TDMS Study 96017-05 Pathology Tables
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
FINAL#1 RATS
Facility: Southern Research Institute
Chemical CAS #: 631-64-1
Lock Date: 11/15/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 11 6 6 4
Moribund Sacrifice 4 5 9 14
Survivors
Natural Death 1
Terminal Sacrifice 35 38 34 32
Moribund Sacrifice 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (49) (50) (50) (48)
Polyp Adenomatous 1 (2%)
Liver (50) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Hepatocellular Adenoma 2 (4%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Serosa, Osteosarcoma, Metastatic, Bone 1 (2%)
Mesentery (12) (15) (15) (8)
Osteosarcoma, Metastatic, Bone 1 (13%)
Oral Mucosa (1) (1) (1)
Pharyngeal, Squamous Cell Papilloma 1 (100%) 1 (100%)
Pancreas (47) (50) (49) (48)
Acinus, Adenoma 1 (2%)
Salivary Glands (50) (50) (50) (50)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (49) (50) (50) (49)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (49)
Adenoma 1 (2%)
Adrenal Medulla (49) (50) (50) (49)
Pheochromocytoma Benign 1 (2%) 3 (6%) 2 (4%) 1 (2%)
Parathyroid Gland (50) (48) (49) (47)
Adenoma 1 (2%)
Pituitary Gland (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Pars Distalis, Adenoma 25 (50%) 27 (54%) 27 (54%) 22 (45%)
Pars Distalis, Adenoma, Multiple 1 (2%) 3 (6%) 1 (2%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50) (50) (49)
Bilateral, C-Cell, Adenoma 1 (2%) 1 (2%)
C-Cell, Adenoma 5 (10%) 10 (20%) 5 (10%) 5 (10%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 2 (4%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (48) (49)
Adenoma 7 (14%) 10 (20%) 5 (10%) 3 (6%)
Carcinoma 1 (2%) 6 (12%) 1 (2%) 5 (10%)
Squamous Cell Papilloma 1 (2%)
Bilateral, Adenoma 1 (2%)
Ovary (50) (50) (50) (50)
Uterus (50) (50) (50) (50)
Adenoma 1 (2%)
Page 3
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Deciduoma NOS 1 (2%) 1 (2%)
Polyp Stromal 3 (6%) 10 (20%) 7 (14%) 4 (8%)
Bilateral, Polyp Stromal 1 (2%)
Cervix, Polyp Stromal 1 (2%)
Cervix, Sarcoma Stromal 1 (2%)
Vagina (1) (4) (6) (20)
Polyp Adenomatous 1 (17%)
Sarcoma Stromal 1 (17%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymph Node (13) (13) (9) (21)
Mediastinal, Carcinoma, Metastatic, Thyroid
Gland 1 (8%)
Mediastinal, Osteosarcoma, Metastatic, Bone 1 (5%)
Pancreatic, Histiocytic Sarcoma 1 (5%)
Lymph Node, Mandibular (2) (1) (3)
Lymph Node, Mesenteric (49) (50) (50) (48)
Spleen (47) (49) (50) (48)
Histiocytic Sarcoma 1 (2%)
Capsule, Osteosarcoma, Metastatic, Bone 1 (2%)
Thymus (49) (49) (50) (50)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Multiple 1 (2%) 1 (2%)
Fibroadenoma 22 (44%) 18 (36%) 11 (22%) 13 (26%)
Fibroadenoma, Multiple 10 (20%) 15 (30%) 28 (56%) 23 (46%)
Skin (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%) 1 (2%) 1 (2%)
Squamous Cell Papilloma, Multiple 1 (2%)
Trichoepithelioma 1 (2%)
Pinna, Neural Crest Tumor 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteoma 1 (2%)
Osteosarcoma 1 (2%)
Cranium, Meningioma Malignant, Metastatic,
Brain 1 (2%)
Skeletal Muscle (1) (1)
Osteosarcoma, Metastatic, Bone 1 (100%)
Rhabdomyosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Glioma Malignant, Mixed Cell 1 (2%)
Meningioma Malignant 1 (2%)
Spinal Cord (2) (4) (1) (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 2 (4%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (50) (50) (50) (50)
Pleura (1)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (50) (50) (50) (50)
Zymbal's Gland (1) (2)
Carcinoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Renal Tubule, Adenoma 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leukemia Mononuclear 11 (22%) 13 (26%) 16 (32%) 22 (44%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 49 48 49
Total Primary Neoplasms 103 129 118 126
Total Animals with Benign Neoplasms 42 47 43 43
Total Benign Neoplasms 85 102 91 87
Total Animals with Malignant Neoplasms 16 24 20 32
Total Malignant Neoplasms 18 26 27 37
Total Animals with Metastatic Neoplasms 1 3 1 2
Total Metastatic Neoplasm 1 5 1 7
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 2
Total Uncertain Neoplasms 1 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 4 15 12 12
Natural Death 12 11 8 9
Accidently Killed 1
Survivors
Terminal Sacrifice 34 24 27 28
Moribund Sacrifice 1
Natural Death 2
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (49) (48) (50)
Polyp Adenomatous 1 (2%)
Intestine Large, Cecum (45) (47) (46) (47)
Intestine Small, Duodenum (45) (48) (47) (48)
Liver (50) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mesentery (10) (14) (11) (17)
Fibrosarcoma, Metastatic, Skin 1 (9%)
Histiocytic Sarcoma 1 (10%)
Rhabdomyosarcoma 1 (10%)
Oral Mucosa (1)
Pharyngeal, Squamous Cell Carcinoma 1 (100%)
