TDMS Study 88138-04 Pathology Tables
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
FINAL#2 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 119-61-9
Lock Date: 04/26/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 4 2 5 6
Natural Death 6 6 4 12
Accidently Killed 1
Survivors
Terminal Sacrifice 40 42 41 31
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (49) (50) (50) (50)
Cyst 1 [2.0] 1 [2.0]
Infiltration Cellular, Lymphoid 1 [2.0]
Inflammation, Chronic Active 1 [2.0] 1 [2.0] 1 [1.0]
Mineralization 1 [1.0]
Intestine Large, Colon (50) (50) (50) (50)
Inflammation, Chronic Active 1 [2.0]
Intestine Small, Duodenum (50) (50) (50) (50)
Inflammation, Chronic Active 1 [3.0]
Intestine Small, Jejunum (50) (50) (50) (50)
Peyer's Patch, Hyperplasia, Lymphoid 3 [3.0] 1 [4.0]
Intestine Small, Ileum (50) (50) (50) (50)
Peyer's Patch, Hyperplasia, Lymphoid 1 [4.0]
Liver (50) (50) (50) (50)
Angiectasis 2 [2.5] 1 [2.0] 4 [2.3]
Basophilic Focus 3 1 2
Clear Cell Focus 3 2 4 4
Eosinophilic Focus 2 2 7 7
Hematopoietic Cell Proliferation 18 [1.3] 11 [1.1] 20 [1.3] 19 [1.1]
Infarct 1 [4.0]
Infiltration Cellular, Lymphoid 36 [1.2] 38 [1.2] 35 [1.2] 35 [1.2]
Inflammation, Chronic Active 44 [1.1] 40 [1.1] 41 [1.0] 36 [1.1]
Mineralization 1 [2.0]
Mixed Cell Focus 2 5 3 2
Tension Lipidosis 4 [1.3] 8 [1.5] 3 [1.7] 7 [1.1]
Bile Duct, Hyperplasia 1 [1.0]
Hepatocyte, Autolysis 1
Hepatocyte, Mitotic Alteration 1 [2.0]
Hepatocyte, Multinucleated 2 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Necrosis 3 [2.0] 5 [2.0] 4 [1.5]
Hepatocyte, Vacuolization Cytoplasmic 41 [1.1] 43 [1.0] 39 [1.0] 34 [1.2]
Hepatocyte, Centrilobular, Degeneration 1 [4.0]
Hepatocyte, Centrilobular, Hypertrophy 29 [2.0] 44 [2.0] 37 [2.9]
Mesentery (6) (9) (11) (9)
Fat, Fibrosis 1 [2.0] 2 [2.0] 8 [2.0] 4 [2.0]
Fat, Hemorrhage 1 [4.0]
Fat, Infiltration Cellular, Lymphoid 4 [2.3]
Fat, Inflammation, Chronic Active 1 [4.0] 3 [2.0] 7 [2.0] 3 [1.7]
Fat, Mineralization 1 [2.0] 2 [1.5] 1 [1.0]
Fat, Necrosis 1 [4.0] 4 [4.0] 9 [4.0] 4 [4.0]
Pancreas (50) (50) (50) (50)
Cyst 1 [3.0] 2 [3.5]
Infiltration Cellular, Lymphoid 20 [1.1] 24 [1.0] 33 [1.2] 18 [1.3]
Acinus, Atrophy 1 [4.0] 1 [4.0] 1 [4.0] 2 [4.0]
Acinus, Cytoplasmic Alteration 1 [1.0]
Duct, Inflammation, Chronic Active 1 [3.0]
Duct, Pigmentation 1 [3.0]
Salivary Glands (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 27 [1.1] 34 [1.2] 30 [1.3] 28 [1.1]
Stomach, Forestomach (50) (50) (50) (50)
Inflammation, Chronic Active 1 [3.0] 1 [2.0]
Epithelium, Hyperkeratosis 1 [2.0] 1 [2.0] 1 [2.0] 1 [1.0]
Epithelium, Hyperplasia, Squamous 1 [2.0] 1 [3.0] 1 [2.0]
Epithelium, Ulcer 1 [4.0] 1 [2.0]
