https://ntp.niehs.nih.gov/go/18189

TDMS Study 54591-09 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: BIORELIANCE                                       TRANS-1,2-DICHLOROETHYLENE                              DATE: 10/25/04       
EXPERIMENT: 54591 TEST: 09                                                                                     TIME: 11:05:04       
TEST TYPE:  SUBCHRON 90-DAY                                                                                    PAGE:       1        
CONT: NO1-ES-15319                              ROUTE: DOSED FEED                                              NTP C#: 54591D       
PATHOLOGIST: MISSING                                                                                           CAS: 156-60-5        
------------------------------------------------------------------------------------------------------------------------------------
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: BIORELIANCE                                       TRANS-1,2-DICHLOROETHYLENE                              DATE: 10/25/04       
EXPERIMENT: 54591 TEST: 09                                                                                     TIME: 11:05:04       
TEST TYPE:  SUBCHRON 90-DAY                                                                                                         
CONT: NO1-ES-15319                              ROUTE: DOSED FEED                                              NTP C#: 54591D       
PATHOLOGIST: MISSING                                                                                           CAS: 156-60-5        
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF               TRANS-1,2-DICHLOROETHYLENE                                                                         
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Kidney: Bilateral                      Nephropathy Chronic                                                                          
Liver                                  Hepatodiaphragmatic Nodule                                                                   
Lymph Node, Mandibular                 Hemorrhage                                                                                   
Preputial Gland                        Inflammation Chronic                                                                         
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Lung: Interstitium                     Inflammation Chronic                                                                         
Ovary                                  Cyst                                                                                         
Uterus                                 Hydrometra                                                                                   
===============================================================                                                                     
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE             
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/20.00          0/0.00           0/0.00           0/0.00           0/0.00           0/10.00         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/20 (30%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)      | 
|POLY-3 RATE (b)    |        6/20.00          0/0.00           0/0.00           0/0.00           0/0.00           2/10.00         | 
|POLY-3 PERCENT (g) |        30.0%            0.0%             0.0%             0.0%             0.0%             20.0%           | 
|TERMINAL (d)       |        6/20 (30%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.360N         P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.443N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.444N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.444N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.444N        | 
|LOGISTIC REGRESSION|        P=0.360N         (e)              (e)              (e)              (e)              P=0.443N        | 
|COCH-ARM / FISHERS |        P=0.358N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.452N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/20.00          0/0.00           0/0.00           0/0.00           0/0.00           0/10.00         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/20 (5%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)      | 
|POLY-3 RATE (b)    |        1/20.00          0/0.00           0/0.00           0/0.00           0/0.00           3/10.00         | 
|POLY-3 PERCENT (g) |        5.0%             0.0%             0.0%             0.0%             0.0%             30.0%           | 
|TERMINAL (d)       |        1/20 (5%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.056          P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.096         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.085         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.085         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.085         | 
|LOGISTIC REGRESSION|        P=0.056          (e)              (e)              (e)              (e)              P=0.096         | 
|COCH-ARM / FISHERS |        P=0.053          P=1.000          P=1.000          P=1.000          P=1.000          P=0.095         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/20 (45%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)      | 
|POLY-3 RATE (b)    |        9/20.00          0/0.00           0/0.00           0/0.00           0/0.00           3/10.00         | 
|POLY-3 PERCENT (g) |        45.0%            0.0%             0.0%             0.0%             0.0%             30.0%           | 
|TERMINAL (d)       |        9/20 (45%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.280N         P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.349N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.350N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.350N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.350N        | 
|LOGISTIC REGRESSION|        P=0.280N         (e)              (e)              (e)              (e)              P=0.349N        | 
|COCH-ARM / FISHERS |        P=0.277N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.350N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland: Bilateral                                                                                                        | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland: Bilateral                                                                                                        | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/20 (25%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)      | 
|POLY-3 RATE (b)    |        5/20.00          0/0.00           0/0.00           0/0.00           0/0.00           2/10.00         | 
|POLY-3 PERCENT (g) |        25.0%            0.0%             0.0%             0.0%             0.0%             20.0%           | 
|TERMINAL (d)       |        5/20 (25%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.470N         P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.560N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.559N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.559N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.559N        | 
