TDMS Study 88138-04 Pathology Tables
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 FINAL#2 MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 119-61-9 Lock Date: 04/26/02 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 4 2 5 6 Natural Death 6 6 4 12 Accidently Killed 1 Survivors Terminal Sacrifice 40 42 41 31 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (49) (50) (50) (50) Cyst 1 (2%) 1 (2%) Infiltration Cellular, Lymphoid 1 (2%) Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%) Mineralization 1 (2%) Intestine Large, Colon (50) (50) (50) (50) Inflammation, Chronic Active 1 (2%) Intestine Small, Duodenum (50) (50) (50) (50) Inflammation, Chronic Active 1 (2%) Intestine Small, Jejunum (50) (50) (50) (50) Peyer's Patch, Hyperplasia, Lymphoid 3 (6%) 1 (2%) Intestine Small, Ileum (50) (50) (50) (50) Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) Liver (50) (50) (50) (50) Angiectasis 2 (4%) 1 (2%) 4 (8%) Basophilic Focus 3 (6%) 1 (2%) 2 (4%) Clear Cell Focus 3 (6%) 2 (4%) 4 (8%) 4 (8%) Eosinophilic Focus 2 (4%) 2 (4%) 7 (14%) 7 (14%) Hematopoietic Cell Proliferation 18 (36%) 11 (22%) 20 (40%) 19 (38%) Infarct 1 (2%) Infiltration Cellular, Lymphoid 36 (72%) 38 (76%) 35 (70%) 35 (70%) Inflammation, Chronic Active 44 (88%) 40 (80%) 41 (82%) 36 (72%) Mineralization 1 (2%) Mixed Cell Focus 2 (4%) 5 (10%) 3 (6%) 2 (4%) Tension Lipidosis 4 (8%) 8 (16%) 3 (6%) 7 (14%) Bile Duct, Hyperplasia 1 (2%) Hepatocyte, Autolysis 1 (2%) Hepatocyte, Mitotic Alteration 1 (2%) Hepatocyte, Multinucleated 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Hepatocyte, Necrosis 3 (6%) 5 (10%) 4 (8%) Hepatocyte, Vacuolization Cytoplasmic 41 (82%) 43 (86%) 39 (78%) 34 (68%) Hepatocyte, Centrilobular, Degeneration 1 (2%) Hepatocyte, Centrilobular, Hypertrophy 29 (58%) 44 (88%) 37 (74%) Mesentery (6) (9) (11) (9) Fat, Fibrosis 1 (17%) 2 (22%) 8 (73%) 4 (44%) Fat, Hemorrhage 1 (11%) Fat, Infiltration Cellular, Lymphoid 4 (36%) Fat, Inflammation, Chronic Active 1 (17%) 3 (33%) 7 (64%) 3 (33%) Fat, Mineralization 1 (11%) 2 (18%) 1 (11%) Fat, Necrosis 1 (17%) 4 (44%) 9 (82%) 4 (44%) Pancreas (50) (50) (50) (50) Cyst 1 (2%) 2 (4%) Infiltration Cellular, Lymphoid 20 (40%) 24 (48%) 33 (66%) 18 (36%) Acinus, Atrophy 1 (2%) 1 (2%) 1 (2%) 2 (4%) Acinus, Cytoplasmic Alteration 1 (2%) Duct, Inflammation, Chronic Active 1 (2%) Duct, Pigmentation 1 (2%) Salivary Glands (50) (50) (50) (50) Infiltration Cellular, Lymphoid 27 (54%) 34 (68%) 30 (60%) 28 (56%) Stomach, Forestomach (50) (50) (50) (50) Inflammation, Chronic Active 1 (2%) 1 (2%) Epithelium, Hyperkeratosis 1 (2%) 1 (2%) 1 (2%) 1 (2%) Epithelium, Hyperplasia, Squamous 1 (2%) 1 (2%) 1 (2%) Epithelium, Ulcer 1 (2%) 1 (2%) Stomach, Glandular (50) (50) (50) (50) Epithelium, Glands, Hyperplasia 1 (2%) Glands, Ectasia 18 (36%) 16 (32%) 22 (44%) 10 (20%) Glands, Mineralization 3 (6%) 2 (4%) Tooth (21) (29) (24) (20) Malformation 1 (4%) Gingiva, Inflammation, Chronic Active 21 (100%) 29 (100%) 24 (100%) 20 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (50) (50) (50) (50) Aorta, Mineralization 1 (2%) Heart (50) (50) (50) (50) Cardiomyopathy 1 (2%) Hyperplasia, Atypical 1 (2%) 1 (2%) Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%) Mineralization 