TDMS Study 88138-04 Pathology Tables
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
FINAL#2 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 119-61-9
Lock Date: 04/26/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 0| 2| 2| 2| 3| 3| 2| 5| 3| 3| 2| 2| 0| 2| 3| 3| 3| 1| 3| 1| 2| 2|
| 9| 0| 9| 6| 9| 9| 9| 0| 0| 9| 6| 0| 1| 9| 9| 9| 9| 1| 0| 0| 0| 1| 3| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | X X |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 2 1 1 2 2 1 2 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 2 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 2 2 1 1 1|
Mixed Cell Focus | |
Tension Lipidosis | |
Bile Duct, Hyperplasia | 1 |
Hepatocyte, Necrosis | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 4 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Mesentery | + + + + |
Fat, Fibrosis | 2 |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 4 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 0| 2| 2| 2| 3| 3| 2| 5| 3| 3| 2| 2| 0| 2| 3| 3| 3| 1| 3| 1| 2| 2|
| 9| 0| 9| 6| 9| 9| 9| 0| 0| 9| 6| 0| 1| 9| 9| 9| 9| 1| 0| 0| 0| 1| 3| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Cyst | |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 2 |
Acinus, Atrophy | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 2 2 1 1 1|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Epithelium, Hyperkeratosis | 2 |
Epithelium, Hyperplasia, Squamous | 2 |
Epithelium, Ulcer | 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Glands, Hyperplasia | 2 |
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + |
Gingiva, Inflammation, Chronic Active| 1 1 2 2 1 2 1 1 1 1 2 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Necrosis | 3 |
Valve, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 |
Hypertrophy | 1 |
Inflammation, Chronic Active | |
Subcapsular, Hyperplasia | 1 3 2 1 3 1 2 2 1 1 1 2 2 2 2 2 1 3 2 2 2 1 1 1 1|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 0| 2| 2| 2| 3| 3| 2| 5| 3| 3| 2| 2| 0| 2| 3| 3| 3| 1| 3| 1| 2| 2|
| 9| 0| 9| 6| 9| 9| 9| 0| 0| 9| 6| 0| 1| 9| 9| 9| 9| 1| 0| 0| 0| 1| 3| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 1 1 |
Pars Distalis, Hyperplasia | 2 3 3 2 1 1 1 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Degeneration | 1 1 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 4 2 4 1 |
Duct, Cyst | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 4 3 4 4 4 4 4 4 4 3 4 3 4 4 4 4 4 4 4 4 4 4 3 3|
Cyst | 4 3 2 3 3 2 3 3 2 3 2 2 2 2 3 2 |
Hemorrhage | 4 |
Inflammation, Chronic Active | 3 |
Pigmentation | 2 1 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Inflammation, Chronic Active | 2 2 |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 1 3 1 2 2 3 4 2 4 3 2 4 2 2 4 2 1|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 0| 2| 2| 2| 3| 3| 2| 5| 3| 3| 2| 2| 0| 2| 3| 3| 3| 1| 3| 1| 2| 2|
| 9| 0| 9| 6| 9| 9| 9| 0| 0| 9| 6| 0| 1| 9| 9| 9| 9| 1| 0| 0| 0| 1| 3| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 2 1 1 2 1 2 1 1 2 |
Myeloid Cell, Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + + + + + |
Lumbar, Hyperplasia, Lymphoid | |
Mediastinal, Atrophy | 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
Mediastinal, Inflammation, Chronic | |
Active | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 3 4 4 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 4 2 2 2 4 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 2 2 2 3 3 3 3 4 3 3 2 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + M + M + + + M + + + + + M + + + +|
Atrophy | 4 3 4 |
Cyst | X X X X X X X X X X X X|
Ectopic Parathyroid Gland | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Infiltration | |
Cellular, Polymorphonuclear | |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 0| 2| 2| 2| 3| 3| 2| 5| 3| 3| 2| 2| 0| 2| 3| 3| 3| 1| 3| 1| 2| 2|
| 9| 0| 9| 6| 9| 9| 9| 0| 0| 9| 6| 0| 1| 9| 9| 9| 9| 1| 0| 0| 0| 1| 3| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 2 1 1 1 1 2 2 2 2 1 1 |
Alveolar Epithelium, Hyperplasia | 2|
Alveolus, Hemorrhage | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 4 |
Mediastinum, Inflammation, Chronic | |
Active | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 2| 0| 2| 2| 2| 3| 3| 2| 5| 3| 3| 2| 2| 0| 2| 3| 3| 3| 1| 3| 1| 2| 2|
| 9| 0| 9| 6| 9| 9| 9| 0| 0| 9| 6| 0| 1| 9| 9| 9| 9| 1| 0| 0| 0| 1| 3| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hydronephrosis | 3 2 |
Infarct | 4 |
Infiltration Cellular, Lymphoid | 2 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Inflammation, Chronic Active | |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1|
Nephropathy | 1 1 3 1 1 2 1 1 1 1 1|
Artery, Inflammation, Chronic Active | |
Renal Tubule, Pigmentation | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 2 1 1 2 2 1 1 1 1 1 1 1 2 1 2 1 1|
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 1| 2| 2| 2| 2| 3| 3| 2| 2| 3| 3| 0| 2| 3| 2| 2| 2| 3| 3| 0| 3| 2| 0| 3| |
| 8| 4| 9| 9| 9| 9| 1| 1| 9| 9| 1| 1| 8| 9| 0| 9| 9| 9| 0| 0| 9| 0| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 | 2 2.5|
Basophilic Focus | X X | 3 |
Clear Cell Focus | X | 3 |
Eosinophilic Focus | X X | 2 |
Hematopoietic Cell Proliferation | 1 1 2 1 1 1 1 1 1 2 1| 18 1.3|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 2 2 1 1 2 1 1 2 2 1 1 1| 36 1.2|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1| 44 1.1|
Mixed Cell Focus | X X | 2 |
Tension Lipidosis | 2 1 1 1 | 4 1.3|
Bile Duct, Hyperplasia | | 1 1.0|
Hepatocyte, Necrosis | 2 2 | 3 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 41 1.1|
|__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 1| 2| 2| 2| 2| 3| 3| 2| 2| 3| 3| 0| 2| 3| 2| 2| 2| 3| 3| 0| 3| 2| 0| 3| |
| 8| 4| 9| 9| 9| 9| 1| 1| 9| 9| 1| 1| 8| 9| 0| 9| 9| 9| 0| 0| 9| 0| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Inflammation, Chronic Active | 4 | 1 4.0|
Fat, Necrosis | | 1 4.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Infiltration Cellular, Lymphoid | 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 20 1.1|
Acinus, Atrophy | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 2 1 1 1 1 1 1 1 1 1 1 1| 27 1.1|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Epithelium, Hyperkeratosis | | 1 2.0|
Epithelium, Hyperplasia, Squamous | | 1 2.0|
Epithelium, Ulcer | | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Glands, Hyperplasia | | 1 2.0|
Glands, Ectasia | 1 1 1 1 1 1 1 1 1 | 18 1.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + | 21 |
Gingiva, Inflammation, Chronic Active| 2 2 2 2 2 2 1 2 | 21 1.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 2 1.5|
Necrosis | | 1 3.0|
Valve, Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 1| 2| 2| 2| 2| 3| 3| 2| 2| 3| 3| 0| 2| 3| 2| 2| 2| 3| 3| 0| 3| 2| 0| 3| |
| 8| 4| 9| 9| 9| 9| 1| 1| 9| 9| 1| 1| 8| 9| 0| 9| 9| 9| 0| 0| 9| 0| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 1 | 2 1.0|
Hypertrophy | | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Subcapsular, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2| 49 1.8|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 3 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + M + M M + M M| 42 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 3 | 2 2.5|
Pars Distalis, Cyst | 1 1 1 | 5 1.0|
Pars Distalis, Hyperplasia | 2 3 2 2 1 1 | 14 1.9|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Degeneration | 1 1 2 1 1 1 1 1 1 | 17 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 1 1 | 8 2.1|
Duct, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Ovary | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 1| 2| 2| 2| 2| 3| 3| 2| 2| 3| 3| 0| 2| 3| 2| 2| 2| 3| 3| 0| 3| 2| 0| 3| |
| 8| 4| 9| 9| 9| 9| 1| 1| 9| 9| 1| 1| 8| 9| 0| 9| 9| 9| 0| 0| 9| 0| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Angiectasis | 2 | 1 2.0|
Atrophy | 4 4 4 4 4 4 3 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 48 3.9|
Cyst | 3 2 2 2 4 3 | 22 2.6|
Hemorrhage | 4 | 2 4.0|
Inflammation, Chronic Active | 4 | 2 3.5|
Pigmentation | 1 1 1 1 | 6 1.2|
|__________________________________________________________________________|____________|
Uterus | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Inflammation, Chronic Active | 2 1 4 | 5 2.2|
Endometrium, Hyperplasia, Cystic | 2 2 2 3 1 2 1 3 3 2 1 2 2 1 2 3 1 2 3 2 3 3 2 3| 47 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 1 2 2 1 2 2 2 | 18 1.6|
Myeloid Cell, Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 8 |
Lumbar, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Atrophy | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 2 2.5|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Mediastinal, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 4 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 3 | 6 3.3|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 1| 2| 2| 2| 2| 3| 3| 2| 2| 3| 3| 0| 2| 3| 2| 2| 2| 3| 3| 0| 3| 2| 0| 3| |
| 8| 4| 9| 9| 9| 9| 1| 1| 9| 9| 1| 1| 8| 9| 0| 9| 9| 9| 0| 0| 9| 0| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hematopoietic Cell Proliferation | 2 2 2 3 3 2 2 3 4 | 16 2.6|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 2 2 2 2 3 2 3 2 2 3 3 | 24 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Atrophy | 4 3 4 3 3 | 8 3.5|
Cyst | X X X X X X X X X X X | 23 |
Ectopic Parathyroid Gland | 2 | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Infiltration | | |
Cellular, Polymorphonuclear | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 1| 2| 2| 2| 2| 3| 3| 2| 2| 3| 3| 0| 2| 3| 2| 2| 2| 3| 3| 0| 3| 2| 0| 3| |
