TDMS Study 88138-04 Pathology Tables
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 06/24/03
Route: DOSED FEED Time: 08:31:29
FINAL#1/MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 119-61-9
Lock Date: 04/26/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 06/24/03
Route: DOSED FEED Time: 08:31:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 4 2 5 6
Natural Death 6 6 4 12
Accidently Killed 1
Survivors
Terminal Sacrifice 40 42 41 31
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Gallbladder (49) (50) (50) (50)
Histiocytic Sarcoma 2 (4%)
Intestine Large, Colon (50) (50) (50) (50)
Hemangiosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Intestine Large, Cecum (50) (50) (50) (50)
Intestine Small, Duodenum (50) (50) (50) (50)
Polyp Adenomatous 1 (2%) 3 (6%)
Intestine Small, Jejunum (50) (50) (50) (50)
Carcinoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Liver (50) (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Hepatocellular Adenoma 4 (8%) 3 (6%) 7 (14%) 5 (10%)
Hepatocellular Adenoma, Multiple 1 (2%) 1 (2%) 3 (6%) 3 (6%)
Histiocytic Sarcoma 5 (10%) 3 (6%)
Mast Cell Tumor Malignant 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Mesentery (6) (9) (11) (9)
Fat, Fibrosarcoma, Metastatic, Skin 1 (11%)
Fat, Fibrous Histiocytoma, Metastatic, Skin 1 (11%)
Fat, Hemangiosarcoma, Metastatic, Skeletal
Muscle 1 (11%)
Page 2
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 06/24/03
Route: DOSED FEED Time: 08:31:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Fat, Histiocytic Sarcoma 2 (22%)
Fat, Sarcoma Stromal, Metastatic, Uterus 1 (17%)
Oral Mucosa (2)
Gingival, Mast Cell Tumor Malignant 1 (50%)
Pharyngeal, Squamous Cell Papilloma 1 (50%)
Pancreas (50) (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Histiocytic Sarcoma 2 (4%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Salivary Glands (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 2 (4%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Aorta, Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Aorta, Histiocytic Sarcoma 1 (2%)
Heart (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Histiocytic Sarcoma 3 (6%)
Subcapsular, Adenoma 1 (2%)
Adrenal Medulla (50) (50) (50) (49)
Pheochromocytoma Benign 1 (2%) 1 (2%) 2 (4%)
Islets, Pancreatic (50) (50) (50) (50)
Carcinoma 1 (2%)
Page 3
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 06/24/03
Route: DOSED FEED Time: 08:31:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Parathyroid Gland (42) (41) (40) (40)
Pituitary Gland (50) (50) (49) (47)
Pars Distalis, Adenoma 2 (4%) 2 (4%) 3 (6%)
Pars Distalis, Histiocytic Sarcoma 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (49) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Ovary (49) (50) (50) (50)
Cystadenoma 1 (2%) 3 (6%) 3 (6%) 2 (4%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Histiocytic Sarcoma 2 (4%) 3 (6%)
Bilateral, Granulosa Cell Tumor Malignant 1 (2%)
Bilateral, Tubulostromal Adenoma 1 (2%)
Uterus (49) (50) (50) (50)
Hemangiosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Histiocytic Sarcoma 1 (2%) 3 (6%)
Leiomyoma 1 (2%)
Polyp Stromal 3 (6%)
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 1 (2%)
Bilateral, Polyp Stromal 1 (2%)
Endometrium, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (4%)
Page 4
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 06/24/03
Route: DOSED FEED Time: 08:31:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Mast Cell Tumor Malignant 1 (2%)
Lymph Node (8) (12) (11) (15)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (8%)
Inguinal, Histiocytic Sarcoma 1 (7%)
Lumbar, Histiocytic Sarcoma 1 (9%) 2 (13%)
Mediastinal, Carcinoma, Metastatic, Thyroid
Gland 1 (7%)
Mediastinal, Fibrous Histiocytoma,
Metastatic, Skin 1 (7%)
Mediastinal, Hemangiosarcoma, Metastatic,
Skeletal Muscle 1 (7%)
Mediastinal, Histiocytic Sarcoma 3 (20%)
Pancreatic, Fibrous Histiocytoma, Metastatic,
Skin 1 (7%)
Pancreatic, Histiocytic Sarcoma 1 (7%)
Renal, Fibrous Histiocytoma, Metastatic, Skin 1 (7%)
Renal, Histiocytic Sarcoma 1 (9%) 2 (13%)
Lymph Node, Mandibular (50) (50) (50) (49)
Histiocytic Sarcoma 3 (6%) 2 (4%)
Mast Cell Tumor Malignant, Metastatic, Oral
Mucosa 1 (2%)
Lymph Node, Mesenteric (50) (49) (49) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Histiocytic Sarcoma 2 (4%) 3 (6%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Spleen (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma, Metastatic, Bone Marrow 1 (2%)
Histiocytic Sarcoma 2 (4%) 3 (6%)
Thymus (46) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mast Cell Tumor Malignant 1 (2%)
Mast Cell Tumor Malignant, Metastatic, Oral
Mucosa 1 (2%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 06/24/03
Route: DOSED FEED Time: 08:31:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Skin (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 4 (8%) 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant,
Multiple 1 (2%)
Subcutaneous Tissue, Trichoepithelioma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Skeletal Muscle (2) (4) (2) (4)
Hemangiosarcoma 1 (25%)
Histiocytic Sarcoma 1 (25%)
Sarcoma Stromal, Metastatic, Uterus 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 5 (10%) 2 (4%) 2 (4%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%) 1 (2%)