Stomach, Glandular (50) (50) (50) (50)
Epithelium, Glands, Hyperplasia 1 [2.0]
Glands, Ectasia 18 [1.0] 16 [1.2] 22 [1.2] 10 [1.3]
Glands, Mineralization 3 [1.0] 2 [1.0]
Tooth (21) (29) (24) (20)
Malformation 1
Gingiva, Inflammation, Chronic Active 21 [1.6] 29 [1.8] 24 [1.7] 20 [1.6]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Aorta, Mineralization 1 [2.0]
Heart (50) (50) (50) (50)
Cardiomyopathy 1 [2.0]
Hyperplasia, Atypical 1 [2.0] 1 [4.0]
Inflammation, Chronic Active 2 [1.5] 1 [1.0] 1 [2.0]
Mineralization 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Necrosis 1 [3.0]
Valve, Inflammation, Chronic Active 1 [4.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Accessory Adrenal Cortical Nodule 1 [2.0] 1 [1.0]
Hematopoietic Cell Proliferation 1 [2.0] 1 [2.0]
Hemorrhage 1 [4.0]
Hyperplasia 2 [1.0]
Hypertrophy 1 [1.0] 1 [2.0]
Inflammation, Chronic Active 1 [2.0]
Mineralization 1 [2.0]
Necrosis 1 [2.0] 1 [1.0]
Subcapsular, Hyperplasia 49 [1.8] 49 [1.9] 49 [1.8] 49 [1.8]
Adrenal Medulla (50) (50) (50) (49)
Hyperplasia 2 [1.5]
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 3 [2.0] 1 [2.0]
Parathyroid Gland (42) (41) (40) (40)
Cyst 3 [2.0] 1 [2.0]
Pituitary Gland (50) (50) (49) (47)
Pars Distalis, Angiectasis 2 [2.5] 4 [1.5] 5 [1.8] 3 [2.7]
Pars Distalis, Cyst 5 [1.0] 3 [2.0] 2 [1.0]
Pars Distalis, Hyperplasia 14 [1.9] 14 [2.1] 13 [2.2] 3 [2.7]
Pars Distalis, Hypertrophy 1 [1.0]
Pars Distalis, Pigmentation 1 [1.0]
Thyroid Gland (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 1 [1.0] 2 [1.0] 2 [1.5]
Inflammation, Chronic Active 1 [2.0] 2 [1.5]
C-Cell, Hyperplasia 1 [1.0]
Follicle, Cyst 1 [2.0]
Follicle, Degeneration 17 [1.1] 19 [1.4] 12 [1.3] 9 [1.4]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Clitoral Gland (50) (49) (50) (50)
Inflammation, Chronic Active 8 [2.1] 1 [1.0] 2 [1.5]
Duct, Cyst 1 [2.0]
Ovary (49) (50) (50) (50)
Angiectasis 1 [2.0] 1 [2.0]
Atrophy 48 [3.9] 48 [3.7] 46 [3.8] 45 [4.0]
Cyst 22 [2.6] 17 [2.6] 17 [2.9] 14 [2.7]
Hemorrhage 2 [4.0] 5 [4.0] 3 [4.0] 4 [4.0]
Infiltration Cellular, Lymphoid 1 [4.0]
Inflammation, Chronic Active 2 [3.5] 1 [2.0] 1 [4.0]
Mineralization 4 [1.8] 2 [2.0]
Pigmentation 6 [1.2] 2 [1.0] 3 [1.7] 1 [1.0]
Uterus (49) (50) (50) (50)
Angiectasis 1 [2.0] 1 [3.0]
Inflammation, Chronic Active 5 [2.2] 4 [2.0] 2 [3.5] 2 [2.0]
Endometrium, Hyperplasia, Cystic 47 [2.2] 45 [2.4] 44 [2.3] 43 [2.1]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Myelofibrosis 18 [1.6] 30 [1.5] 20 [1.5] 26 [1.6]
Myeloid Cell, Hyperplasia 1 [4.0]
Lymph Node (8) (12) (11) (15)
Lumbar, Hyperplasia, Lymphoid 1 [3.0] 1 [3.0] 2 [3.0]
Mediastinal, Atrophy 1 [3.0]
