TDMS Study 96017-05 Pathology Tables
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/14/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 10:12:24
FINAL#1 RATS
Facility: Southern Research Institute
Chemical CAS #: 631-64-1
Lock Date: 11/15/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/14/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 10:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 11 6 6 4
Moribund Sacrifice 4 5 9 14
Survivors
Natural Death 1
Terminal Sacrifice 35 38 34 32
Moribund Sacrifice 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (49) (49) (48)
Edema 2 [1.5]
Inflammation 1 [1.0]
Intestine Large, Rectum (49) (50) (50) (48)
Inflammation 1 [2.0]
Intestine Small, Ileum (44) (47) (45) (48)
Inflammation, Suppurative 1 [3.0]
Liver (50) (50) (50) (50)
Basophilic Focus 36 41 29 15
Clear Cell Focus 8 4 14 18
Degeneration, Cystic 1 [2.0]
Eosinophilic Focus 4 4 5 9
Hematopoietic Cell Proliferation 1 [1.0]
Hepatodiaphragmatic Nodule 3 [1.0] 9 [1.4] 2 [1.0] 5 [1.0]
Inflammation, Chronic 2 [1.5] 3 [1.7] 3 [1.0] 1 [1.0]
Inflammation, Granulomatous 8 [1.3] 1 [1.0] 2 [1.0]
Mixed Cell Focus 1 1 1 4
Necrosis, Focal 1 [2.0] 1 [1.0]
Bile Duct, Hyperplasia 17 [1.5] 15 [1.5] 15 [1.7] 19 [1.6]
Centrilobular, Necrosis 1 [1.0] 1 [1.0] 1 [2.0]
Hepatocyte, Vacuolization Cytoplasmic 3 [1.7] 2 [2.5] 1 [3.0]
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 1 [2.0]
Serosa, Fibrosis 2 [1.0] 2 [1.0]
Mesentery (12) (15) (15) (8)
Accessory Spleen 1 [1.0] 1 [1.0]
Fat, Necrosis 9 [2.1] 12 [2.2] 14 [2.2] 6 [2.0]
Pancreas (47) (50) (49) (48)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/14/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 10:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 19 [1.4] 15 [1.4] 20 [1.4] 23 [1.2]
Cyst 1 [1.0] 1 [1.0] 1 [1.0]
Acinus, Hyperplasia, Focal 1 [1.0] 2 [1.5] 2 [1.0]
Salivary Glands (50) (50) (50) (50)
Inflammation 1 [2.0] 2 [2.0]
Stomach, Forestomach (50) (50) (50) (50)
Edema 2 [1.5] 5 [1.4] 1 [2.0]
Erosion 1 [1.0] 1 [1.0] 1 [1.0]
Ulcer 3 [1.7] 5 [2.6] 1 [2.0]
Epithelium, Hyperplasia 6 [2.0] 2 [1.0]
Stomach, Glandular (49) (50) (50) (49)
Edema 1 [1.0] 2 [2.0] 2 [1.5]
Erosion 1 [3.0] 2 [1.5]
Ulcer 1 [2.0] 2 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 37 [1.2] 29 [1.1] 34 [1.3] 35 [1.1]
Mineralization 1 [1.0]
Thrombosis 2 [2.5] 1 [3.0] 1 [3.0] 1 [3.0]
Valve, Inflammation, Suppurative 1 [4.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (49)
Accessory Adrenal Cortical Nodule 17 [1.1] 8 [1.0] 6 [1.0] 6 [1.0]
Degeneration, Fatty 14 [1.4] 19 [1.4] 15 [1.2] 14 [1.6]
Hyperplasia, Focal 8 [1.0] 6 [1.0] 4 [1.5] 5 [1.0]
Hypertrophy, Focal 18 [1.3] 19 [1.6] 21 [1.3] 17 [1.5]
Necrosis 3 [2.3] 1 [1.0] 1 [2.0] 1 [3.0]
Adrenal Medulla (49) (50) (50) (49)
Hyperplasia 5 [1.2] 1 [3.0] 2 [1.0] 4 [2.0]
Islets, Pancreatic (47) (49) (49) (48)
Metaplasia, Hepatocyte 1 [1.0] 3 [2.7]
Pituitary Gland (50) (50) (50) (49)
Pars Distalis, Angiectasis 32 [1.5] 24 [2.0] 23 [1.9] 23 [1.7]
Pars Distalis, Cyst 20 [1.2] 24 [1.4] 20 [1.4] 18 [1.1]
Pars Distalis, Hyperplasia, Focal 11 [1.6] 9 [1.7] 8 [2.0] 6 [1.5]
Pars Intermedia, Angiectasis 1 [2.0]
Pars Intermedia, Cyst 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/14/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 10:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (50) (50) (50) (49)
