TDMS Study 05135-03 Pathology Tables
NTP Experiment-Test: 05135-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:03:48
Facility: Battelle Northwest
Chemical CAS #: 78-79-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05135-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Hepatodiaphragmatic Nodule 1 (10%) 1 (10%) 1 (10%) 3 (30%)
Pharynx (10) (10)
Palate, Inflammation, Suppurative 1 (10%)
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CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10) (10) (10)
Cardiomyopathy, Focal 2 (20%)
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (3) (10)
Follicle, Cyst 1 (33%)
Periovarian Tissue, Cyst 2 (20%) 2 (67%)
Uterus (10) (10)
Dilatation 1 (10%)
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05135-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Bronchial (10) (4) (10) (7) (7) (10)
Congestion 7 (70%) 4 (100%) 10 (100%) 7 (100%) 7 (100%) 7 (70%)
Hyperplasia 4 (40%)
Lymph Node, Mandibular (9) (10)
Congestion 1 (11%)
Hyperplasia 1 (11%) 1 (10%)
Lymph Node, Mediastinal (9) (10)
Congestion 8 (89%) 8 (80%)
Hyperplasia 7 (78%) 4 (40%)
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INTEGUMENTARY SYSTEM
Skin (10) (10)
Subcutaneous Tissue, Hemorrhage 1 (10%)
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MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Diaphragm, Hernia 1 (100%)
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10) (10)
Hemorrhage, Focal 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Alveolar Epithelium, Hyperplasia, Focal 8 (80%)
Alveolus, Infiltration Cellular, Focal,
Histiocyte 8 (80%) 1 (10%)
Alveolus, Inflammation, Focal, Suppurative 5 (50%)
Peribronchial, Hyperplasia, Focal, Lymphoid 4 (40%)
Perivascular, Hyperplasia, Focal, Lymphoid 6 (60%)
Perivascular, Hyperplasia, Lymphoid 1 (10%)
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a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05135-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (10) (10)
Hyperplasia, Focal, Lymphoid 1 (10%)
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URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Bilateral, Mineralization, Focal 9 (90%) 1 (10%) 8 (80%)
Bilateral, Pelvis, Dilatation 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05135-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 11 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Hepatodiaphragmatic Nodule 1 (10%) 2 (20%) 1 (10%) 1 (10%)
Mesentery (1) (1)
Necrosis 1 (100%)
Pancreas (10) (1) (3) (10)
Accessory Spleen 1 (100%) 2 (67%)
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CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10) (10) (10)
Cardiomyopathy, Focal 5 (50%) 5 (50%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Pituitary Gland (10) (10)
Pars Distalis, Cyst 1 (10%)
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GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Testes (10) (10) (10) (10) (10) (10)
Degeneration 1 (10%)
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a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05135-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (2)
Iliac, Pigmentation 1 (50%)
Renal, Congestion 1 (50%)
Lymph Node, Bronchial (10) (9) (7) (7) (8) (9)
Congestion 9 (90%) 9 (100%) 7 (100%) 7 (100%) 8 (100%) 8 (89%)
Hyperplasia 8 (80%)
Lymph Node, Mandibular (8) (8)
Congestion 1 (13%)
Hyperplasia 1 (13%)
Lymph Node, Mesenteric (10) (1) (1) (10)
Congestion 1 (10%) 1 (100%) 1 (100%)
Hyperplasia 1 (10%)
Pigmentation, Hemosiderin 1 (10%)
Lymph Node, Mediastinal (10) (9)
Congestion 8 (80%) 9 (100%)
Hyperplasia 9 (90%) 1 (11%)
Spleen (10) (10) (10) (10) (10) (10)
Developmental Malformation 1 (10%)
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INTEGUMENTARY SYSTEM
Skin (10) (1) (10)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10) (10)
Hemorrhage, Focal 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Alveolar Epithelium, Hyperplasia, Focal 9 (90%)
Alveolus, Infiltration Cellular, Focal,
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05135-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Histiocyte 9 (90%)
Alveolus, Inflammation, Focal, Suppurative 6 (60%)
Peribronchial, Hyperplasia, Focal, Lymphoid 6 (60%)
Perivascular, Hyperplasia, Focal, Lymphoid 9 (90%)
Trachea (10) (1) (10)
Submucosa, Infiltration Cellular, Focal,
Mononuclear Cell 1 (10%)
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SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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