TDMS Study 88138-04 Pathology Tables
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
FINAL#2 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 119-61-9
Lock Date: 04/26/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 4 2 5 6
Natural Death 6 6 4 12
Accidently Killed 1
Survivors
Terminal Sacrifice 40 42 41 31
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (49) (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Infiltration Cellular, Lymphoid 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Intestine Large, Colon (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Peyer's Patch, Hyperplasia, Lymphoid 3 (6%) 1 (2%)
Intestine Small, Ileum (50) (50) (50) (50)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 1 (2%) 4 (8%)
Basophilic Focus 3 (6%) 1 (2%) 2 (4%)
Clear Cell Focus 3 (6%) 2 (4%) 4 (8%) 4 (8%)
Eosinophilic Focus 2 (4%) 2 (4%) 7 (14%) 7 (14%)
Hematopoietic Cell Proliferation 18 (36%) 11 (22%) 20 (40%) 19 (38%)
Infarct 1 (2%)
Infiltration Cellular, Lymphoid 36 (72%) 38 (76%) 35 (70%) 35 (70%)
Inflammation, Chronic Active 44 (88%) 40 (80%) 41 (82%) 36 (72%)
Mineralization 1 (2%)
Mixed Cell Focus 2 (4%) 5 (10%) 3 (6%) 2 (4%)
Tension Lipidosis 4 (8%) 8 (16%) 3 (6%) 7 (14%)
Bile Duct, Hyperplasia 1 (2%)
Hepatocyte, Autolysis 1 (2%)
Hepatocyte, Mitotic Alteration 1 (2%)
Hepatocyte, Multinucleated 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Necrosis 3 (6%) 5 (10%) 4 (8%)
Hepatocyte, Vacuolization Cytoplasmic 41 (82%) 43 (86%) 39 (78%) 34 (68%)
Hepatocyte, Centrilobular, Degeneration 1 (2%)
Hepatocyte, Centrilobular, Hypertrophy 29 (58%) 44 (88%) 37 (74%)
Mesentery (6) (9) (11) (9)
Fat, Fibrosis 1 (17%) 2 (22%) 8 (73%) 4 (44%)
Fat, Hemorrhage 1 (11%)
Fat, Infiltration Cellular, Lymphoid 4 (36%)
Fat, Inflammation, Chronic Active 1 (17%) 3 (33%) 7 (64%) 3 (33%)
Fat, Mineralization 1 (11%) 2 (18%) 1 (11%)
Fat, Necrosis 1 (17%) 4 (44%) 9 (82%) 4 (44%)
Pancreas (50) (50) (50) (50)
Cyst 1 (2%) 2 (4%)
Infiltration Cellular, Lymphoid 20 (40%) 24 (48%) 33 (66%) 18 (36%)
Acinus, Atrophy 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Acinus, Cytoplasmic Alteration 1 (2%)
Duct, Inflammation, Chronic Active 1 (2%)
Duct, Pigmentation 1 (2%)
Salivary Glands (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 27 (54%) 34 (68%) 30 (60%) 28 (56%)
Stomach, Forestomach (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Epithelium, Hyperkeratosis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia, Squamous 1 (2%) 1 (2%) 1 (2%)
Epithelium, Ulcer 1 (2%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Epithelium, Glands, Hyperplasia 1 (2%)
Glands, Ectasia 18 (36%) 16 (32%) 22 (44%) 10 (20%)
Glands, Mineralization 3 (6%) 2 (4%)
Tooth (21) (29) (24) (20)
Malformation 1 (4%)
Gingiva, Inflammation, Chronic Active 21 (100%) 29 (100%) 24 (100%) 20 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Aorta, Mineralization 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy 1 (2%)
Hyperplasia, Atypical 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Necrosis 1 (2%)
Valve, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 2 (4%)
Hypertrophy 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%) 1 (2%)
Subcapsular, Hyperplasia 49 (98%) 49 (98%) 49 (98%) 49 (100%)
Adrenal Medulla (50) (50) (50) (49)
Hyperplasia 2 (4%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 3 (6%) 1 (2%)
Parathyroid Gland (42) (41) (40) (40)
Cyst 3 (8%) 1 (3%)
Pituitary Gland (50) (50) (49) (47)
Pars Distalis, Angiectasis 2 (4%) 4 (8%) 5 (10%) 3 (6%)
Pars Distalis, Cyst 5 (10%) 3 (6%) 2 (4%)
Pars Distalis, Hyperplasia 14 (28%) 14 (28%) 13 (27%) 3 (6%)
Pars Distalis, Hypertrophy 1 (2%)
