|COCH-ARM / FISHERS |        P=0.411          P=0.582N         P=0.500          P=0.509          P=0.488                          | 
|ORDER RESTRICTED   |        P=0.555          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 29      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/37 (0%)        0/32 (0%)                        | 
|POLY-3 RATE (b)    |        0/33.13          0/30.37          0/29.15          0/20.93          0/19.14                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/19 (0%)        0/21 (0%)        0/13 (0%)        0/7 (0%)         0/8 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)        1/40 (3%)        0/42 (0%)                        | 
|POLY-3 RATE (b)    |        0/34.96          2/31.79          0/36.65          1/31.97          0/28.81                          | 
|POLY-3 PERCENT (g) |        0.0%             6.3%             0.0%             3.1%             0.0%                             | 
|TERMINAL (d)       |        0/20 (0%)        0/18 (0%)        0/24 (0%)        1/20 (5%)        0/19 (0%)                        | 
|FIRST INCIDENCE    |        ---              565              ---              668 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.444N         P=0.160          (e)              P=0.500          (e)                              | 
|POLY 3             |        P=0.504N         P=0.215          (e)              P=0.482          (e)                              | 
|POLY 1.5           |        P=0.493N         P=0.226          (e)              P=0.476          (e)                              | 
|POLY 6             |        P=0.516N         P=0.206          (e)              P=0.487          (e)                              | 
|LOGISTIC REGRESSION|        P=0.461N         P=0.231          (e)              P=0.500          (e)                              | 
|COCH-ARM / FISHERS |        P=0.471N         P=0.247          (e)              P=0.444          (e)                              | 
|ORDER RESTRICTED   |        P=0.334N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 30      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        27/50 (54%)      23/50 (46%)      27/50 (54%)      18/37 (49%)      16/32 (50%)                      | 
|POLY-3 RATE (b)    |        27/38.82         23/35.83         27/35.35         18/25.42         16/24.75                         | 
|POLY-3 PERCENT (g) |        69.6%            64.2%            76.4%            70.8%            64.6%                            | 
|TERMINAL (d)       |        11/19 (58%)      12/21 (57%)      11/13 (85%)      7/7 (100%)       5/8 (63%)                        | 
|FIRST INCIDENCE    |        413              229              322              167              229                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.113          P=0.311N         P=0.146          P=0.140          P=0.359                          | 
|POLY 3             |        P=0.451N         P=0.398N         P=0.330          P=0.573          P=0.444N                         | 
|POLY 1.5           |        P=0.443N         P=0.378N         P=0.430          P=0.543N         P=0.463N                         | 
|POLY 6             |        P=0.542N         P=0.394N         P=0.233          P=0.425          P=0.476N                         | 
|LOGISTIC REGRESSION|        P=0.469          P=0.413N         P=0.355          P=0.581          P=0.577N                         | 
|COCH-ARM / FISHERS |        P=0.438N         P=0.274N         P=0.579N         P=0.391N         P=0.449N                         | 
|ORDER RESTRICTED   |        P=0.545N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        17/50 (34%)      17/50 (34%)      23/50 (46%)      14/40 (35%)      16/42 (38%)                      | 
|POLY-3 RATE (b)    |        17/38.06         17/32.74         23/39.33         14/34.17         16/31.28                         | 
|POLY-3 PERCENT (g) |        44.7%            51.9%            58.5%            41.0%            51.2%                            | 
|TERMINAL (d)       |        7/20 (35%)       11/18 (61%)      14/24 (58%)      8/20 (40%)       10/19 (53%)                      | 
|FIRST INCIDENCE    |        510              560              432              359              453                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.376N         P=0.337          P=0.354          P=0.389N         P=0.487                          | 
|POLY 3             |        P=0.492N         P=0.349          P=0.153          P=0.468N         P=0.380                          | 
|POLY 1.5           |        P=0.520          P=0.470          P=0.151          P=0.494N         P=0.394                          | 
|POLY 6             |        P=0.480N         P=0.222          P=0.162          P=0.480N         P=0.353                          | 
|LOGISTIC REGRESSION|        P=0.512N         P=0.347          P=0.179          P=0.484N         P=0.391                          | 
|COCH-ARM / FISHERS |        P=0.418          P=0.583N         P=0.154          P=0.548          P=0.424                          | 
|ORDER RESTRICTED   |        P=0.504          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 31      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        19/50 (38%)      27/50 (54%)      20/50 (40%)      20/37 (54%)      17/32 (53%)                      | 
|POLY-3 RATE (b)    |        19/39.22         27/39.79         20/36.28         20/27.27         17/24.12                         | 
|POLY-3 PERCENT (g) |        48.4%            67.9%            55.1%            73.3%            70.5%                            | 
|TERMINAL (d)       |        5/19 (26%)       10/21 (48%)      6/13 (46%)       4/7 (57%)        5/8 (63%)                        | 
|FIRST INCIDENCE    |        373              157              187              341              376                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.026 *        P=0.117          P=0.229          P=0.019 *        P=0.063                          | 
