TDMS Study 96017-05 Pathology Tables
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 08:50:24
FINAL#1 RATS
Facility: Southern Research Institute
Chemical CAS #: 631-64-1
Lock Date: 11/15/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 08:50:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 11 6 6 4
Moribund Sacrifice 4 5 9 14
Survivors
Natural Death 1
Terminal Sacrifice 35 38 34 32
Moribund Sacrifice 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (49) (49) (48)
Edema 2 (4%)
Inflammation 1 (2%)
Intestine Large, Rectum (49) (50) (50) (48)
Inflammation 1 (2%)
Intestine Small, Ileum (44) (47) (45) (48)
Inflammation, Suppurative 1 (2%)
Liver (50) (50) (50) (50)
Basophilic Focus 36 (72%) 41 (82%) 29 (58%) 15 (30%)
Clear Cell Focus 8 (16%) 4 (8%) 14 (28%) 18 (36%)
Degeneration, Cystic 1 (2%)
Eosinophilic Focus 4 (8%) 4 (8%) 5 (10%) 9 (18%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 9 (18%) 2 (4%) 5 (10%)
Inflammation, Chronic 2 (4%) 3 (6%) 3 (6%) 1 (2%)
Inflammation, Granulomatous 8 (16%) 1 (2%) 2 (4%)
Mixed Cell Focus 1 (2%) 1 (2%) 1 (2%) 4 (8%)
Necrosis, Focal 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 17 (34%) 15 (30%) 15 (30%) 19 (38%)
Centrilobular, Necrosis 1 (2%) 1 (2%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 3 (6%) 2 (4%) 1 (2%)
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 1 (2%)
Serosa, Fibrosis 2 (4%) 2 (4%)
Mesentery (12) (15) (15) (8)
Accessory Spleen 1 (8%) 1 (7%)
Fat, Necrosis 9 (75%) 12 (80%) 14 (93%) 6 (75%)
Pancreas (47) (50) (49) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 08:50:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 19 (40%) 15 (30%) 20 (41%) 23 (48%)
Cyst 1 (2%) 1 (2%) 1 (2%)
Acinus, Hyperplasia, Focal 1 (2%) 2 (4%) 2 (4%)
Salivary Glands (50) (50) (50) (50)
Inflammation 1 (2%) 2 (4%)
Stomach, Forestomach (50) (50) (50) (50)
Edema 2 (4%) 5 (10%) 1 (2%)
Erosion 1 (2%) 1 (2%) 1 (2%)
Ulcer 3 (6%) 5 (10%) 1 (2%)
Epithelium, Hyperplasia 6 (12%) 2 (4%)
Stomach, Glandular (49) (50) (50) (49)
Edema 1 (2%) 2 (4%) 2 (4%)
Erosion 1 (2%) 2 (4%)
Ulcer 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 37 (74%) 29 (58%) 34 (68%) 35 (70%)
Mineralization 1 (2%)
Thrombosis 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Valve, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (49)
Accessory Adrenal Cortical Nodule 17 (35%) 8 (16%) 6 (12%) 6 (12%)
Degeneration, Fatty 14 (29%) 19 (38%) 15 (30%) 14 (29%)
Hyperplasia, Focal 8 (16%) 6 (12%) 4 (8%) 5 (10%)
Hypertrophy, Focal 18 (37%) 19 (38%) 21 (42%) 17 (35%)
Necrosis 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Adrenal Medulla (49) (50) (50) (49)
Hyperplasia 5 (10%) 1 (2%) 2 (4%) 4 (8%)
Islets, Pancreatic (47) (49) (49) (48)
Metaplasia, Hepatocyte 1 (2%) 3 (6%)
Pituitary Gland (50) (50) (50) (49)
Pars Distalis, Angiectasis 32 (64%) 24 (48%) 23 (46%) 23 (47%)
Pars Distalis, Cyst 20 (40%) 24 (48%) 20 (40%) 18 (37%)
Pars Distalis, Hyperplasia, Focal 11 (22%) 9 (18%) 8 (16%) 6 (12%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 08:50:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (50) (50) (50) (49)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 23 (46%) 6 (12%) 18 (36%) 18 (37%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (48) (49)