| 8| 4| 9| 9| 9| 9| 1| 1| 9| 9| 1| 1| 8| 9| 0| 9| 9| 9| 0| 0| 9| 0| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Infiltration Cellular, Lymphoid | 2 1 2 2 2 1 1 1 1 2 1 2 1 1 1 1 1| 33 1.3|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Hemorrhage | 2 | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 4.0|
Mediastinum, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hydronephrosis | | 2 2.5|
Infarct | 3 2 2 | 4 2.8|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 41 1.1|
Inflammation, Chronic Active | 3 | 1 3.0|
Metaplasia, Osseous | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 1| 2| 2| 2| 2| 3| 3| 2| 2| 3| 3| 0| 2| 3| 2| 2| 2| 3| 3| 0| 3| 2| 0| 3| |
| 8| 4| 9| 9| 9| 9| 1| 1| 9| 9| 1| 1| 8| 9| 0| 9| 9| 9| 0| 0| 9| 0| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Mineralization | 1 1 1 1 1 1 1 1| 15 1.0|
Nephropathy | 1 1 1 1 2 1 1 1 1 1 | 21 1.2|
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
Renal Tubule, Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 2 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 2 1| 37 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 2| 3| 2| 2| 0| 3| 3| 2| 3| 1| 2| 6| 2| 3| 2| 2| 2| 3| 2| 3| 2|
| 5| 9| 1| 0| 9| 0| 9| 9| 3| 0| 0| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 1| 2| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 4 |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 1 1 1 1 1 |
Infiltration Cellular, Lymphoid | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
Inflammation, Chronic Active | 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 2 1 1 |
Mixed Cell Focus | X X X X |
Tension Lipidosis | 2 2 1 1 1 2 |
Hepatocyte, Necrosis | 2 3 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
Hepatocyte, Centrilobular, | |
Hypertrophy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Mesentery | + + + + |
Fat, Fibrosis | |
Fat, Inflammation, Chronic Active | 4 |
Fat, Mineralization | 2 |
Fat, Necrosis | 4 4 |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 2| 3| 2| 2| 0| 3| 3| 2| 3| 1| 2| 6| 2| 3| 2| 2| 2| 3| 2| 3| 2|
| 5| 9| 1| 0| 9| 0| 9| 9| 3| 0| 0| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 1| 2| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Oral Mucosa | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Infiltration Cellular, Lymphoid | 1 1 2 1 1 1 1 1 1 1 1 |
Acinus, Atrophy | |
Acinus, Cytoplasmic Alteration | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperkeratosis | 2 |
Epithelium, Hyperplasia, Squamous | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Ectasia | 1 2 2 1 1 2 1 |
Glands, Mineralization | 1 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + |
Gingiva, Inflammation, Chronic Active| 2 2 2 1 1 2 1 2 2 2 2 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2 |
Necrosis | |
Subcapsular, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 2| 3| 2| 2| 0| 3| 3| 2| 3| 1| 2| 6| 2| 3| 2| 2| 2| 3| 2| 3| 2|
| 5| 9| 1| 0| 9| 0| 9| 9| 3| 0| 0| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 1| 2| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M + M M M + + + M + + + + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Hyperplasia | 2 4 2 2 2 1|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | |
Inflammation, Chronic Active | |
Follicle, Cyst | |
Follicle, Degeneration | 1 2 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 4 4 4 4 4 4 4 3 4 4 4 4 4 4 3 3 4 4 3 4 4 3 3|
Cyst | 4 3 2 4 3 2 2 4 2|
Hemorrhage | 4 4 4 |
Inflammation, Chronic Active | |
Mineralization | 2 1 |
Pigmentation | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 |
Endometrium, Hyperplasia, Cystic | 2 4 3 3 1 1 2 2 3 2 4 2 1 2 3 2 3 3 3 3 2|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 2| 3| 2| 2| 0| 3| 3| 2| 3| 1| 2| 6| 2| 3| 2| 2| 2| 3| 2| 3| 2|
| 5| 9| 1| 0| 9| 0| 9| 9| 3| 0| 0| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 1| 2| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 1 2 2 1 1 2 2 1 1 1 1 2 1 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + +|
Lumbar, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Renal, Hemorrhage | |
Renal, Hyperplasia, Lymphoid | 4 4 4|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 3 3 3 3 4 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 3 4 2 2 4 4|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 2 2 2 2 3 2 1 2 2|
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 2 2 2 2 3 3 3 3 2 3 2 3 3 3|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 4 3 3 |
Cyst | X X X X X X X X X X X X X X X X|
Ectopic Parathyroid Gland | 1 |
Hyperplasia, Lymphoid | 3 3 2 4 |
Thymocyte, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Infiltration | |
Cellular, Lymphoid | 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 2| 3| 2| 2| 0| 3| 3| 2| 3| 1| 2| 6| 2| 3| 2| 2| 2| 3| 2| 3| 2|
| 5| 9| 1| 0| 9| 0| 9| 9| 3| 0| 0| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 1| 2| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + |
Infiltration Cellular, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 2 2 1 1 1 2 1 1 2 2 1 1 1 1 1 1 1 1 1 2 2 1|
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Cyst | 2 |
Glands, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1|
Metaplasia, Osseous | 2 |
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 2| 3| 2| 2| 0| 3| 3| 2| 3| 1| 2| 6| 2| 3| 2| 2| 2| 3| 2| 3| 2|
| 5| 9| 1| 0| 9| 0| 9| 9| 3| 0| 0| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 1| 2| 0| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Mineralization | 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1|
Cortex, Cyst | X |
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 2 1 2 1 1 1 2 1 1 1 1 2 2 1 1 1 1|
__________________________________________|__________________________________________________________________________
Page 20
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 2| 3| 3| 8| 3| 3| 0| 2| 3| 2| 4| 2| |
| 1| 0| 9| 0| 1| 9| 0| 0| 0| 9| 1| 9| 0| 9| 1| 0| 0| 0| 0| 9| 9| 0| 9| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | 4 | 3 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 4.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | 1 1 1 2 1 1| 11 1.1|
Infiltration Cellular, Lymphoid | 1 1 1 2 1 1 1 1 1 1 1 2 2 2 1 1 1 1 2 2 1 1| 38 1.2|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 40 1.1|
Mixed Cell Focus | X | 5 |
Tension Lipidosis | 2 1 | 8 1.5|
Hepatocyte, Necrosis | 2 2 | 5 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 29 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 2| 3| 3| 8| 3| 3| 0| 2| 3| 2| 4| 2| |
| 1| 0| 9| 0| 1| 9| 0| 0| 0| 9| 1| 9| 0| 9| 1| 0| 0| 0| 0| 9| 9| 0| 9| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Fibrosis | 2 2 | 2 2.0|
Fat, Inflammation, Chronic Active | 1 1 | 3 2.0|
Fat, Mineralization | | 1 2.0|
Fat, Necrosis | 4 4 | 4 4.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 2 3.5|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1| 24 1.0|
Acinus, Atrophy | 4 | 1 4.0|
Acinus, Cytoplasmic Alteration | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 2 1 2 1 1 1 1 2 1 2 1 1 | 34 1.2|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperkeratosis | | 1 2.0|
Epithelium, Hyperplasia, Squamous | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Ectasia | 1 1 1 1 1 1 1 1 1| 16 1.2|
Glands, Mineralization | 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + +| 29 |
Gingiva, Inflammation, Chronic Active| 2 2 2 2 2 1 2 2 2 2 2 1 2| 29 1.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 2| 3| 3| 8| 3| 3| 0| 2| 3| 2| 4| 2| |
| 1| 0| 9| 0| 1| 9| 0| 0| 0| 9| 1| 9| 0| 9| 1| 0| 0| 0| 0| 9| 9| 0| 9| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | | 1 2.0|
Necrosis | 2 | 1 2.0|
Subcapsular, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2| 49 1.9|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + M + + + + + +| 41 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 1 1 2 | 4 1.5|
Pars Distalis, Cyst | 2 | 3 2.0|
Pars Distalis, Hyperplasia | 2 2 2 2 2 3 2 2| 14 2.1|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Follicle, Cyst | 2 | 1 2.0|
Follicle, Degeneration | 1 2 1 1 1 3 2 1 1 2 1 | 19 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 2| 3| 3| 8| 3| 3| 0| 2| 3| 2| 4| 2| |
| 1| 0| 9| 0| 1| 9| 0| 0| 0| 9| 1| 9| 0| 9| 1| 0| 0| 0| 0| 9| 9| 0| 9| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Atrophy | 3 4 4 4 4 4 3 3 4 4 3 4 4 4 4 4 4 4 3 3 4 3 4 3 3| 48 3.7|
Cyst | 2 3 2 2 2 2 4 2 | 17 2.6|
Hemorrhage | 4 4 | 5 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 2 2 | 4 1.8|
Pigmentation | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 4 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 4 2 3 2 2 3 3 1 2 3 4 2 3 2 2 2 2 1 2 2 2 2| 45 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 2 3 1 1 2 1 2 1 2 1 1 1 1 1 | 30 1.5|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 12 |
Lumbar, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 2 3 3 | 5 2.8|
Renal, Hemorrhage | 4 | 1 4.0|
Renal, Hyperplasia, Lymphoid | | 3 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 3 3 3 4 2 2 3 3 3 3 2 3 | 20 2.9|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 4 3 3 3 3| 12 3.3|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2 2 2 2| 35 2.1|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 3 3 2 3 2 2 3 2 3 2 2 2 2 3 3 3 3 3 2 3 2| 36 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 2| 3| 3| 8| 3| 3| 0| 2| 3| 2| 4| 2| |