Ultimobranchial Cyst 1 [1.0]
C-Cell, Hyperplasia 23 [1.2] 6 [1.3] 18 [1.3] 18 [1.6]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (48) (49)
Cyst 12 [1.2] 4 [1.3] 8 [1.4] 13 [1.3]
Hyperplasia 1 [1.0] 4 [2.3] 2 [1.5]
Inflammation, Chronic 3 [1.7] 2 [2.0] 5 [1.4] 3 [1.7]
Ovary (50) (50) (50) (50)
Cyst 8 [1.4] 9 [1.4] 14 [1.1] 8 [1.3]
Uterus (50) (50) (50) (50)
Cyst 3 [1.0] 1 [2.0] 3 [1.0]
Hemorrhage 1 [4.0]
Hydrometra 1 [2.0] 2 [2.0] 1 [1.0]
Inflammation, Chronic 1 [2.0] 2 [1.0]
Cervix, Cyst 1
Cervix, Inflammation, Suppurative 1 [1.0]
Endometrium, Hyperplasia, Cystic 2 [2.0] 1 [3.0]
Vagina (1) (4) (6) (20)
Cyst 3 10
Inflammation 1 [2.0] 1 [2.0] 9 [1.1]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Depletion Cellular 1 [1.0]
Hyperplasia 5 [1.4] 8 [2.0] 5 [1.6] 3 [1.7]
Myelofibrosis 1 [3.0] 2 [2.0]
Lymph Node (13) (13) (9) (21)
Deep Cervical, Hemorrhage 1 [2.0]
Deep Cervical, Hyperplasia 1 [2.0]
Mediastinal, Congestion 2 [1.5]
Mediastinal, Hyperplasia, Lymphoid 7 [1.7] 4 [2.0] 3 [1.3] 5 [1.6]
Pancreatic, Hyperplasia, Lymphoid 2 [2.0] 4 [1.8] 2 [1.0] 3 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/14/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 10:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pancreatic, Pigmentation 1 [1.0]
Lymph Node, Mandibular (2) (1) (3)
Hyperplasia, Lymphoid 1 [1.0] 1 [2.0]
Lymph Node, Mesenteric (49) (50) (50) (48)
Hyperplasia, Lymphoid 1 [2.0] 3 [1.3]
Hyperplasia, Reticulum Cell 1 [4.0]
Spleen (47) (49) (50) (48)
Fibrosis 3 [1.7] 1 [1.0]
Hematopoietic Cell Proliferation 5 [2.0] 16 [1.8] 7 [1.9] 5 [2.2]
Necrosis 2 [2.5]
Pigmentation 8 [1.1] 9 [1.2] 6 [1.0] 1 [2.0]
Lymphoid Follicle, Hyperplasia 1 [3.0] 1 [2.0] 1 [2.0]
Thymus (49) (49) (50) (50)
Hemorrhage 2 [1.5] 1 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Cyst 45 [1.2] 48 [1.1] 41 [1.3] 37 [1.4]
Galactocele 1 1
Hyperplasia 2 [2.0] 3 [2.3] 4 [2.5] 2 [2.0]
Hyperplasia, Atypical 5 [1.0] 2 [1.0] 4 [1.3] 4 [1.8]
Hyperplasia, Lobular 1 [3.0]
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 2 1
Hemorrhage 1 [1.0]
Inflammation, Chronic 1 [2.0] 3 [1.7] 3 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 6 [2.2] 9 [2.4] 7 [2.1] 5 [1.8]
Hemorrhage 1 [1.0] 5 [2.0] 2 [1.5] 3 [1.3]
Necrosis 2 [2.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/14/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 10:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (1) (1)
Inflammation, Chronic, Suppurative 1 [4.0]
Lung (50) (50) (50) (50)
Congestion 4 [1.5] 2 [2.0] 5 [2.0] 3 [1.3]
Hemorrhage 1 [1.0] 1 [1.0] 1 [2.0]
Infiltration Cellular, Histiocyte 45 [1.0] 47 [1.0] 46 [1.0] 45 [1.0]
Inflammation, Chronic 31 [1.0] 31 [1.0] 40 [1.0] 36 [1.1]
Alveolar Epithelium, Hyperplasia 3 [1.3] 7 [1.9] 13 [1.7] 14 [1.9]
Nose (50) (50) (50) (50)
Foreign Body 2 [1.0] 1 [1.0] 1 [1.0]
Inflammation, Chronic 2 [1.0] 3 [1.0] 4 [1.0] 6 [1.0]
Inflammation, Suppurative 1 [2.0]
Respiratory Epithelium, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Cataract 2 [2.0] 2 [2.0] 2 [1.5] 1 [1.0]
Inflammation, Chronic 1 [2.0] 2 [1.5]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Hydronephrosis 1 [3.0] 1 [3.0]
Infarct 2 [3.5] 2 [2.0]
Inflammation, Chronic 2 [1.5]
Nephropathy 18 [1.1] 32 [1.3] 37 [1.4] 40 [1.3]
Renal Tubule, Hyperplasia 1 [2.0]
Transitional Epithelium, Hyperplasia 2 [2.0] 2 [2.5]