Cyst 12 (24%) 4 (8%) 8 (17%) 13 (27%)
Hyperplasia 1 (2%) 4 (8%) 2 (4%)
Inflammation, Chronic 3 (6%) 2 (4%) 5 (10%) 3 (6%)
Ovary (50) (50) (50) (50)
Cyst 8 (16%) 9 (18%) 14 (28%) 8 (16%)
Uterus (50) (50) (50) (50)
Cyst 3 (6%) 1 (2%) 3 (6%)
Hemorrhage 1 (2%)
Hydrometra 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%)
Cervix, Cyst 1 (2%)
Cervix, Inflammation, Suppurative 1 (2%)
Endometrium, Hyperplasia, Cystic 2 (4%) 1 (2%)
Vagina (1) (4) (6) (20)
Cyst 3 (50%) 10 (50%)
Inflammation 1 (25%) 1 (17%) 9 (45%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Depletion Cellular 1 (2%)
Hyperplasia 5 (10%) 8 (16%) 5 (10%) 3 (6%)
Myelofibrosis 1 (2%) 2 (4%)
Lymph Node (13) (13) (9) (21)
Deep Cervical, Hemorrhage 1 (8%)
Deep Cervical, Hyperplasia 1 (5%)
Mediastinal, Congestion 2 (22%)
Mediastinal, Hyperplasia, Lymphoid 7 (54%) 4 (31%) 3 (33%) 5 (24%)
Pancreatic, Hyperplasia, Lymphoid 2 (15%) 4 (31%) 2 (22%) 3 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 08:50:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pancreatic, Pigmentation 1 (8%)
Lymph Node, Mandibular (2) (1) (3)
Hyperplasia, Lymphoid 1 (50%) 1 (100%)
Lymph Node, Mesenteric (49) (50) (50) (48)
Hyperplasia, Lymphoid 1 (2%) 3 (6%)
Hyperplasia, Reticulum Cell 1 (2%)
Spleen (47) (49) (50) (48)
Fibrosis 3 (6%) 1 (2%)
Hematopoietic Cell Proliferation 5 (11%) 16 (33%) 7 (14%) 5 (10%)
Necrosis 2 (4%)
Pigmentation 8 (17%) 9 (18%) 6 (12%) 1 (2%)
Lymphoid Follicle, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Thymus (49) (49) (50) (50)
Hemorrhage 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Cyst 45 (90%) 48 (96%) 41 (82%) 37 (74%)
Galactocele 1 (2%) 1 (2%)
Hyperplasia 2 (4%) 3 (6%) 4 (8%) 2 (4%)
Hyperplasia, Atypical 5 (10%) 2 (4%) 4 (8%) 4 (8%)
Hyperplasia, Lobular 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 2 (4%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%) 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 6 (12%) 9 (18%) 7 (14%) 5 (10%)
Hemorrhage 1 (2%) 5 (10%) 2 (4%) 3 (6%)
Necrosis 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 08:50:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (1) (1)
Inflammation, Chronic, Suppurative 1 (100%)
Lung (50) (50) (50) (50)
Congestion 4 (8%) 2 (4%) 5 (10%) 3 (6%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 45 (90%) 47 (94%) 46 (92%) 45 (90%)
Inflammation, Chronic 31 (62%) 31 (62%) 40 (80%) 36 (72%)
Alveolar Epithelium, Hyperplasia 3 (6%) 7 (14%) 13 (26%) 14 (28%)
Nose (50) (50) (50) (50)
Foreign Body 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic 2 (4%) 3 (6%) 4 (8%) 6 (12%)
Inflammation, Suppurative 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Cataract 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Hydronephrosis 1 (2%) 1 (2%)
Infarct 2 (4%) 2 (4%)
Inflammation, Chronic 2 (4%)
Nephropathy 18 (36%) 32 (64%) 37 (74%) 40 (80%)
Renal Tubule, Hyperplasia 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%) 2 (4%)
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 08:50:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 4 15 12 12