| 1| 0| 9| 0| 1| 9| 0| 0| 0| 9| 1| 9| 0| 9| 1| 0| 0| 0| 0| 9| 9| 0| 9| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Atrophy | 3 3 | 7 3.1|
Cyst | X X X X X X X X X X X X X X X X X X X| 35 |
Ectopic Parathyroid Gland | 2 1 | 3 1.3|
Hyperplasia, Lymphoid | 3 3 3 3 | 8 3.0|
Thymocyte, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibrosis | 3 | 1 3.0|
Subcutaneous Tissue, Infiltration | | |
Cellular, Lymphoid | 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + +| 4 |
Infiltration Cellular, Lymphoid | 1 1| 3 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 2 2 2 2 2 2 1 2 2 1 1 1 1 1 1 2 2 2 2 2 2 2| 44 1.5|
Inflammation, Chronic Active | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2| 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 2| 3| 3| 8| 3| 3| 0| 2| 3| 2| 4| 2| |
| 1| 0| 9| 0| 1| 9| 0| 0| 0| 9| 1| 9| 0| 9| 1| 0| 0| 0| 0| 9| 9| 0| 9| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Cyst | | 1 2.0|
Glands, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 | 3 2.7|
Infiltration Cellular, Lymphoid | 1 1 1 2 1 1 1 1 1 1 | 27 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 1.0|
Infiltration Cellular, Lymphoid | 1 1 1 1 2 1 1 2 1 1 1 2 1 1 1 1 1 1 2 2 2 1 1| 45 1.2|
Metaplasia, Osseous | 1 | 2 1.5|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 | 33 1.1|
Cortex, Cyst | | 1 |
Renal Tubule, Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphoid | 1 1 1 1 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1| 38 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 3| 0| 2| 3| 3| 3| 3| 3| 2| 2| 3| 2| 3| 7| 2| 2| 5| 3| 3| 2| 3|
| 9| 9| 0| 9| 0| 0| 9| 0| 0| 0| 0| 0| 9| 9| 0| 9| 0| 8| 9| 9| 5| 1| 1| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, Lymphoid | 2 |
Inflammation, Chronic Active | |
Mineralization | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 2 1 1 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 2 1 1 2 1 1|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Mineralization | |
Mixed Cell Focus | X X |
Tension Lipidosis | 2 |
Hepatocyte, Mitotic Alteration | |
Hepatocyte, Necrosis | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hepatocyte, Centrilobular, | |
Hypertrophy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2|
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 3| 0| 2| 3| 3| 3| 3| 3| 2| 2| 3| 2| 3| 7| 2| 2| 5| 3| 3| 2| 3|
| 9| 9| 0| 9| 0| 0| 9| 0| 0| 0| 0| 0| 9| 9| 0| 9| 0| 8| 9| 9| 5| 1| 1| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Fibrosis | 2 2 2 2 |
Fat, Infiltration Cellular, Lymphoid | 3 2 |
Fat, Inflammation, Chronic Active | 1 2 2 |
Fat, Mineralization | 2 |
Fat, Necrosis | 4 4 4 4 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 2 1 1 1 2 1 1 1 2 1 2 1 1 1 |
Acinus, Atrophy | 4 |
Duct, Inflammation, Chronic Active | 3 |
Duct, Pigmentation | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 2 1 2 1 2 1 2 1 1 2 1 1 1 2 1 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperkeratosis | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Ectasia | 1 2 1 2 1 1 1 1 2 1 1 1|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + |
Malformation | X |
Gingiva, Inflammation, Chronic Active| 2 1 2 3 1 2 1 1 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Hyperplasia, Atypical | |
Inflammation, Chronic Active | 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 3| 0| 2| 3| 3| 3| 3| 3| 2| 2| 3| 2| 3| 7| 2| 2| 5| 3| 3| 2| 3|
| 9| 9| 0| 9| 0| 0| 9| 0| 0| 0| 0| 0| 9| 9| 0| 9| 0| 8| 9| 9| 5| 1| 1| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 2 2 2 2 2 2 1 2 2 1 2 1 1 2 2 2 1 1 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M M + + M M M + + + + + M + + + +|
Cyst | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 1 |
Pars Distalis, Cyst | 1 1 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 3 |
Pars Distalis, Hypertrophy | |
Pars Distalis, Pigmentation | 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | |
Inflammation, Chronic Active | 2 |
Follicle, Degeneration | 2 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 4 4 3 4 4 2 2 |
Hemorrhage | 4 4 |
Inflammation, Chronic Active | |
Mineralization | 2 |
Pigmentation | 1 2 |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 3| 0| 2| 3| 3| 3| 3| 3| 2| 2| 3| 2| 3| 7| 2| 2| 5| 3| 3| 2| 3|
| 9| 9| 0| 9| 0| 0| 9| 0| 0| 0| 0| 0| 9| 9| 0| 9| 0| 8| 9| 9| 5| 1| 1| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Inflammation, Chronic Active | |
Endometrium, Hyperplasia, Cystic | 3 2 2 3 2 2 4 2 4 3 3 2 2 3 2 2 4 3 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 1 2 1 1 2 1 2 2 1 2 1 1|
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Hyperplasia, Lymphoid | 3 4 3 |
Pancreatic, Hyperplasia, Lymphoid | 4 |
Pancreatic, Pigmentation | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 3 3 3 3 2 2 3 3|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 4 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2 2 2 2 3 2 2 2 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 2 2 3 2 3 3 2 3 3 2 4 3 3 3 3 2 3 2 3 3|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X X X X X X X X X X X X X X X X|
Ectopic Parathyroid Gland | 2 |
Hyperplasia, Lymphoid | 3 2 3 4 |
Infiltration Cellular, Mast Cell | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 3| 0| 2| 3| 3| 3| 3| 3| 2| 2| 3| 2| 3| 7| 2| 2| 5| 3| 3| 2| 3|
| 9| 9| 0| 9| 0| 0| 9| 0| 0| 0| 0| 0| 9| 9| 0| 9| 0| 8| 9| 9| 5| 1| 1| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Infiltration | |
Cellular, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
Infiltration Cellular, Lymphoid | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 2 3 1 2 2 1 2 1 1 2 2 2 1 2 1 1 2 1 1 2 1 2 1|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Cataract | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 3| 0| 2| 3| 3| 3| 3| 3| 2| 2| 3| 2| 3| 7| 2| 2| 5| 3| 3| 2| 3|
| 9| 9| 0| 9| 0| 0| 9| 0| 0| 0| 0| 0| 9| 9| 0| 9| 0| 8| 9| 9| 5| 1| 1| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Infarct | 3 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 2 1 2 1 1 1 2 1 2 1 1 1 2 1 2 1 1 1|
Metaplasia, Osseous | 1 1 1 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 2 2 1 2 1 1 1 1 2 1|
Renal Tubule, Pigmentation | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
__________________________________________|__________________________________________________________________________
Page 32
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 4| 3| 3| 0| 3| 3| 3| 1| 3| 3| 2| 3| 2| 3| 2| 3| 9| 2| 3| 3| 3| 2| |
| 0| 0| 4| 5| 1| 1| 4| 0| 0| 4| 8| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Infiltration Cellular, Lymphoid | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 4 |
Eosinophilic Focus | X X X X | 7 |
Hematopoietic Cell Proliferation | 1 2 1 2 1 3 1 2 1 1 1 | 20 1.3|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 2 2 2 1 1| 35 1.2|
Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 41 1.0|
Mineralization | 2 | 1 2.0|
Mixed Cell Focus | X | 3 |
Tension Lipidosis | 1 2 | 3 1.7|
Hepatocyte, Mitotic Alteration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 4| 3| 3| 0| 3| 3| 3| 1| 3| 3| 2| 3| 2| 3| 2| 3| 9| 2| 3| 3| 3| 2| |
| 0| 0| 4| 5| 1| 1| 4| 0| 0| 4| 8| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Necrosis | 2 1 2 | 4 1.5|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2| 44 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Fat, Fibrosis | 2 2 2 2 | 8 2.0|
Fat, Infiltration Cellular, Lymphoid | 2 2 | 4 2.3|
Fat, Inflammation, Chronic Active | 3 2 1 3 | 7 2.0|
Fat, Mineralization | 1 | 2 1.5|
Fat, Necrosis | 4 4 4 4 4 | 9 4.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1| 33 1.2|
Acinus, Atrophy | | 1 4.0|
Duct, Inflammation, Chronic Active | | 1 3.0|
Duct, Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 2 1 1 1 2 1 1 2 1 1 1 2 1 1| 30 1.3|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperkeratosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Ectasia | 1 1 1 2 2 1 1 1 1 1| 22 1.2|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + | 24 |
Malformation | | 1 |
Gingiva, Inflammation, Chronic Active| 1 2 1 2 1 2 2 2 1 2 2 | 24 1.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 4| 3| 3| 0| 3| 3| 3| 1| 3| 3| 2| 3| 2| 3| 2| 3| 9| 2| 3| 3| 3| 2| |
| 0| 0| 4| 5| 1| 1| 4| 0| 0| 4| 8| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 | 1 2.0|
Hyperplasia, Atypical | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcapsular, Hyperplasia | 2 2 2 1 2 2 1 2 3 1 2 1 2 2 2 3 2 2 2 2 2 2 2 1| 49 1.8|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 1.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + M + + + + + + M + + M + + + + +| 40 |
Cyst | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Pars Distalis, Angiectasis | 2 2 | 5 1.8|
Pars Distalis, Cyst | | 2 1.0|
Pars Distalis, Hyperplasia | 1 3 3 2 3 2 | 13 2.2|
Pars Distalis, Hypertrophy | 1 | 1 1.0|
Pars Distalis, Pigmentation | | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 | 2 1.0|
Inflammation, Chronic Active | 1 | 2 1.5|
Follicle, Degeneration | 1 1 1 2 2 1| 12 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 4| 3| 3| 0| 3| 3| 3| 1| 3| 3| 2| 3| 2| 3| 2| 3| 9| 2| 3| 3| 3| 2| |
| 0| 0| 4| 5| 1| 1| 4| 0| 0| 4| 8| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 4 3 4 4 4 4 4 4 4 4 3 4 4 4 4 4 4 4 3 3| 46 3.8|
Cyst | 3 2 3 2 2 3 3 4 2 2 | 17 2.9|
Hemorrhage | 4 | 3 4.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Mineralization | 2 | 2 2.0|