|LOGISTIC REGRESSION|        P=0.470N         (e)              (e)              (e)              (e)              P=0.560N        | 
|COCH-ARM / FISHERS |        P=0.470N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.571N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        15/20 (75%)      0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         7/10 (70%)      | 
|POLY-3 RATE (b)    |        15/20.00         0/0.00           0/0.00           0/0.00           0/0.00           7/10.00         | 
|POLY-3 PERCENT (g) |        75.0%            0.0%             0.0%             0.0%             0.0%             70.0%           | 
|TERMINAL (d)       |        15/20 (75%)      0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         7/10 (70%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.471N         P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.557N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.556N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.556N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.556N        | 
|LOGISTIC REGRESSION|        P=0.471N         (e)              (e)              (e)              (e)              P=0.557N        | 
|COCH-ARM / FISHERS |        P=0.471N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.548N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/20 (15%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)      | 
|POLY-3 RATE (b)    |        3/20.00          0/0.00           0/0.00           0/0.00           0/0.00           2/10.00         | 
|POLY-3 PERCENT (g) |        15.0%            0.0%             0.0%             0.0%             0.0%             20.0%           | 
|TERMINAL (d)       |        3/20 (15%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.466          P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.568         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.567         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.567         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.567         | 
|LOGISTIC REGRESSION|        P=0.466          (e)              (e)              (e)              (e)              P=0.568         | 
|COCH-ARM / FISHERS |        P=0.465          P=1.000          P=1.000          P=1.000          P=1.000          P=0.551         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/20.00          0/0.00           0/0.00           0/0.00           0/0.00           0/10.00         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        20/20 (100%)     0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         10/10 (100%)    | 
|POLY-3 RATE (b)    |        20/20.00         0/0.00           0/0.00           0/0.00           0/0.00           10/10.00        | 
|POLY-3 PERCENT (g) |        100.0%           0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        20/20 (100%)     0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         10/10 (100%)    | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy Chronic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        19/20 (95%)      0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         8/10 (80%)      | 
|POLY-3 RATE (b)    |        19/20.00         0/0.00           0/0.00           0/0.00           0/0.00           8/10.00         | 
|POLY-3 PERCENT (g) |        95.0%            0.0%             0.0%             0.0%             0.0%             80.0%           | 
|TERMINAL (d)       |        19/20 (95%)      0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         8/10 (80%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.171N         P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.263N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.261N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.261N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.261N        | 
|LOGISTIC REGRESSION|        P=0.171N         (e)              (e)              (e)              (e)              P=0.263N        | 
|COCH-ARM / FISHERS |        P=0.166N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.251N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy Chronic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/20 (10%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|POLY-3 RATE (b)    |        2/20.00          0/0.00           0/0.00           0/0.00           0/0.00           0/10.00         | 
|POLY-3 PERCENT (g) |        10.0%            0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        2/20 (10%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.262N         P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.400N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.400N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.400N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.400N        | 
|LOGISTIC REGRESSION|        P=0.262N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.259N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.437N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Bilateral                                                                                                                | 
|     Mineralization Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/20.00          0/0.00           0/0.00           0/0.00           0/0.00           0/10.00         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Bilateral                                                                                                                | 
|     Mineralization Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        20/20 (100%)     0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         10/10 (100%)    | 
|POLY-3 RATE (b)    |        20/20.00         0/0.00           0/0.00           0/0.00           0/0.00           10/10.00        | 
|POLY-3 PERCENT (g) |        100.0%           0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        20/20 (100%)     0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         10/10 (100%)    | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Bilateral                                                                                                                | 
|     Nephropathy Chronic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        16/20 (80%)      0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         4/10 (40%)      | 
|POLY-3 RATE (b)    |        16/20.00         0/0.00           0/0.00           0/0.00           0/0.00           4/10.00         | 
|POLY-3 PERCENT (g) |        80.0%            0.0%             0.0%             0.0%             0.0%             40.0%           | 
|TERMINAL (d)       |        16/20 (80%)      0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         4/10 (40%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.025N*        P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.040N*       | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.030N*       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.030N*       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.030N*       | 
|LOGISTIC REGRESSION|        P=0.025N*        (e)              (e)              (e)              (e)              P=0.040N*       | 
|COCH-ARM / FISHERS |        P=0.024N*        P=1.000          P=1.000          P=1.000          P=1.000          P=0.039N*       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Bilateral                                                                                                                | 