Mediastinal, Hyperplasia, Lymphoid 2 [2.5] 5 [2.8] 4 [3.5] 4 [2.0]
Mediastinal, Infiltration Cellular,
Histiocyte 1 [3.0]
Mediastinal, Inflammation, Chronic Active 1 [3.0]
Pancreatic, Hyperplasia, Lymphoid 2 [4.0] 1 [4.0]
Pancreatic, Pigmentation 1 [2.0]
Renal, Hemorrhage 1 [4.0] 1 [3.0]
Renal, Hyperplasia, Lymphoid 3 [4.0] 1 [4.0]
Lymph Node, Mandibular (50) (50) (50) (49)
Hyperplasia, Lymphoid 4 [2.3] 20 [2.9] 12 [2.8] 9 [2.7]
Lymph Node, Mesenteric (50) (49) (49) (50)
Hyperplasia, Lymphoid 6 [3.3] 12 [3.3] 6 [3.2] 4 [2.5]
Spleen (50) (50) (50) (50)
Hematopoietic Cell Proliferation 16 [2.6] 35 [2.1] 32 [2.4] 27 [2.8]
Hemorrhage 2 [4.0]
Inflammation, Chronic Active 1 [2.0]
Necrosis 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymphoid Follicle, Hyperplasia, Lymphoid 24 [2.5] 36 [2.5] 37 [2.7] 22 [2.9]
Thymus (46) (50) (50) (50)
Atrophy 8 [3.5] 7 [3.1] 3 [4.0] 13 [3.2]
Cyst 23 35 31 24
Ectopic Parathyroid Gland 1 [2.0] 3 [1.3] 1 [2.0] 1 [1.0]
Hyperplasia, Lymphoid 8 [3.0] 5 [3.0] 2 [2.0]
Infiltration Cellular, Mast Cell 1 [3.0]
Inflammation, Chronic Active 1 [3.0]
Thymocyte, Necrosis 1 [3.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Fibrosis 1 [3.0]
Subcutaneous Tissue, Infiltration Cellular,
Lymphoid 4 [1.0] 1 [2.0]
Subcutaneous Tissue, Infiltration Cellular,
Polymorphonuclear 1 [3.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Maxilla, Fracture 1
Skeletal Muscle (2) (4) (2) (4)
Infiltration Cellular, Lymphoid 3 [1.0] 2 [2.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 2 [2.0]
Infiltration Cellular, Lymphoid 1 [2.0] 2 [2.0]
Inflammation, Chronic Active 1 [2.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Foreign Body 1
Infiltration Cellular, Lymphoid 33 [1.3] 44 [1.5] 44 [1.6] 35 [1.4]
Inflammation, Chronic Active 1 [1.0] 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Metaplasia, Osseous 1 [1.0]
Pigmentation 2 [2.5]
Alveolar Epithelium, Hyperplasia 1 [2.0] 1 [2.0] 2 [3.0] 2 [1.0]
Alveolus, Hemorrhage 2 [2.0] 3 [1.7]
Alveolus, Infiltration Cellular, Histiocyte 1 [4.0] 2 [2.5]
Mediastinum, Inflammation, Chronic Active 1 [3.0]
Nose (50) (50) (50) (50)
Hemorrhage 1 [3.0]
Inflammation, Chronic Active 1 [1.0] 1 [2.0] 1 [2.0]
Nasolacrimal Duct, Inflammation, Chronic
Active 1 [2.0]
Olfactory Epithelium, Metaplasia 39 [1.7]
Trachea (50) (50) (50) (50)
Glands, Cyst 1 [2.0]
Glands, Inflammation, Chronic Active 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Atrophy 2 [4.0]
Lens, Cataract 1 [3.0]
Harderian Gland (50) (50) (50) (49)
Hyperplasia 3 [2.7] 3 [2.0] 1 [2.0]
Infiltration Cellular, Lymphoid 29 [1.0] 27 [1.0] 27 [1.0] 23 [1.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 1 [3.0] 1 [4.0]
Atrophy 1 [3.0]