Pigmentation | 2 | 3 1.7|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Inflammation, Chronic Active | 3 4 | 2 3.5|
Endometrium, Hyperplasia, Cystic | 1 2 2 1 2 3 2 2 2 2 2 2 3 1 2 2 2 2 2 3 | 44 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 2 1 2 1 2| 20 1.5|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + | 11 |
Mediastinal, Hyperplasia, Lymphoid | 4 | 4 3.5|
Pancreatic, Hyperplasia, Lymphoid | 4 | 2 4.0|
Pancreatic, Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 3 3 | 12 2.8|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Hyperplasia, Lymphoid | 3 3 | 6 3.2|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 3 2 3 2 3 2 3 4 3 3 2 3 2 3 2 3 | 32 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 4| 3| 3| 0| 3| 3| 3| 1| 3| 3| 2| 3| 2| 3| 2| 3| 9| 2| 3| 3| 3| 2| |
| 0| 0| 4| 5| 1| 1| 4| 0| 0| 4| 8| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 2 2 3 2 3 3 3 3 3 2 3 3 3 3 3 3| 37 2.7|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 4 4 | 3 4.0|
Cyst | X X X X X X X X X X X X X X X | 31 |
Ectopic Parathyroid Gland | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 5 3.0|
Infiltration Cellular, Mast Cell | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Infiltration | | |
Cellular, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
Infiltration Cellular, Lymphoid | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 2 2 2 2 1 2 1 2 1 2 2 1 2 2 1 2 2 1| 44 1.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 4| 3| 3| 0| 3| 3| 3| 1| 3| 3| 2| 3| 2| 3| 2| 3| 9| 2| 3| 3| 3| 2| |
| 0| 0| 4| 5| 1| 1| 4| 0| 0| 4| 8| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Inflammation, Chronic Active | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 4 2 | 2 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lens, Cataract | | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 3 2.0|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 2 1 1 1 | 27 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 3 | 1 3.0|
Infarct | 2 3 | 3 2.7|
Infiltration Cellular, Lymphoid | 1 2 1 1 1 1 1 1 2 2 2 2 1 2 1 1 1 2 1 1| 43 1.3|
Metaplasia, Osseous | | 4 1.0|
Mineralization | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 2| 36 1.1|
Nephropathy | 2 1 1 1 2 2 2 1 2 2 2 2 1 1 2 2| 31 1.5|
Renal Tubule, Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 2 2 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1| 40 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 1| 2| 4| 3| 1|
| 0| 2| 6| 0| 0| 3| 0| 1| 0| 0| 0| 1| 5| 1| 5| 6| 0| 1| 0| 0| 4| 9| 5| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 4 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 3 |
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 2|
Infarct | |
Infiltration Cellular, Lymphoid | 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2|
Inflammation, Chronic Active | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X |
Tension Lipidosis | 1 1 1 |
Hepatocyte, Autolysis | X |
Hepatocyte, Multinucleated | |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 1 1 1 2 2 1 1 1 2 1 1 1 1 1 2|
Hepatocyte, Centrilobular, | |
Degeneration | |
Hepatocyte, Centrilobular, | |
Hypertrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 1| 2| 4| 3| 1|
| 0| 2| 6| 0| 0| 3| 0| 1| 0| 0| 0| 1| 5| 1| 5| 6| 0| 1| 0| 0| 4| 9| 5| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Mesentery | + +|
Fat, Fibrosis | |
Fat, Hemorrhage | 4|
Fat, Inflammation, Chronic Active | |
Fat, Mineralization | 1|
Fat, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 2 2 1 |
Acinus, Atrophy | 4 4 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Hyperkeratosis | |
Epithelium, Hyperplasia, Squamous | |
Epithelium, Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Ectasia | 1 1 1 1 1 |
Glands, Mineralization | |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + |
Gingiva, Inflammation, Chronic Active| 1 2 1 1 2 2 2 1 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Atypical | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 1| 2| 4| 3| 1|
| 0| 2| 6| 0| 0| 3| 0| 1| 0| 0| 0| 1| 5| 1| 5| 6| 0| 1| 0| 0| 4| 9| 5| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Cortex | + + + + + + + + + + + + + + M + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Mineralization | |
Necrosis | 1 |
Subcapsular, Hyperplasia | 2 1 1 1 2 1 2 2 2 2 2 2 1 2 2 2 2 1 2 2 1 2 2 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + M + + + + M + + + + + + + + + + M +|
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + M + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hyperplasia | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 |
C-Cell, Hyperplasia | 1 |
Follicle, Degeneration | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 4 4 2 3 2 3 3 |
Hemorrhage | 4 4 4 |
Infiltration Cellular, Lymphoid | |
Pigmentation | |
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 1| 2| 4| 3| 1|
| 0| 2| 6| 0| 0| 3| 0| 1| 0| 0| 0| 1| 5| 1| 5| 6| 0| 1| 0| 0| 4| 9| 5| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Endometrium, Hyperplasia, Cystic | 2 1 2 2 4 3 2 3 1 2 3 1 1 2 3 2 1 2 1 2 1 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 2 2 1 2 1 1 2 1 1 2 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + |
Lumbar, Hyperplasia, Lymphoid | 2 4 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 |
Pancreatic, Hyperplasia, Lymphoid | 4 |
Renal, Hemorrhage | |
Renal, Hyperplasia, Lymphoid | 4 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 3 3 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 4 2 3 4 2 4 2 2 4|
Hemorrhage | |
Inflammation, Chronic Active | |
Necrosis | |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 3 3 3 4 3 3 2 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 4 3 3 3|
Cyst | X X X X X X X X X |
Ectopic Parathyroid Gland | 1 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 1| 2| 4| 3| 1|
| 0| 2| 6| 0| 0| 3| 0| 1| 0| 0| 0| 1| 5| 1| 5| 6| 0| 1| 0| 0| 4| 9| 5| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Fracture | |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 2 2 1 1 |
Metaplasia, Osseous | 1 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 1 1 |
Alveolus, Hemorrhage | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | |
Olfactory Epithelium, Metaplasia | 2 1 2 2 2 1 2 1 1 1 2 1 1 1 2 2 2 2|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 1| 2| 4| 3| 1|
| 0| 2| 6| 0| 0| 3| 0| 1| 0| 0| 0| 1| 5| 1| 5| 6| 0| 1| 0| 0| 4| 9| 5| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Ear | + + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Glomerulosclerosis | 4 |
Hydronephrosis | 3 |
Infarct | 3 |
Infiltration Cellular, Lymphoid | 1 1 1 2 1 2 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1|
Metaplasia, Osseous | 2 |
Mineralization | 1 1 1 2 2 1 1 1 1 1 2 2 2 1 2 2 2 1 2 2 1 1 2 1 2|
Nephropathy | 1 4 1 1 1 1 1 2 1 2 2 2 |
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 3 |
__________________________________________|__________________________________________________________________________
Page 44
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 6| 7| 4| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 3| 2| 3| 0| 4| 3| 2| 2| 7| 5| 2| 0| 7| 3| 2| 3| 3| 0| 2| 3| 1| |
| 9| 9| 9| 0| 8| 9| 0| 4| 4| 1| 9| 9| 5| 1| 9| 6| 7| 1| 9| 7| 0| 0| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 4 2.3|
Basophilic Focus | X | 2 |
Clear Cell Focus | X X X | 4 |
Eosinophilic Focus | X X X X| 7 |
Hematopoietic Cell Proliferation | 1 1 1 2 1 1 1 1 1| 19 1.1|
Infarct | 4 | 1 4.0|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 2 2 1 1 1 1 2 1 1 1 | 35 1.2|
Inflammation, Chronic Active | 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1| 36 1.1|
Mixed Cell Focus | X | 2 |
Tension Lipidosis | 1 1 1 2 | 7 1.1|
Hepatocyte, Autolysis | | 1 |
Hepatocyte, Multinucleated | 1 1 | 2 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 | 34 1.2|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 6| 7| 4| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 3| 2| 3| 0| 4| 3| 2| 2| 7| 5| 2| 0| 7| 3| 2| 3| 3| 0| 2| 3| 1| |
| 9| 9| 9| 0| 8| 9| 0| 4| 4| 1| 9| 9| 5| 1| 9| 6| 7| 1| 9| 7| 0| 0| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Centrilobular, | | |
Degeneration | 4 | 1 4.0|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 3 3 3 3 3 3 1 1 3 3 3 3 3 3 3| 37 2.9|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 9 |
Fat, Fibrosis | 2 2 2 2 | 4 2.0|
Fat, Hemorrhage | | 1 4.0|
Fat, Inflammation, Chronic Active | 2 2 1 | 3 1.7|
Fat, Mineralization | | 1 1.0|
Fat, Necrosis | 4 4 4 4 | 4 4.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 2 1 1 2 2 1 1 1 2 1 | 18 1.3|
Acinus, Atrophy | | 2 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 2 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 | 28 1.1|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Epithelium, Hyperkeratosis | 1 | 1 1.0|
Epithelium, Hyperplasia, Squamous | 2 | 1 2.0|
Epithelium, Ulcer | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Ectasia | 1 2 2 2 1 | 10 1.3|
Glands, Mineralization | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + +| 20 |
Gingiva, Inflammation, Chronic Active| 1 2 2 2 2 1 2 1 2 1| 20 1.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 6| 7| 4| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 3| 2| 3| 0| 4| 3| 2| 2| 7| 5| 2| 0| 7| 3| 2| 3| 3| 0| 2| 3| 1| |