Natural Death 12 11 8 9
Accidently Killed 1
Survivors
Terminal Sacrifice 34 24 27 28
Moribund Sacrifice 1
Natural Death 2
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (49) (48) (50)
Edema 1 (2%) 1 (2%)
Inflammation 1 (2%)
Polyp, Inflammatory 1 (2%)
Intestine Large, Cecum (45) (47) (46) (47)
Congestion 1 (2%)
Edema 1 (2%)
Liver (50) (50) (50) (50)
Basophilic Focus 14 (28%) 4 (8%) 1 (2%) 1 (2%)
Cholangiofibrosis 1 (2%)
Clear Cell Focus 18 (36%) 19 (38%) 16 (32%) 21 (42%)
Cyst 1 (2%)
Degeneration, Cystic 3 (6%) 9 (18%) 11 (22%) 15 (30%)
Eosinophilic Focus 16 (32%) 4 (8%) 3 (6%) 9 (18%)
Hepatodiaphragmatic Nodule 2 (4%) 1 (2%) 2 (4%) 5 (10%)
Inflammation, Granulomatous 6 (12%) 1 (2%) 1 (2%)
Mixed Cell Focus 8 (16%) 1 (2%) 5 (10%) 2 (4%)
Necrosis, Focal 3 (6%) 2 (4%)
Regeneration 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 43 (86%) 42 (84%) 35 (70%) 38 (76%)
Centrilobular, Necrosis 1 (2%) 1 (2%) 5 (10%)
Hepatocyte, Vacuolization Cytoplasmic 14 (28%) 6 (12%) 12 (24%) 12 (24%)
Hepatocyte, Midzonal, Vacuolization
Cytoplasmic 1 (2%)
Serosa, Fibrosis 1 (2%)
Serosa, Inflammation 1 (2%)
Mesentery (10) (14) (11) (17)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 08:50:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Accessory Spleen 1 (7%) 1 (9%)
Fat, Necrosis 8 (80%) 7 (50%) 7 (64%) 5 (29%)
Pancreas (48) (50) (48) (49)
Atrophy 23 (48%) 28 (56%) 25 (52%) 23 (47%)
Cyst 1 (2%) 1 (2%) 1 (2%)
Acinus, Hyperplasia, Focal 3 (6%) 5 (10%) 1 (2%)
Salivary Glands (50) (50) (49) (50)
Inflammation, Chronic 1 (2%) 1 (2%)
Stomach, Forestomach (50) (49) (49) (50)
Edema 2 (4%) 5 (10%) 5 (10%) 2 (4%)
Erosion 4 (8%) 3 (6%) 1 (2%)
Ulcer 2 (4%) 5 (10%) 5 (10%) 3 (6%)
Epithelium, Hyperplasia 7 (14%) 5 (10%) 5 (10%) 1 (2%)
Stomach, Glandular (50) (48) (48) (50)
Edema 5 (10%) 3 (6%) 1 (2%)
Erosion 6 (13%) 4 (8%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Ulcer 3 (6%) 4 (8%) 2 (4%)
Tongue (1)
Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 45 (90%) 41 (82%) 43 (86%) 41 (82%)
Thrombosis 4 (8%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (49) (50)
Accessory Adrenal Cortical Nodule 26 (53%) 18 (36%) 20 (41%) 14 (28%)
Degeneration, Fatty 5 (10%) 12 (24%) 9 (18%) 4 (8%)
Hyperplasia, Focal 6 (12%) 4 (8%) 2 (4%) 6 (12%)
Hypertrophy, Focal 10 (20%) 12 (24%) 13 (27%) 8 (16%)
Necrosis 1 (2%) 1 (2%)
Adrenal Medulla (49) (50) (49) (50)
Hyperplasia 6 (12%) 8 (16%) 7 (14%) 8 (16%)
Necrosis 1 (2%)
Islets, Pancreatic (48) (50) (48) (50)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (50) (49) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 08:50:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Angiectasis 16 (32%) 14 (29%) 13 (27%) 9 (18%)
Pars Distalis, Cyst 1 (2%) 2 (4%) 5 (10%) 1 (2%)
Pars Distalis, Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 2 (4%)
Pars Distalis, Hyperplasia, Focal 6 (12%) 10 (20%) 4 (8%) 3 (6%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Cyst 1 (2%) 2 (4%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (49) (50)
Ultimobranchial Cyst 5 (10%) 2 (4%) 3 (6%)
C-Cell, Hyperplasia 9 (18%) 13 (26%) 15 (31%) 4 (8%)