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - CONT Necrosis 1 (2%) Valve, Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (49) Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hemorrhage 1 (2%) Hyperplasia 2 (4%) Hypertrophy 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) Mineralization 1 (2%) Necrosis 1 (2%) 1 (2%) Subcapsular, Hyperplasia 49 (98%) 49 (98%) 49 (98%) 49 (100%) Adrenal Medulla (50) (50) (50) (49) Hyperplasia 2 (4%) Islets, Pancreatic (50) (50) (50) (50) Hyperplasia 3 (6%) 1 (2%) Parathyroid Gland (42) (41) (40) (40) Cyst 3 (8%) 1 (3%) Pituitary Gland (50) (50) (49) (47) Pars Distalis, Angiectasis 2 (4%) 4 (8%) 5 (10%) 3 (6%) Pars Distalis, Cyst 5 (10%) 3 (6%) 2 (4%) Pars Distalis, Hyperplasia 14 (28%) 14 (28%) 13 (27%) 3 (6%) Pars Distalis, Hypertrophy 1 (2%) Pars Distalis, Pigmentation 1 (2%) Thyroid Gland (50) (50) (50) (50) Infiltration Cellular, Lymphoid 1 (2%) 2 (4%) 2 (4%) Inflammation, Chronic Active 1 (2%) 2 (4%) C-Cell, Hyperplasia 1 (2%) Follicle, Cyst 1 (2%) Follicle, Degeneration 17 (34%) 19 (38%) 12 (24%) 9 (18%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Clitoral Gland (50) (49) (50) (50) Inflammation, Chronic Active 8 (16%) 1 (2%) 2 (4%) Duct, Cyst 1 (2%) Ovary (49) (50) (50) (50) Angiectasis 1 (2%) 1 (2%) Atrophy 48 (98%) 48 (96%) 46 (92%) 45 (90%) Cyst 22 (45%) 17 (34%) 17 (34%) 14 (28%) Hemorrhage 2 (4%) 5 (10%) 3 (6%) 4 (8%) Infiltration Cellular, Lymphoid 1 (2%) Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%) Mineralization 4 (8%) 2 (4%) Pigmentation 6 (12%) 2 (4%) 3 (6%) 1 (2%) Uterus (49) (50) (50) (50) Angiectasis 1 (2%) 1 (2%) Inflammation, Chronic Active 5 (10%) 4 (8%) 2 (4%) 2 (4%) Endometrium, Hyperplasia, Cystic 47 (96%) 45 (90%) 44 (88%) 43 (86%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Myelofibrosis 18 (36%) 30 (60%) 20 (40%) 26 (52%) Myeloid Cell, Hyperplasia 1 (2%) Lymph Node (8) (12) (11) (15) Lumbar, Hyperplasia, Lymphoid 1 (13%) 1 (8%) 2 (13%) Mediastinal, Atrophy 1 (13%) Mediastinal, Hyperplasia, Lymphoid 2 (25%) 5 (42%) 4 (36%) 4 (27%) Mediastinal, Infiltration Cellular, Histiocyte 1 (13%) Mediastinal, Inflammation, Chronic Active 1 (13%) Pancreatic, Hyperplasia, Lymphoid 2 (18%) 1 (7%) Pancreatic, Pigmentation 1 (9%) Renal, Hemorrhage 1 (8%) 1 (7%) Renal, Hyperplasia, Lymphoid 3 (25%) 1 (7%) Lymph Node, Mandibular (50) (50) (50) (49) Hyperplasia, Lymphoid 4 (8%) 20 (40%) 12 (24%) 9 (18%) Lymph Node, Mesenteric (50) (49) (49) (50) Hyperplasia, Lymphoid 6 (12%) 12 (24%) 6 (12%) 4 (8%) Spleen (50) (50) (50) (50) Hematopoietic Cell Proliferation 16 (32%) 35 (70%) 32 (64%) 27 (54%) Hemorrhage 2 (4%) Inflammation, Chronic Active 1 (2%) Necrosis 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Lymphoid Follicle, Hyperplasia, Lymphoid 24 (48%) 36 (72%) 37 (74%) 22 (44%) Thymus (46) (50) (50) (50) Atrophy 8 (17%) 7 (14%) 3 (6%) 13 (26%) Cyst 23 (50%) 35 (70%) 31 (62%) 24 (48%) Ectopic Parathyroid Gland 1 (2%) 3 (6%) 1 (2%) 1 (2%) Hyperplasia, Lymphoid 8 (16%) 5 (10%) 2 (4%) Infiltration Cellular, Mast Cell 1 (2%) Inflammation, Chronic Active 1 (2%) Thymocyte, Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (50) (50) Subcutaneous Tissue, Fibrosis 1 (2%) Subcutaneous