TDMS Study 99022-02 Pathology Tables
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
FINAL/MICE
Facility: Southern Research Institute
Chemical CAS #: 30516-87-1
Lock Date: 06/20/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Merge 001 001,011
Merge 002 002,012
Merge 003 003,013
Merge 004 004,014
Merge 005 005,015
Merge 006 006,016
Merge 007 007,017
Merge 008 008,018
Merge 009 009,019
Merge 010 010,020
Note: Animals arranged according to days on test
Page 1
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
DAY ON TEST | 0| 7| 4| 5| 8| 5| 7| 9| 4| 4| 6| 9| 1| 3| 5| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0|
| 5| 9| 8| 5| 7| 2| 2| 1| 3| 3| 0| 7| 0| 5| 8| 3| 7| 1| 8| 8| 3| 8| 8| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 4| 4| 4| 7| 4| 5| 5| 4| 6| 5| 4| 5| 4| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 5|
0 | 8| 4| 4| 6| 1| 6| 8| 7| 5| 9| 9| 6| 7| 6| 8| 5| 6| 5| 8| 9| 6| 5| 5| 8| 7|
MG/KG/DY | 5| 8| 9| 3| 9| 1| 9| 2| 5| 3| 1| 2| 5| 6| 1| 8| 7| 2| 0| 0| 5| 3| 6| 3| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Gallbladder | A + + + + A + + + + + + + A + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + M + + + + + + + A|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + A + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | |
|__________________________________________________________________________|
Mesentery | + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
DAY ON TEST | 0| 7| 4| 5| 8| 5| 7| 9| 4| 4| 6| 9| 1| 3| 5| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0|
| 5| 9| 8| 5| 7| 2| 2| 1| 3| 3| 0| 7| 0| 5| 8| 3| 7| 1| 8| 8| 3| 8| 8| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 4| 4| 4| 7| 4| 5| 5| 4| 6| 5| 4| 5| 4| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 5|
0 | 8| 4| 4| 6| 1| 6| 8| 7| 5| 9| 9| 6| 7| 6| 8| 5| 6| 5| 8| 9| 6| 5| 5| 8| 7|
MG/KG/DY | 5| 8| 9| 3| 9| 1| 9| 2| 5| 3| 1| 2| 5| 6| 1| 8| 7| 2| 0| 0| 5| 3| 6| 3| 8|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Adenoma | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + M + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | |
Polyp Stromal | |
|__________________________________________________________________________|
Vagina | I + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
DAY ON TEST | 0| 7| 4| 5| 8| 5| 7| 9| 4| 4| 6| 9| 1| 3| 5| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0|
| 5| 9| 8| 5| 7| 2| 2| 1| 3| 3| 0| 7| 0| 5| 8| 3| 7| 1| 8| 8| 3| 8| 8| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 4| 4| 4| 7| 4| 5| 5| 4| 6| 5| 4| 5| 4| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 5|
0 | 8| 4| 4| 6| 1| 6| 8| 7| 5| 9| 9| 6| 7| 6| 8| 5| 6| 5| 8| 9| 6| 5| 5| 8| 7|
MG/KG/DY | 5| 8| 9| 3| 9| 1| 9| 2| 5| 3| 1| 2| 5| 6| 1| 8| 7| 2| 0| 0| 5| 3| 6| 3| 8|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Sarcoma, Metastatic, Skeletal Muscle | X |
|__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
DAY ON TEST | 0| 7| 4| 5| 8| 5| 7| 9| 4| 4| 6| 9| 1| 3| 5| 7| 7| 8| 8| 8| 9| 9| 9| 9| 0|
| 5| 9| 8| 5| 7| 2| 2| 1| 3| 3| 0| 7| 0| 5| 8| 3| 7| 1| 8| 8| 3| 8| 8| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 4| 4| 4| 7| 4| 5| 5| 4| 6| 5| 4| 5| 4| 5| 4| 4| 4| 5| 5| 4| 4| 4| 5| 5|
0 | 8| 4| 4| 6| 1| 6| 8| 7| 5| 9| 9| 6| 7| 6| 8| 5| 6| 5| 8| 9| 6| 5| 5| 8| 7|
MG/KG/DY | 5| 8| 9| 3| 9| 1| 9| 2| 5| 3| 1| 2| 5| 6| 1| 8| 7| 2| 0| 0| 5| 3| 6| 3| 8|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Sarcoma, Metastatic, Skeletal Muscle | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X X X X X X|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 1| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 2| 4| 8| 1| 8| 8| 8| 9| 9| 0| 1| 1| 1| 1| 2| 2| 4| 5| 5| 5| 5| 6| 8| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 4| 4| 4| 4| 4| 4| 4| 7| 4| A |
0 | 8| 7| 5| 4| 7| 7| 8| 7| 7| 7| 7| 8| 8| 9| 8| 9| 4| 5| 5| 6| 6| 5| 5| 2| 4| L |
MG/KG/DY | 6| 3| 1| 3| 0| 9| 4| 6| 7| 1| 4| 2| 8| 2| 7| 4| 4| 0| 7| 0| 4| 4| 9| 1| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + I + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma | X X | 2 |
Hepatocellular Adenoma | X X | 2 |
Hepatocellular Adenoma, Multiple | X | 1 |
|__________________________________________________________________________|____________|
Mesentery | + | 4 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Papilloma | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 1| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 2| 4| 8| 1| 8| 8| 8| 9| 9| 0| 1| 1| 1| 1| 2| 2| 4| 5| 5| 5| 5| 6| 8| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 4| 4| 4| 4| 4| 4| 4| 7| 4| A |
0 | 8| 7| 5| 4| 7| 7| 8| 7| 7| 7| 7| 8| 8| 9| 8| 9| 4| 5| 5| 6| 6| 5| 5| 2| 4| L |
MG/KG/DY | 6| 3| 1| 3| 0| 9| 4| 6| 7| 1| 4| 2| 8| 2| 7| 4| 4| 0| 7| 0| 4| 4| 9| 1| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 3 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcapsular, Adenoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + M + + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cystadenoma | | 2 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 1| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 2| 4| 8| 1| 8| 8| 8| 9| 9| 0| 1| 1| 1| 1| 2| 2| 4| 5| 5| 5| 5| 6| 8| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 4| 4| 4| 4| 4| 4| 4| 7| 4| A |
0 | 8| 7| 5| 4| 7| 7| 8| 7| 7| 7| 7| 8| 8| 9| 8| 9| 4| 5| 5| 6| 6| 5| 5| 2| 4| L |
MG/KG/DY | 6| 3| 1| 3| 0| 9| 4| 6| 7| 1| 4| 2| 8| 2| 7| 4| 4| 0| 7| 0| 4| 4| 9| 1| 5| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | X | 1 |
Polyp Stromal | X | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X | 2 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
Subcutaneous Tissue, Fibrous | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 1| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 2| 4| 8| 1| 8| 8| 8| 9| 9| 0| 1| 1| 1| 1| 2| 2| 4| 5| 5| 5| 5| 6| 8| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 4| 4| 4| 4| 4| 4| 4| 7| 4| A |
0 | 8| 7| 5| 4| 7| 7| 8| 7| 7| 7| 7| 8| 8| 9| 8| 9| 4| 5| 5| 6| 6| 5| 5| 2| 4| L |
MG/KG/DY | 6| 3| 1| 3| 0| 9| 4| 6| 7| 1| 4| 2| 8| 2| 7| 4| 4| 0| 7| 0| 4| 4| 9| 1| 5| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Histiocytoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 5 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 7 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X | 7 |
Alveolar/Bronchiolar Carcinoma | X X X X | 4 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 1| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 2| 4| 8| 1| 8| 8| 8| 9| 9| 0| 1| 1| 1| 1| 2| 2| 4| 5| 5| 5| 5| 6| 8| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 4| 4| 4| 4| 4| 4| 4| 7| 4| A |
0 | 8| 7| 5| 4| 7| 7| 8| 7| 7| 7| 7| 8| 8| 9| 8| 9| 4| 5| 5| 6| 6| 5| 5| 2| 4| L |
MG/KG/DY | 6| 3| 1| 3| 0| 9| 4| 6| 7| 1| 4| 2| 8| 2| 7| 4| 4| 0| 7| 0| 4| 4| 9| 1| 5| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X X | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X X X X X X X X X| 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 0| 1| 9| 2| 4| 5| 6| 9| 0| 1| 1| 4| 7| 7| 7| 7| 0| 0| 2| 3| 3| 4| 5| 5| 6|
| 7| 9| 0| 6| 1| 0| 9| 5| 2| 2| 7| 1| 2| 5| 5| 6| 0| 0| 1| 6| 9| 9| 6| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 4| 6| 6| 4| 6| 4| 6| 6| 6| 7| 4| 5| 6| 6| 4| 4| 4| 7| 5| 4| 4| 4| 4| 5|
50 | 1| 8| 1| 0| 8| 1| 7| 1| 0| 0| 3| 8| 9| 0| 1| 8| 7| 8| 3| 9| 8| 9| 8| 9| 9|
MG/KG/DY | 4| 5| 3| 0| 9| 1| 1| 6| 8| 6| 1| 3| 6| 7| 7| 2| 2| 4| 3| 9| 8| 1| 1| 0| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + A + + A + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + A + + M + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X |
Osteosarcoma, Metastatic, Bone | |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Mesentery | + + + + |
Fibrosarcoma, Metastatic, Skin | |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 11
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 0| 1| 9| 2| 4| 5| 6| 9| 0| 1| 1| 4| 7| 7| 7| 7| 0| 0| 2| 3| 3| 4| 5| 5| 6|
| 7| 9| 0| 6| 1| 0| 9| 5| 2| 2| 7| 1| 2| 5| 5| 6| 0| 0| 1| 6| 9| 9| 6| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 4| 6| 6| 4| 6| 4| 6| 6| 6| 7| 4| 5| 6| 6| 4| 4| 4| 7| 5| 4| 4| 4| 4| 5|
50 | 1| 8| 1| 0| 8| 1| 7| 1| 0| 0| 3| 8| 9| 0| 1| 8| 7| 8| 3| 9| 8| 9| 8| 9| 9|
MG/KG/DY | 4| 5| 3| 0| 9| 1| 1| 6| 8| 6| 1| 3| 6| 7| 7| 2| 2| 4| 3| 9| 8| 1| 1| 0| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + M + + + + + + + + + + + + + + + + + + + + + +|
Plasma Cell Tumor Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Plasma Cell Tumor Malignant | X |
Subcapsular, Adenoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + M + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | |
Pars Intermedia, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Luteoma | |
__________________________________________|__________________________________________________________________________|
Page 12
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 0| 1| 9| 2| 4| 5| 6| 9| 0| 1| 1| 4| 7| 7| 7| 7| 0| 0| 2| 3| 3| 4| 5| 5| 6|
| 7| 9| 0| 6| 1| 0| 9| 5| 2| 2| 7| 1| 2| 5| 5| 6| 0| 0| 1| 6| 9| 9| 6| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 4| 6| 6| 4| 6| 4| 6| 6| 6| 7| 4| 5| 6| 6| 4| 4| 4| 7| 5| 4| 4| 4| 4| 5|