| 9| 9| 9| 0| 8| 9| 0| 4| 4| 1| 9| 9| 5| 1| 9| 6| 7| 1| 9| 7| 0| 0| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Atypical | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hemorrhage | 4 | 1 4.0|
Mineralization | 2 | 1 2.0|
Necrosis | | 1 1.0|
Subcapsular, Hyperplasia | 2 3 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2| 49 1.8|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + M + + M + + + + M M + M + +| 40 |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 47 |
Pars Distalis, Angiectasis | 3 2 | 3 2.7|
Pars Distalis, Hyperplasia | 4 2 2 | 3 2.7|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 2 | 2 1.5|
C-Cell, Hyperplasia | | 1 1.0|
Follicle, Degeneration | 2 2 2 1 1 1 | 9 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 6| 7| 4| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 3| 2| 3| 0| 4| 3| 2| 2| 7| 5| 2| 0| 7| 3| 2| 3| 3| 0| 2| 3| 1| |
| 9| 9| 9| 0| 8| 9| 0| 4| 4| 1| 9| 9| 5| 1| 9| 6| 7| 1| 9| 7| 0| 0| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 1.5|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4| 45 4.0|
Cyst | 2 2 4 2 3 2 2 | 14 2.7|
Hemorrhage | 4 | 4 4.0|
Infiltration Cellular, Lymphoid | 4 | 1 4.0|
Pigmentation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Oviduct | + + | 3 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 2 2.0|
Endometrium, Hyperplasia, Cystic | 2 3 1 4 2 3 2 3 2 3 2 2 2 3 3 1 1 2 3 2 1| 43 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 2 1 2 1 2 1 1 1 2 1 1 3 3 | 26 1.6|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + +| 15 |
Lumbar, Hyperplasia, Lymphoid | | 2 3.0|
Mediastinal, Hyperplasia, Lymphoid | 2 2 | 4 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 4.0|
Renal, Hemorrhage | 3| 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 3 4 | 9 2.7|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 2 3 | 4 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 6| 7| 4| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 3| 2| 3| 0| 4| 3| 2| 2| 7| 5| 2| 0| 7| 3| 2| 3| 3| 0| 2| 3| 1| |
| 9| 9| 9| 0| 8| 9| 0| 4| 4| 1| 9| 9| 5| 1| 9| 6| 7| 1| 9| 7| 0| 0| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 4 3 2 3 3 4 1 2 4 2 2 3| 27 2.8|
Hemorrhage | 4 4 | 2 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis | 4| 1 4.0|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 3 3 3 3 3 3 3 3 3 2 3 3 3 | 22 2.9|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 3 3 4 3 3 | 13 3.2|
Cyst | X X X X X X X X X X X X X X X | 24 |
Ectopic Parathyroid Gland | | 1 1.0|
Hyperplasia, Lymphoid | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Maxilla, Fracture | X | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 | 2 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 6| 7| 4| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 3| 2| 3| 0| 4| 3| 2| 2| 7| 5| 2| 0| 7| 3| 2| 3| 3| 0| 2| 3| 1| |
| 9| 9| 9| 0| 8| 9| 0| 4| 4| 1| 9| 9| 5| 1| 9| 6| 7| 1| 9| 7| 0| 0| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 2 2 1 2 1 1 2 2 2 1 2 2 1 2 2 | 35 1.4|
Metaplasia, Osseous | | 1 1.0|
Pigmentation | 2 3 | 2 2.5|
Alveolar Epithelium, Hyperplasia | | 2 1.0|
Alveolus, Hemorrhage | 2 1 2 | 3 1.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Olfactory Epithelium, Metaplasia | 2 2 1 2 1 2 1 2 2 1 2 2 3 2 1 3 2 2 2 2 3| 39 1.7|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 2 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 | 23 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 4 | 1 4.0|
Glomerulosclerosis | | 1 4.0|
Hydronephrosis | | 1 3.0|
Infarct | 3 2 | 3 2.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 6| 7| 4| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 3| 3| 2| 3| 0| 4| 3| 2| 2| 7| 5| 2| 0| 7| 3| 2| 3| 3| 0| 2| 3| 1| |
| 9| 9| 9| 0| 8| 9| 0| 4| 4| 1| 9| 9| 5| 1| 9| 6| 7| 1| 9| 7| 0| 0| 9| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Infiltration Cellular, Lymphoid | 2 1 1 1 2 2 1 1 2 2 1 1 1 1 1 2 1 | 39 1.3|
Metaplasia, Osseous | 1 | 2 1.5|
Mineralization | 2 2 2 1 2 1 2 1 1 2 1 1 2 1 1 3 2 3 1 2 1 1 1 2| 49 1.5|
Nephropathy | 2 1 2 2 1 1 2 3 1 2 2 2 2 2 2 1 2 1| 30 1.7|
Artery, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3|
| 1| 0| 3| 2| 1| 2| 2| 2| 0| 1| 2| 0| 0| 0| 0| 0| 0| 0| 9| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + M + + M + + + M + + + + + + + + + M +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, Lymphoid | 2 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X X X X |
Tension Lipidosis | |
Hepatocyte, Necrosis | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 2 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3|
| 1| 0| 3| 2| 1| 2| 2| 2| 0| 1| 2| 0| 0| 0| 0| 0| 0| 0| 9| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Epithelium, Hyperkeratosis | 2 |
Epithelium, Hyperplasia, Squamous | 3 |
Epithelium, Ulcer | 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Ectasia | 2 |
|__________________________________________________________________________|
Tooth | + + + + + |
Inflammation, Chronic Active | |
Malformation | |
Gingiva, Inflammation, Chronic Active| 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 1 1|
Hypertrophy | 1 2 2 1 1 2 1 2 1 2 1 2 2 1 |
Subcapsular, Hyperplasia | 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M M + + + + + + + +|
Pars Distalis, Cyst | 1 2 1 1 |
Pars Distalis, Hyperplasia | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3|
| 1| 0| 3| 2| 1| 2| 2| 2| 0| 1| 2| 0| 0| 0| 0| 0| 0| 0| 9| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Follicle, Cyst | 3 |
Follicle, Degeneration | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Duct, Ectasia | 2 2 2 2 2 2 3 3 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + M + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3|
| 1| 0| 3| 2| 1| 2| 2| 2| 0| 1| 2| 0| 0| 0| 0| 0| 0| 0| 9| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 2 1 1 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 4 2 2 2 2 2 2 3|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Atrophy | 2 2 2 2 2 2 |
Cyst | 2 2 1 1 2 1 1 1 2 1 2 |
Ectopic Parathyroid Gland | 1 |
Infiltration Cellular, Histiocyte | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + M + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
Degeneration | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3|
| 1| 0| 3| 2| 1| 2| 2| 2| 0| 1| 2| 0| 0| 0| 0| 0| 0| 0| 9| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 |
Inflammation, Chronic Active | |
Necrosis | |
Alveolar Epithelium, Hyperplasia | 1 1 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 3 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Olfactory Epithelium, Degeneration | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Infiltration Cellular, Lymphoid | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 |
Metaplasia, Osseous | 1 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Artery, Inflammation, Chronic Active | |
Cortex, Cyst | X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 2 1 1 1 1 1 1 1 1 1 1 |
__________________________________________|__________________________________________________________________________
Page 56
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| |
| 2| 1| 1| 1| 2| 2| 2| 0| 2| 0| 2| 2| 0| 2| 1| 1| 2| 1| 0| 2| 3| 0| 0| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X | 4 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | X X | 5 |
Hematopoietic Cell Proliferation | 1 | 2 1.0|
Infiltration Cellular, Lymphoid | 1 1| 6 1.2|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.0|
Mixed Cell Focus | X X X X | 8 |
Tension Lipidosis | 2 | 1 2.0|
Hepatocyte, Necrosis | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytoplasmic Alteration | | 1 2.0|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 | 14 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| |
| 2| 1| 1| 1| 2| 2| 2| 0| 2| 0| 2| 2| 0| 2| 1| 1| 2| 1| 0| 2| 3| 0| 0| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.1|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Epithelium, Hyperkeratosis | | 1 2.0|
Epithelium, Hyperplasia, Squamous | | 1 3.0|
Epithelium, Ulcer | | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Ectasia | 1 1 1 1 1 1 | 7 1.1|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + +| 20 |
Inflammation, Chronic Active | 3 | 1 3.0|
Malformation | X X 3 | 3 3.0|
Gingiva, Inflammation, Chronic Active| 2 2 2 2 1 1 2 2 2 1 2 2 1| 18 1.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 | 3 1.0|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 7 1.7|
Hypertrophy | 1 2 1 1 1 2 1 1 1 1 1 1 | 26 1.3|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 2 1 1| 50 1.1|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| |
| 2| 1| 1| 1| 2| 2| 2| 0| 2| 0| 2| 2| 0| 2| 1| 1| 2| 1| 0| 2| 3| 0| 0| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + M + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | 2 2 1 | 7 1.4|
Pars Distalis, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 1.0|
Follicle, Cyst | 2 | 2 2.5|
Follicle, Degeneration | 2 1 1 1 1 1 1 1 | 12 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 | 1 2.0|
Infiltration Cellular, Lymphoid | 1 2 1 1 2 1 1 1 1 1 1 1 1| 32 1.1|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 1 1 1 2 1 1 | 21 1.1|
Duct, Ectasia | 2 3 3 2 2 2 2 2 2 2 | 20 2.2|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.0|
Inflammation, Chronic Active | | 1 1.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| |
