TDMS Study 88138-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus BENZOPHENONE DATE: 06/24/03
EXPERIMENT: 88138 TEST: 04 TIME: 08:39:48
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55388 ROUTE: DOSED FEED NTP C#: 88138B
PATHOLOGIST: MISSING CAS: 119-61-9
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1/MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus BENZOPHENONE DATE: 06/24/03
EXPERIMENT: 88138 TEST: 04 TIME: 08:39:48
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55388 ROUTE: DOSED FEED NTP C#: 88138B
PATHOLOGIST: MISSING CAS: 119-61-9
BENZOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 463 540 652 679 690 703 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 312 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 449 554 585 606 620 695 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 625 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 585 589 671 679 683 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
BENZOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 568 606 656 695 700 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
BENZOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 96.0 94.0 88.0 |
| | |
| | |
|312 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 94.0 90.0 88.0 |
| | |
| | |
|625 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 96.0 88.0 |
| | |
| | |
|1250 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 94.0 90.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 312 PPM 625 PPM 1250 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 88.0% 88.0% 88.0% 90.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.825N P=1.000 P=1.000N P=0.977N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 621.2 584.8 654.8 645.0 |
|NATURAL DEATHS (C) | (39.7) (33.3) (22.6) (25.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 716.9 712.6 721.0 721.5 |
|(STANDARD ERROR) | ( 6.7) ( 7.7) ( 4.3) ( 4.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 414 456 606 608 610 613 708 709 709 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 312 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 316 522 561 595 641 680 703 709 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 625 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 204 478 555 634 645 690 700 704 718 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
BENZOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 1 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 344 435 466 536 606 637 638 645 651 672 |
| 675 677 704 705 711 712 714 723 |
| CENSORED DEATHS |
| 400 |
| |
==================================================================================
BENZOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 98.0 96.0 96.0 96.0 88.0 80.0 |
| | |
| | |
|312 PPM | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 92.0 90.0 84.0 |
| | |
| | |
|625 PPM | 100.0 100.0 98.0 98.0 98.0 96.0 96.0 94.0 90.0 82.0 |
| | |
| | |
|1250 PPM | 100.0 100.0 100.0 98.0 98.0 93.9 91.9 91.9 81.7 63.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 312 PPM 625 PPM 1250 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 84.0% 82.0% 63.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.032 P=0.813N P=0.992N P=0.107 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 616.1 590.9 592.0 625.1 |
|NATURAL DEATHS (C) | (34.1) (45.9) (55.2) (25.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 706.4 706.9 704.3 685.0 |
|(STANDARD ERROR) | ( 9.2) (10.0) (12.1) (12.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZOPHENONE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
312 PPM = 2
625 PPM = 3
1250 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 4 3
|
|
|
P 98 + 2 1 1 2 4 3 3 4
E |
R |
C |
E 96 + 1 2 2 3 4 1 3
N |
T |
|
S 94 + 2 2 1 31 4
U |
R |
V |
I 92 + 2 2 131
V |
A |
L |
90 + 2 3121 3 4
|
|
|
88 + 21 3 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.
BENZOPHENONE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
312 PPM = 2
625 PPM = 3
1250 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 4 1
|
| 3 2 4 1 4 1 3 2
| 4 14 3 2 32 1
95 +
| 4 4 32 2 3
| 4 2 11 323
|
P 90 + 4 423 23
E |
R | 1 44 23321
C | 44 322
E 85 +
N | 323 2
T | 131 3
| 4 4
S 80 + 44 1 1
U |
R |
V |
I 75 + 4 4
V |
A |
L | 44
70 +
|
|
|
65 + 4 4
| 4 4
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.