50 | 1| 8| 1| 0| 8| 1| 7| 1| 0| 0| 3| 8| 9| 0| 1| 8| 7| 8| 3| 9| 8| 9| 8| 9| 9|
MG/KG/DY | 4| 5| 3| 0| 9| 1| 1| 6| 8| 6| 1| 3| 6| 7| 7| 2| 2| 4| 3| 9| 8| 1| 1| 0| 7|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Leiomyoma | |
Polyp Stromal | |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Plasma Cell Tumor Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Iliac, Histiocytic Sarcoma | X |
Mediastinal, Plasma Cell Tumor | |
Malignant | X X |
Renal, Histiocytic Sarcoma | X |
Renal, Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + I + + + +|
Histiocytic Sarcoma | X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + M + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Osteosarcoma, Metastatic, Bone | |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 0| 1| 9| 2| 4| 5| 6| 9| 0| 1| 1| 4| 7| 7| 7| 7| 0| 0| 2| 3| 3| 4| 5| 5| 6|
| 7| 9| 0| 6| 1| 0| 9| 5| 2| 2| 7| 1| 2| 5| 5| 6| 0| 0| 1| 6| 9| 9| 6| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 4| 6| 6| 4| 6| 4| 6| 6| 6| 7| 4| 5| 6| 6| 4| 4| 4| 7| 5| 4| 4| 4| 4| 5|
50 | 1| 8| 1| 0| 8| 1| 7| 1| 0| 0| 3| 8| 9| 0| 1| 8| 7| 8| 3| 9| 8| 9| 8| 9| 9|
MG/KG/DY | 4| 5| 3| 0| 9| 1| 1| 6| 8| 6| 1| 3| 6| 7| 7| 2| 2| 4| 3| 9| 8| 1| 1| 0| 7|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Thymus | M M M + + + + + + + + + + + + + + + + M + + + + M|
Histiocytic Sarcoma | X |
Plasma Cell Tumor Malignant | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteoma | |
Osteosarcoma | |
|__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + M + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 0| 1| 9| 2| 4| 5| 6| 9| 0| 1| 1| 4| 7| 7| 7| 7| 0| 0| 2| 3| 3| 4| 5| 5| 6|
| 7| 9| 0| 6| 1| 0| 9| 5| 2| 2| 7| 1| 2| 5| 5| 6| 0| 0| 1| 6| 9| 9| 6| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 4| 6| 6| 4| 6| 4| 6| 6| 6| 7| 4| 5| 6| 6| 4| 4| 4| 7| 5| 4| 4| 4| 4| 5|
50 | 1| 8| 1| 0| 8| 1| 7| 1| 0| 0| 3| 8| 9| 0| 1| 8| 7| 8| 3| 9| 8| 9| 8| 9| 9|
MG/KG/DY | 4| 5| 3| 0| 9| 1| 1| 6| 8| 6| 1| 3| 6| 7| 7| 2| 2| 4| 3| 9| 8| 1| 1| 0| 7|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | X|
Osteosarcoma, Metastatic, Bone | |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X X X|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 6| 7| 7| 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 0| 5| 7| 7| 0| 4| 5| 8| 8| 9| 1| 1| 2| 2| 5| 5| 6| 7| 7| 7| 7| 7| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 4| 4| 4| 6| 5| 5| 6| 7| 7| 6| 6| 6| 6| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| A |
50 | 1| 8| 7| 7| 1| 9| 9| 1| 3| 3| 0| 0| 0| 0| 7| 7| 8| 6| 7| 7| 8| 2| 7| 6| 9| L |
MG/KG/DY | 5| 7| 3| 8| 0| 3| 4| 2| 5| 6| 2| 3| 5| 9| 4| 5| 6| 8| 7| 9| 0| 4| 6| 9| 2| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X | 1 |
Hepatocellular Adenoma | X X X | 3 |
Hepatocellular Adenoma, Multiple | X| 1 |
Histiocytic Sarcoma | | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 6| 7| 7| 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 0| 5| 7| 7| 0| 4| 5| 8| 8| 9| 1| 1| 2| 2| 5| 5| 6| 7| 7| 7| 7| 7| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 4| 4| 4| 6| 5| 5| 6| 7| 7| 6| 6| 6| 6| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| A |
50 | 1| 8| 7| 7| 1| 9| 9| 1| 3| 3| 0| 0| 0| 0| 7| 7| 8| 6| 7| 7| 8| 2| 7| 6| 9| L |
MG/KG/DY | 5| 7| 3| 8| 0| 3| 4| 2| 5| 6| 2| 3| 5| 9| 4| 5| 6| 8| 7| 9| 0| 4| 6| 9| 2| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Plasma Cell Tumor Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Plasma Cell Tumor Malignant | | 1 |
Subcapsular, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + M + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Adenoma | X| 1 |
Pars Intermedia, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 6| 7| 7| 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 0| 5| 7| 7| 0| 4| 5| 8| 8| 9| 1| 1| 2| 2| 5| 5| 6| 7| 7| 7| 7| 7| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 4| 4| 4| 6| 5| 5| 6| 7| 7| 6| 6| 6| 6| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| A |
50 | 1| 8| 7| 7| 1| 9| 9| 1| 3| 3| 0| 0| 0| 0| 7| 7| 8| 6| 7| 7| 8| 2| 7| 6| 9| L |
MG/KG/DY | 5| 7| 3| 8| 0| 3| 4| 2| 5| 6| 2| 3| 5| 9| 4| 5| 6| 8| 7| 9| 0| 4| 6| 9| 2| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cystadenoma | X | 1 |
Luteoma | X | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | X | 1 |
Leiomyoma | X | 1 |
Polyp Stromal | X | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Plasma Cell Tumor Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + +| 23 |
Histiocytic Sarcoma | | 1 |
Iliac, Histiocytic Sarcoma | | 1 |
Mediastinal, Plasma Cell Tumor | | |
Malignant | | 2 |
Renal, Histiocytic Sarcoma | | 1 |
Renal, Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + I +| 47 |
Histiocytic Sarcoma | | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 6| 7| 7| 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 0| 5| 7| 7| 0| 4| 5| 8| 8| 9| 1| 1| 2| 2| 5| 5| 6| 7| 7| 7| 7| 7| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 4| 4| 4| 6| 5| 5| 6| 7| 7| 6| 6| 6| 6| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| A |
50 | 1| 8| 7| 7| 1| 9| 9| 1| 3| 3| 0| 0| 0| 0| 7| 7| 8| 6| 7| 7| 8| 2| 7| 6| 9| L |
MG/KG/DY | 5| 7| 3| 8| 0| 3| 4| 2| 5| 6| 2| 3| 5| 9| 4| 5| 6| 8| 7| 9| 0| 4| 6| 9| 2| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Histiocytic Sarcoma | | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + I + +| 44 |
Histiocytic Sarcoma | | 1 |
Plasma Cell Tumor Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X X | 2 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Papilloma | X| 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
Subcutaneous Tissue, Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteoma | X | 1 |
Osteosarcoma | X | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 6| 7| 7| 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 0| 5| 7| 7| 0| 4| 5| 8| 8| 9| 1| 1| 2| 2| 5| 5| 6| 7| 7| 7| 7| 7| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 4| 4| 4| 6| 5| 5| 6| 7| 7| 6| 6| 6| 6| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| A |
50 | 1| 8| 7| 7| 1| 9| 9| 1| 3| 3| 0| 0| 0| 0| 7| 7| 8| 6| 7| 7| 8| 2| 7| 6| 9| L |
MG/KG/DY | 5| 7| 3| 8| 0| 3| 4| 2| 5| 6| 2| 3| 5| 9| 4| 5| 6| 8| 7| 9| 0| 4| 6| 9| 2| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 5 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X X X | 3 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X X X| 3 |
Alveolar/Bronchiolar Carcinoma | X X X X X | 6 |
Osteosarcoma, Metastatic, Bone | X | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X X X X X X| 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 6| 7| 7| 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 0| 5| 7| 7| 0| 4| 5| 8| 8| 9| 1| 1| 2| 2| 5| 5| 6| 7| 7| 7| 7| 7| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 4| 4| 4| 6| 5| 5| 6| 7| 7| 6| 6| 6| 6| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| A |
50 | 1| 8| 7| 7| 1| 9| 9| 1| 3| 3| 0| 0| 0| 0| 7| 7| 8| 6| 7| 7| 8| 2| 7| 6| 9| L |
MG/KG/DY | 5| 7| 3| 8| 0| 3| 4| 2| 5| 6| 2| 3| 5| 9| 4| 5| 6| 8| 7| 9| 0| 4| 6| 9| 2| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X X X X X X X X X | 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 8| 3| 2| 2| 3| 6| 2| 3| 6| 9| 9| 1| 2| 3| 7| 8| 9| 1| 1| 2| 3| 4| 5| 5|
| 1| 2| 7| 2| 8| 2| 2| 5| 2| 0| 0| 5| 4| 4| 7| 4| 5| 0| 2| 9| 1| 1| 0| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 6| 6| 4| 6| 6| 5| 4| 6| 6| 4| 6| 6| 4| 6| 5| 5| 5| 5| 6| 7| 6| 5|
100 | 0| 0| 1| 3| 3| 9| 2| 2| 1| 9| 3| 2| 9| 3| 2| 9| 3| 0| 0| 0| 1| 4| 2| 2| 1|
MG/KG/DY | 8| 6| 1| 7| 1| 9| 0| 2| 0| 8| 5| 9| 7| 3| 3| 3| 9| 0| 1| 9| 7| 0| 9| 8| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + A + A + + + + + + + + + + A A + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + A A + + + + + + + + + + + A + A + + A + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + M + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + + + A + + + + + + + A + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + A + + + + + + + M + + + + M + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Hemangiosarcoma | |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Mesentery | + + + + |
Hemangioma | X |
|__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
|__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 22
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 8| 3| 2| 2| 3| 6| 2| 3| 6| 9| 9| 1| 2| 3| 7| 8| 9| 1| 1| 2| 3| 4| 5| 5|
| 1| 2| 7| 2| 8| 2| 2| 5| 2| 0| 0| 5| 4| 4| 7| 4| 5| 0| 2| 9| 1| 1| 0| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 6| 6| 4| 6| 6| 5| 4| 6| 6| 4| 6| 6| 4| 6| 5| 5| 5| 5| 6| 7| 6| 5|
100 | 0| 0| 1| 3| 3| 9| 2| 2| 1| 9| 3| 2| 9| 3| 2| 9| 3| 0| 0| 0| 1| 4| 2| 2| 1|
MG/KG/DY | 8| 6| 1| 7| 1| 9| 0| 2| 0| 8| 5| 9| 7| 3| 3| 3| 9| 0| 1| 9| 7| 0| 9| 8| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Plasma Cell Tumor Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + A + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X|
Plasma Cell Tumor Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 8| 3| 2| 2| 3| 6| 2| 3| 6| 9| 9| 1| 2| 3| 7| 8| 9| 1| 1| 2| 3| 4| 5| 5|
| 1| 2| 7| 2| 8| 2| 2| 5| 2| 0| 0| 5| 4| 4| 7| 4| 5| 0| 2| 9| 1| 1| 0| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 6| 6| 4| 6| 6| 5| 4| 6| 6| 4| 6| 6| 4| 6| 5| 5| 5| 5| 6| 7| 6| 5|
