TDMS Study 89009-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Southern Research Inst PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 DATE: 10/18/04
EXPERIMENT: 89009 TEST: 02 TIME: 10:25:27
TEST TYPE: SUBCHRON 26-WEEK PAGE: 1
CONT: NO1-ES-95275 ROUTE: DOSED WATER NTP C#: C89009
PATHOLOGIST: J.E. HEATH CAS: PESTFERTMIX2
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REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Southern Research Inst PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 DATE: 10/18/04
EXPERIMENT: 89009 TEST: 02 TIME: 10:25:27
TEST TYPE: SUBCHRON 26-WEEK
CONT: NO1-ES-95275 ROUTE: DOSED WATER NTP C#: C89009
PATHOLOGIST: J.E. HEATH CAS: PESTFERTMIX2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF PESTICIDE/FERTILIZER CONTAMINATION--M
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Uterus Hyperplasia Cystic
===============================================================
Date: 10/18/04 EXPERIMENT: 89009 TEST: 02 Page 1
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - PESTICIDE/FERTILIZER CONTAMINATION--M
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | VEHICLE 0.1X 1X 10X 100X |
| | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Accessory Adrenal Cortical Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/20 (10%) 3/20 (15%) 1/20 (5%) 2/20 (10%) 2/20 (10%) |
|POLY-3 RATE (b) | 2/11.27 3/13.02 1/12.14 2/13.02 2/11.15 |
|POLY-3 PERCENT (g) | 17.8% 23.1% 8.2% 15.4% 18.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 2/10 (20%) 1/10 (10%) 2/10 (20%) 1/10 (10%) |
|TERMINAL (d) | 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/9 (11%) |
|FIRST INCIDENCE | 183 (T) 92 (I) 92 (I) 92 (I) 92 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.633 P=0.500 P=0.500N P=0.696 P=0.670 |
|POLY 3 | P=0.612 P=0.570 P=0.473N P=0.649N P=0.702 |
|POLY 1.5 | P=0.619 P=0.544 P=0.483N P=0.668N P=0.695 |
|POLY 6 | P=0.607 P=0.586 P=0.466N P=0.636N P=0.706 |
|LOGISTIC REGRESSION| P=0.631N P=0.500 P=0.500N P=0.701N P=0.678 |
|COCH-ARM / FISHERS | P=0.647N P=0.500 P=0.500N P=0.698N P=0.698N |
|ORDER RESTRICTED | P=0.585N (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | VEHICLE 0.1X 1X 10X 100X |
| | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Accessory Adrenal Cortical Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/20 (15%) 2/20 (10%) 2/20 (10%) 3/20 (15%) 3/20 (15%) |
|POLY-3 RATE (b) | 3/12.14 2/12.14 2/11.27 3/13.02 3/13.02 |
|POLY-3 PERCENT (g) | 24.7% 16.5% 17.8% 23.1% 23.1% |
|INT SACRIFICE 1 (c)| 1/10 (10%) 1/10 (10%) 0/10 (0%) 2/10 (20%) 2/10 (20%) |
|TERMINAL (d) | 2/10 (20%) 1/10 (10%) 2/10 (20%) 0/9 (0%) 1/10 (10%) |
|FIRST INCIDENCE | 92 (I) 92 (I) 183 (T) 51 92 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.510 P=0.500N P=0.500N P=0.645 P=0.667 |
|POLY 3 | P=0.561 P=0.500N P=0.537N P=0.643N P=0.643N |
|POLY 1.5 | P=0.540 P=0.500N P=0.523N P=0.653N P=0.653N |
|POLY 6 | P=0.573 P=0.500N P=0.546N P=0.635N P=0.635N |
|LOGISTIC REGRESSION| P=0.503 P=0.500N P=0.500N P=0.642N P=0.671N |
|COCH-ARM / FISHERS | P=0.505 P=0.500N P=0.500N P=0.669N P=0.669N |
|ORDER RESTRICTED | P=0.660N (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/18/04 EXPERIMENT: 89009 TEST: 02 Page 2
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - PESTICIDE/FERTILIZER CONTAMINATION--M
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | VEHICLE 0.1X 1X 10X 100X |
| | CONTROL |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/20 (0%) 3/20 (15%) 1/20 (5%) 3/20 (15%) 0/20 (0%) |
|POLY-3 RATE (b) | 0/11.27 3/11.27 1/11.27 3/11.27 0/10.27 |