|     Nephropathy Chronic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/20.00          0/0.00           0/0.00           0/0.00           0/0.00           0/10.00         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/20 (0%)        1/1 (100%)       0/0 (0%)         1/2 (50%)        0/0 (0%)         0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/20.00          1/1.00           0/0.00           1/2.00           0/0.00           0/10.00         | 
|POLY-3 PERCENT (g) |        0.0%             100.0%           0.0%             50.0%            0.0%             0.0%            | 
|TERMINAL (d)       |        0/20 (0%)        1/1 (100%)       0/0 (0%)         1/2 (50%)        0/0 (0%)         0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              92 (T)           ---              92 (T)           ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.451N         P=0.017 *        (e)              P=0.077          (e)              (e)             | 
|POLY 3             |        (e)              P=0.048 *        (e)              P=0.028 *        (e)              (e)             | 
|POLY 1.5           |        (e)              P=0.048 *        (e)              P=0.028 *        (e)              (e)             | 
|POLY 6             |        (e)              P=0.048 *        (e)              P=0.028 *        (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              P=0.017 *        (e)              P=0.077          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.450N         P=0.048 *        (e)              P=0.091          (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/20 (15%)       1/2 (50%)        0/0 (0%)         1/1 (100%)       0/1 (0%)         2/10 (20%)      | 
|POLY-3 RATE (b)    |        3/20.00          1/2.00           0/0.00           1/1.00           0/1.00           2/10.00         | 
|POLY-3 PERCENT (g) |        15.0%            50.0%            0.0%             100.0%           0.0%             20.0%           | 
|TERMINAL (d)       |        3/20 (15%)       1/2 (50%)        0/0 (0%)         1/1 (100%)       0/1 (0%)         2/10 (20%)      | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           ---              92 (T)           ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.565          P=0.399          P=1.000N         P=0.215          P=0.846N         P=0.568         | 
|POLY 3             |        (e)              P=0.398          (e)              P=0.193          P=0.841N         P=0.567         | 
|POLY 1.5           |        (e)              P=0.398          (e)              P=0.193          P=0.841N         P=0.567         | 
|POLY 6             |        (e)              P=0.398          (e)              P=0.193          P=0.841N         P=0.567         | 
|LOGISTIC REGRESSION|        P=0.565          P=0.399          (e)              P=0.215          (e)              P=0.568         | 
|COCH-ARM / FISHERS |        P=0.566          P=0.338          P=1.000          P=0.190          P=0.857N         P=0.551         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/20 (15%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)      | 
|POLY-3 RATE (b)    |        3/20.00          0/0.00           0/0.00           0/0.00           0/0.00           3/10.00         | 
|POLY-3 PERCENT (g) |        15.0%            0.0%             0.0%             0.0%             0.0%             30.0%           | 
|TERMINAL (d)       |        3/20 (15%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.238          P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.317         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.317         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.317         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.317         | 
|LOGISTIC REGRESSION|        P=0.238          (e)              (e)              (e)              (e)              P=0.317         | 
|COCH-ARM / FISHERS |        P=0.234          P=1.000          P=1.000          P=1.000          P=1.000          P=0.306         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/20.00          0/0.00           0/0.00           0/0.00           0/0.00           1/10.00         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             10.0%           | 
|TERMINAL (d)       |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.188          (e)              (e)              (e)              (e)              P=0.362         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.359         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.359         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.359         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.362         | 
|COCH-ARM / FISHERS |        P=0.184          (e)              (e)              (e)              (e)              P=0.333         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Interstitium                                                                                                               | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/20 (15%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)      | 
|POLY-3 RATE (b)    |        3/20.00          0/0.00           0/0.00           0/0.00           0/0.00           3/10.00         | 
|POLY-3 PERCENT (g) |        15.0%            0.0%             0.0%             0.0%             0.0%             30.0%           | 
|TERMINAL (d)       |        3/20 (15%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.238          P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.317         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.317         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.317         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.317         | 
|LOGISTIC REGRESSION|        P=0.238          (e)              (e)              (e)              (e)              P=0.317         | 
|COCH-ARM / FISHERS |        P=0.234          P=1.000          P=1.000          P=1.000          P=1.000          P=0.306         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Interstitium                                                                                                               | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/20 (5%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         4/10 (40%)      | 
|POLY-3 RATE (b)    |        1/20.00          0/0.00           0/0.00           0/0.00           0/0.00           4/10.00         | 
|POLY-3 PERCENT (g) |        5.0%             0.0%             0.0%             0.0%             0.0%             40.0%           | 
|TERMINAL (d)       |        1/20 (5%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         4/10 (40%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.017 *        P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.031 *       | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.020 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.020 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.020 *       | 
|LOGISTIC REGRESSION|        P=0.017 *        (e)              (e)              (e)              (e)              P=0.031 *       | 