100 | 0| 0| 1| 3| 3| 9| 2| 2| 1| 9| 3| 2| 9| 3| 2| 9| 3| 0| 0| 0| 1| 4| 2| 2| 1|
MG/KG/DY | 8| 6| 1| 7| 1| 9| 0| 2| 0| 8| 5| 9| 7| 3| 3| 3| 9| 0| 1| 9| 7| 0| 9| 8| 3|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Sertoli Cell Tumor Benign | |
|__________________________________________________________________________|
Uterus | + + + A + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
Leiomyosarcoma | X |
Polyp Stromal | |
|__________________________________________________________________________|
Vagina | + + M A + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Plasma Cell Tumor Malignant | X |
Deep Cervical, Plasma Cell Tumor | |
Malignant | X |
Iliac, Plasma Cell Tumor Malignant | X |
Inguinal, Plasma Cell Tumor Malignant| X |
Mediastinal, Histiocytic Sarcoma | X |
Mediastinal, Plasma Cell Tumor | |
Malignant | X |
Pancreatic, Hemangioma | |
Pancreatic, Plasma Cell Tumor | |
Malignant | X |
Popliteal, Plasma Cell Tumor | |
Malignant | X |
Renal, Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Histiocytic Sarcoma | X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + M + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 8| 3| 2| 2| 3| 6| 2| 3| 6| 9| 9| 1| 2| 3| 7| 8| 9| 1| 1| 2| 3| 4| 5| 5|
| 1| 2| 7| 2| 8| 2| 2| 5| 2| 0| 0| 5| 4| 4| 7| 4| 5| 0| 2| 9| 1| 1| 0| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 6| 6| 4| 6| 6| 5| 4| 6| 6| 4| 6| 6| 4| 6| 5| 5| 5| 5| 6| 7| 6| 5|
100 | 0| 0| 1| 3| 3| 9| 2| 2| 1| 9| 3| 2| 9| 3| 2| 9| 3| 0| 0| 0| 1| 4| 2| 2| 1|
MG/KG/DY | 8| 6| 1| 7| 1| 9| 0| 2| 0| 8| 5| 9| 7| 3| 3| 3| 9| 0| 1| 9| 7| 0| 9| 8| 3|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Thymus | + + + + + M + M + + + + + + M + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Histiocytic Sarcoma | X |
Plasma Cell Tumor Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
|__________________________________________________________________________|
Skin | + + + A + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
|__________________________________________________________________________|
Peripheral Nerve | + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 8| 8| 3| 2| 2| 3| 6| 2| 3| 6| 9| 9| 1| 2| 3| 7| 8| 9| 1| 1| 2| 3| 4| 5| 5|
| 1| 2| 7| 2| 8| 2| 2| 5| 2| 0| 0| 5| 4| 4| 7| 4| 5| 0| 2| 9| 1| 1| 0| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 6| 6| 4| 6| 6| 5| 4| 6| 6| 4| 6| 6| 4| 6| 5| 5| 5| 5| 6| 7| 6| 5|
100 | 0| 0| 1| 3| 3| 9| 2| 2| 1| 9| 3| 2| 9| 3| 2| 9| 3| 0| 0| 0| 1| 4| 2| 2| 1|
MG/KG/DY | 8| 6| 1| 7| 1| 9| 0| 2| 0| 8| 5| 9| 7| 3| 3| 3| 9| 0| 1| 9| 7| 0| 9| 8| 3|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Carcinoma, Metastatic, Harderian | |
Gland | X |
Carcinoma, Metastatic, Mammary Gland | X |
Histiocytic Sarcoma | X |
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Plasma Cell Tumor Malignant | X |
|__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Granulocytic | X |
Lymphoma Malignant | X X X X X |
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 6| 8| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 5| 5| 5| 5| 7| 7| 8| 8| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 7| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 6| 4| 4| 5| 5| 4| 5| 5| 5| 5| 5| 5| A |
100 | 2| 3| 1| 4| 2| 2| 2| 3| 3| 2| 3| 4| 3| 3| 9| 9| 0| 0| 9| 0| 0| 0| 1| 1| 1| L |
MG/KG/DY | 4| 7| 9| 2| 1| 5| 7| 2| 8| 6| 6| 1| 9| 4| 4| 6| 3| 4| 5| 7| 2| 5| 4| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Hemangiosarcoma | X | 1 |
Hepatocellular Adenoma | X X| 4 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Hemangioma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 6| 8| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 5| 5| 5| 5| 7| 7| 8| 8| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 7| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 6| 4| 4| 5| 5| 4| 5| 5| 5| 5| 5| 5| A |
100 | 2| 3| 1| 4| 2| 2| 2| 3| 3| 2| 3| 4| 3| 3| 9| 9| 0| 0| 9| 0| 0| 0| 1| 1| 1| L |
MG/KG/DY | 4| 7| 9| 2| 1| 5| 7| 2| 8| 6| 6| 1| 9| 4| 4| 6| 3| 4| 5| 7| 2| 5| 4| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Squamous Cell Papilloma | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Plasma Cell Tumor Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Adenoma | | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 6| 8| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 5| 5| 5| 5| 7| 7| 8| 8| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 7| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 6| 4| 4| 5| 5| 4| 5| 5| 5| 5| 5| 5| A |
100 | 2| 3| 1| 4| 2| 2| 2| 3| 3| 2| 3| 4| 3| 3| 9| 9| 0| 0| 9| 0| 0| 0| 1| 1| 1| L |
MG/KG/DY | 4| 7| 9| 2| 1| 5| 7| 2| 8| 6| 6| 1| 9| 4| 4| 6| 3| 4| 5| 7| 2| 5| 4| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cystadenoma | X | 2 |
Plasma Cell Tumor Malignant | | 1 |
Sertoli Cell Tumor Benign | X | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leiomyoma | X | 1 |
Leiomyosarcoma | | 1 |
Polyp Stromal | X| 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 16 |
Plasma Cell Tumor Malignant | | 1 |
Deep Cervical, Plasma Cell Tumor | | |
Malignant | | 1 |
Iliac, Plasma Cell Tumor Malignant | | 1 |
Inguinal, Plasma Cell Tumor Malignant| | 1 |
Mediastinal, Histiocytic Sarcoma | | 1 |
Mediastinal, Plasma Cell Tumor | | |
Malignant | | 1 |
Pancreatic, Hemangioma | X | 1 |
Pancreatic, Plasma Cell Tumor | | |
Malignant | | 1 |
Popliteal, Plasma Cell Tumor | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 6| 8| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 5| 5| 5| 5| 7| 7| 8| 8| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 7| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 6| 4| 4| 5| 5| 4| 5| 5| 5| 5| 5| 5| A |
100 | 2| 3| 1| 4| 2| 2| 2| 3| 3| 2| 3| 4| 3| 3| 9| 9| 0| 0| 9| 0| 0| 0| 1| 1| 1| L |
MG/KG/DY | 4| 7| 9| 2| 1| 5| 7| 2| 8| 6| 6| 1| 9| 4| 4| 6| 3| 4| 5| 7| 2| 5| 4| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Malignant | | 1 |
Renal, Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + M + + + + + +| 46 |
Histiocytic Sarcoma | | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 1 |
Plasma Cell Tumor Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 6| 8| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 5| 5| 5| 5| 7| 7| 8| 8| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 7| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 6| 4| 4| 5| 5| 4| 5| 5| 5| 5| 5| 5| A |
100 | 2| 3| 1| 4| 2| 2| 2| 3| 3| 2| 3| 4| 3| 3| 9| 9| 0| 0| 9| 0| 0| 0| 1| 1| 1| L |
MG/KG/DY | 4| 7| 9| 2| 1| 5| 7| 2| 8| 6| 6| 1| 9| 4| 4| 6| 3| 4| 5| 7| 2| 5| 4| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X | 7 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X X X X X X | 6 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 2 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
Histiocytic Sarcoma | | 1 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 6| 8| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 5| 5| 5| 5| 7| 7| 8| 8| 8| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 7| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 6| 4| 4| 5| 5| 4| 5| 5| 5| 5| 5| 5| A |
100 | 2| 3| 1| 4| 2| 2| 2| 3| 3| 2| 3| 4| 3| 3| 9| 9| 0| 0| 9| 0| 0| 0| 1| 1| 1| L |
MG/KG/DY | 4| 7| 9| 2| 1| 5| 7| 2| 8| 6| 6| 1| 9| 4| 4| 6| 3| 4| 5| 7| 2| 5| 4| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 2 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X X X X X X | 9 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Plasma Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X X X X X X X X X X X X X X| 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 5| 1| 8| 9| 1| 1| 2| 3| 3| 4| 6| 6| 7| 0| 0| 1| 4| 4| 6| 6| 6| 6| 6| 6| 7|
| 9| 4| 8| 7| 0| 0| 3| 0| 9| 1| 1| 5| 2| 3| 8| 4| 1| 6| 2| 7| 8| 9| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 2| 5| 4| 2| 4| 6| 4| 5| 3| 2| 6| 2| 5| 3| 1| 6| 5| 5| 5| 5| 6| 4| 5| 6| 4|
MG/KG/DY | 4| 4| 7| 6| 9| 4| 5| 5| 2| 5| 0| 3| 7| 0| 8| 2| 9| 1| 2| 3| 1| 4| 6| 3| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Mesentery | + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 5| 1| 8| 9| 1| 1| 2| 3| 3| 4| 6| 6| 7| 0| 0| 1| 4| 4| 6| 6| 6| 6| 6| 6| 7|
| 9| 4| 8| 7| 0| 0| 3| 0| 9| 1| 1| 5| 2| 3| 8| 4| 1| 6| 2| 7| 8| 9| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 2| 5| 4| 2| 4| 6| 4| 5| 3| 2| 6| 2| 5| 3| 1| 6| 5| 5| 5| 5| 6| 4| 5| 6| 4|
MG/KG/DY | 4| 4| 7| 6| 9| 4| 5| 5| 2| 5| 0| 3| 7| 0| 8| 2| 9| 1| 2| 3| 1| 4| 6| 3| 3|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X X |
Hemangioma | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Histiocytic Sarcoma | X |
Polyp Stromal | |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 5| 1| 8| 9| 1| 1| 2| 3| 3| 4| 6| 6| 7| 0| 0| 1| 4| 4| 6| 6| 6| 6| 6| 6| 7|
| 9| 4| 8| 7| 0| 0| 3| 0| 9| 1| 1| 5| 2| 3| 8| 4| 1| 6| 2| 7| 8| 9| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 2| 5| 4| 2| 4| 6| 4| 5| 3| 2| 6| 2| 5| 3| 1| 6| 5| 5| 5| 5| 6| 4| 5| 6| 4|
MG/KG/DY | 4| 4| 7| 6| 9| 4| 5| 5| 2| 5| 0| 3| 7| 0| 8| 2| 9| 1| 2| 3| 1| 4| 6| 3| 3|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + M + + M M + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteoma | |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 5| 1| 8| 9| 1| 1| 2| 3| 3| 4| 6| 6| 7| 0| 0| 1| 4| 4| 6| 6| 6| 6| 6| 6| 7|