|POLY-3 PERCENT (g) | 0.0% 26.6% 8.9% 26.6% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 3/10 (30%) 1/10 (10%) 3/10 (30%) 0/9 (0%) |
|FIRST INCIDENCE | --- 183 (T) 183 (T) 183 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.233N P=0.111 P=0.500 P=0.111 (e) |
|POLY 3 | P=0.234N P=0.101 P=0.500 P=0.101 (e) |
|POLY 1.5 | P=0.230N P=0.104 P=0.500 P=0.104 (e) |
|POLY 6 | P=0.238N P=0.101 P=0.500 P=0.101 (e) |
|LOGISTIC REGRESSION| (e) P=0.111 P=0.500 P=0.111 (e) |
|COCH-ARM / FISHERS | P=0.213N P=0.115 P=0.500 P=0.115 (e) |
|ORDER RESTRICTED | P=0.224 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | VEHICLE 0.1X 1X 10X 100X |
| | CONTROL |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/20 (0%) 0/20 (0%) 0/20 (0%) 0/20 (0%) 0/20 (0%) |
|POLY-3 RATE (b) | 0/11.27 0/11.27 0/11.27 0/10.29 0/11.27 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/18/04 EXPERIMENT: 89009 TEST: 02 Page 3
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - PESTICIDE/FERTILIZER CONTAMINATION--M
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | VEHICLE 0.1X 1X 10X 100X |
| | CONTROL |
|=================================================================================================================================|
| |
|Kidney |
| Casts Protein |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/20 (0%) 1/20 (5%) 0/20 (0%) 0/20 (0%) 0/20 (0%) |
|POLY-3 RATE (b) | 0/11.27 1/12.14 0/11.27 0/11.27 0/10.27 |
|POLY-3 PERCENT (g) | 0.0% 8.2% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- 92 (I) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.721N P=0.500 (e) (e) (e) |
|POLY 3 | P=0.720N P=0.515 (e) (e) (e) |
|POLY 1.5 | P=0.722N P=0.509 (e) (e) (e) |
|POLY 6 | P=0.719N P=0.519 (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.650N (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.722N P=0.500 (e) (e) (e) |
|ORDER RESTRICTED | P=0.407N (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | VEHICLE 0.1X 1X 10X 100X |
| | CONTROL |
|=================================================================================================================================|
| |
|Kidney |
| Casts Protein |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/20 (5%) 1/20 (5%) 1/20 (5%) 2/20 (10%) 0/20 (0%) |
|POLY-3 RATE (b) | 1/11.27 1/11.27 1/12.14 2/11.17 0/11.27 |
|POLY-3 PERCENT (g) | 8.9% 8.9% 8.2% 17.9% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 1/10 (10%) 0/10 (0%) 1/9 (11%) 0/10 (0%) |
|FIRST INCIDENCE | 183 (T) 183 (T) 92 (I) 92 (I) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.298N P=0.766 P=0.760 P=0.475 P=0.500N |
|POLY 3 | P=0.304N P=0.766 P=0.748N P=0.497 P=0.500N |
|POLY 1.5 | P=0.302N P=0.765 P=0.754N P=0.494 P=0.500N |
|POLY 6 | P=0.306N P=0.766 P=0.744N P=0.499 P=0.500N |
|LOGISTIC REGRESSION| P=0.297N P=0.772N P=0.766N P=0.482 (e) |
|COCH-ARM / FISHERS | P=0.299N P=0.756N P=0.756N P=0.500 P=0.500N |
|ORDER RESTRICTED | P=0.317N (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/18/04 EXPERIMENT: 89009 TEST: 02 Page 4
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - PESTICIDE/FERTILIZER CONTAMINATION--M
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | VEHICLE 0.1X 1X 10X 100X |
| | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Acute |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/20 (0%) 0/20 (0%) 0/20 (0%) 0/20 (0%) 0/20 (0%) |
|POLY-3 RATE (b) | 0/11.27 0/11.27 0/11.27 0/11.27 0/10.27 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | VEHICLE 0.1X 1X 10X 100X |
| | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Acute |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/20 (10%) 1/20 (5%) 2/20 (10%) 1/20 (5%) 0/20 (0%) |