| 2| 1| 1| 1| 2| 2| 2| 0| 2| 0| 2| 2| 0| 2| 1| 1| 2| 1| 0| 2| 3| 0| 0| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 3 3 3 4 | 5 3.2|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 2 2 4 3 | 11 2.3|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 1 2 1 3 3 1 2 2| 17 2.1|
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + M + + + + M + + + + + + + + + + +| 46 |
Atrophy | 2 2 2 4 2 3 | 12 2.3|
Cyst | 4 1 2 1 2| 16 1.6|
Ectopic Parathyroid Gland | 2 | 2 1.5|
Infiltration Cellular, Histiocyte | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| |
| 2| 1| 1| 1| 2| 2| 2| 0| 2| 0| 2| 2| 0| 2| 1| 1| 2| 1| 0| 2| 3| 0| 0| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 | 32 1.1|
Inflammation, Chronic Active | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 3 2 2 | 6 1.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 3 3 2 | 7 2.4|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 2 | 2 2.5|
Olfactory Epithelium, Degeneration | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| |
| 2| 1| 1| 1| 2| 2| 2| 0| 2| 0| 2| 2| 0| 2| 1| 1| 2| 1| 0| 2| 3| 0| 0| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Hyperplasia | | 2 1.5|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 37 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 2.0|
Infiltration Cellular, Lymphoid | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.1|
Metaplasia, Osseous | 1 1 | 4 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 49 1.0|
Nephropathy | 1 2 3 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 2 2| 49 1.2|
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
Cortex, Cyst | X X | 4 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1| 24 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 2| 0| 0| 0| 2| 5| 0| 0| 2| 1| 4| 2| 2| 0| 0| 0| 2| 1| 0| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | |
Infarct | 4 4 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X |
Tension Lipidosis | 2 |
Bile Duct, Cyst | X X |
Hepatocyte, Multinucleated | 2 2 1 1 1 1 1 2 2 1 2 1 1 1 2 2 1 1 2|
Hepatocyte, Necrosis | 1 2 1 2 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 2 1 1 4 1 1 1 2 1 1 2 1 1 4 2 1 1 1 1 1|
Hepatocyte, Centrilobular, | |
Hypertrophy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Mesentery | + + |
Fat, Fibrosis | 3 |
Fat, Inflammation, Chronic Active | 2 |
Fat, Mineralization | 1 |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 2| 0| 0| 0| 2| 5| 0| 0| 2| 1| 4| 2| 2| 0| 0| 0| 2| 1| 0| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Fat, Necrosis | 4 |
Fat, Pigmentation | 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 |
Acinus, Atrophy | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 3 3 |
Epithelium, Cyst | 2 |
Epithelium, Hyperkeratosis | 2 |
Epithelium, Hyperplasia, Squamous | 3 |
Epithelium, Ulcer | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Ectasia | 1 1 1 1 1 1 2|
|__________________________________________________________________________|
Tongue | |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + +|
Malformation | |
Gingiva, Inflammation, Chronic Active| 2 2 2 2 2 2 2 1 1 2 2 1 2 2 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 2| 0| 0| 0| 2| 5| 0| 0| 2| 1| 4| 2| 2| 0| 0| 0| 2| 1| 0| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hyperplasia | 2 1 2 2 1 2 2 |
Hypertrophy | 1 2 1 2 1 1 1 2 1 1 1 |
Necrosis | |
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + M + + + M + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Cyst | 1 1 |
Pars Distalis, Hyperplasia | |
Pars Nervosa, Cyst | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Degeneration | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 4 |
Granuloma Sperm | 2 2 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 4 1 1 1 1 1 1 1 1 |
Duct, Ectasia | 2 3 3 2 3 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Artery, Inflammation, Chronic Active | 4 |
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 2| 0| 0| 0| 2| 5| 0| 0| 2| 1| 4| 2| 2| 0| 0| 0| 2| 1| 0| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Germinal Epithelium, Degeneration | 2 2 |
Rete Testes, Cyst | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | |
Mediastinal, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 2 3 3 2 2 2 2 2 3 2 3 3 3 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +|
Atrophy | 2 3 2 3 |
Cyst | 2 1 1 1 1 2 2 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 2| 0| 0| 0| 2| 5| 0| 0| 2| 1| 4| 2| 2| 0| 0| 0| 2| 1| 0| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1|
Inflammation, Chronic Active | 1 2 |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Metaplasia | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anterior Chamber, Iris, Inflammation,| |
Suppurative | |
Cornea, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 2| 0| 0| 0| 2| 5| 0| 0| 2| 1| 4| 2| 2| 0| 0| 0| 2| 1| 0| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | |
Metaplasia, Osseous | 2 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 2 1 1 2 1 2 1 1 1 1 1 1 2 1 1 2 2 1 2 1 2 1|
Artery, Inflammation, Chronic Active | 2 |
Cortex, Cyst | X X X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 2 1 1 1 1 1 |
__________________________________________|__________________________________________________________________________
Page 68
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 1| 0| 2| 2| 1| 2| 2| 1| 0| 2| 0| 0| 2| 2| 9| 5| 2| 2| 2| 1| 1| 1| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Clear Cell Focus | X X X | 7 |
Eosinophilic Focus | X X X X X X | 8 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Infarct | | 2 4.0|
Infiltration Cellular, Lymphoid | 2 2 2 1 1 | 10 1.3|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 2| 47 1.1|
Mixed Cell Focus | X X X X X | 9 |
Tension Lipidosis | | 1 2.0|
Bile Duct, Cyst | X | 3 |
Hepatocyte, Multinucleated | 1 1 1 1 1 1 2 1 1 2 1 1 2 1 2 2 2 1 2 1 1 2| 41 1.4|
Hepatocyte, Necrosis | 2 2 | 6 1.7|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 2 2 2 2 1 1 1 1 1 1 1 1 1 2 1 1 1 2 2 2 1| 45 1.4|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 44 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 1| 0| 2| 2| 1| 2| 2| 1| 0| 2| 0| 0| 2| 2| 9| 5| 2| 2| 2| 1| 1| 1| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | | 2 |
Fat, Fibrosis | | 1 3.0|
Fat, Inflammation, Chronic Active | | 1 2.0|
Fat, Mineralization | | 1 1.0|
Fat, Necrosis | | 1 4.0|
Fat, Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1| 11 1.0|
Acinus, Atrophy | | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic Active | | 2 3.0|
Epithelium, Cyst | | 1 2.0|
Epithelium, Hyperkeratosis | 2 | 2 2.0|
Epithelium, Hyperplasia, Squamous | 2 | 2 2.5|
Epithelium, Ulcer | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Ectasia | 1 1 1 1 2 1 | 13 1.2|
|__________________________________________________________________________|____________|
Tongue | +| 1 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + | 31 |
Malformation | X | 1 |
Gingiva, Inflammation, Chronic Active| 2 2 2 2 2 1 2 2 1 2 2 2 2 2 2 | 30 1.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 1| 0| 2| 2| 1| 2| 2| 1| 0| 2| 0| 0| 2| 2| 9| 5| 2| 2| 2| 1| 1| 1| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 | 5 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 | 10 1.6|
Hypertrophy | 1 1 1 1 3 1 1 2 1 3 1| 22 1.4|
Necrosis | 3 | 1 3.0|
Subcapsular, Hyperplasia | 1 2 1 2 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1| 46 1.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + + + + M M + + + M + + + + + + + M M + +| 38 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | 1 2 2 | 5 1.4|
Pars Distalis, Hyperplasia | 2 | 1 2.0|
Pars Nervosa, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Degeneration | 1 1 1 1 1 1| 9 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 1| 0| 2| 2| 1| 2| 2| 1| 0| 2| 0| 0| 2| 2| 9| 5| 2| 2| 2| 1| 1| 1| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | | 1 4.0|
Granuloma Sperm | | 2 2.0|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1| 27 1.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 23 1.2|
Duct, Ectasia | 2 2 2 2 3 3 2 3 | 15 2.4|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1| 43 1.0|
Artery, Inflammation, Chronic Active | | 1 4.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
Germinal Epithelium, Degeneration | 2 | 3 2.0|
Rete Testes, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 1| 0| 2| 2| 1| 2| 2| 1| 0| 2| 0| 0| 2| 2| 9| 5| 2| 2| 2| 1| 1| 1| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hematopoietic Cell Proliferation | 3 3 3 3 2 | 7 2.6|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 3 3 3 3 2 2 3 3 2 3 2 3 3 2 2 2| 31 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Atrophy | 3 3 3 3 3 | 9 2.8|
Cyst | 2 2 1 1 1 1 1 2 2 2 1 2 1 | 25 1.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 38 1.1|
Inflammation, Chronic Active | | 2 1.5|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 4 4 2 | 7 2.6|
Alveolus, Infiltration Cellular, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 1| 0| 2| 2| 1| 2| 2| 1| 0| 2| 0| 0| 2| 2| 9| 5| 2| 2| 2| 1| 1| 1| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Histiocyte | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Olfactory Epithelium, Metaplasia | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Anterior Chamber, Iris, Inflammation,| | |
Suppurative | 3 | 1 3.0|
Cornea, Inflammation, Chronic Active | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 | 3 3.0|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 3.0|