Tissue, Infiltration Cellular, Lymphoid 4 (8%) 1 (2%) Subcutaneous Tissue, Infiltration Cellular, Polymorphonuclear 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Maxilla, Fracture 1 (2%) Skeletal Muscle (2) (4) (2) (4) Infiltration Cellular, Lymphoid 3 (75%) 2 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Hemorrhage 2 (4%) Infiltration Cellular, Lymphoid 1 (2%) 2 (4%) Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Foreign Body 1 (2%) Infiltration Cellular, Lymphoid 33 (66%) 44 (88%) 44 (88%) 35 (70%) Inflammation, Chronic Active 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Metaplasia, Osseous 1 (2%) Pigmentation 2 (4%) Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 2 (4%) 2 (4%) Alveolus, Hemorrhage 2 (4%) 3 (6%) Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 2 (4%) Mediastinum, Inflammation, Chronic Active 1 (2%) Nose (50) (50) (50) (50) Hemorrhage 1 (2%) Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%) Nasolacrimal Duct, Inflammation, Chronic Active 1 (2%) Olfactory Epithelium, Metaplasia 39 (78%) Trachea (50) (50) (50) (50) Glands, Cyst 1 (2%) Glands, Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (50) (50) (50) (50) Atrophy 2 (4%) Lens, Cataract 1 (2%) Harderian Gland (50) (50) (50) (49) Hyperplasia 3 (6%) 3 (6%) 1 (2%) Infiltration Cellular, Lymphoid 29 (58%) 27 (54%) 27 (54%) 23 (47%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Accumulation, Hyaline Droplet 1 (2%) 1 (2%) Atrophy 1 (2%) Glomerulosclerosis 1 (2%) Hydronephrosis 2 (4%) 1 (2%) Infarct 4 (8%) 1 (2%) 3 (6%) 3 (6%) Infiltration Cellular, Lymphoid 41 (82%) 45 (90%) 43 (86%) 39 (78%) Inflammation, Chronic Active 1 (2%) Metaplasia, Osseous 1 (2%) 2 (4%) 4 (8%) 2 (4%) Mineralization 15 (30%) 31 (62%) 36 (72%) 49 (98%) Nephropathy 21 (42%) 33 (66%) 31 (62%) 30 (60%) Artery, Inflammation, Chronic Active 1 (2%) 1 (2%) Cortex, Cyst 1 (2%) Renal Tubule, Pigmentation 1 (2%) 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Urinary Bladder (50) (49) (50) (50) Infiltration Cellular, Lymphoid 37 (74%) 38 (78%) 40 (80%) 39 (78%) Inflammation, Chronic Active 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 5 3 5 2 Natural Death 1 3 1 3 Survivors Terminal Sacrifice 44 44 44 45 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (45) (49) (49) (49) Cyst 1 (2%) Intestine Small, Jejunum (50) (50) (50) (50) Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) Liver (50) (50) (50) (50) Basophilic Focus 4 (8%) 2 (4%) 5 (10%) Clear Cell Focus 2 (4%) 7 (14%) 7 (14%) 12 (24%) Eosinophilic Focus 5 (10%) 8 (16%) 11 (22%) 10 (20%) Fatty Change 1 (2%) Fibrosis 1 (2%) Hematopoietic Cell Proliferation 2 (4%) 1 (2%) Infarct 2 (4%) 1 (2%) Infiltration Cellular, Lymphoid 6 (12%) 10 (20%) 4 (8%) Inflammation, Chronic Active 33 (66%) 47 (94%) 44 (88%) 42 (84%) Mixed Cell Focus 8 (16%) 9 (18%) 15 (30%) 13 (26%) Tension Lipidosis 1 (2%) 1 (2%) 1 (2%) Bile Duct, Cyst 3 (6%) 1 (2%) Hepatocyte, Degeneration, Cystic 5 (10%) 30 (60%) Hepatocyte, Multinucleated 41 (82%) 47 (94%) 48 (96%) Hepatocyte, Necrosis 1 (2%) 6 (12%) 8 (16%) 8 (16%) Hepatocyte, Vacuolization Cytoplasmic 44 (88%) 45 (90%) 46 (92%) 44 (88%) Hepatocyte, Centrilobular, Hypertrophy 44 (88%) 50 (100%) 48 (96%) Oval Cell, Hyperplasia 1 (2%) Mesentery (2) (8) (5) Fat, Fibrosis 1 (50%) 5 (63%) 1 (20%) Fat, Inflammation, Chronic Active 1 (50%) 5 (63%) 2 (40%) Fat, Mineralization 1 (50%) 3 (38%) Fat, Necrosis 1 (50%) 5 (63%) Fat, Pigmentation 1 (50%) Pancreas (50) (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Cyst 1 (2%) 2 (4%) Cytoplasmic Alteration 1 (2%) Infiltration Cellular, Lymphoid 14 (28%) 11 (22%) 8 (16%) 8 (16%) Acinus, Atrophy 1 (2%) 1 (2%) 1 (2%) Acinus, Cytoplasmic Alteration 1 (2%) Salivary Glands (50) (50) (50) (50) Atrophy 1 (2%) Infiltration Cellular, Lymphoid 31 (62%) 40 (80%) 40 (80%) 28 (56%) Stomach, Forestomach (50) (50) (50) (50) Hyperplasia 1 (2%) Inflammation, Chronic Active 1 (2%) 2 (4%) Epithelium, Cyst 1 (2%) Epithelium, Hyperkeratosis 1 (2%) 2 (4%) 1 (2%) 1 (2%) Epithelium, Hyperplasia, Squamous 1 (2%) 2 (4%) 1 (2%) 1 (2%) Epithelium, Ulcer 1 (2%) 1 (2%) Stomach, Glandular (50) (50) (50) (50) Glands, Ectasia 7 (14%) 13 (26%) 18 (36%) 5 (10%) Glands, Mineralization 1 (2%) 1 (2%) Tooth (20) (31) (33) (21) Inflammation, Chronic Active 1 (5%) 3 (9%) Malformation 3 (15%) 1 (3%) 3 (9%) Gingiva, Inflammation, Chronic Active 18 (90%) 30 (97%) 32 (97%) 20 (95%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Hyperplasia, Atypical 1 (2%) Inflammation, Chronic Active 3 (6%) 5 (10%) 3 (6%) 3 (6%) Mineralization 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Degeneration, Fatty 2 (4%) Hyperplasia 7 (14%) 10 (20%) 9 (18%) 6 (12%) Hypertrophy 26 (52%) 22 (44%) 24 (48%) 18 (36%) Inflammation, Chronic Active 1 (2%) Necrosis 1 (2%) Subcapsular, Hyperplasia 50 (100%) 46 (92%) 46 (92%) 47 (94%) Adrenal Medulla (50) (50) (50) (50) Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Islets, Pancreatic (50) (50) (50) (50) Hyperplasia 1 (2%) 1 (2%) Pituitary Gland (48) (49) (50) (50) Pars Distalis, Cyst 7 (15%) 5 (10%) 5 (10%) 4 (8%) Pars Distalis, Hyperplasia 1 (2%) 1 (2%) Pars Nervosa, Cyst 1 (2%) Thyroid Gland (50) (50) (50) (50) Infiltration Cellular, Lymphoid 1 (2%) 1 (2%) Inflammation, Chronic Active 2 (4%) Follicle, Cyst 2 (4%) 1 (2%) Follicle, Degeneration 12 (24%) 9 (18%) 6 (12%) 6 (12%) Follicular Cell, Hyperplasia 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Degeneration 1 (2%) Granuloma Sperm 1 (2%) 2 (4%) 2 (4%) 1 (2%) Infiltration Cellular, Lymphoid 32 (64%) 27 (54%) 30 (60%) 31 (62%) Mineralization 4 (8%) Spermatocele 1 (2%) Preputial Gland (50) (50) (50) (50) Inflammation, Chronic Active 21 (42%) 23 (46%) 25 (50%) 32 (64%) Duct, Ectasia 20 (40%) 15 (30%) 15 (30%) 28 (56%) Prostate (50) (50) (50) (50) Infiltration Cellular, Lymphoid 32 (64%) 43 (86%) 46 (92%) 28 (56%) Inflammation, Chronic Active 1 (2%) Artery, Inflammation, Chronic Active 1 (2%) 1 (2%) Seminal Vesicle (50) (50) (50) (50) Artery, Inflammation, Chronic Active 1 (2%) Testes (50) (50) (50) (50) Mineralization 1 (2%) 4 (8%) 12 (24%) Germinal Epithelium, Degeneration 3 (6%) 1 (2%) 2 (4%) Rete Testes, Cyst 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (50) (50) (50) Myeloid Cell, Hyperplasia 1 (2%) Lymph Node (1) (1) (3) (5) Deep Cervical, Hyperplasia, Lymphoid 1 (33%) Mediastinal, Hyperplasia, Lymphoid 1 (100%) 1 (33%) Mediastinal, Infiltration Cellular, Histiocyte 1 (100%) Mediastinal, Inflammation, Granulomatous 