Pars Distalis, Pigmentation 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 1 (2%) 2 (4%) 2 (4%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
C-Cell, Hyperplasia 1 (2%)
Follicle, Cyst 1 (2%)
Follicle, Degeneration 17 (34%) 19 (38%) 12 (24%) 9 (18%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Clitoral Gland (50) (49) (50) (50)
Inflammation, Chronic Active 8 (16%) 1 (2%) 2 (4%)
Duct, Cyst 1 (2%)
Ovary (49) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Atrophy 48 (98%) 48 (96%) 46 (92%) 45 (90%)
Cyst 22 (45%) 17 (34%) 17 (34%) 14 (28%)
Hemorrhage 2 (4%) 5 (10%) 3 (6%) 4 (8%)
Infiltration Cellular, Lymphoid 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%)
Mineralization 4 (8%) 2 (4%)
Pigmentation 6 (12%) 2 (4%) 3 (6%) 1 (2%)
Uterus (49) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Inflammation, Chronic Active 5 (10%) 4 (8%) 2 (4%) 2 (4%)
Endometrium, Hyperplasia, Cystic 47 (96%) 45 (90%) 44 (88%) 43 (86%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Myelofibrosis 18 (36%) 30 (60%) 20 (40%) 26 (52%)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (8) (12) (11) (15)
Lumbar, Hyperplasia, Lymphoid 1 (13%) 1 (8%) 2 (13%)
Mediastinal, Atrophy 1 (13%)
Mediastinal, Hyperplasia, Lymphoid 2 (25%) 5 (42%) 4 (36%) 4 (27%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (13%)
Mediastinal, Inflammation, Chronic Active 1 (13%)
Pancreatic, Hyperplasia, Lymphoid 2 (18%) 1 (7%)
Pancreatic, Pigmentation 1 (9%)
Renal, Hemorrhage 1 (8%) 1 (7%)
Renal, Hyperplasia, Lymphoid 3 (25%) 1 (7%)
Lymph Node, Mandibular (50) (50) (50) (49)
Hyperplasia, Lymphoid 4 (8%) 20 (40%) 12 (24%) 9 (18%)
Lymph Node, Mesenteric (50) (49) (49) (50)
Hyperplasia, Lymphoid 6 (12%) 12 (24%) 6 (12%) 4 (8%)
Spleen (50) (50) (50) (50)
Hematopoietic Cell Proliferation 16 (32%) 35 (70%) 32 (64%) 27 (54%)
Hemorrhage 2 (4%)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymphoid Follicle, Hyperplasia, Lymphoid 24 (48%) 36 (72%) 37 (74%) 22 (44%)
Thymus (46) (50) (50) (50)
Atrophy 8 (17%) 7 (14%) 3 (6%) 13 (26%)
Cyst 23 (50%) 35 (70%) 31 (62%) 24 (48%)
Ectopic Parathyroid Gland 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 8 (16%) 5 (10%) 2 (4%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Chronic Active 1 (2%)
Thymocyte, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Fibrosis 1 (2%)
Subcutaneous Tissue, Infiltration Cellular,
Lymphoid 4 (8%) 1 (2%)
Subcutaneous Tissue, Infiltration Cellular,
Polymorphonuclear 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Maxilla, Fracture 1 (2%)
Skeletal Muscle (2) (4) (2) (4)
Infiltration Cellular, Lymphoid 3 (75%) 2 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 2 (4%)
Infiltration Cellular, Lymphoid 1 (2%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Foreign Body 1 (2%)
Infiltration Cellular, Lymphoid 33 (66%) 44 (88%) 44 (88%) 35 (70%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Metaplasia, Osseous 1 (2%)
Pigmentation 2 (4%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Alveolus, Hemorrhage 2 (4%) 3 (6%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 2 (4%)
Mediastinum, Inflammation, Chronic Active 1 (2%)
Nose (50) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (2%)
Olfactory Epithelium, Metaplasia 39 (78%)
Trachea (50) (50) (50) (50)
Glands, Cyst 1 (2%)
Glands, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Atrophy 2 (4%)
Lens, Cataract 1 (2%)
Harderian Gland (50) (50) (50) (49)
Hyperplasia 3 (6%) 3 (6%) 1 (2%)
Infiltration Cellular, Lymphoid 29 (58%) 27 (54%) 27 (54%) 23 (47%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 1 (2%) 1 (2%)
Atrophy 1 (2%)
Glomerulosclerosis 1 (2%)
Hydronephrosis 2 (4%) 1 (2%)
Infarct 4 (8%) 1 (2%) 3 (6%) 3 (6%)