Glomerulosclerosis 1 [4.0]
Hydronephrosis 2 [2.5] 1 [3.0]
Infarct 4 [2.8] 1 [1.0] 3 [2.7] 3 [2.7]
Infiltration Cellular, Lymphoid 41 [1.1] 45 [1.2] 43 [1.3] 39 [1.3]
Inflammation, Chronic Active 1 [3.0]
Metaplasia, Osseous 1 [3.0] 2 [1.5] 4 [1.0] 2 [1.5]
Mineralization 15 [1.0] 31 [1.0] 36 [1.1] 49 [1.5]
Nephropathy 21 [1.2] 33 [1.1] 31 [1.5] 30 [1.7]
Artery, Inflammation, Chronic Active 1 [2.0] 1 [3.0]
Cortex, Cyst 1
Renal Tubule, Pigmentation 1 [3.0] 1 [3.0] 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Urinary Bladder (50) (49) (50) (50)
Infiltration Cellular, Lymphoid 37 [1.2] 38 [1.2] 40 [1.2] 39 [1.0]
Inflammation, Chronic Active 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 5 3 5 2
Natural Death 1 3 1 3
Survivors
Terminal Sacrifice 44 44 44 45
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (49) (49) (49)
Cyst 1 [2.0]
Intestine Small, Jejunum (50) (50) (50) (50)
Peyer's Patch, Hyperplasia, Lymphoid 1 [2.0]
Liver (50) (50) (50) (50)
Basophilic Focus 4 2 5
Clear Cell Focus 2 7 7 12
Eosinophilic Focus 5 8 11 10
Fatty Change 1 [4.0]
Fibrosis 1 [2.0]
Hematopoietic Cell Proliferation 2 [1.0] 1 [2.0]
Infarct 2 [4.0] 1 [4.0]
Infiltration Cellular, Lymphoid 6 [1.2] 10 [1.3] 4 [1.0]
Inflammation, Chronic Active 33 [1.0] 47 [1.1] 44 [1.2] 42 [1.1]
Mixed Cell Focus 8 9 15 13
Tension Lipidosis 1 1 1
Bile Duct, Cyst 3 1
Hepatocyte, Degeneration, Cystic 5 [1.2] 30 [1.9]
Hepatocyte, Multinucleated 41 [1.4] 47 [1.5] 48 [1.8]
Hepatocyte, Necrosis 1 [1.0] 6 [1.7] 8 [1.8] 8 [1.3]
Hepatocyte, Vacuolization Cytoplasmic 44 [1.0] 45 [1.4] 46 [1.8] 44 [1.4]
Hepatocyte, Centrilobular, Hypertrophy 44 [2.0] 50 [2.0] 48 [3.0]
Oval Cell, Hyperplasia 1 [2.0]
Mesentery (2) (8) (5)
Fat, Fibrosis 1 [3.0] 5 [2.4] 1 [3.0]
Fat, Inflammation, Chronic Active 1 [2.0] 5 [2.2] 2 [1.5]
Fat, Mineralization 1 [1.0] 3 [1.3]
Fat, Necrosis 1 [4.0] 5 [4.0]
Fat, Pigmentation 1 [3.0]
Pancreas (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Cyst 1 [2.0] 2 [2.5]
Cytoplasmic Alteration 1 [2.0]
Infiltration Cellular, Lymphoid 14 [1.0] 11 [1.0] 8 [1.1] 8 [1.0]
Acinus, Atrophy 1 [1.0] 1 [4.0] 1 [3.0]
Acinus, Cytoplasmic Alteration 1 [2.0]
Salivary Glands (50) (50) (50) (50)
Atrophy 1 [4.0]
Infiltration Cellular, Lymphoid 31 [1.1] 40 [1.0] 40 [1.1] 28 [1.0]
Stomach, Forestomach (50) (50) (50) (50)
Hyperplasia 1 [3.0]
Inflammation, Chronic Active 1 [3.0] 2 [3.0]
Epithelium, Cyst 1 [2.0]
Epithelium, Hyperkeratosis 1 [2.0] 2 [2.0] 1 [4.0] 1 [2.0]
Epithelium, Hyperplasia, Squamous 1 [3.0] 2 [2.5] 1 [2.0] 1 [1.0]
Epithelium, Ulcer 1 [4.0] 1 [3.0]
Stomach, Glandular (50) (50) (50) (50)
Glands, Ectasia 7 [1.1] 13 [1.2] 18 [1.1] 5 [1.0]