Infiltration Cellular, Lymphoid | 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1| 44 1.1|
Inflammation, Chronic Active | 1 | 1 1.0|
Metaplasia, Osseous | 1 | 2 1.5|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 50 1.0|
Nephropathy | 1 1 1 2 1 2 2 1 1 1 1 2 1 2 2 2 2 1 1 2 1 2 1 2 1| 48 1.4|
Artery, Inflammation, Chronic Active | | 1 2.0|
Cortex, Cyst | X X X X| 8 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1| 24 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 8| 3|
| 0| 2| 1| 2| 1| 0| 2| 1| 0| 0| 1| 1| 1| 2| 2| 1| 2| 1| 5| 0| 2| 1| 1| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X |
Fatty Change | |
Fibrosis | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X |
Hepatocyte, Degeneration, Cystic | 2 1 |
Hepatocyte, Multinucleated | 1 2 1 1 2 2 1 1 1 1 1 1 2 1 1 1 1 1 2 1 2 2 1|
Hepatocyte, Necrosis | 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 1 1 2 2 1 2 1 2 2 2 1 2 2 2 2 2 1 1 2 2 1 2|
Hepatocyte, Centrilobular, | |
Hypertrophy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Oval Cell, Hyperplasia | |
|__________________________________________________________________________|
Mesentery | + + |
Fat, Fibrosis | 2 2 |
Fat, Inflammation, Chronic Active | 1 |
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 8| 3|
| 0| 2| 1| 2| 1| 0| 2| 1| 0| 0| 1| 1| 1| 2| 2| 1| 2| 1| 5| 0| 2| 1| 1| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Fat, Mineralization | 1 |
Fat, Necrosis | 4 4 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Infiltration Cellular, Lymphoid | 1 1 1 1 |
Acinus, Atrophy | |
Acinus, Cytoplasmic Alteration | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 2 2 1 2 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperkeratosis | |
Epithelium, Hyperplasia, Squamous | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Ectasia | 1 1 1 1 2 1 1 1 |
Glands, Mineralization | |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Malformation | |
Gingiva, Inflammation, Chronic Active| 2 2 2 2 2 2 2 2 2 1 1 2 1 1 1 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 4 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 |
Hyperplasia | 1 1 2 2 |
Hypertrophy | 1 1 1 2 1 1 2 1 |
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 8| 3|
| 0| 2| 1| 2| 1| 0| 2| 1| 0| 0| 1| 1| 1| 2| 2| 1| 2| 1| 5| 0| 2| 1| 1| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Inflammation, Chronic Active | |
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 1 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 2|
Follicle, Degeneration | 1 1 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 |
Mineralization | 1 2 |
Spermatocele | 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 4 1 1 1 1 1 1 1 1 |
Duct, Ectasia | 2 2 2 2 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 77
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 8| 3|
| 0| 2| 1| 2| 1| 0| 2| 1| 0| 0| 1| 1| 1| 2| 2| 1| 2| 1| 5| 0| 2| 1| 1| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Mineralization | 1 1 1 |
Germinal Epithelium, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + |
Deep Cervical, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hematopoietic Cell Proliferation | 2 3 2 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 3 1 2 2 2 1 2 2 1 1 2 2 1 2 2|
|__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + M + + + + + + +|
Atrophy | 2 |
Cyst | 1 1 1 1 2 1 2 2 1 2 1|
Ectopic Thyroid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 8| 3|
| 0| 2| 1| 2| 1| 0| 2| 1| 0| 0| 1| 1| 1| 2| 2| 1| 2| 1| 5| 0| 2| 1| 1| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinum, Inflammation, | |
Suppurative | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Olfactory Epithelium, Metaplasia | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Cornea, Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 79
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 8| 3|
| 0| 2| 1| 2| 1| 0| 2| 1| 0| 0| 1| 1| 1| 2| 2| 1| 2| 1| 5| 0| 2| 1| 1| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 |
Metaplasia, Osseous | 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis | 1 |
Nephropathy | 2 2 2 1 2 2 1 2 1 1 1 1 1 1 2 1 1 2 1 1 1 1 2 2 2|
Cortex, Cyst | X X X X X X X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________|__________________________________________________________________________
Page 80
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| |
| 1| 2| 2| 1| 2| 2| 1| 2| 2| 1| 2| 1| 2| 3| 1| 0| 9| 2| 1| 2| 2| 1| 1| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 5 |
Clear Cell Focus | X X X X | 7 |
Eosinophilic Focus | X X X X X X X | 11 |
Fatty Change | 4 | 1 4.0|
Fibrosis | 2 | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 2 1 1 1 2 3 1 1 2 1 1 1 1 1 1 1 1| 44 1.2|
Mixed Cell Focus | X X X X X X X X X X X | 15 |
Hepatocyte, Degeneration, Cystic | 1 1 1 | 5 1.2|
Hepatocyte, Multinucleated | 1 2 1 2 2 1 2 1 2 2 2 2 1 1 1 3 1 2 2 2 1 2 2 1| 47 1.5|
Hepatocyte, Necrosis | 2 1 3 1 2 1 | 8 1.8|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 2 2 2 1 2 3 1 2 2 1 2 3 2 2 2 2 1 3 2 1| 46 1.8|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 2.0|
Oval Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| |
| 1| 2| 2| 1| 2| 2| 1| 2| 2| 1| 2| 1| 2| 3| 1| 0| 9| 2| 1| 2| 2| 1| 1| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 8 |
Fat, Fibrosis | 2 3 3 | 5 2.4|
Fat, Inflammation, Chronic Active | 2 2 3 3 | 5 2.2|
Fat, Mineralization | 1 2 | 3 1.3|
Fat, Necrosis | 4 4 4 | 5 4.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Infiltration Cellular, Lymphoid | 2 1 1 1 | 8 1.1|
Acinus, Atrophy | 4 | 1 4.0|
Acinus, Cytoplasmic Alteration | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1| 40 1.1|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperkeratosis | 4 | 1 4.0|
Epithelium, Hyperplasia, Squamous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Ectasia | 1 1 1 1 1 1 2 1 1 1 | 18 1.1|
Glands, Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + | 33 |
Inflammation, Chronic Active | 3 4 3 | 3 3.3|
Malformation | 4 4 4 | 3 4.0|
Gingiva, Inflammation, Chronic Active| 1 2 3 2 1 2 2 1 2 1 1 1 | 32 1.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| |
| 1| 2| 2| 1| 2| 2| 1| 2| 2| 1| 2| 1| 2| 3| 1| 0| 9| 2| 1| 2| 2| 1| 1| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Inflammation, Chronic Active | | 3 2.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 1 | 2 1.0|
Hyperplasia | 2 2 2 2 2 | 9 1.8|
Hypertrophy | 1 2 2 2 1 3 1 1 1 1 2 1 1 2 2 1| 24 1.4|
Inflammation, Chronic Active | 1 | 1 1.0|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1| 46 1.1|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + M| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 2 2 | 5 1.6|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | | 1 2.0|
Follicle, Degeneration | 1 1 | 6 1.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 | 2 2.5|
Infiltration Cellular, Lymphoid | 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1| 30 1.1|
Mineralization | 2 1 | 4 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| |
| 1| 2| 2| 1| 2| 2| 1| 2| 2| 1| 2| 1| 2| 3| 1| 0| 9| 2| 1| 2| 2| 1| 1| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Spermatocele | | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 1 2 1 1 1 1 1 1 1 4 1 3 2 1 | 25 1.4|
Duct, Ectasia | 4 3 2 2 2 2 3 2 2 | 15 2.3|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1| 46 1.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1| 4 1.0|
Germinal Epithelium, Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node | + + | 3 |
Deep Cervical, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 2 2 | 6 2.2|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Hematopoietic Cell Proliferation | 2 3 2 4 2 2| 9 2.4|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 3 2 2 2 2 2 2 1 2 2 2 2 3 2 3 3 3 2| 34 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| |
| 1| 2| 2| 1| 2| 2| 1| 2| 2| 1| 2| 1| 2| 3| 1| 0| 9| 2| 1| 2| 2| 1| 1| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + M + + + + + + + +| 46 |
Atrophy | 4 3 3 3 2 | 6 2.8|
Cyst | 2 1 2 2 2 1 2 2 1 | 20 1.5|
Ectopic Thyroid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M + M M M M M M M M M M M| 2 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 2 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.1|
Inflammation, Chronic Active | 1 | 1 1.0|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 3 1 | 8 1.9|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Mediastinum, Inflammation, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| |
| 1| 2| 2| 1| 2| 2| 1| 2| 2| 1| 2| 1| 2| 3| 1| 0| 9| 2| 1| 2| 2| 1| 1| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Suppurative | | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 1 1.0|
Inflammation, Suppurative | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 3 | 2 2.5|
Olfactory Epithelium, Metaplasia | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
Cornea, Inflammation, Chronic Active | 1| 2 1.5|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 3 2.7|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 24 1.0|
Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 4 | 1 4.0|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| 45 1.0|
Inflammation, Chronic Active | 3 | 2 2.0|
Metaplasia, Osseous | | 1 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 50 1.0|
Necrosis | | 1 1.0|
Nephropathy | 2 2 2 2 2 2 2 3 2 2 1 1 2 2 2 2 2 2 2 2 2 1 2 2 2| 50 1.7|
Cortex, Cyst | X X X X | 12 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| |
