TDMS Study 96017-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) DATE: 04/14/04
EXPERIMENT: 96017 TEST: 05 TIME: 09:34:02
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96017
PATHOLOGIST: HERSCHELL, GILES CAS: 631-64-1
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1 RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) DATE: 04/14/04
EXPERIMENT: 96017 TEST: 05 TIME: 09:34:02
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96017
PATHOLOGIST: HERSCHELL, GILES CAS: 631-64-1
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 222 433 437 516 530 591 616 622 629 629 |
| 661 682 692 693 703 711 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 437 446 471 510 519 547 602 612 615 618 |
| 626 641 651 651 651 679 679 691 693 697 |
| 701 701 709 710 721 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 22 253 402 423 437 521 560 560 578 580 |
| 590 594 602 607 607 608 679 700 700 701 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1000 MG/L |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 1 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 356 423 512 514 521 561 570 571 610 618 |
| 624 631 633 644 651 651 651 674 679 701 |
| 723 |
| CENSORED DEATHS |
| 386 |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 100.0 98.0 98.0 98.0 94.0 90.0 88.0 78.0 68.0 |
| | |
| | |
|50 MG/L | 100.0 100.0 100.0 100.0 100.0 94.0 90.0 86.0 70.0 48.0 |
| | |
| | |
|500 MG/L | 98.0 98.0 96.0 96.0 92.0 90.0 88.0 74.0 68.0 60.0 |
| | |
| | |
|1000 | 100.0 100.0 100.0 98.0 96.0 96.0 89.8 83.7 65.3 57.2 |
|MG/L | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 50 MG/L 500 MG/L 1000 |
| MG/L |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 48.0% 60.0% 57.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.784 P=0.092 P=0.406 P=0.332 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 585.4 627.0 536.2 596.1 |
|NATURAL DEATHS (C) | (32.8) (17.1) (36.9) (19.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 683.1 676.0 651.9 666.3 |
|(STANDARD ERROR) | (14.0) (11.4) (19.8) (13.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 161 519 595 602 604 605 611 632 633 640 |
| 641 651 665 701 702 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 392 509 520 521 669 682 682 699 700 701 |
| 720 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 430 441 506 519 618 622 622 624 640 651 |
| 657 696 701 714 715 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1000 MG/L |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 254 395 566 577 580 602 621 622 622 637 |
| 651 651 664 664 679 679 682 682 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 98.0 98.0 98.0 98.0 98.0 96.0 88.0 74.0 70.0 |
| | |
| | |
|50 MG/L | 100.0 100.0 100.0 100.0 98.0 98.0 92.0 92.0 92.0 78.0 |
| | |
| | |
|500 MG/L | 100.0 100.0 100.0 100.0 100.0 96.0 92.0 92.0 78.0 70.0 |
| | |
| | |
|1000 | 100.0 100.0 98.0 98.0 96.0 96.0 96.0 88.0 72.0 64.0 |
|MG/L | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 50 MG/L 500 MG/L 1000 |
| MG/L |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.0% 78.0% 70.0% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.232 P=0.427N P=1.000N P=0.674 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 597.5 617.7 610.4 601.6 |
|NATURAL DEATHS (C) | (33.3) (33.5) (24.2) (25.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 689.5 704.5 693.4 683.1 |
|(STANDARD ERROR) | (13.0) ( 9.7) (10.5) (12.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
50 MG/L = 2
500 MG/L = 3
1000 MG/L = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 4 2
| 3 1 3 4 4122
| 3 3 3112 2 21
| 3 3 21 21
P 90 + 3 21 2 4 1
E | 3 2344 12 1
R | 3 3 2 111
C | 4 22
E 80 + 3 3 21 1
N | 242 1 1
T | 333 22 11
| 444 1 1
S 70 + 2 2 11
U | 3 3 1 1
R | 4 2 23
V | 4 223
I 60 + 22 4 3
V | 4 4
A | 22
L | 22
50 + 22
| 2 2
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 29 obs hidden.
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
50 MG/L = 2
500 MG/L = 3
1000 MG/L = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 4 2 3
|
| 1 4 24 33 2 1
| 4 3 2 1 4 1
95 +
| 3 3 4 4 11
| 2 11 3 2
|
P 90 + 4 4 2 2
E |
R | 4114
C | 1331 2 2
E 85 +
N | 3 3
T | 4 113 22
|
S 80 + 4 33 2 2
U |
R | 113 3 2 2
V | 1 1 33
I 75 +
V | 1 13
A | 4 4 33
L |
70 + 1 3 1
|
| 44
|
65 +
| 4 4
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.