| 9| 4| 8| 7| 0| 0| 3| 0| 9| 1| 1| 5| 2| 3| 8| 4| 1| 6| 2| 7| 8| 9| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 2| 5| 4| 2| 4| 6| 4| 5| 3| 2| 6| 2| 5| 3| 1| 6| 5| 5| 5| 5| 6| 4| 5| 6| 4|
MG/KG/DY | 4| 4| 7| 6| 9| 4| 5| 5| 2| 5| 0| 3| 7| 0| 8| 2| 9| 1| 2| 3| 1| 4| 6| 3| 3|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X |
Granulosa Cell Tumor Malignant, | |
Metastatic, Lung | X |
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 0| 1| 1| 2| 2| 5| 5| 5| 6| 7| 7| 7| 8| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
200 | 5| 4| 5| 4| 6| 2| 3| 3| 2| 2| 2| 2| 2| 1| 3| | L |
MG/KG/DY | 0| 6| 8| 8| 5| 2| 1| 4| 0| 1| 7| 8| 9| 9| 3| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + | 38 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
Hepatocellular Adenoma | X | 2 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + | 3 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 0| 1| 1| 2| 2| 5| 5| 5| 6| 7| 7| 7| 8| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
200 | 5| 4| 5| 4| 6| 2| 3| 3| 2| 2| 2| 2| 2| 1| 3| | L |
MG/KG/DY | 0| 6| 8| 8| 5| 2| 1| 4| 0| 1| 7| 8| 9| 9| 3| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Heart | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + M + M + + + + | 38 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + M + M + + + + | 38 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 40 |
Pars Distalis, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 40 |
Granulosa Cell Tumor Malignant | | 2 |
Hemangioma | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 40 |
Hemangioma | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 0| 1| 1| 2| 2| 5| 5| 5| 6| 7| 7| 7| 8| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
200 | 5| 4| 5| 4| 6| 2| 3| 3| 2| 2| 2| 2| 2| 1| 3| | L |
MG/KG/DY | 0| 6| 8| 8| 5| 2| 1| 4| 0| 1| 7| 8| 9| 9| 3| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Histiocytic Sarcoma | X | 2 |
Polyp Stromal | X | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + | 36 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 40 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 40 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 0| 1| 1| 2| 2| 5| 5| 5| 6| 7| 7| 7| 8| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
200 | 5| 4| 5| 4| 6| 2| 3| 3| 2| 2| 2| 2| 2| 1| 3| | L |
MG/KG/DY | 0| 6| 8| 8| 5| 2| 1| 4| 0| 1| 7| 8| 9| 9| 3| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Bone | + + + + + + + + + + + + + + + | 40 |
Osteoma | X | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 5 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Alveolar/Bronchiolar Adenoma | X X | 4 |
Alveolar/Bronchiolar Carcinoma | X X | 4 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X X | 4 |
Granulosa Cell Tumor Malignant, | | |
Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 0| 1| 1| 2| 2| 5| 5| 5| 6| 7| 7| 7| 8| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
200 | 5| 4| 5| 4| 6| 2| 3| 3| 2| 2| 2| 2| 2| 1| 3| | L |
MG/KG/DY | 0| 6| 8| 8| 5| 2| 1| 4| 0| 1| 7| 8| 9| 9| 3| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 40 |
Adenoma | X X X | 4 |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 40 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 40 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant | X X X X X X | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 0| 0| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
DAY ON TEST | 4| 4| 0| 2| 3| 1| 5| 5| 6| 7| 7| 8| 8| 3| 3| 6| 8| 8| 9| 9| 9| 4| 4| 6| 6|
| 3| 9| 7| 5| 2| 2| 3| 5| 7| 4| 9| 2| 2| 0| 9| 5| 0| 5| 3| 3| 8| 1| 5| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 6| 6|
300 | 6| 5| 4| 7| 4| 4| 6| 5| 6| 6| 4| 5| 6| 5| 6| 6| 6| 7| 4| 5| 6| 5| 4| 7| 7|
MG/KG/DY | 8| 0| 5| 8| 8| 6| 5| 9| 4| 3| 4| 8| 6| 3| 7| 9| 2| 1| 7| 7| 1| 5| 9| 5| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + I + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + M + + +|
Leiomyosarcoma | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + A + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X|
|__________________________________________________________________________|
Mesentery | + +|
Histiocytic Sarcoma | X|
|__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoid Tumor Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 0| 0| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
DAY ON TEST | 4| 4| 0| 2| 3| 1| 5| 5| 6| 7| 7| 8| 8| 3| 3| 6| 8| 8| 9| 9| 9| 4| 4| 6| 6|
| 3| 9| 7| 5| 2| 2| 3| 5| 7| 4| 9| 2| 2| 0| 9| 5| 0| 5| 3| 3| 8| 1| 5| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 6| 6|
300 | 6| 5| 4| 7| 4| 4| 6| 5| 6| 6| 4| 5| 6| 5| 6| 6| 6| 7| 4| 5| 6| 5| 4| 7| 7|
MG/KG/DY | 8| 0| 5| 8| 8| 6| 5| 9| 4| 3| 4| 8| 6| 3| 7| 9| 2| 1| 7| 7| 1| 5| 9| 5| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Malignant | |
Hemangiosarcoma | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 0| 0| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
DAY ON TEST | 4| 4| 0| 2| 3| 1| 5| 5| 6| 7| 7| 8| 8| 3| 3| 6| 8| 8| 9| 9| 9| 4| 4| 6| 6|
| 3| 9| 7| 5| 2| 2| 3| 5| 7| 4| 9| 2| 2| 0| 9| 5| 0| 5| 3| 3| 8| 1| 5| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 6| 6|
300 | 6| 5| 4| 7| 4| 4| 6| 5| 6| 6| 4| 5| 6| 5| 6| 6| 6| 7| 4| 5| 6| 5| 4| 7| 7|
MG/KG/DY | 8| 0| 5| 8| 8| 6| 5| 9| 4| 3| 4| 8| 6| 3| 7| 9| 2| 1| 7| 7| 1| 5| 9| 5| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Vagina | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Mediastinal, Histiocytic Sarcoma | X|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 0| 0| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
DAY ON TEST | 4| 4| 0| 2| 3| 1| 5| 5| 6| 7| 7| 8| 8| 3| 3| 6| 8| 8| 9| 9| 9| 4| 4| 6| 6|
| 3| 9| 7| 5| 2| 2| 3| 5| 7| 4| 9| 2| 2| 0| 9| 5| 0| 5| 3| 3| 8| 1| 5| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 6| 6|
300 | 6| 5| 4| 7| 4| 4| 6| 5| 6| 6| 4| 5| 6| 5| 6| 6| 6| 7| 4| 5| 6| 5| 4| 7| 7|
MG/KG/DY | 8| 0| 5| 8| 8| 6| 5| 9| 4| 3| 4| 8| 6| 3| 7| 9| 2| 1| 7| 7| 1| 5| 9| 5| 9|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + M + + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Hemangiosarcoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + M|
|__________________________________________________________________________|
Harderian Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X X|
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________|__________________________________________________________________________
| 0| 0| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
DAY ON TEST | 4| 4| 0| 2| 3| 1| 5| 5| 6| 7| 7| 8| 8| 3| 3| 6| 8| 8| 9| 9| 9| 4| 4| 6| 6|
| 3| 9| 7| 5| 2| 2| 3| 5| 7| 4| 9| 2| 2| 0| 9| 5| 0| 5| 3| 3| 8| 1| 5| 8| 8|
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 6| 6|
300 | 6| 5| 4| 7| 4| 4| 6| 5| 6| 6| 4| 5| 6| 5| 6| 6| 6| 7| 4| 5| 6| 5| 4| 7| 7|
MG/KG/DY | 8| 0| 5| 8| 8| 6| 5| 9| 4| 3| 4| 8| 6| 3| 7| 9| 2| 1| 7| 7| 1| 5| 9| 5| 9|
_____________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | |
| |
Leukemia Granulocytic | X |
Lymphoma Malignant | X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 6| 7| 7| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| | A |
300 | 5| 7| 7| 6| 7| 7| 6| 8| 8| 8| 7| 7| 6| 5| 5| 4| 5| | L |
MG/KG/DY | 6| 2| 3| 9| 0| 7| 8| 0| 1| 2| 4| 6| 0| 1| 4| 3| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + M + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | I + + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + | 40 |
Leiomyosarcoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + | 40 |
Histiocytic Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 42 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Adenoma | X X | 2 |
Hepatocellular Adenoma, Multiple | X | 2 |
Histiocytic Sarcoma | X | 2 |
|__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 41 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 6| 7| 7| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| | A |
300 | 5| 7| 7| 6| 7| 7| 6| 8| 8| 8| 7| 7| 6| 5| 5| 4| 5| | L |
MG/KG/DY | 6| 2| 3| 9| 0| 7| 8| 0| 1| 2| 4| 6| 0| 1| 4| 3| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 42 |
Carcinoid Tumor Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + | 41 |
Adenoma | X | 2 |
|__________________________________________________________________________|____________|
Parathyroid Gland | I + + + + + M + + + + + + + + + M | 36 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 42 |
Pars Distalis, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 6| 7| 7| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| | A |
300 | 5| 7| 7| 6| 7| 7| 6| 8| 8| 8| 7| 7| 6| 5| 5| 4| 5| | L |
MG/KG/DY | 6| 2| 3| 9| 0| 7| 8| 0| 1| 2| 4| 6| 0| 1| 4| 3| 2| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Ovary | + + + + + + + + + + + + + + + + + | 42 |
Cystadenoma | | 1 |
Granulosa Cell Tumor Malignant | X | 1 |
Hemangiosarcoma | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + | 42 |
Polyp Stromal | X | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + | 41 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 42 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 16 |