1 (20%) Lymph Node, Mandibular (48) (50) (49) (47) Hyperplasia, Lymphoid 5 (10%) 1 (2%) 6 (12%) 5 (11%) Lymph Node, Mesenteric (49) (50) (49) (48) Hyperplasia, Lymphoid 2 (4%) 2 (4%) 2 (4%) Infiltration Cellular, Histiocyte 1 (2%) Inflammation, Granulomatous 1 (2%) Spleen (50) (50) (50) (50) Angiectasis 1 (2%) Hematopoietic Cell Proliferation 11 (22%) 7 (14%) 9 (18%) 14 (28%) Lymphoid Follicle, Hyperplasia, Lymphoid 17 (34%) 31 (62%) 34 (68%) 32 (64%) Thymus (46) (48) (46) (47) Atrophy 12 (26%) 9 (19%) 6 (13%) 5 (11%) Cyst 16 (35%) 25 (52%) 20 (43%) 20 (43%) Ectopic Parathyroid Gland 2 (4%) Ectopic Thyroid 1 (2%) Infiltration Cellular, Histiocyte 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (50) (50) Cyst Epithelial Inclusion 1 (2%) Inflammation, Granulomatous 1 (2%) Mineralization 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Spinal Cord (1) (1) (1) a Number of animals examined microscopically at site and number of animals with lesion Page 12 NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - CONT Degeneration 1 (100%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Infiltration Cellular, Lymphoid 32 (64%) 38 (76%) 47 (94%) 36 (72%) Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%) 1 (2%) Metaplasia, Osseous 1 (2%) Necrosis 1 (2%) Thrombosis 1 (2%) Alveolar Epithelium, Hyperplasia 6 (12%) 7 (14%) 8 (16%) 4 (8%) Alveolus, Infiltration Cellular, Histiocyte 7 (14%) 1 (2%) 1 (2%) 3 (6%) Mediastinum, Inflammation, Suppurative 1 (2%) Nose (50) (50) (50) (50) Inflammation, Chronic Active 2 (4%) 1 (2%) 2 (4%) Inflammation, Focal, Suppurative 1 (2%) Inflammation, Suppurative 1 (2%) Nasolacrimal Duct, Inflammation, Chronic Active 2 (4%) 1 (2%) Olfactory Epithelium, Degeneration 1 (2%) Olfactory Epithelium, Metaplasia 2 (4%) 2 (4%) 24 (48%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (50) (50) (50) (50) Inflammation, Suppurative 1 (2%) Anterior Chamber, Iris, Inflammation, Suppurative 1 (2%) Cornea, Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%) Harderian Gland (50) (50) (50) (50) Hyperplasia 2 (4%) 3 (6%) 3 (6%) 2 (4%) Infiltration Cellular, Lymphoid 37 (74%) 33 (66%) 24 (48%) 29 (58%) Inflammation, Chronic Active 1 (2%) 1 (2%) Mineralization 1 (2%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Infarct 1 (2%) 1 (2%) 1 (2%) 4 (8%) Infiltration Cellular, Lymphoid 44 (88%) 44 (88%) 45 (90%) 45 (90%) a Number of animals examined microscopically at site and number of animals with lesion Page 13 NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZOPHENONE Date: 06/01/04 Route: DOSED FEED Time: 13:24:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Inflammation, Chronic Active 1 (2%) 2 (4%) Metaplasia, Osseous 4 (8%) 2 (4%) 1 (2%) 8 (16%) Mineralization 49 (98%) 50 (100%) 50 (100%) 50 (100%) Necrosis 1 (2%) Nephropathy 49 (98%) 48 (96%) 50 (100%) 50 (100%) Artery, Inflammation, Chronic Active 1 (2%) 1 (2%) Cortex, Cyst 4 (8%) 8 (16%) 12 (24%) 22 (44%) Renal Tubule, Pigmentation 1 (2%) Urinary Bladder (50) (50) (50) (50) Infiltration Cellular, Lymphoid 24 (48%) 24 (48%) 32 (64%) 23 (46%) a Number of animals examined microscopically at site and number of animals with lesion Page 14 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------