TDMS Study 54591-10 Pathology Tables

NTP Experiment-Test: 54591-10               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                             TRANS-1,2-DICHLOROETHYLENE                                Date: 08/05/02
Route: DOSED FEED                                                                                                 Time: 09:56:59
       Facility:  BIORELIANCE
       Chemical CAS #:  156-60-5
       Lock Date:  02/15/94
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 54591-10               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                             TRANS-1,2-DICHLOROETHYLENE                                Date: 08/05/02  
Route: DOSED FEED                                                                                                 Time: 09:56:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREAT      VEHICLE      3125 PPM     6250 PPM     12500        25000           
                                                   CONTROL      CONTROL                                PPM          PPM             
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8           10           10            9           10            9           
    Accidently Killed                                  2                                      1                         1           
  Animals Examined Microscopically                    10           10                                      1            2           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                             Page   2                                                               
NTP Experiment-Test: 54591-10               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                             TRANS-1,2-DICHLOROETHYLENE                                Date: 08/05/02  
Route: DOSED FEED                                                                                                 Time: 09:56:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREAT      VEHICLE      3125 PPM     6250 PPM     12500        25000           
                                                   CONTROL      CONTROL                                PPM          PPM             
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
                                                             Page   3                                                               
NTP Experiment-Test: 54591-10               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                             TRANS-1,2-DICHLOROETHYLENE                                Date: 08/05/02  
Route: DOSED FEED                                                                                                 Time: 09:56:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        50000                                                                            
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          10                                                                            
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9                                                                            
    Accidently Killed                                  1                                                                            
  Animals Examined Microscopically                    10                                                                            
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 54591-10               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                             TRANS-1,2-DICHLOROETHYLENE                                Date: 08/05/02  
Route: DOSED FEED                                                                                                 Time: 09:56:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        50000                                                                            
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
                                                             Page   5                                                               
NTP Experiment-Test: 54591-10               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                             TRANS-1,2-DICHLOROETHYLENE                                Date: 08/05/02  
Route: DOSED FEED                                                                                                 Time: 09:56:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREAT      VEHICLE      3125 PPM     6250 PPM     12500        25000           
                                                   CONTROL      CONTROL                                PPM          PPM             
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10                                                               
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                             Page   6                                                               
NTP Experiment-Test: 54591-10               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                             TRANS-1,2-DICHLOROETHYLENE                                Date: 08/05/02  
Route: DOSED FEED                                                                                                 Time: 09:56:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREAT      VEHICLE      3125 PPM     6250 PPM     12500        25000           
                                                   CONTROL      CONTROL                                PPM          PPM             
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
                                                             Page   7                                                               
NTP Experiment-Test: 54591-10               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                             TRANS-1,2-DICHLOROETHYLENE                                Date: 08/05/02  
Route: DOSED FEED                                                                                                 Time: 09:56:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          50000                                                                            
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          10                                                                            
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10                                                                            
  Animals Examined Microscopically                    10                                                                            
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 54591-10               INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a)                     Report: PEIRPT02
Study Type: SUBCHRON 90-DAY                             TRANS-1,2-DICHLOROETHYLENE                                Date: 08/05/02  
Route: DOSED FEED                                                                                                 Time: 09:56:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          50000                                                                            
                                                   PPM                                                                              
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
                                                             Page   9                                                               
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