Mediastinal, Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + | 42 |
Histiocytic Sarcoma | X | 2 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 42 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + | 42 |
Histiocytic Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 6| 7| 7| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| | A |
300 | 5| 7| 7| 6| 7| 7| 6| 8| 8| 8| 7| 7| 6| 5| 5| 4| 5| | L |
MG/KG/DY | 6| 2| 3| 9| 0| 7| 8| 0| 1| 2| 4| 6| 0| 1| 4| 3| 2| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 6 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 42 |
Alveolar/Bronchiolar Adenoma | X X X X X | 7 |
Alveolar/Bronchiolar Carcinoma | X X | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X X | 2 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 6| 7| 7| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| | A |
300 | 5| 7| 7| 6| 7| 7| 6| 8| 8| 8| 7| 7| 6| 5| 5| 4| 5| | L |
MG/KG/DY | 6| 2| 3| 9| 0| 7| 8| 0| 1| 2| 4| 6| 0| 1| 4| 3| 2| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 2 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + | 41 |
Adenoma | X X | 7 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + | 42 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + | 42 |
Histiocytic Sarcoma | X | 2 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | X X X X X X X X X X | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6|
DAY ON TEST | 0| 1| 0| 2| 2| 2| 7| 9| 1| 1| 4| 5| 6| 7| 8| 8| 9| 3| 3| 6| 6| 6| 0| 0| 1|
| 4| 1| 8| 2| 9| 9| 3| 2| 3| 8| 6| 3| 3| 5| 6| 8| 7| 2| 8| 0| 5| 7| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 3| 2| 2| 3| 2| 3| 2| 3| 1| 3| 3| 2| 7| 2| 3| 2| 3| 3| 3| 3| 2| 3|
0 | 1| 9| 9| 2| 0| 1| 3| 0| 2| 1| 3| 9| 3| 4| 0| 1| 1| 3| 0| 2| 1| 3| 2| 1| 2|
MG/KG/DY | 6| 7| 8| 0| 9| 0| 1| 5| 5| 5| 4| 9| 0| 1| 4| 2| 7| 5| 0| 3| 9| 3| 9| 1| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + A + + A + + M + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Polyp Adenomatous | X |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X X X|
Hepatoblastoma | X |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X X|
Hepatocellular Adenoma, Multiple | |
|__________________________________________________________________________|
Mesentery | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6|
DAY ON TEST | 0| 1| 0| 2| 2| 2| 7| 9| 1| 1| 4| 5| 6| 7| 8| 8| 9| 3| 3| 6| 6| 6| 0| 0| 1|
| 4| 1| 8| 2| 9| 9| 3| 2| 3| 8| 6| 3| 3| 5| 6| 8| 7| 2| 8| 0| 5| 7| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 3| 2| 2| 3| 2| 3| 2| 3| 1| 3| 3| 2| 7| 2| 3| 2| 3| 3| 3| 3| 2| 3|
0 | 1| 9| 9| 2| 0| 1| 3| 0| 2| 1| 3| 9| 3| 4| 0| 1| 1| 3| 0| 2| 1| 3| 2| 1| 2|
MG/KG/DY | 6| 7| 8| 0| 9| 0| 1| 5| 5| 5| 4| 9| 0| 1| 4| 2| 7| 5| 0| 3| 9| 3| 9| 1| 8|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + I + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Brain | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6|
DAY ON TEST | 0| 1| 0| 2| 2| 2| 7| 9| 1| 1| 4| 5| 6| 7| 8| 8| 9| 3| 3| 6| 6| 6| 0| 0| 1|
| 4| 1| 8| 2| 9| 9| 3| 2| 3| 8| 6| 3| 3| 5| 6| 8| 7| 2| 8| 0| 5| 7| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 3| 2| 2| 3| 2| 3| 2| 3| 1| 3| 3| 2| 7| 2| 3| 2| 3| 3| 3| 3| 2| 3|
0 | 1| 9| 9| 2| 0| 1| 3| 0| 2| 1| 3| 9| 3| 4| 0| 1| 1| 3| 0| 2| 1| 3| 2| 1| 2|
MG/KG/DY | 6| 7| 8| 0| 9| 0| 1| 5| 5| 5| 4| 9| 0| 1| 4| 2| 7| 5| 0| 3| 9| 3| 9| 1| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cranial Nerve, Schwannoma Malignant | |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6|
DAY ON TEST | 0| 1| 0| 2| 2| 2| 7| 9| 1| 1| 4| 5| 6| 7| 8| 8| 9| 3| 3| 6| 6| 6| 0| 0| 1|
| 4| 1| 8| 2| 9| 9| 3| 2| 3| 8| 6| 3| 3| 5| 6| 8| 7| 2| 8| 0| 5| 7| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 3| 2| 2| 3| 2| 3| 2| 3| 1| 3| 3| 2| 7| 2| 3| 2| 3| 3| 3| 3| 2| 3|
0 | 1| 9| 9| 2| 0| 1| 3| 0| 2| 1| 3| 9| 3| 4| 0| 1| 1| 3| 0| 2| 1| 3| 2| 1| 2|
MG/KG/DY | 6| 7| 8| 0| 9| 0| 1| 5| 5| 5| 4| 9| 0| 1| 4| 2| 7| 5| 0| 3| 9| 3| 9| 1| 8|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ureter | M |
|__________________________________________________________________________|
Urethra | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X |
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 1| 2| 3| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 9| 1| 5| 1| 4| 1| 8| 8| 9| 0| 0| 0| 1| 1| 1| 2| 2| 5| 6| 7| 7| 8| 8| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 1| 1| 1| 2| A |
0 | 0| 0| 1| 3| 0| 2| 2| 3| 4| 2| 2| 3| 1| 3| 3| 2| 4| 0| 0| 0| 1| 9| 9| 9| 1| L |
MG/KG/DY | 3| 1| 4| 2| 6| 6| 1| 9| 2| 2| 4| 6| 8| 7| 8| 7| 0| 8| 2| 7| 3| 3| 4| 5| 2| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + I + + + + + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Polyp Adenomatous | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 7 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | X X X | 4 |
Hepatocellular Carcinoma, Multiple | | 2 |
Hepatocellular Adenoma | X X X X X X X| 12 |
Hepatocellular Adenoma, Multiple | X X | 2 |
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 1| 2| 3| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 9| 1| 5| 1| 4| 1| 8| 8| 9| 0| 0| 0| 1| 1| 1| 2| 2| 5| 6| 7| 7| 8| 8| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 1| 1| 1| 2| A |
0 | 0| 0| 1| 3| 0| 2| 2| 3| 4| 2| 2| 3| 1| 3| 3| 2| 4| 0| 0| 0| 1| 9| 9| 9| 1| L |
MG/KG/DY | 3| 1| 4| 2| 6| 6| 1| 9| 2| 2| 4| 6| 8| 7| 8| 7| 0| 8| 2| 7| 3| 3| 4| 5| 2| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X | 2 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Schwannoma Malignant, Metastatic, | | |
Brain | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 1| 2| 3| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 9| 1| 5| 1| 4| 1| 8| 8| 9| 0| 0| 0| 1| 1| 1| 2| 2| 5| 6| 7| 7| 8| 8| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 1| 1| 1| 2| A |
0 | 0| 0| 1| 3| 0| 2| 2| 3| 4| 2| 2| 3| 1| 3| 3| 2| 4| 0| 0| 0| 1| 9| 9| 9| 1| L |
MG/KG/DY | 3| 1| 4| 2| 6| 6| 1| 9| 2| 2| 4| 6| 8| 7| 8| 7| 0| 8| 2| 7| 3| 3| 4| 5| 2| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | | 3 |
|__________________________________________________________________________|____________|
Thymus | M + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 1| 2| 3| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 9| 1| 5| 1| 4| 1| 8| 8| 9| 0| 0| 0| 1| 1| 1| 2| 2| 5| 6| 7| 7| 8| 8| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 1| 1| 1| 2| A |
0 | 0| 0| 1| 3| 0| 2| 2| 3| 4| 2| 2| 3| 1| 3| 3| 2| 4| 0| 0| 0| 1| 9| 9| 9| 1| L |
MG/KG/DY | 3| 1| 4| 2| 6| 6| 1| 9| 2| 2| 4| 6| 8| 7| 8| 7| 0| 8| 2| 7| 3| 3| 4| 5| 2| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cranial Nerve, Schwannoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 7 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X| 7 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X X X | 3 |
Alveolar/Bronchiolar Carcinoma | X X X X | 4 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 1| 2| 3| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 9| 1| 5| 1| 4| 1| 8| 8| 9| 0| 0| 0| 1| 1| 1| 2| 2| 5| 6| 7| 7| 8| 8| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 1| 1| 1| 2| A |
0 | 0| 0| 1| 3| 0| 2| 2| 3| 4| 2| 2| 3| 1| 3| 3| 2| 4| 0| 0| 0| 1| 9| 9| 9| 1| L |
MG/KG/DY | 3| 1| 4| 2| 6| 6| 1| 9| 2| 2| 4| 6| 8| 7| 8| 7| 0| 8| 2| 7| 3| 3| 4| 5| 2| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X X X X X X| 11 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Ureter | | |
|__________________________________________________________________________|____________|
Urethra | + | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
DAY ON TEST | 4| 4| 5| 6| 2| 3| 5| 0| 2| 2| 2| 6| 8| 1| 3| 4| 6| 7| 7| 9| 2| 6| 6| 8| 8|
| 5| 7| 7| 8| 9| 6| 4| 0| 2| 2| 9| 3| 5| 8| 2| 4| 7| 5| 9| 5| 3| 2| 7| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 2| 3| 3| 2| 7| 2| 3| 2| 3| 2| 3| 3| 2| 2| 3| 3| 3| 3| 2| 2| 7| 3| 7| 3|
50 | 4| 3| 4| 6| 3| 3| 4| 5| 3| 5| 3| 5| 5| 2| 2| 6| 6| 4| 6| 2| 3| 3| 4| 2| 6|
MG/KG/DY | 4| 8| 6| 1| 5| 0| 0| 9| 4| 7| 0| 8| 6| 2| 5| 2| 6| 7| 3| 1| 7| 4| 3| 3| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + A + + A + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
DAY ON TEST | 4| 4| 5| 6| 2| 3| 5| 0| 2| 2| 2| 6| 8| 1| 3| 4| 6| 7| 7| 9| 2| 6| 6| 8| 8|
| 5| 7| 7| 8| 9| 6| 4| 0| 2| 2| 9| 3| 5| 8| 2| 4| 7| 5| 9| 5| 3| 2| 7| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 2| 3| 3| 2| 7| 2| 3| 2| 3| 2| 3| 3| 2| 2| 3| 3| 3| 3| 2| 2| 7| 3| 7| 3|
50 | 4| 3| 4| 6| 3| 3| 4| 5| 3| 5| 3| 5| 5| 2| 2| 6| 6| 4| 6| 2| 3| 3| 4| 2| 6|
MG/KG/DY | 4| 8| 6| 1| 5| 0| 0| 9| 4| 7| 0| 8| 6| 2| 5| 2| 6| 7| 3| 1| 7| 4| 3| 3| 7|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Penis | + + |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
DAY ON TEST | 4| 4| 5| 6| 2| 3| 5| 0| 2| 2| 2| 6| 8| 1| 3| 4| 6| 7| 7| 9| 2| 6| 6| 8| 8|
| 5| 7| 7| 8| 9| 6| 4| 0| 2| 2| 9| 3| 5| 8| 2| 4| 7| 5| 9| 5| 3| 2| 7| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 2| 3| 3| 2| 7| 2| 3| 2| 3| 2| 3| 3| 2| 2| 3| 3| 3| 3| 2| 2| 7| 3| 7| 3|
50 | 4| 3| 4| 6| 3| 3| 4| 5| 3| 5| 3| 5| 5| 2| 2| 6| 6| 4| 6| 2| 3| 3| 4| 2| 6|
MG/KG/DY | 4| 8| 6| 1| 5| 0| 0| 9| 4| 7| 0| 8| 6| 2| 5| 2| 6| 7| 3| 1| 7| 4| 3| 3| 7|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Basal Cell | |
