https://ntp.niehs.nih.gov/go/17707

TDMS Study 05135-03 Pathology Tables

NTP Experiment-Test: 05135-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                      ISOPRENE                                         Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:03:48
       Facility:  Battelle Northwest
       Chemical CAS #:  78-79-5
       Lock Date:  None
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 05135-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                      ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:03:48    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Hepatodiaphragmatic Nodule                       1 (10%)      1 (10%)      1 (10%)                                3 (30%)     
   Pharynx                                            (10)                                                             (10)         
      Palate, Inflammation, Suppurative                1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cardiomyopathy, Focal                            2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (10)                      (3)                                    (10)         
      Follicle, Cyst                                                             1 (33%)                                            
      Periovarian Tissue, Cyst                         2 (20%)                   2 (67%)                                            
   Uterus                                             (10)                                                             (10)         
      Dilatation                                                                                                        1 (10%)     
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05135-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                      ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:03:48    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Lymph Node, Bronchial                              (10)         (4)          (10)         (7)          (7)          (10)         
      Congestion                                       7 (70%)      4 (100%)    10 (100%)     7 (100%)     7 (100%)     7 (70%)     
      Hyperplasia                                      4 (40%)                                                                      
   Lymph Node, Mandibular                             (9)                                                              (10)         
      Congestion                                       1 (11%)                                                                      
      Hyperplasia                                      1 (11%)                                                          1 (10%)     
   Lymph Node, Mediastinal                            (9)                                                              (10)         
      Congestion                                       8 (89%)                                                          8 (80%)     
      Hyperplasia                                      7 (78%)                                                          4 (40%)     
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (10)                                                             (10)         
      Subcutaneous Tissue, Hemorrhage                  1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Skeletal Muscle                                    (1)                                                                           
      Diaphragm, Hernia                                1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Hemorrhage, Focal                               10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Alveolar Epithelium, Hyperplasia, Focal          8 (80%)                                                                      
      Alveolus, Infiltration Cellular, Focal,                                                                                       
        Histiocyte                                     8 (80%)                                                          1 (10%)     
      Alveolus, Inflammation, Focal, Suppurative       5 (50%)                                                                      
      Peribronchial, Hyperplasia, Focal, Lymphoid      4 (40%)                                                                      
      Perivascular, Hyperplasia, Focal, Lymphoid       6 (60%)                                                                      
      Perivascular, Hyperplasia, Lymphoid              1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05135-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                      ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:03:48    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Harderian Gland                                    (10)                                                             (10)         
      Hyperplasia, Focal, Lymphoid                     1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Bilateral, Mineralization, Focal                 9 (90%)                                             1 (10%)      8 (80%)     
      Bilateral, Pelvis, Dilatation                                                                                     1 (10%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05135-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                      ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:03:48    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           11           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Hepatodiaphragmatic Nodule                       1 (10%)                   2 (20%)      1 (10%)                   1 (10%)     
   Mesentery                                          (1)          (1)                                                              
      Necrosis                                         1 (100%)                                                                     
   Pancreas                                           (10)                                   (1)          (3)          (10)         
      Accessory Spleen                                                                        1 (100%)     2 (67%)                  
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cardiomyopathy, Focal                            5 (50%)                                                          5 (50%)     
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Pituitary Gland                                    (10)                                                             (10)         
      Pars Distalis, Cyst                              1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Testes                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Degeneration                                                                            1 (10%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05135-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                      ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:03:48    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Lymph Node                                                      (2)                                                              
      Iliac, Pigmentation                                           1 (50%)                                                         
      Renal, Congestion                                             1 (50%)                                                         
   Lymph Node, Bronchial                              (10)         (9)          (7)          (7)          (8)          (9)          
      Congestion                                       9 (90%)      9 (100%)     7 (100%)     7 (100%)     8 (100%)     8 (89%)     
      Hyperplasia                                      8 (80%)                                                                      
   Lymph Node, Mandibular                             (8)                                                              (8)          
      Congestion                                                                                                        1 (13%)     
      Hyperplasia                                      1 (13%)                                                                      
   Lymph Node, Mesenteric                             (10)         (1)                                    (1)          (10)         
      Congestion                                       1 (10%)      1 (100%)                               1 (100%)                 
      Hyperplasia                                      1 (10%)                                                                      
      Pigmentation, Hemosiderin                        1 (10%)                                                                      
   Lymph Node, Mediastinal                            (10)                                                             (9)          
      Congestion                                       8 (80%)                                                          9 (100%)    
      Hyperplasia                                      9 (90%)                                                          1 (11%)     
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Developmental Malformation                                                                           1 (10%)                  
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (10)                      (1)                                    (10)         
      Inflammation, Chronic                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Hemorrhage, Focal                               10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Alveolar Epithelium, Hyperplasia, Focal          9 (90%)                                                                      
      Alveolus, Infiltration Cellular, Focal,                                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05135-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                      ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:03:48    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT                                                                                                           
        Histiocyte                                     9 (90%)                                                                      
      Alveolus, Inflammation, Focal, Suppurative       6 (60%)                                                                      
      Peribronchial, Hyperplasia, Focal, Lymphoid      6 (60%)                                                                      
      Perivascular, Hyperplasia, Focal, Lymphoid       9 (90%)                                                                      
   Trachea                                            (10)         (1)                                                 (10)         
      Submucosa, Infiltration Cellular, Focal,                                                                                      
         Mononuclear Cell                              1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------