|COCH-ARM / FISHERS |        P=0.015 *        P=1.000          P=1.000          P=1.000          P=1.000          P=0.031 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/20.00          0/0.00           0/0.00           0/0.00           0/0.00           2/10.00         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             20.0%           | 
|TERMINAL (d)       |        0/20 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.049 *        (e)              (e)              (e)              (e)              P=0.102         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.088         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.088         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.088         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.102         | 
|COCH-ARM / FISHERS |        P=0.046 *        (e)              (e)              (e)              (e)              P=0.103         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/20 (5%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|POLY-3 RATE (b)    |        1/20.00          0/0.00           0/0.00           0/0.00           0/0.00           0/10.00         | 
|POLY-3 PERCENT (g) |        5.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        1/20 (5%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.430N         P=1.000N         P=1.000N         P=1.000N         P=1.000          P=0.638N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.637N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.637N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.637N        | 
|LOGISTIC REGRESSION|        P=0.430N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.429N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.667N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/20 (5%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)      | 
|POLY-3 RATE (b)    |        1/20.00          0/0.00           0/0.00           0/0.00           0/0.00           3/10.00         | 
|POLY-3 PERCENT (g) |        5.0%             0.0%             0.0%             0.0%             0.0%             30.0%           | 
|TERMINAL (d)       |        1/20 (5%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.056          P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.096         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.085         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.085         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.085         | 
|LOGISTIC REGRESSION|        P=0.056          (e)              (e)              (e)              (e)              P=0.096         | 
|COCH-ARM / FISHERS |        P=0.053          P=1.000          P=1.000          P=1.000          P=1.000          P=0.095         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/20 (35%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)      | 
|POLY-3 RATE (b)    |        7/20.00          0/0.00           0/0.00           0/0.00           0/0.00           3/10.00         | 
|POLY-3 PERCENT (g) |        35.0%            0.0%             0.0%             0.0%             0.0%             30.0%           | 
|TERMINAL (d)       |        7/20 (35%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.473N         P=1.000N         P=1.000N         P=1.000N         P=1.000          P=0.554N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.553N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.553N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.553N        | 
|LOGISTIC REGRESSION|        P=0.473N         (e)              (e)              (e)              (e)              P=0.554N        | 
|COCH-ARM / FISHERS |        P=0.473N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.560N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/20 (0%)        2/2 (100%)       1/1 (100%)       1/1 (100%)       0/0 (0%)         1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/20.00          2/2.00           1/1.00           1/1.00           0/0.00           1/10.00         | 
|POLY-3 PERCENT (g) |        0.0%             100.0%           100.0%           100.0%           0.0%             10.0%           | 
|TERMINAL (d)       |        0/20 (0%)        2/2 (100%)       1/1 (100%)       1/1 (100%)       0/0 (0%)         1/10 (10%)      | 
|FIRST INCIDENCE    |        ---              92 (T)           92 (T)           92 (T)           ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.587N         P<0.001 **       P=0.017 *        P=0.017 *        (e)              P=0.362         | 
|POLY 3             |        (e)              P=0.004 **       P=0.048 *        P=0.048 *        (e)              P=0.359         | 
|POLY 1.5           |        (e)              P=0.004 **       P=0.048 *        P=0.048 *        (e)              P=0.359         | 
|POLY 6             |        (e)              P=0.004 **       P=0.048 *        P=0.048 *        (e)              P=0.359         | 
|LOGISTIC REGRESSION|        (e)              P<0.001 **       P=0.017 *        P=0.017 *        (e)              P=0.362         | 
|COCH-ARM / FISHERS |        P=0.588N         P=0.004 **       P=0.048 *        P=0.048 *        (e)              P=0.333         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/20 (25%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|POLY-3 RATE (b)    |        5/20.00          0/0.00           0/0.00           0/0.00           0/0.00           0/10.00         | 
|POLY-3 PERCENT (g) |        25.0%            0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        5/20 (25%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.074N         P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.117N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.108N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.108N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.108N        | 
|LOGISTIC REGRESSION|        P=0.074N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.070N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.109N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/20 (10%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|POLY-3 RATE (b)    |        2/20.00          0/0.00           0/0.00           0/0.00           0/0.00           0/10.00         | 
|POLY-3 PERCENT (g) |        10.0%            0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        2/20 (10%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.262N         P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.400N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.400N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.400N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.400N        | 
|LOGISTIC REGRESSION|        P=0.262N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.259N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.437N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        14/20 (70%)      0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/9 (33%)       | 
|POLY-3 RATE (b)    |        14/20.00         0/0.00           0/0.00           0/0.00           0/0.00           3/9.00          | 
|POLY-3 PERCENT (g) |        70.0%            0.0%             0.0%             0.0%             0.0%             33.3%           | 