Carcinoma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Hemangioma | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
DAY ON TEST | 4| 4| 5| 6| 2| 3| 5| 0| 2| 2| 2| 6| 8| 1| 3| 4| 6| 7| 7| 9| 2| 6| 6| 8| 8|
| 5| 7| 7| 8| 9| 6| 4| 0| 2| 2| 9| 3| 5| 8| 2| 4| 7| 5| 9| 5| 3| 2| 7| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 2| 3| 3| 2| 7| 2| 3| 2| 3| 2| 3| 3| 2| 2| 3| 3| 3| 3| 2| 2| 7| 3| 7| 3|
50 | 4| 3| 4| 6| 3| 3| 4| 5| 3| 5| 3| 5| 5| 2| 2| 6| 6| 4| 6| 2| 3| 3| 4| 2| 6|
MG/KG/DY | 4| 8| 6| 1| 5| 0| 0| 9| 4| 7| 0| 8| 6| 2| 5| 2| 6| 7| 3| 1| 7| 4| 3| 3| 7|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X|
Alveolar/Bronchiolar Carcinoma | X X|
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal Tubule, Adenoma | |
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
Urethra | + + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________|__________________________________________________________________________
| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
DAY ON TEST | 4| 4| 5| 6| 2| 3| 5| 0| 2| 2| 2| 6| 8| 1| 3| 4| 6| 7| 7| 9| 2| 6| 6| 8| 8|
| 5| 7| 7| 8| 9| 6| 4| 0| 2| 2| 9| 3| 5| 8| 2| 4| 7| 5| 9| 5| 3| 2| 7| 0| 8|
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 2| 3| 3| 2| 7| 2| 3| 2| 3| 2| 3| 3| 2| 2| 3| 3| 3| 3| 2| 2| 7| 3| 7| 3|
50 | 4| 3| 4| 6| 3| 3| 4| 5| 3| 5| 3| 5| 5| 2| 2| 6| 6| 4| 6| 2| 3| 3| 4| 2| 6|
MG/KG/DY | 4| 8| 6| 1| 5| 0| 0| 9| 4| 7| 0| 8| 6| 2| 5| 2| 6| 7| 3| 1| 7| 4| 3| 3| 7|
_____________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant | X X X X X|
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 9| 9| 2| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 2| 5| 4| 0| 8| 8| 0| 0| 0| 1| 1| 1| 2| 6| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 7| 3| 3| 3| 7| 3| 3| 7| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
50 | 3| 2| 6| 4| 5| 3| 5| 5| 2| 5| 5| 6| 6| 1| 2| 2| 1| 2| 3| 4| 2| 3| 3| 3| 4| L |
MG/KG/DY | 9| 6| 5| 9| 2| 2| 3| 5| 5| 0| 4| 4| 0| 9| 8| 9| 8| 4| 3| 2| 7| 1| 2| 6| 1| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X X | 4 |
Hepatocellular Carcinoma | X X X X | 5 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X X X X X | 5 |
Hepatocellular Adenoma, Multiple | X X X X X X | 6 |
|__________________________________________________________________________|____________|
Mesentery | + | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 9| 9| 2| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 2| 5| 4| 0| 8| 8| 0| 0| 0| 1| 1| 1| 2| 6| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 7| 3| 3| 3| 7| 3| 3| 7| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
50 | 3| 2| 6| 4| 5| 3| 5| 5| 2| 5| 5| 6| 6| 1| 2| 2| 1| 2| 3| 4| 2| 3| 3| 3| 4| L |
MG/KG/DY | 9| 6| 5| 9| 2| 2| 3| 5| 5| 0| 4| 4| 0| 9| 8| 9| 8| 4| 3| 2| 7| 1| 2| 6| 1| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + + | 2 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 9| 9| 2| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 2| 5| 4| 0| 8| 8| 0| 0| 0| 1| 1| 1| 2| 6| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 7| 3| 3| 3| 7| 3| 3| 7| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
50 | 3| 2| 6| 4| 5| 3| 5| 5| 2| 5| 5| 6| 6| 1| 2| 2| 1| 2| 3| 4| 2| 3| 3| 3| 4| L |
MG/KG/DY | 9| 6| 5| 9| 2| 2| 3| 5| 5| 0| 4| 4| 0| 9| 8| 9| 8| 4| 3| 2| 7| 1| 2| 6| 1| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Penis | | 2 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 2 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + I + + + M + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 9| 9| 2| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 2| 5| 4| 0| 8| 8| 0| 0| 0| 1| 1| 1| 2| 6| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 7| 3| 3| 3| 7| 3| 3| 7| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
50 | 3| 2| 6| 4| 5| 3| 5| 5| 2| 5| 5| 6| 6| 1| 2| 2| 1| 2| 3| 4| 2| 3| 3| 3| 4| L |
MG/KG/DY | 9| 6| 5| 9| 2| 2| 3| 5| 5| 0| 4| 4| 0| 9| 8| 9| 8| 4| 3| 2| 7| 1| 2| 6| 1| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Basal Cell | | |
Carcinoma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Hemangioma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 4 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X X| 13 |
Alveolar/Bronchiolar Carcinoma | X X X X | 6 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X X | 5 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 9| 9| 2| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 2| 5| 4| 0| 8| 8| 0| 0| 0| 1| 1| 1| 2| 6| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 7| 3| 3| 3| 7| 3| 3| 7| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
50 | 3| 2| 6| 4| 5| 3| 5| 5| 2| 5| 5| 6| 6| 1| 2| 2| 1| 2| 3| 4| 2| 3| 3| 3| 4| L |
MG/KG/DY | 9| 6| 5| 9| 2| 2| 3| 5| 5| 0| 4| 4| 0| 9| 8| 9| 8| 4| 3| 2| 7| 1| 2| 6| 1| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X X X | 8 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Renal Tubule, Adenoma | X| 1 |
|__________________________________________________________________________|____________|
Ureter | + + + | 3 |
|__________________________________________________________________________|____________|
Urethra | + + | 4 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X| 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 4| 8| 1| 2| 4| 0| 1| 2| 2| 7| 7| 1| 3| 7| 8| 8| 8| 9| 0| 1| 3| 3| 3| 4| 4|
| 7| 7| 4| 9| 3| 8| 5| 0| 2| 6| 6| 3| 4| 4| 1| 2| 9| 0| 5| 0| 2| 6| 8| 4| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 2| 2| 3| 2| 3| 3| 7| 3| 7| 2| 2| 2| 2| 2| 2| 3| 3| 2| 2| 2| 3|
100 | 7| 7| 8| 8| 5| 4| 9| 4| 9| 7| 2| 8| 2| 5| 5| 5| 5| 6| 6| 8| 7| 4| 6| 6| 8|
MG/KG/DY | 3| 6| 3| 1| 2| 5| 0| 9| 1| 8| 7| 9| 8| 7| 0| 6| 5| 7| 4| 0| 7| 7| 1| 5| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + + M + + A + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + M + + + + + + + + + + + + + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + A + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M A + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | X X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 4| 8| 1| 2| 4| 0| 1| 2| 2| 7| 7| 1| 3| 7| 8| 8| 8| 9| 0| 1| 3| 3| 3| 4| 4|
| 7| 7| 4| 9| 3| 8| 5| 0| 2| 6| 6| 3| 4| 4| 1| 2| 9| 0| 5| 0| 2| 6| 8| 4| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 2| 2| 3| 2| 3| 3| 7| 3| 7| 2| 2| 2| 2| 2| 2| 3| 3| 2| 2| 2| 3|
100 | 7| 7| 8| 8| 5| 4| 9| 4| 9| 7| 2| 8| 2| 5| 5| 5| 5| 6| 6| 8| 7| 4| 6| 6| 8|
MG/KG/DY | 3| 6| 3| 1| 2| 5| 0| 9| 1| 8| 7| 9| 8| 7| 0| 6| 5| 7| 4| 0| 7| 7| 1| 5| 4|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + I + + + + +|
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Brain | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Penis | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 4| 8| 1| 2| 4| 0| 1| 2| 2| 7| 7| 1| 3| 7| 8| 8| 8| 9| 0| 1| 3| 3| 3| 4| 4|
| 7| 7| 4| 9| 3| 8| 5| 0| 2| 6| 6| 3| 4| 4| 1| 2| 9| 0| 5| 0| 2| 6| 8| 4| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 2| 2| 3| 2| 3| 3| 7| 3| 7| 2| 2| 2| 2| 2| 2| 3| 3| 2| 2| 2| 3|
100 | 7| 7| 8| 8| 5| 4| 9| 4| 9| 7| 2| 8| 2| 5| 5| 5| 5| 6| 6| 8| 7| 4| 6| 6| 8|
MG/KG/DY | 3| 6| 3| 1| 2| 5| 0| 9| 1| 8| 7| 9| 8| 7| 0| 6| 5| 7| 4| 0| 7| 7| 1| 5| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Hemangiosarcoma | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
|__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Brain | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 4| 8| 1| 2| 4| 0| 1| 2| 2| 7| 7| 1| 3| 7| 8| 8| 8| 9| 0| 1| 3| 3| 3| 4| 4|
| 7| 7| 4| 9| 3| 8| 5| 0| 2| 6| 6| 3| 4| 4| 1| 2| 9| 0| 5| 0| 2| 6| 8| 4| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 2| 2| 3| 2| 3| 3| 7| 3| 7| 2| 2| 2| 2| 2| 2| 3| 3| 2| 2| 2| 3|
100 | 7| 7| 8| 8| 5| 4| 9| 4| 9| 7| 2| 8| 2| 5| 5| 5| 5| 6| 6| 8| 7| 4| 6| 6| 8|
MG/KG/DY | 3| 6| 3| 1| 2| 5| 0| 9| 1| 8| 7| 9| 8| 7| 0| 6| 5| 7| 4| 0| 7| 7| 1| 5| 4|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | X |
|__________________________________________________________________________|
Peripheral Nerve | + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X|
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ureter | |
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 4| 8| 1| 2| 4| 0| 1| 2| 2| 7| 7| 1| 3| 7| 8| 8| 8| 9| 0| 1| 3| 3| 3| 4| 4|
| 7| 7| 4| 9| 3| 8| 5| 0| 2| 6| 6| 3| 4| 4| 1| 2| 9| 0| 5| 0| 2| 6| 8| 4| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 2| 2| 3| 2| 3| 3| 7| 3| 7| 2| 2| 2| 2| 2| 2| 3| 3| 2| 2| 2| 3|
100 | 7| 7| 8| 8| 5| 4| 9| 4| 9| 7| 2| 8| 2| 5| 5| 5| 5| 6| 6| 8| 7| 4| 6| 6| 8|
MG/KG/DY | 3| 6| 3| 1| 2| 5| 0| 9| 1| 8| 7| 9| 8| 7| 0| 6| 5| 7| 4| 0| 7| 7| 1| 5| 4|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Urethra | + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X |
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 9| 0| 0| 0| 0| 2| 3| 3| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 7| 0| 8| 5| 6| 7| 8| 7| 1| 3| 8| 1| 8| 8| 9| 0| 0| 0| 1| 1| 2| 5| 5| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 2| 3| 2| 2| 2| 3| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| A |
100 | 9| 8| 4| 8| 6| 4| 6| 8| 5| 7| 4| 5| 6| 7| 7| 6| 7| 8| 7| 8| 7| 4| 5| 5| 6| L |
