TDMS Study 88138-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus BENZOPHENONE DATE: 07/21/03
EXPERIMENT: 88138 TEST: 03 TIME: 15:28:34
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55388 ROUTE: DOSED FEED NTP C#: 88138B
PATHOLOGIST: MISSING CAS: 119-61-9
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1 RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus BENZOPHENONE DATE: 07/21/03
EXPERIMENT: 88138 TEST: 03 TIME: 15:28:34
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55388 ROUTE: DOSED FEED NTP C#: 88138B
PATHOLOGIST: MISSING CAS: 119-61-9
BENZOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 425 495 506 549 553 582 584 632 634 638 |
| 645 662 666 676 676 680 680 681 690 693 |
| 694 704 704 709 709 715 725 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 312 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 344 373 484 499 526 535 543 590 609 610 |
| 624 641 653 657 673 698 698 702 704 709 |
| 710 715 715 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 625 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 486 494 499 543 543 590 613 624 669 687 |
| 690 691 705 708 708 708 708 711 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
BENZOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 48 CENSORED DEATHS 0 TERMINAL 2 |
| |
| UNCENSORED DEATHS |
| 487 488 507 529 529 529 537 537 540 549 |
| 555 569 569 582 593 593 601 604 604 613 |
| 617 621 621 624 624 632 634 634 634 635 |
| 637 639 641 641 653 662 669 675 680 681 |
| 691 694 708 708 708 708 708 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
BENZOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 98.0 98.0 94.0 86.0 76.0 44.0 |
| | |
| | |
|312 PPM | 100.0 100.0 100.0 98.0 96.0 94.0 86.0 84.0 72.0 54.0 |
| | |
| | |
|625 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 90.0 88.0 84.0 62.0 |
| | |
| | |
|1250 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 82.0 62.0 28.0 4.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 312 PPM 625 PPM 1250 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 44.0% 54.0% 62.0% 4.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.517N P=0.099N P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 644.0 609.2 637.0 617.1 |
|NATURAL DEATHS (C) | (14.6) (22.5) (19.5) ( 9.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 681.4 673.9 694.0 621.6 |
|(STANDARD ERROR) | (10.1) (13.3) ( 9.7) ( 9.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 288 358 430 528 543 613 624 634 637 673 |
| 697 708 708 724 724 724 724 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 312 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 609 613 613 633 653 690 693 697 697 710 |
| 725 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 625 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 528 609 633 644 662 679 690 699 701 704 |
| 709 709 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
BENZOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 480 528 581 624 638 653 659 679 679 681 |
| 686 687 701 709 714 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
BENZOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 96.0 96.0 94.0 90.0 90.0 82.0 64.0 |
| | |
| | |
|312 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 90.0 76.0 |
| | |
| | |
|625 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 90.0 74.0 |
| | |
| | |
|1250 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 94.0 86.0 68.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 312 PPM 625 PPM 1250 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 64.0% 76.0% 74.0% 68.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.985N P=0.246N P=0.354N P=0.809N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 614.6 671.5 668.8 651.5 |
|NATURAL DEATHS (C) | (31.7) (12.9) (15.2) (17.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 687.8 715.2 713.4 704.2 |
|(STANDARD ERROR) | (13.7) ( 4.6) ( 5.4) ( 7.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZOPHENONE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
312 PPM = 2
625 PPM = 3
1250 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 2 1 3
| 2 2 1 31
| 2 2121 4 31
| 2 2
90 + 2231 1 3
| 422 3 3
| 42 1 2 23 31 3
| 44 22 11 3 3
80 + 44 2 2 11
| 4 4 2 21 1
| 4 4 2 2 111 3 33
| 4 4 2 2
P 70 + 11 2
E | 44
R | 44 11223 3
C | 44 22 3 3
E 60 + 44 11
N | 1122
T | 44 112 2
|
S 50 + 44 11
U | 11
R | 1 1
V |
I 40 +
V | 44
A |
L | 4 4
30 + 4 4
| 44
| 444
|
20 + 44
| 44
| 4 4
|
10 +
|
| 4 4 4
|
0 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 22 obs hidden.
BENZOPHENONE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
312 PPM = 2
625 PPM = 3
1250 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 4 3 2
|
| 1 1 4 3 22
| 1 1 4 4 3 3
95 +
| 1 1 4 2 423
| 1 1 423 2 3
|
P 90 + 1 1 4 2 3 3 2
E |
R | 1 1 4 4 3 3
C | 11 4 4 22
E 85 +
N | 33
T | 1 14 2 2
|
S 80 + 1 132 2
U |
R | 441 1
V | 4 43 2 2
I 75 +
V | 41 1 3
A |
L |
70 + 4 4
|
| 4 4
|
65 +
| 1 1
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.