|TERMINAL (d)       |        14/20 (70%)      0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/9 (33%)       | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.052N         P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.077N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.068N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.068N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.068N        | 
|LOGISTIC REGRESSION|        P=0.052N         (e)              (e)              (e)              (e)              P=0.077N        | 
|COCH-ARM / FISHERS |        P=0.049N*        P=1.000          P=1.000          P=1.000          P=1.000          P=0.074N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland: Bilateral                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/20 (25%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/9 (22%)       | 
|POLY-3 RATE (b)    |        5/20.00          0/0.00           0/0.00           0/0.00           0/0.00           2/9.00          | 
|POLY-3 PERCENT (g) |        25.0%            0.0%             0.0%             0.0%             0.0%             22.2%           | 
|TERMINAL (d)       |        5/20 (25%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/9 (22%)       | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.529N         P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.619N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.617N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.617N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.617N        | 
|LOGISTIC REGRESSION|        P=0.529N         (e)              (e)              (e)              (e)              P=0.619N        | 
|COCH-ARM / FISHERS |        P=0.529N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.631N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland: Bilateral                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/20 (20%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         1/9 (11%)       | 
|POLY-3 RATE (b)    |        4/20.00          0/0.00           0/0.00           0/0.00           0/0.00           1/9.00          | 
|POLY-3 PERCENT (g) |        20.0%            0.0%             0.0%             0.0%             0.0%             11.1%           | 
|TERMINAL (d)       |        4/20 (20%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         1/9 (11%)       | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.376N         P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.478N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.479N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.479N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.479N        | 
|LOGISTIC REGRESSION|        P=0.376N         (e)              (e)              (e)              (e)              P=0.478N        | 
|COCH-ARM / FISHERS |        P=0.374N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.498N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/20 (5%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)      | 
|POLY-3 RATE (b)    |        1/20.00          0/0.00           0/0.00           0/0.00           0/0.00           1/10.00         | 
|POLY-3 PERCENT (g) |        5.0%             0.0%             0.0%             0.0%             0.0%             10.0%           | 
|TERMINAL (d)       |        1/20 (5%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)      | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.449          P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.600         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.599         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.599         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.599         | 
|LOGISTIC REGRESSION|        P=0.449          (e)              (e)              (e)              (e)              P=0.600         | 
|COCH-ARM / FISHERS |        P=0.449          P=1.000          P=1.000          P=1.000          P=1.000          P=0.563         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/20 (20%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|POLY-3 RATE (b)    |        4/20.00          0/0.00           0/0.00           0/0.00           0/0.00           0/10.00         | 
|POLY-3 PERCENT (g) |        20.0%            0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        4/20 (20%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.112N         P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.175N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.170N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.170N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.170N        | 
|LOGISTIC REGRESSION|        P=0.112N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.109N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.177N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/20 (5%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|POLY-3 RATE (b)    |        1/20.00          0/0.00           0/0.00           0/0.00           0/0.00           0/10.00         | 
|POLY-3 PERCENT (g) |        5.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        1/20 (5%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.430N         P=1.000N         P=1.000N         P=1.000N         P=1.000N         P=0.638N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.637N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.637N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.637N        | 
|LOGISTIC REGRESSION|        P=0.430N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.429N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.667N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
       Date:  10/25/04                           EXPERIMENT: 54591 TEST: 09                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                TRANS-1,2-DICHLOROETHYLENE              
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        UNTREAT          3125 PPM         6250 PPM         12500            25000            50000           | 
|                   |        CONTROL                                            PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/20 (25%)       1/1 (100%)       4/4 (100%)       2/2 (100%)       1/1 (100%)       4/10 (40%)      | 
|POLY-3 RATE (b)    |        5/20.00          1/1.00           4/4.00           2/2.00           1/1.00           4/10.00         | 
|POLY-3 PERCENT (g) |        25.0%            100.0%           100.0%           100.0%           100.0%           40.0%           | 
|TERMINAL (d)       |        5/20 (25%)       1/1 (100%)       4/4 (100%)       2/2 (100%)       1/1 (100%)       4/10 (40%)      | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.458          P=0.318          P=0.013 *        P=0.090          P=0.318          P=0.339         | 
|POLY 3             |        P=0.452          P=0.311          P=0.004 **       P=0.070          P=0.311          P=0.340         | 
|POLY 1.5           |        P=0.452          P=0.311          P=0.004 **       P=0.070          P=0.311          P=0.340         | 
|POLY 6             |        P=0.452          P=0.311          P=0.004 **       P=0.070          P=0.311          P=0.340         | 
|LOGISTIC REGRESSION|        P=0.458          P=0.318          P=0.013 *        P=0.090          P=0.318          P=0.339         | 
|COCH-ARM / FISHERS |        P=0.457          P=0.286          P=0.012 *        P=0.091          P=0.286          P=0.331         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).