MG/KG/DY | 2| 5| 3| 8| 6| 6| 3| 7| 8| 5| 8| 1| 8| 0| 2| 9| 4| 6| 9| 2| 1| 4| 4| 3| 2| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X X| 3 |
Hepatoblastoma | X | 2 |
Hepatocellular Carcinoma | X X X | 5 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X X X X | 5 |
Hepatocellular Adenoma, Multiple | X X X | 5 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 9| 0| 0| 0| 0| 2| 3| 3| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 7| 0| 8| 5| 6| 7| 8| 7| 1| 3| 8| 1| 8| 8| 9| 0| 0| 0| 1| 1| 2| 5| 5| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 2| 3| 2| 2| 2| 3| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| A |
100 | 9| 8| 4| 8| 6| 4| 6| 8| 5| 7| 4| 5| 6| 7| 7| 6| 7| 8| 7| 8| 7| 4| 5| 5| 6| L |
MG/KG/DY | 2| 5| 3| 8| 6| 6| 3| 7| 8| 5| 8| 1| 8| 0| 2| 9| 4| 6| 9| 2| 1| 4| 4| 3| 2| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pheochromocytoma Benign | X| 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + M + + + + + + + + + M| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Schwannoma Malignant, Metastatic, | | |
Brain | | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Penis | + | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 9| 0| 0| 0| 0| 2| 3| 3| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 7| 0| 8| 5| 6| 7| 8| 7| 1| 3| 8| 1| 8| 8| 9| 0| 0| 0| 1| 1| 2| 5| 5| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 2| 3| 2| 2| 2| 3| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| A |
100 | 9| 8| 4| 8| 6| 4| 6| 8| 5| 7| 4| 5| 6| 7| 7| 6| 7| 8| 7| 8| 7| 4| 5| 5| 6| L |
MG/KG/DY | 2| 5| 3| 8| 6| 6| 3| 7| 8| 5| 8| 1| 8| 0| 2| 9| 4| 6| 9| 2| 1| 4| 4| 3| 2| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | X | 1 |
Hemangiosarcoma | X| 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 15 |
Mediastinal, Hemangiosarcoma | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + I + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X| 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 78
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 9| 0| 0| 0| 0| 2| 3| 3| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 7| 0| 8| 5| 6| 7| 8| 7| 1| 3| 8| 1| 8| 8| 9| 0| 0| 0| 1| 1| 2| 5| 5| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 2| 3| 2| 2| 2| 3| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| A |
100 | 9| 8| 4| 8| 6| 4| 6| 8| 5| 7| 4| 5| 6| 7| 7| 6| 7| 8| 7| 8| 7| 4| 5| 5| 6| L |
MG/KG/DY | 2| 5| 3| 8| 6| 6| 3| 7| 8| 5| 8| 1| 8| 0| 2| 9| 4| 6| 9| 2| 1| 4| 4| 3| 2| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Schwannoma Malignant, Metastatic, | | |
Brain | | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Schwannoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + | 7 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X | 8 |
Alveolar/Bronchiolar Carcinoma | X X X X | 5 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 79
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 9| 0| 0| 0| 0| 2| 3| 3| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
| 7| 0| 8| 5| 6| 7| 8| 7| 1| 3| 8| 1| 8| 8| 9| 0| 0| 0| 1| 1| 2| 5| 5| 8| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 2| 3| 2| 2| 2| 3| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| A |
100 | 9| 8| 4| 8| 6| 4| 6| 8| 5| 7| 4| 5| 6| 7| 7| 6| 7| 8| 7| 8| 7| 4| 5| 5| 6| L |
MG/KG/DY | 2| 5| 3| 8| 6| 6| 3| 7| 8| 5| 8| 1| 8| 0| 2| 9| 4| 6| 9| 2| 1| 4| 4| 3| 2| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | +| 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X X X X X X X | 9 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Ureter | + | 1 |
|__________________________________________________________________________|____________|
Urethra | + | 5 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 1| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
DAY ON TEST | 5| 5| 6| 9| 0| 2| 2| 2| 4| 8| 1| 3| 8| 0| 3| 3| 4| 6| 8| 8| 9| 0| 0| 1| 2|
| 7| 9| 7| 8| 1| 0| 9| 9| 1| 2| 9| 4| 3| 1| 1| 9| 9| 3| 0| 9| 9| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 3| 4| 2| 2| 2| 2| 4| 2| 2| 3| 3| 2| 2| 4| 2| 2| 4| 4| 2| 2| 2| 2|
200 | 7| 7| 8| 9| 0| 7| 7| 8| 8| 0| 8| 8| 9| 9| 8| 7| 0| 7| 7| 0| 0| 7| 8| 6| 7|
MG/KG/DY | 8| 3| 1| 8| 3| 6| 9| 0| 7| 2| 6| 5| 5| 7| 2| 4| 4| 5| 7| 6| 8| 1| 3| 8| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A A + + + + + + + A + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + M + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X |
|__________________________________________________________________________|
Mesentery | + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 1| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
DAY ON TEST | 5| 5| 6| 9| 0| 2| 2| 2| 4| 8| 1| 3| 8| 0| 3| 3| 4| 6| 8| 8| 9| 0| 0| 1| 2|
| 7| 9| 7| 8| 1| 0| 9| 9| 1| 2| 9| 4| 3| 1| 1| 9| 9| 3| 0| 9| 9| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 3| 4| 2| 2| 2| 2| 4| 2| 2| 3| 3| 2| 2| 4| 2| 2| 4| 4| 2| 2| 2| 2|
200 | 7| 7| 8| 9| 0| 7| 7| 8| 8| 0| 8| 8| 9| 9| 8| 7| 0| 7| 7| 0| 0| 7| 8| 6| 7|
MG/KG/DY | 8| 3| 1| 8| 3| 6| 9| 0| 7| 2| 6| 5| 5| 7| 2| 4| 4| 5| 7| 6| 8| 1| 3| 8| 2|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Subcapsular, Adenoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + I + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Penis | + + + |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 1| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
DAY ON TEST | 5| 5| 6| 9| 0| 2| 2| 2| 4| 8| 1| 3| 8| 0| 3| 3| 4| 6| 8| 8| 9| 0| 0| 1| 2|
| 7| 9| 7| 8| 1| 0| 9| 9| 1| 2| 9| 4| 3| 1| 1| 9| 9| 3| 0| 9| 9| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 3| 4| 2| 2| 2| 2| 4| 2| 2| 3| 3| 2| 2| 4| 2| 2| 4| 4| 2| 2| 2| 2|
200 | 7| 7| 8| 9| 0| 7| 7| 8| 8| 0| 8| 8| 9| 9| 8| 7| 0| 7| 7| 0| 0| 7| 8| 6| 7|
MG/KG/DY | 8| 3| 1| 8| 3| 6| 9| 0| 7| 2| 6| 5| 5| 7| 2| 4| 4| 5| 7| 6| 8| 1| 3| 8| 2|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Carcinoma | X |
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + M + M + + + + + + + + + + + + I + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 1| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
DAY ON TEST | 5| 5| 6| 9| 0| 2| 2| 2| 4| 8| 1| 3| 8| 0| 3| 3| 4| 6| 8| 8| 9| 0| 0| 1| 2|
| 7| 9| 7| 8| 1| 0| 9| 9| 1| 2| 9| 4| 3| 1| 1| 9| 9| 3| 0| 9| 9| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 3| 4| 2| 2| 2| 2| 4| 2| 2| 3| 3| 2| 2| 4| 2| 2| 4| 4| 2| 2| 2| 2|
200 | 7| 7| 8| 9| 0| 7| 7| 8| 8| 0| 8| 8| 9| 9| 8| 7| 0| 7| 7| 0| 0| 7| 8| 6| 7|
MG/KG/DY | 8| 3| 1| 8| 3| 6| 9| 0| 7| 2| 6| 5| 5| 7| 2| 4| 4| 5| 7| 6| 8| 1| 3| 8| 2|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Skeletal Muscle | + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X X X |
|__________________________________________________________________________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 1| 1| 1| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
DAY ON TEST | 5| 5| 6| 9| 0| 2| 2| 2| 4| 8| 1| 3| 8| 0| 3| 3| 4| 6| 8| 8| 9| 0| 0| 1| 2|
| 7| 9| 7| 8| 1| 0| 9| 9| 1| 2| 9| 4| 3| 1| 1| 9| 9| 3| 0| 9| 9| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 3| 4| 2| 2| 2| 2| 4| 2| 2| 3| 3| 2| 2| 4| 2| 2| 4| 4| 2| 2| 2| 2|
200 | 7| 7| 8| 9| 0| 7| 7| 8| 8| 0| 8| 8| 9| 9| 8| 7| 0| 7| 7| 0| 0| 7| 8| 6| 7|
MG/KG/DY | 8| 3| 1| 8| 3| 6| 9| 0| 7| 2| 6| 5| 5| 7| 2| 4| 4| 5| 7| 6| 8| 1| 3| 8| 2|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
Urethra | + + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 2| 3| 3| 4| 6| 6| 7| 7| 7| 7| 7| 7| | |
| 5| 1| 1| 7| 2| 8| 0| 0| 1| 6| 8| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 2| 4| 3| 3| 3| 3| 4| 4| 2| 2| 2| | A |
200 | 0| 7| 0| 9| 9| 9| 9| 0| 0| 8| 6| 8| | L |
MG/KG/DY | 5| 0| 0| 9| 4| 6| 3| 7| 1| 4| 9| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + | 33 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + + + + + + + | 35 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + M + + + + + | 36 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + | 36 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + | 35 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 37 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Carcinoma, Multiple | X | 2 |
Hepatocellular Adenoma | X X X | 5 |
Hepatocellular Adenoma, Multiple | X X | 3 |
|__________________________________________________________________________|____________|
Mesentery | + | 3 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 37 |
Squamous Cell Papilloma | X | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 86
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 2| 3| 3| 4| 6| 6| 7| 7| 7| 7| 7| 7| | |
| 5| 1| 1| 7| 2| 8| 0| 0| 1| 6| 8| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 2| 4| 3| 3| 3| 3| 4| 4| 2| 2| 2| | A |
200 | 0| 7| 0| 9| 9| 9| 9| 0| 0| 8| 6| 8| | L |
MG/KG/DY | 5| 0| 0| 9| 4| 6| 3| 7| 1| 4| 9| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Glandular | + + + + + + + + + + + + | 37 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 37 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + | 37 |
Adenoma | X | 1 |
Subcapsular, Adenoma | X X | 2 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + M + + + | 36 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + | 35 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 36 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 37 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 87