|POLY-3 RATE (b) | 2/12.14 1/12.14 2/12.14 1/11.17 0/11.27 |
|POLY-3 PERCENT (g) | 16.5% 8.2% 16.5% 9.0% 0.0% |
|INT SACRIFICE 1 (c)| 1/10 (10%) 1/10 (10%) 1/10 (10%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 0/10 (0%) 1/10 (10%) 0/9 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 92 (I) 92 (I) 92 (I) 92 (I) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.206N P=0.500N P=0.696 P=0.512N P=0.240N |
|POLY 3 | P=0.217N P=0.500N P=0.705 P=0.531N P=0.246N |
|POLY 1.5 | P=0.212N P=0.500N P=0.703 P=0.522N P=0.240N |
|POLY 6 | P=0.221N P=0.500N P=0.705 P=0.534N P=0.250N |
|LOGISTIC REGRESSION| P=0.206N P=0.500N P=0.701N P=0.486N P=0.234N |
|COCH-ARM / FISHERS | P=0.206N P=0.500N P=0.698N P=0.500N P=0.244N |
|ORDER RESTRICTED | P=0.157N (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/18/04 EXPERIMENT: 89009 TEST: 02 Page 5
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - PESTICIDE/FERTILIZER CONTAMINATION--M
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | VEHICLE 0.1X 1X 10X 100X |
| | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/20 (0%) 0/20 (0%) 0/20 (0%) 0/20 (0%) 0/20 (0%) |
|POLY-3 RATE (b) | 0/11.27 0/11.27 0/11.27 0/11.27 0/10.27 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | VEHICLE 0.1X 1X 10X 100X |
| | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/20 (10%) 1/20 (5%) 2/20 (10%) 3/20 (15%) 2/20 (10%) |
|POLY-3 RATE (b) | 2/12.14 1/11.27 2/11.27 3/12.04 2/11.27 |
|POLY-3 PERCENT (g) | 16.5% 8.9% 17.8% 24.9% 17.8% |
|INT SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 2/10 (20%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 1/10 (10%) 2/10 (20%) 1/9 (11%) 2/10 (20%) |
|FIRST INCIDENCE | 92 (I) 183 (T) 183 (T) 92 (I) 183 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.623 P=0.500N P=0.699 P=0.480 P=0.699 |
|POLY 3 | P=0.607 P=0.527N P=0.677 P=0.496 P=0.677 |
|POLY 1.5 | P=0.612 P=0.517N P=0.686 P=0.493 P=0.686 |
|POLY 6 | P=0.603 P=0.534N P=0.670 P=0.499 P=0.670 |
|LOGISTIC REGRESSION| P=0.623 P=0.500N P=0.704N P=0.509 P=0.704N |
|COCH-ARM / FISHERS | P=0.618 P=0.500N P=0.698N P=0.500 P=0.698N |
|ORDER RESTRICTED | P=0.506 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/18/04 EXPERIMENT: 89009 TEST: 02 Page 6
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - PESTICIDE/FERTILIZER CONTAMINATION--M
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | VEHICLE 0.1X 1X 10X 100X |
| | CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|ORDER RESTRICTED | |
|=================================================================================================================================|
| | |
| | Females |
|Dose | VEHICLE 0.1X 1X 10X 100X |
| | CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/20 (20%) 9/20 (45%) 8/20 (40%) 9/20 (45%) 8/20 (40%) |
|POLY-3 RATE (b) | 4/11.27 9/11.27 8/11.27 9/10.29 8/11.27 |
|POLY-3 PERCENT (g) | 35.5% 79.9% 71.0% 87.4% 71.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/10 (40%) 9/10 (90%) 8/10 (80%) 9/9 (100%) 8/10 (80%) |
|FIRST INCIDENCE | 183 (T) 183 (T) 183 (T) 183 (T) 183 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.500 P=0.034 * P=0.091 P=0.012 * P=0.091 |
|POLY 3 | P=0.486 P=0.028 * P=0.086 P=0.009 ** P=0.086 |
|POLY 1.5 | P=0.484 P=0.042 * P=0.104 P=0.023 * P=0.104 |
|POLY 6 | P=0.488 P=0.025 * P=0.082 P=0.006 ** P=0.082 |
|LOGISTIC REGRESSION| P=0.500 P=0.034 * P=0.091 P=0.012 * P=0.091 |
|COCH-ARM / FISHERS | P=0.480 P=0.088 P=0.150 P=0.088 P=0.150 |
|ORDER RESTRICTED | P=0.006 ** (e) (e) (e) (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).