Follicle, Cyst 4 (8%) 2 (4%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (49) (49)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Preputial Gland (50) (50) (50) (50)
Cyst 1 (2%) 6 (12%) 5 (10%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 3 (6%)
Prostate (50) (50) (50) (50)
Inflammation, Chronic 23 (46%) 25 (50%) 29 (58%) 29 (58%)
Seminal Vesicle (50) (50) (49) (50)
Inflammation 1 (2%)
Testes (50) (50) (49) (50)
Germinal Epithelium, Atrophy 11 (22%) 24 (48%) 13 (27%) 10 (20%)
Interstitial Cell, Hyperplasia 1 (2%) 5 (10%) 4 (8%) 4 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (48) (50)
Depletion Cellular 1 (2%)
Hyperplasia 2 (4%) 4 (8%) 2 (4%) 5 (10%)
Myelofibrosis 3 (6%)
Lymph Node (22) (26) (25) (25)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 08:50:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Deep Cervical, Hyperplasia, Lymphoid 1 (4%)
Mediastinal, Congestion 1 (5%) 1 (4%) 2 (8%)
Mediastinal, Hyperplasia, Lymphoid 8 (36%) 8 (31%) 13 (52%) 14 (56%)
Pancreatic, Congestion 1 (5%)
Pancreatic, Hyperplasia, Lymphoid 2 (9%) 2 (8%) 2 (8%) 2 (8%)
Lymph Node, Mesenteric (50) (50) (49) (50)
Congestion 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 5 (10%) 2 (4%) 2 (4%)
Spleen (50) (50) (49) (49)
Fibrosis 2 (4%) 2 (4%) 2 (4%)
Hematopoietic Cell Proliferation 2 (4%) 4 (8%) 7 (14%) 5 (10%)
Hemorrhage 1 (2%)
Necrosis 2 (4%) 2 (4%) 2 (4%)
Pigmentation 4 (8%) 1 (2%) 4 (8%)
Lymphoid Follicle, Hyperplasia 1 (2%)
Thymus (49) (48) (48) (50)
Cyst 2 (4%)
Hemorrhage 1 (2%) 2 (4%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Cyst 15 (30%) 17 (34%) 17 (34%) 8 (16%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 4 (8%) 2 (4%) 4 (8%) 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hypertrophy 1 (2%)
Cranium, Osteopetrosis 1 (2%)
Skeletal Muscle (2) (1) (1) (3)
Hemorrhage 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 08:50:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Compression 7 (14%) 5 (10%) 7 (14%) 2 (4%)
Hemorrhage 1 (2%) 3 (6%) 3 (6%) 3 (6%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 6 (12%) 2 (4%) 6 (12%) 2 (4%)
Hemorrhage 3 (6%) 2 (4%) 3 (6%) 1 (2%)
Infiltration Cellular, Histiocyte 31 (62%) 27 (54%) 26 (52%) 28 (56%)
Inflammation, Chronic 29 (58%) 28 (56%) 27 (54%) 35 (70%)
Inflammation, Suppurative 1 (2%)
Alveolar Epithelium, Hyperplasia 6 (12%) 5 (10%) 10 (20%) 11 (22%)
Nose (49) (50) (49) (50)
Foreign Body 10 (20%) 8 (16%) 10 (20%) 8 (16%)
Inflammation, Chronic 14 (29%) 13 (26%) 14 (29%) 14 (28%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Cataract 3 (6%)
Inflammation, Chronic 2 (4%) 1 (2%)
Harderian Gland (50) (50) (49) (50)
Inflammation, Chronic 1 (2%) 1 (2%)
Lacrimal Gland (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (49) (50)
Cyst 2 (4%) 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Infarct 1 (2%) 1 (2%) 1 (2%)
Nephropathy 43 (88%) 48 (96%) 46 (94%) 47 (94%)
Capsule, Hemorrhage 1 (2%)
Transitional Epithelium, Hyperplasia 3 (6%) 9 (18%) 8 (16%) 3 (6%)
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 2 (4%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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