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 2| 3| 3| 4| 6| 6| 7| 7| 7| 7| 7| 7| | |
| 5| 1| 1| 7| 2| 8| 0| 0| 1| 6| 8| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 2| 4| 3| 3| 3| 3| 4| 4| 2| 2| 2| | A |
200 | 0| 7| 0| 9| 9| 9| 9| 0| 0| 8| 6| 8| | L |
MG/KG/DY | 5| 0| 0| 9| 4| 6| 3| 7| 1| 4| 9| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Penis | | 3 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + | 37 |
Bilateral, Interstitial Cell, | | |
Carcinoma | | 1 |
Interstitial Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + + + | 36 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + | 33 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 88
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 2| 3| 3| 4| 6| 6| 7| 7| 7| 7| 7| 7| | |
| 5| 1| 1| 7| 2| 8| 0| 0| 1| 6| 8| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 2| 4| 3| 3| 3| 3| 4| 4| 2| 2| 2| | A |
200 | 0| 7| 0| 9| 9| 9| 9| 0| 0| 8| 6| 8| | L |
MG/KG/DY | 5| 0| 0| 9| 4| 6| 3| 7| 1| 4| 9| 8| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 37 |
Squamous Cell Papilloma | X | 1 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 7 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + | 37 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 37 |
Alveolar/Bronchiolar Adenoma | X X X | 8 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Alveolar/Bronchiolar Carcinoma | X X | 5 |
Alveolar/Bronchiolar Carcinoma, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 89
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 2| 3| 3| 4| 6| 6| 7| 7| 7| 7| 7| 7| | |
| 5| 1| 1| 7| 2| 8| 0| 0| 1| 6| 8| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 2| 4| 3| 3| 3| 3| 4| 4| 2| 2| 2| | A |
200 | 0| 7| 0| 9| 9| 9| 9| 0| 0| 8| 6| 8| | L |
MG/KG/DY | 5| 0| 0| 9| 4| 6| 3| 7| 1| 4| 9| 8| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Multiple | X X | 6 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 36 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 37 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + | 37 |
Adenoma | X X | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Ureter | + | 1 |
|__________________________________________________________________________|____________|
Urethra | + | 3 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + | 37 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + | 37 |
Lymphoma Malignant | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 90
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 0| 0| 1| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 4| 9| 2| 2| 2| 2| 7| 0| 7| 8| 9| 3| 3| 6| 6| 9| 2| 3| 3| 3| 4| 5| 6| 6|
| 1| 1| 2| 9| 9| 9| 9| 6| 4| 3| 8| 5| 8| 9| 3| 9| 3| 7| 4| 5| 8| 0| 5| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 4| 2| 3| 3| 3| 4| 3| 4| 2| 2| 4| 3| 4| 3| 4| 3| 3| 3| 2| 3| 3| 4|
300 | 1| 1| 0| 2| 9| 0| 0| 0| 2| 1| 2| 9| 9| 2| 1| 1| 0| 2| 0| 0| 1| 9| 0| 1| 1|
MG/KG/DY | 6| 7| 0| 3| 8| 6| 8| 7| 1| 5| 4| 7| 4| 2| 2| 8| 2| 0| 3| 9| 1| 5| 5| 4| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + A A + + + + A + + + + + + A A + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + A + + + + + + + + + + + + A + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X |
Hepatocholangiocarcinoma | X |
|__________________________________________________________________________|
Mesentery | |
|__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 91
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 0| 0| 1| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 4| 9| 2| 2| 2| 2| 7| 0| 7| 8| 9| 3| 3| 6| 6| 9| 2| 3| 3| 3| 4| 5| 6| 6|
| 1| 1| 2| 9| 9| 9| 9| 6| 4| 3| 8| 5| 8| 9| 3| 9| 3| 7| 4| 5| 8| 0| 5| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 4| 2| 3| 3| 3| 4| 3| 4| 2| 2| 4| 3| 4| 3| 4| 3| 3| 3| 2| 3| 3| 4|
300 | 1| 1| 0| 2| 9| 0| 0| 0| 2| 1| 2| 9| 9| 2| 1| 1| 0| 2| 0| 0| 1| 9| 0| 1| 1|
MG/KG/DY | 6| 7| 0| 3| 8| 6| 8| 7| 1| 5| 4| 7| 4| 2| 2| 8| 2| 0| 3| 9| 1| 5| 5| 4| 9|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + I M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Penis | + |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 92
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 0| 0| 1| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 4| 9| 2| 2| 2| 2| 7| 0| 7| 8| 9| 3| 3| 6| 6| 9| 2| 3| 3| 3| 4| 5| 6| 6|
| 1| 1| 2| 9| 9| 9| 9| 6| 4| 3| 8| 5| 8| 9| 3| 9| 3| 7| 4| 5| 8| 0| 5| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 4| 2| 3| 3| 3| 4| 3| 4| 2| 2| 4| 3| 4| 3| 4| 3| 3| 3| 2| 3| 3| 4|
300 | 1| 1| 0| 2| 9| 0| 0| 0| 2| 1| 2| 9| 9| 2| 1| 1| 0| 2| 0| 0| 1| 9| 0| 1| 1|
MG/KG/DY | 6| 7| 0| 3| 8| 6| 8| 7| 1| 5| 4| 7| 4| 2| 2| 8| 2| 0| 3| 9| 1| 5| 5| 4| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Oligodendroglioma Malignant | X |
|__________________________________________________________________________|
Peripheral Nerve | + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 93
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
_____________________________________________________________________________________________________________________
| 0| 0| 1| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 4| 9| 2| 2| 2| 2| 7| 0| 7| 8| 9| 3| 3| 6| 6| 9| 2| 3| 3| 3| 4| 5| 6| 6|
| 1| 1| 2| 9| 9| 9| 9| 6| 4| 3| 8| 5| 8| 9| 3| 9| 3| 7| 4| 5| 8| 0| 5| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 4| 2| 3| 3| 3| 4| 3| 4| 2| 2| 4| 3| 4| 3| 4| 3| 3| 3| 2| 3| 3| 4|
300 | 1| 1| 0| 2| 9| 0| 0| 0| 2| 1| 2| 9| 9| 2| 1| 1| 0| 2| 0| 0| 1| 9| 0| 1| 1|
MG/KG/DY | 6| 7| 0| 3| 8| 6| 8| 7| 1| 5| 4| 7| 4| 2| 2| 8| 2| 0| 3| 9| 1| 5| 5| 4| 9|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X|
Carcinoma | X |
|__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urethra | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________|__________________________________________________________________________|
Page 94
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| | |
| 3| 6| 7| 7| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 2| 2| 2| 3| 3| | A |
300 | 1| 0| 9| 9| 9| 0| 1| | L |
MG/KG/DY | 0| 4| 3| 6| 9| 1| 3| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + | 27 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 31 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 30 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + | 29 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + | 30 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + | 32 |
Hemangiosarcoma | X | 3 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X | 4 |
Hepatocholangiocarcinoma | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 31 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 95
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| | |
| 3| 6| 7| 7| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 2| 2| 2| 3| 3| | A |
300 | 1| 0| 9| 9| 9| 0| 1| | L |
MG/KG/DY | 0| 4| 3| 6| 9| 1| 3| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 31 |
|__________________________________________________________________________|____________|
Parathyroid Gland | I + + + + + + | 28 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 31 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Penis | | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 96
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| | |
| 3| 6| 7| 7| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 2| 2| 2| 3| 3| | A |
300 | 1| 0| 9| 9| 9| 0| 1| | L |
MG/KG/DY | 0| 4| 3| 6| 9| 1| 3| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Lymph Node | | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + | 32 |
Hemangiosarcoma | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 97
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| | |
| 3| 6| 7| 7| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 2| 2| 2| 3| 3| | A |
300 | 1| 0| 9| 9| 9| 0| 1| | L |
MG/KG/DY | 0| 4| 3| 6| 9| 1| 3| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Skeletal Muscle | | 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + | 32 |
Oligodendroglioma Malignant | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | | 1 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + | 32 |
Alveolar/Bronchiolar Adenoma | X X | 10 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Alveolar/Bronchiolar Carcinoma | X X X | 5 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 3 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 98
NTP Experiment-Test: 99022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 10/08/03
Route: IN-UTERO Time: 16:02:51
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| | |
| 3| 6| 7| 7| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 2| 2| 2| 3| 3| | A |
300 | 1| 0| 9| 9| 9| 0| 1| | L |
MG/KG/DY | 0| 4| 3| 6| 9| 1| 3| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Adenoma | X | 4 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Urethra | + + | 3 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 32 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + | 32 |
Lymphoma Malignant | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 99
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