| 1| 2| 2| 1| 2| 2| 1| 2| 2| 1| 2| 1| 2| 3| 1| 0| 9| 2| 1| 2| 2| 1| 1| 0| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 1| 1| 8| 1| 2| 2| 6| 2| 2| 1| 2| 1| 0| 2| 1| 0| 2| 2| 1| 1| 0| 2| 2| 5| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X |
Infarct | |
Infiltration Cellular, Lymphoid | 1 1 |
Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Mixed Cell Focus | X X X X X X X|
Tension Lipidosis | X |
Bile Duct, Cyst | |
Hepatocyte, Degeneration, Cystic | 2 2 2 3 1 1 1 2 2 3 2 2 2 2 2 1|
Hepatocyte, Multinucleated | 2 1 2 1 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 1 2 2|
Hepatocyte, Necrosis | 2 2 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 3 1 3 2 1 1 1 1 3 2 1 1 1 1 3 1 1 1 1 1|
Hepatocyte, Centrilobular, | |
Hypertrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Fibrosis | 3 |
Fat, Inflammation, Chronic Active | 1 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 88
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 1| 1| 8| 1| 2| 2| 6| 2| 2| 1| 2| 1| 0| 2| 1| 0| 2| 2| 1| 1| 0| 2| 2| 5| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Cyst | 2 |
Infiltration Cellular, Lymphoid | 1 1 1 1 |
Acinus, Atrophy | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperkeratosis | 2 |
Epithelium, Hyperplasia, Squamous | 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Ectasia | 1 1 |
Glands, Mineralization | 1 |
|__________________________________________________________________________|
Tooth | + + + + + + + +|
Gingiva, Inflammation, Chronic Active| 2 2 2 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Atypical | 2 |
Inflammation, Chronic Active | 2 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2|
Hypertrophy | 2 1 1 2 2 2 1 1 2|
Subcapsular, Hyperplasia | 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 89
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 1| 1| 8| 1| 2| 2| 6| 2| 2| 1| 2| 1| 0| 2| 1| 0| 2| 2| 1| 1| 0| 2| 2| 5| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Parathyroid Gland | + + + M + + + + + + M M M + + M + + + + + M + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 |
Follicle, Cyst | 2 |
Follicle, Degeneration | 1 1 2 2 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Duct, Ectasia | 2 2 2 2 2 2 2 3 2 3 3 3 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1|
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 2 1 |
Germinal Epithelium, Degeneration | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 90
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 1| 1| 8| 1| 2| 2| 6| 2| 2| 1| 2| 1| 0| 2| 1| 0| 2| 2| 1| 1| 0| 2| 2| 5| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node | + |
Mediastinal, Inflammation, | |
Granulomatous | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + M +|
Hyperplasia, Lymphoid | 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M M|
Hyperplasia, Lymphoid | 3 |
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 4 1 2 3 2 2|
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 2 2 2 2 1 2 2 3 2 2 3 2 2|
|__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + M + + + + + + + + + + +|
Atrophy | 3 |
Cyst | 1 1 1 2 1 2 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 91
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 1| 1| 8| 1| 2| 2| 6| 2| 2| 1| 2| 1| 0| 2| 1| 0| 2| 2| 1| 1| 0| 2| 2| 5| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Focal, Suppurative | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Olfactory Epithelium, Metaplasia | 2 1 2 2 1 1 1 1 2|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cornea, Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 2 2 2 |
Infiltration Cellular, Lymphoid | 2 2 2 2 1 1 1 2 1 1 1 1 1 2 1 2 2 2 1 1 2 1|
Metaplasia, Osseous | 1 1 2 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Nephropathy | 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3|
Cortex, Cyst | X X X X X X X X X X|
Renal Tubule, Pigmentation | 3 |
|__________________________________________________________________________|
Ureter | + |
__________________________________________|__________________________________________________________________________|
Page 92
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 1| 1| 8| 1| 2| 2| 6| 2| 2| 1| 2| 1| 0| 2| 1| 0| 2| 2| 1| 1| 0| 2| 2| 5| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________|__________________________________________________________________________
Page 93
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 1| 2| 0| 6| 1| 2| 2| 1| 1| 2| 1| 0| 2| 1| 2| 0| 1| 2| 1| 0| 0| 0| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X X X X X X X X | 12 |
Eosinophilic Focus | X X X X X X X | 10 |
Infarct | 4 | 1 4.0|
Infiltration Cellular, Lymphoid | 1 1 | 4 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.1|
Mixed Cell Focus | X X X X X X | 13 |
Tension Lipidosis | | 1 |
Bile Duct, Cyst | X | 1 |
Hepatocyte, Degeneration, Cystic | 3 2 1 2 2 1 2 2 2 2 2 1 2 2| 30 1.9|
Hepatocyte, Multinucleated | 2 1 2 1 2 1 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 48 1.8|
Hepatocyte, Necrosis | 1 1 1 | 8 1.3|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2| 44 1.4|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 48 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 1| 2| 0| 6| 1| 2| 2| 1| 1| 2| 1| 0| 2| 1| 2| 0| 1| 2| 1| 0| 0| 0| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Fibrosis | | 1 3.0|
Fat, Inflammation, Chronic Active | | 2 1.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 2 2.5|
Infiltration Cellular, Lymphoid | 1 1 1 1 | 8 1.0|
Acinus, Atrophy | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 | 28 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperkeratosis | | 1 2.0|
Epithelium, Hyperplasia, Squamous | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Ectasia | 1 1 1 | 5 1.0|
Glands, Mineralization | | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + | 21 |
Gingiva, Inflammation, Chronic Active| 1 1 2 3 1 2 2 2 1 2 1 2 | 20 1.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Atypical | | 1 2.0|
Inflammation, Chronic Active | 1 | 3 1.3|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 1| 2| 0| 6| 1| 2| 2| 1| 1| 2| 1| 0| 2| 1| 2| 0| 1| 2| 1| 0| 0| 0| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | 2 1 2 2 | 6 1.8|
Hypertrophy | 1 1 2 1 2 1 2 2 1 | 18 1.5|
Subcapsular, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 47 1.1|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + M + + M + + M M + + + + + M + + M + +| 36 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 1 1| 4 1.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | | 1 1.0|
Follicle, Cyst | | 1 2.0|
Follicle, Degeneration | | 6 1.3|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 2.0|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 32 1.1|
Duct, Ectasia | 3 2 2 2 2 3 2 3 2 2 3 3 2 2 2| 28 2.3|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 28 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 1| 2| 0| 6| 1| 2| 2| 1| 1| 2| 1| 0| 2| 1| 2| 0| 1| 2| 1| 0| 0| 0| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Artery, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 | 12 1.1|
Germinal Epithelium, Degeneration | | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + +| 5 |
Mediastinal, Inflammation, | | |
Granulomatous | 3| 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +| 47 |
Hyperplasia, Lymphoid | 2 2| 5 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
Inflammation, Granulomatous | 3| 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 2 3 2 2 2 | 14 2.4|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 3 2 2 3 2 2 2 2 3 2 3 2 2 2 1 2 3 3| 32 2.2|
|__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | 4 3 4 3 | 5 3.4|
Cyst | 1 1 1 2 1 1 1 1 1 1 1 2 2| 20 1.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 1| 2| 0| 6| 1| 2| 2| 1| 1| 2| 1| 0| 2| 1| 2| 0| 1| 2| 1| 0| 0| 0| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2| 36 1.0|
Inflammation, Chronic Active | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 3 4 | 4 3.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 1 2| 3 1.7|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 | 2 1.0|
Inflammation, Focal, Suppurative | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
Olfactory Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2| 24 1.2|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 88138-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 06/01/04
Route: DOSED FEED Time: 13:33:34
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 1| 2| 0| 6| 1| 2| 2| 1| 1| 2| 1| 0| 2| 1| 2| 0| 1| 2| 1| 0| 0| 0| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cornea, Inflammation, Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 3.5|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 4 2.0|
Infiltration Cellular, Lymphoid | 1 2 1 1 1 1 2 1 1 1 1 2 1 1 1 2 1 2 1 1 1 1 1| 45 1.3|
Metaplasia, Osseous | 1 1 2 1 2 | 8 1.4|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 50 1.0|
Nephropathy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 50 3.0|
Cortex, Cyst | X X X X X X X X X X X X | 22 |
Renal Tubule, Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Ureter | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 1| 23 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
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---------- END OF REPORT ----------
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