Page 6
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 06/24/03
Route: DOSED FEED Time: 08:31:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Granulosa Cell Tumor Malignant, Metastatic,
Ovary 1 (2%) 1 (2%)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Hemangiosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Histiocytic Sarcoma 5 (10%) 3 (6%)
Osteosarcoma, Metastatic, Skin 1 (2%)
Mediastinum, Fibrosarcoma, Metastatic, Skin 1 (2%)
Nose (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mast Cell Tumor Malignant 1 (2%)
Trachea (50) (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Harderian Gland (50) (50) (50) (49)
Adenoma 1 (2%) 3 (6%) 2 (4%) 3 (6%)
Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Histiocytic Sarcoma 3 (6%) 3 (6%)
Urinary Bladder (50) (49) (50) (50)
Histiocytic Sarcoma 3 (6%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 5 (10%) 3 (6%)
Lymphoma Malignant 8 (16%) 9 (18%) 5 (10%) 10 (20%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 7
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 06/24/03
Route: DOSED FEED Time: 08:31:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 25 28 32 30
Total Primary Neoplasms 34 39 49 45
Total Animals with Benign Neoplasms 15 17 19 19
Total Benign Neoplasms 18 23 25 24
Total Animals with Malignant Neoplasms 16 13 18 20
Total Malignant Neoplasms 16 16 24 21
Total Animals with Metastatic Neoplasms 3 2 3 6
Total Metastatic Neoplasm 10 7 3 31
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 8
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 06/24/03
Route: DOSED FEED Time: 08:31:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 5 3 5 2
Natural Death 1 3 1 3
Survivors
Terminal Sacrifice 44 44 44 45
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (49) (49) (49)
Intestine Large, Cecum (50) (50) (50) (50)
Intestine Small, Duodenum (50) (50) (50) (50)
Polyp Adenomatous 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Carcinoma 1 (2%)
Liver (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Hepatoblastoma 1 (2%) 1 (2%) 3 (6%)
Hepatocellular Carcinoma 6 (12%) 5 (10%) 4 (8%) 6 (12%)
Hepatocellular Carcinoma, Multiple 2 (4%) 2 (4%)
Hepatocellular Adenoma 9 (18%) 7 (14%) 15 (30%) 11 (22%)
Hepatocellular Adenoma, Multiple 2 (4%) 8 (16%) 8 (16%) 12 (24%)
Ito Cell Tumor Benign 1 (2%)
Mesentery (2) (8) (5)
Fat, Hemangiosarcoma, Metastatic, Spleen 1 (50%)
Pancreas (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 2 (4%) 3 (6%)
Squamous Cell Papilloma, Multiple 1 (2%)
Tongue (1)
Squamous Cell Carcinoma 1 (100%)
Tooth (20) (31) (33) (21)
Odontoma 1 (5%) 1 (5%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 06/24/03
Route: DOSED FEED Time: 08:31:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Aorta, Adventitia, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (2%)
Heart (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adrenal Medulla (50) (50) (50) (50)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Prostate (50) (50) (50) (50)
Adenoma 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Testes (50) (50) (50) (50)
Interstitial Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Hemangiosarcoma, Metastatic, Skeletal Muscle 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Lymph Node (1) (1) (3) (5)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (100%)
Page 10
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 06/24/03
Route: DOSED FEED Time: 08:31:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Lymph Node, Mandibular (48) (50) (49) (47)
Lymph Node, Mesenteric (49) (50) (49) (48)
Spleen (50) (50) (50) (50)
Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%)
Thymus (46) (48) (46) (47)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (50)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Skeletal Muscle (1) (1) (2)
Hemangiosarcoma 1 (100%)
Hemangiosarcoma, Metastatic, Spleen 1 (100%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 10 (20%) 9 (18%) 4 (8%) 8 (16%)
Alveolar/Bronchiolar Adenoma, Multiple 4 (8%) 2 (4%) 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 1 (2%)
Carcinoma, Metastatic, Harderian Gland 1 (2%) 1 (2%)
Hepatoblastoma, Metastatic, Liver 1 (2%) 2 (4%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Mediastinum, Alveolus, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (2%)
Page 11
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 06/24/03
Route: DOSED FEED Time: 08:31:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (50) (50) (50) (50)
Adenoma 6 (12%) 6 (12%) 4 (8%) 4 (8%)
Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant 2 (4%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BENZOPHENONE Date: 06/24/03
Route: DOSED FEED Time: 08:31:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 38 30 34 35
Total Primary Neoplasms 52 46 52 52
Total Animals with Benign Neoplasms 27 23 30 27
Total Benign Neoplasms 34 36 40 39
Total Animals with Malignant Neoplasms 17 10 11 13
Total Malignant Neoplasms 18 10 12 13
Total Animals with Metastatic Neoplasms 6 5 3 3
Total Metastatic Neoplasm 11 7 3 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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