Glands, Mineralization 1 [2.0] 1 [1.0]
Tooth (20) (31) (33) (21)
Inflammation, Chronic Active 1 [3.0] 3 [3.3]
Malformation 3 [3.0] 1 [3.0] 3 [4.0]
Gingiva, Inflammation, Chronic Active 18 [1.7] 30 [1.8] 32 [1.6] 20 [1.8]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Hyperplasia, Atypical 1 [2.0]
Inflammation, Chronic Active 3 [1.0] 5 [1.2] 3 [2.7] 3 [1.3]
Mineralization 1 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Degeneration, Fatty 2 [1.0]
Hyperplasia 7 [1.7] 10 [1.6] 9 [1.8] 6 [1.8]
Hypertrophy 26 [1.3] 22 [1.4] 24 [1.4] 18 [1.5]
Inflammation, Chronic Active 1 [1.0]
Necrosis 1 [3.0]
Subcapsular, Hyperplasia 50 [1.1] 46 [1.2] 46 [1.1] 47 [1.1]
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 [2.0] 1 [2.0]
Pituitary Gland (48) (49) (50) (50)
Pars Distalis, Cyst 7 [1.4] 5 [1.4] 5 [1.6] 4 [1.3]
Pars Distalis, Hyperplasia 1 [1.0] 1 [2.0]
Pars Nervosa, Cyst 1 [2.0]
Thyroid Gland (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 1 [2.0] 1 [1.0]
Inflammation, Chronic Active 2 [1.0]
Follicle, Cyst 2 [2.5] 1 [2.0]
Follicle, Degeneration 12 [1.1] 9 [1.0] 6 [1.0] 6 [1.3]
Follicular Cell, Hyperplasia 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Degeneration 1 [4.0]
Granuloma Sperm 1 [2.0] 2 [2.0] 2 [2.5] 1 [2.0]
Infiltration Cellular, Lymphoid 32 [1.1] 27 [1.0] 30 [1.1] 31 [1.0]
Mineralization 4 [1.5]
Spermatocele 1 [2.0]
Preputial Gland (50) (50) (50) (50)
Inflammation, Chronic Active 21 [1.1] 23 [1.2] 25 [1.4] 32 [1.1]
Duct, Ectasia 20 [2.2] 15 [2.4] 15 [2.3] 28 [2.3]
Prostate (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 32 [1.0] 43 [1.0] 46 [1.0] 28 [1.0]
Inflammation, Chronic Active 1 [1.0]
Artery, Inflammation, Chronic Active 1 [4.0] 1 [3.0]
Seminal Vesicle (50) (50) (50) (50)
Artery, Inflammation, Chronic Active 1 [2.0]
Testes (50) (50) (50) (50)
Mineralization 1 [1.0] 4 [1.0] 12 [1.1]
Germinal Epithelium, Degeneration 3 [2.0] 1 [1.0] 2 [1.0]
Rete Testes, Cyst 1 [3.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 11
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Myeloid Cell, Hyperplasia 1 [4.0]
Lymph Node (1) (1) (3) (5)
Deep Cervical, Hyperplasia, Lymphoid 1 [2.0]
Mediastinal, Hyperplasia, Lymphoid 1 [3.0] 1 [2.0]
Mediastinal, Infiltration Cellular,
Histiocyte 1 [3.0]
Mediastinal, Inflammation, Granulomatous 1 [3.0]
Lymph Node, Mandibular (48) (50) (49) (47)
Hyperplasia, Lymphoid 5 [3.2] 1 [2.0] 6 [2.2] 5 [2.0]
Lymph Node, Mesenteric (49) (50) (49) (48)
Hyperplasia, Lymphoid 2 [3.0] 2 [3.0] 2 [3.0]
Infiltration Cellular, Histiocyte 1 [2.0]
Inflammation, Granulomatous 1 [3.0]
Spleen (50) (50) (50) (50)
Angiectasis 1 [3.0]
Hematopoietic Cell Proliferation 11 [2.3] 7 [2.6] 9 [2.4] 14 [2.4]