|POLY 3             |        P=0.036 *        P=0.056          P=0.358          P=0.030 *        P=0.064                          | 
|POLY 1.5           |        P=0.044 *        P=0.050          P=0.414          P=0.041 *        P=0.066                          | 
|POLY 6             |        P=0.031 *        P=0.078          P=0.293          P=0.027 *        P=0.066                          | 
|LOGISTIC REGRESSION|        P=0.076          P=0.058          P=0.443          P=0.054          P=0.084                          | 
|COCH-ARM / FISHERS |        P=0.120          P=0.080          P=0.500          P=0.102          P=0.132                          | 
|ORDER RESTRICTED   |        P=0.049 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        30/50 (60%)      28/50 (56%)      31/50 (62%)      25/40 (63%)      27/42 (64%)                      | 
|POLY-3 RATE (b)    |        30/40.73         28/39.76         31/41.49         25/37.56         27/33.48                         | 
|POLY-3 PERCENT (g) |        73.7%            70.4%            74.7%            66.6%            80.6%                            | 
|TERMINAL (d)       |        15/20 (75%)      12/18 (67%)      19/24 (79%)      11/20 (55%)      17/19 (90%)                      | 
|FIRST INCIDENCE    |        352              341              182              359              325                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.419N         P=0.382          P=0.361N         P=0.332N         P=0.523                          | 
|POLY 3             |        P=0.374          P=0.468N         P=0.560          P=0.323N         P=0.318                          | 
|POLY 1.5           |        P=0.330          P=0.418N         P=0.556          P=0.410N         P=0.353                          | 
|POLY 6             |        P=0.387          P=0.542N         P=0.559          P=0.278N         P=0.254                          | 
|LOGISTIC REGRESSION|        P=0.362          P=0.543N         P=0.566          P=0.498N         P=0.363                          | 
|COCH-ARM / FISHERS |        P=0.274          P=0.420N         P=0.500          P=0.491          P=0.419                          | 
|ORDER RESTRICTED   |        P=0.307          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  10/08/03                           EXPERIMENT: 99022 TEST: 02                                            Page 32      
                     Statistical Analysis of Primary Tumors in Mice(SWISS)       -          AZT TRANSPLACENTAL CARCINOGENESIS       
                                         Terminal Sacrifice at 96 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        35/50 (70%)      35/50 (70%)      34/50 (68%)      25/37 (68%)      26/32 (81%)                      | 
|POLY-3 RATE (b)    |        35/42.09         35/41.72         34/39.18         25/28.41         26/27.62                         | 
|POLY-3 PERCENT (g) |        83.2%            83.9%            86.8%            88.0%            94.1%                            | 
|TERMINAL (d)       |        14/19 (74%)      15/21 (71%)      12/13 (92%)      7/7 (100%)       8/8 (100%)                       | 
|FIRST INCIDENCE    |        373              157              187              167              229                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.019 *        P=0.536          P=0.163          P=0.077          P=0.063                          | 
|POLY 3             |        P=0.070          P=0.585          P=0.434          P=0.404          P=0.137                          | 
|POLY 1.5           |        P=0.087          P=0.541          P=0.551          P=0.525          P=0.110                          | 
|POLY 6             |        P=0.049 *        P=0.589N         P=0.302          P=0.291          P=0.160                          | 
|LOGISTIC REGRESSION|        P=0.079          P=0.400          P=0.487          P=0.455          P=0.062                          | 
|COCH-ARM / FISHERS |        P=0.206          P=0.586N         P=0.500N         P=0.495N         P=0.190                          | 
|ORDER RESTRICTED   |        P=0.130          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                50               100              200              300                              | 
|                   |        MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY         MG/KG/DY                         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        35/50 (70%)      33/50 (66%)      38/50 (76%)      31/40 (78%)      33/42 (79%)                      | 
|POLY-3 RATE (b)    |        35/41.62         33/39.81         38/42.65         31/38.17         33/35.51                         | 
|POLY-3 PERCENT (g) |        84.1%            82.9%            89.1%            81.2%            92.9%                            | 
|TERMINAL (d)       |        16/20 (80%)      16/18 (89%)      23/24 (96%)      16/20 (80%)      19/19 (100%)                     | 
|FIRST INCIDENCE    |        352              341              182              359              325                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.515          P=0.343          P=0.435N         P=0.402N         P=0.399                          | 
|POLY 3             |        P=0.207          P=0.568N         P=0.347          P=0.481N         P=0.167                          | 
|POLY 1.5           |        P=0.140          P=0.447N         P=0.357          P=0.586N         P=0.175                          | 
|POLY 6             |        P=0.257          P=0.538          P=0.324          P=0.451N         P=0.141                          | 
|LOGISTIC REGRESSION|        P=0.158          P=0.595          P=0.364          P=0.575          P=0.162                          | 
|COCH-ARM / FISHERS |        P=0.101          P=0.415N         P=0.326          P=0.289          P=0.245                          | 
|ORDER RESTRICTED   |        P=0.150          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).