Infiltration Cellular, Lymphoid 41 (82%) 45 (90%) 43 (86%) 39 (78%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Osseous 1 (2%) 2 (4%) 4 (8%) 2 (4%)
Mineralization 15 (30%) 31 (62%) 36 (72%) 49 (98%)
Nephropathy 21 (42%) 33 (66%) 31 (62%) 30 (60%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
Cortex, Cyst 1 (2%)
Renal Tubule, Pigmentation 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Urinary Bladder (50) (49) (50) (50)
Infiltration Cellular, Lymphoid 37 (74%) 38 (78%) 40 (80%) 39 (78%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 5 3 5 2
Natural Death 1 3 1 3
Survivors
Terminal Sacrifice 44 44 44 45
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (49) (49) (49)
Cyst 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (50) (50) (50) (50)
Basophilic Focus 4 (8%) 2 (4%) 5 (10%)
Clear Cell Focus 2 (4%) 7 (14%) 7 (14%) 12 (24%)
Eosinophilic Focus 5 (10%) 8 (16%) 11 (22%) 10 (20%)
Fatty Change 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%)
Infarct 2 (4%) 1 (2%)
Infiltration Cellular, Lymphoid 6 (12%) 10 (20%) 4 (8%)
Inflammation, Chronic Active 33 (66%) 47 (94%) 44 (88%) 42 (84%)
Mixed Cell Focus 8 (16%) 9 (18%) 15 (30%) 13 (26%)
Tension Lipidosis 1 (2%) 1 (2%) 1 (2%)
Bile Duct, Cyst 3 (6%) 1 (2%)
Hepatocyte, Degeneration, Cystic 5 (10%) 30 (60%)
Hepatocyte, Multinucleated 41 (82%) 47 (94%) 48 (96%)
Hepatocyte, Necrosis 1 (2%) 6 (12%) 8 (16%) 8 (16%)
Hepatocyte, Vacuolization Cytoplasmic 44 (88%) 45 (90%) 46 (92%) 44 (88%)
Hepatocyte, Centrilobular, Hypertrophy 44 (88%) 50 (100%) 48 (96%)
Oval Cell, Hyperplasia 1 (2%)
Mesentery (2) (8) (5)
Fat, Fibrosis 1 (50%) 5 (63%) 1 (20%)
Fat, Inflammation, Chronic Active 1 (50%) 5 (63%) 2 (40%)
Fat, Mineralization 1 (50%) 3 (38%)
Fat, Necrosis 1 (50%) 5 (63%)
Fat, Pigmentation 1 (50%)
Pancreas (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Cyst 1 (2%) 2 (4%)
Cytoplasmic Alteration 1 (2%)
Infiltration Cellular, Lymphoid 14 (28%) 11 (22%) 8 (16%) 8 (16%)
Acinus, Atrophy 1 (2%) 1 (2%) 1 (2%)
Acinus, Cytoplasmic Alteration 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%)
Infiltration Cellular, Lymphoid 31 (62%) 40 (80%) 40 (80%) 28 (56%)
Stomach, Forestomach (50) (50) (50) (50)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
Epithelium, Cyst 1 (2%)
Epithelium, Hyperkeratosis 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia, Squamous 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Epithelium, Ulcer 1 (2%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Glands, Ectasia 7 (14%) 13 (26%) 18 (36%) 5 (10%)
Glands, Mineralization 1 (2%) 1 (2%)
Tooth (20) (31) (33) (21)
Inflammation, Chronic Active 1 (5%) 3 (9%)
Malformation 3 (15%) 1 (3%) 3 (9%)
Gingiva, Inflammation, Chronic Active 18 (90%) 30 (97%) 32 (97%) 20 (95%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Hyperplasia, Atypical 1 (2%)
Inflammation, Chronic Active 3 (6%) 5 (10%) 3 (6%) 3 (6%)
Mineralization 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Degeneration, Fatty 2 (4%)
Hyperplasia 7 (14%) 10 (20%) 9 (18%) 6 (12%)
Hypertrophy 26 (52%) 22 (44%) 24 (48%) 18 (36%)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
Subcapsular, Hyperplasia 50 (100%) 46 (92%) 46 (92%) 47 (94%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (48) (49) (50) (50)
Pars Distalis, Cyst 7 (15%) 5 (10%) 5 (10%) 4 (8%)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%)
Pars Nervosa, Cyst 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (4%)
Follicle, Cyst 2 (4%) 1 (2%)
Follicle, Degeneration 12 (24%) 9 (18%) 6 (12%) 6 (12%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Degeneration 1 (2%)
Granuloma Sperm 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Infiltration Cellular, Lymphoid 32 (64%) 27 (54%) 30 (60%) 31 (62%)