Pancreas (48) (50) (48) (49)
Histiocytic Sarcoma 1 (2%)
Acinus, Adenoma 2 (4%) 2 (4%) 1 (2%)
Salivary Glands (50) (50) (49) (50)
Stomach, Forestomach (50) (49) (49) (50)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Stomach, Glandular (50) (48) (48) (50)
Tooth (1)
Odontoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Histiocytic Sarcoma 1 (2%)
Schwannoma Malignant, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (49) (50)
Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Adrenal Medulla (49) (50) (49) (50)
Pheochromocytoma Malignant 2 (4%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 7 (14%) 5 (10%) 7 (14%) 5 (10%)
Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (48) (50) (48) (50)
Adenoma 5 (10%) 3 (6%) 4 (8%) 1 (2%)
Carcinoma 1 (2%)
Parathyroid Gland (50) (50) (48) (47)
Adenoma 1 (2%)
Pituitary Gland (50) (49) (49) (50)
Pars Distalis, Adenoma 23 (46%) 21 (43%) 17 (35%) 8 (16%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50) (49) (50)
C-Cell, Adenoma 6 (12%) 5 (10%) 5 (10%) 7 (14%)
C-Cell, Carcinoma 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1) (4)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (49) (49)
Preputial Gland (50) (50) (50) (50)
Adenoma 3 (6%) 5 (10%) 8 (16%) 4 (8%)
Squamous Cell Papilloma 1 (2%)
Prostate (50) (50) (50) (50)
Seminal Vesicle (50) (50) (49) (50)
Testes (50) (50) (49) (50)
Bilateral, Interstitial Cell, Adenoma 34 (68%) 42 (84%) 34 (69%) 39 (78%)
Interstitial Cell, Adenoma 7 (14%) 4 (8%) 7 (14%) 7 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (48) (50)
Histiocytic Sarcoma 1 (2%)
Schwannoma Malignant, Metastatic, Lung 1 (2%)
Lymph Node (22) (26) (25) (25)
Bronchial, Thymoma Malignant, Metastatic,
Thymus 1 (4%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (4%)
Lymph Node, Mesenteric (50) (50) (49) (50)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (50) (49) (49)
Histiocytic Sarcoma 1 (2%)
Schwannoma Malignant, Metastatic, Lung 1 (2%)
Thymus (49) (48) (48) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Histiocytic Sarcoma 1 (2%)
Sarcoma 1 (2%)
Thymoma Benign 1 (2%)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Fibroadenoma 4 (8%) 5 (10%) 3 (6%) 5 (10%)
Page 10
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Fibroadenoma, Multiple 1 (2%)
Skin (50) (50) (50) (50)
Basal Cell Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Keratoacanthoma 3 (6%) 1 (2%) 1 (2%) 2 (4%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (4%) 1 (2%) 2 (4%) 3 (6%)
Trichoepithelioma 1 (2%) 1 (2%)
Sebaceous Gland, Adenoma, Multiple 1 (2%)
Subcutaneous Tissue, Fibroma 5 (10%) 4 (8%) 3 (6%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 3 (6%) 3 (6%) 2 (4%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Neural Crest Tumor 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Vertebra, Chordoma 1 (2%)
Skeletal Muscle (2) (1) (1) (3)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
Hemangioma 1 (50%)
Histiocytic Sarcoma 1 (100%)
Sarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Glioma Malignant, Mixed Cell 1 (2%)
Pineal Gland, Glioma Malignant 1 (2%)
Peripheral Nerve (2) (1) (2) (2)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 4 (8%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Schwannoma Malignant, Metastatic, Eye 1 (2%)
Schwannoma Malignant, Metastatic, Heart 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Mediastinum, Sarcoma 1 (2%)
Serosa, Thymoma Malignant, Metastatic, Thymus 1 (2%)
Pleura (1) (1)
Histiocytic Sarcoma 1 (100%)
Thymoma Malignant, Metastatic, Thymus 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Schwannoma Malignant 1 (2%)
Harderian Gland (50) (50) (49) (50)
Zymbal's Gland (2) (2)
Adenoma 1 (50%) 1 (50%)
Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (49) (50)
Lipoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%) 1 (2%)
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 17 (34%) 31 (62%) 24 (48%) 13 (26%)
Lymphoma Malignant Lymphocytic 1 (2%)
Mesothelioma Malignant 3 (6%) 1 (2%) 10 (20%)
____________________________________________________________________________________________________________________________________
Page 13
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 04/14/04
Route: DOSED WATER Time: 09:19:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 49 50
Total Primary Neoplasms 145 146 147 127
Total Animals with Benign Neoplasms 47 48 45 48
Total Benign Neoplasms 111 103 108 94
Total Animals with Malignant Neoplasms 29 38 35 26
Total Malignant Neoplasms 33 43 39 33
Total Animals with Metastatic Neoplasms 4 3
Total Metastatic Neoplasm 7 8
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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