Lymphoid Follicle, Hyperplasia, Lymphoid 17 [2.1] 31 [2.5] 34 [2.0] 32 [2.2]
Thymus (46) (48) (46) (47)
Atrophy 12 [2.3] 9 [2.8] 6 [2.8] 5 [3.4]
Cyst 16 [1.6] 25 [1.4] 20 [1.5] 20 [1.3]
Ectopic Parathyroid Gland 2 [1.5]
Ectopic Thyroid 1 [2.0]
Infiltration Cellular, Histiocyte 1 [3.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1
Inflammation, Granulomatous 1 [3.0]
Mineralization 1 [1.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Spinal Cord (1) (1) (1)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 12
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Degeneration 1 [3.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 32 [1.1] 38 [1.1] 47 [1.1] 36 [1.0]
Inflammation, Chronic Active 1 [3.0] 2 [1.5] 1 [1.0] 1 [1.0]
Metaplasia, Osseous 1 [1.0]
Necrosis 1 [3.0]
Thrombosis 1 [2.0]
Alveolar Epithelium, Hyperplasia 6 [1.7] 7 [2.6] 8 [1.9] 4 [3.3]
Alveolus, Infiltration Cellular, Histiocyte 7 [2.4] 1 [2.0] 1 [2.0] 3 [1.7]
Mediastinum, Inflammation, Suppurative 1 [3.0]
Nose (50) (50) (50) (50)
Inflammation, Chronic Active 2 [2.5] 1 [1.0] 2 [1.0]
Inflammation, Focal, Suppurative 1 [1.0]
Inflammation, Suppurative 1 [2.0]
Nasolacrimal Duct, Inflammation, Chronic
Active 2 [2.5] 1 [1.0]
Olfactory Epithelium, Degeneration 1 [3.0]
Olfactory Epithelium, Metaplasia 2 [1.0] 2 [1.0] 24 [1.2]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Inflammation, Suppurative 1 [3.0]
Anterior Chamber, Iris, Inflammation,
Suppurative 1 [3.0]
Cornea, Inflammation, Chronic Active 1 [4.0] 2 [1.5] 1 [2.0]
Harderian Gland (50) (50) (50) (50)
Hyperplasia 2 [1.5] 3 [3.0] 3 [2.7] 2 [3.5]
Infiltration Cellular, Lymphoid 37 [1.0] 33 [1.0] 24 [1.0] 29 [1.0]
Inflammation, Chronic Active 1 [1.0] 1 [1.0]
Mineralization 1 [1.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Infarct 1 [2.0] 1 [3.0] 1 [4.0] 4 [2.0]
Infiltration Cellular, Lymphoid 44 [1.1] 44 [1.1] 45 [1.0] 45 [1.3]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 13
NTP Experiment-Test: 88138-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 06/01/04
Route: DOSED FEED BENZOPHENONE Time: 14:05:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic Active 1 [1.0] 2 [2.0]
Metaplasia, Osseous 4 [1.0] 2 [1.5] 1 [1.0] 8 [1.4]
Mineralization 49 [1.0] 50 [1.0] 50 [1.0] 50 [1.0]
Necrosis 1 [1.0]
Nephropathy 49 [1.2] 48 [1.4] 50 [1.7] 50 [3.0]
Artery, Inflammation, Chronic Active 1 [2.0] 1 [2.0]
Cortex, Cyst 4 8 12 22
Renal Tubule, Pigmentation 1 [3.0]
Urinary Bladder (50) (50) (50) (50)
Infiltration Cellular, Lymphoid 24 [1.0] 24 [1.0] 32 [1.0] 23 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 14
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