Mineralization 4 (8%)
Spermatocele 1 (2%)
Preputial Gland (50) (50) (50) (50)
Inflammation, Chronic Active 21 (42%) 23 (46%) 25 (50%) 32 (64%)
Duct, Ectasia 20 (40%) 15 (30%) 15 (30%) 28 (56%)
Prostate (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 32 (64%) 43 (86%) 46 (92%) 28 (56%)
Inflammation, Chronic Active 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Artery, Inflammation, Chronic Active 1 (2%)
Testes (50) (50) (50) (50)
Mineralization 1 (2%) 4 (8%) 12 (24%)
Germinal Epithelium, Degeneration 3 (6%) 1 (2%) 2 (4%)
Rete Testes, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (1) (1) (3) (5)
Deep Cervical, Hyperplasia, Lymphoid 1 (33%)
Mediastinal, Hyperplasia, Lymphoid 1 (100%) 1 (33%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (100%)
Mediastinal, Inflammation, Granulomatous 1 (20%)
Lymph Node, Mandibular (48) (50) (49) (47)
Hyperplasia, Lymphoid 5 (10%) 1 (2%) 6 (12%) 5 (11%)
Lymph Node, Mesenteric (49) (50) (49) (48)
Hyperplasia, Lymphoid 2 (4%) 2 (4%) 2 (4%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Granulomatous 1 (2%)
Spleen (50) (50) (50) (50)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 11 (22%) 7 (14%) 9 (18%) 14 (28%)
Lymphoid Follicle, Hyperplasia, Lymphoid 17 (34%) 31 (62%) 34 (68%) 32 (64%)
Thymus (46) (48) (46) (47)
Atrophy 12 (26%) 9 (19%) 6 (13%) 5 (11%)
Cyst 16 (35%) 25 (52%) 20 (43%) 20 (43%)
Ectopic Parathyroid Gland 2 (4%)
Ectopic Thyroid 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Granulomatous 1 (2%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Spinal Cord (1) (1) (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 32 (64%) 38 (76%) 47 (94%) 36 (72%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 6 (12%) 7 (14%) 8 (16%) 4 (8%)
Alveolus, Infiltration Cellular, Histiocyte 7 (14%) 1 (2%) 1 (2%) 3 (6%)
Mediastinum, Inflammation, Suppurative 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Chronic Active 2 (4%) 1 (2%) 2 (4%)
Inflammation, Focal, Suppurative 1 (2%)
Inflammation, Suppurative 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic
Active 2 (4%) 1 (2%)
Olfactory Epithelium, Degeneration 1 (2%)
Olfactory Epithelium, Metaplasia 2 (4%) 2 (4%) 24 (48%)
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SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
Anterior Chamber, Iris, Inflammation,
Suppurative 1 (2%)
Cornea, Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%)
Harderian Gland (50) (50) (50) (50)
Hyperplasia 2 (4%) 3 (6%) 3 (6%) 2 (4%)
Infiltration Cellular, Lymphoid 37 (74%) 33 (66%) 24 (48%) 29 (58%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%)
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URINARY SYSTEM
Kidney (50) (50) (50) (50)
Infarct 1 (2%) 1 (2%) 1 (2%) 4 (8%)
Infiltration Cellular, Lymphoid 44 (88%) 44 (88%) 45 (90%) 45 (90%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:24:25
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B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
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URINARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%) 2 (4%)
Metaplasia, Osseous 4 (8%) 2 (4%) 1 (2%) 8 (16%)
Mineralization 49 (98%) 50 (100%) 50 (100%) 50 (100%)
Necrosis 1 (2%)
Nephropathy 49 (98%) 48 (96%) 50 (100%) 50 (100%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
Cortex, Cyst 4 (8%) 8 (16%) 12 (24%) 22 (44%)
Renal Tubule, Pigmentation 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 24 (48%) 24 (48%) 32 (64%) 23 (46%)
a Number of animals examined microscopically at site and number of animals with lesion
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