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 1 [2.0]
Inflammation, Chronic 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/14/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 10:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 4 15 12 12
Natural Death 12 11 8 9
Accidently Killed 1
Survivors
Terminal Sacrifice 34 24 27 28
Moribund Sacrifice 1
Natural Death 2
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (49) (48) (50)
Edema 1 [2.0] 1 [3.0]
Inflammation 1 [3.0]
Polyp, Inflammatory 1 [1.0]
Intestine Large, Cecum (45) (47) (46) (47)
Congestion 1 [3.0]
Edema 1 [2.0]
Liver (50) (50) (50) (50)
Basophilic Focus 14 4 1 1
Cholangiofibrosis 1 [2.0]
Clear Cell Focus 18 19 16 21
Cyst 1 [1.0]
Degeneration, Cystic 3 [1.0] 9 [1.4] 11 [1.5] 15 [1.3]
Eosinophilic Focus 16 4 3 9
Hepatodiaphragmatic Nodule 2 1 2 5
Inflammation, Granulomatous 6 [1.0] 1 [1.0] 1 [1.0]
Mixed Cell Focus 8 1 5 2
Necrosis, Focal 3 [1.7] 2 [1.5]
Regeneration 1 1
Bile Duct, Hyperplasia 43 [1.7] 42 [1.9] 35 [1.8] 38 [1.6]
Centrilobular, Necrosis 1 [3.0] 1 [1.0] 5 [2.2]
Hepatocyte, Vacuolization Cytoplasmic 14 [1.6] 6 [1.8] 12 [2.4] 12 [1.9]
Hepatocyte, Midzonal, Vacuolization
Cytoplasmic 1 [2.0]
Serosa, Fibrosis 1 [1.0]
Serosa, Inflammation 1 [1.0]
Mesentery (10) (14) (11) (17)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/14/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 10:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Accessory Spleen 1 [1.0] 1 [2.0]
Fat, Necrosis 8 [2.0] 7 [2.0] 7 [1.7] 5 [2.0]
Pancreas (48) (50) (48) (49)
Atrophy 23 [1.4] 28 [1.5] 25 [1.4] 23 [1.3]
Cyst 1 [1.0] 1 [1.0] 1 [1.0]
Acinus, Hyperplasia, Focal 3 [2.0] 5 [2.0] 1 [2.0]
Salivary Glands (50) (50) (49) (50)
Inflammation, Chronic 1 [1.0] 1 [2.0]
Stomach, Forestomach (50) (49) (49) (50)
Edema 2 [1.0] 5 [1.4] 5 [1.8] 2 [2.0]
Erosion 4 [1.8] 3 [1.3] 1 [1.0]
Ulcer 2 [2.5] 5 [1.8] 5 [2.4] 3 [2.7]
Epithelium, Hyperplasia 7 [1.4] 5 [1.4] 5 [1.8] 1 [1.0]
Stomach, Glandular (50) (48) (48) (50)
Edema 5 [1.2] 3 [1.7] 1 [2.0]
Erosion 6 [1.8] 4 [1.5] 1 [1.0]
Hyperplasia, Focal 1 [2.0]
Ulcer 3 [2.3] 4 [2.0] 2 [2.0]
Tongue (1)
Hyperplasia 1 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 45 [1.5] 41 [1.4] 43 [1.4] 41 [1.5]
Thrombosis 4 [3.0] 1 [3.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (49) (50)
Accessory Adrenal Cortical Nodule 26 [1.0] 18 [1.1] 20 [1.1] 14 [1.0]
Degeneration, Fatty 5 [1.6] 12 [1.3] 9 [1.4] 4 [1.0]
Hyperplasia, Focal 6 [1.0] 4 [1.0] 2 [1.0] 6 [1.0]
Hypertrophy, Focal 10 [1.3] 12 [1.3] 13 [1.5] 8 [1.4]
Necrosis 1 [2.0] 1 [1.0]
Adrenal Medulla (49) (50) (49) (50)
Hyperplasia 6 [1.3] 8 [1.6] 7 [1.6] 8 [1.1]
Necrosis 1 [2.0]
Islets, Pancreatic (48) (50) (48) (50)
Hyperplasia 1 [1.0] 1 [2.0] 1 [1.0]
Pituitary Gland (50) (49) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/14/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 10:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Angiectasis 16 [1.6] 14 [2.3] 13 [2.2] 9 [2.0]
Pars Distalis, Cyst 1 [1.0] 2 [2.0] 5 [1.0] 1 [2.0]
Pars Distalis, Hemorrhage 1 [2.0] 1 [2.0] 1 [2.0]
Pars Distalis, Hyperplasia 2 [2.5]
Pars Distalis, Hyperplasia, Focal 6 [1.7] 10 [1.8] 4 [1.8] 3 [1.7]
Pars Intermedia, Angiectasis 1 [1.0]
Pars Intermedia, Cyst 1 [1.0] 2 [1.0]
Pars Intermedia, Hyperplasia 1 [1.0]
Thyroid Gland (50) (50) (49) (50)
Ultimobranchial Cyst 5 [1.0] 2 [1.0] 3 [1.0]
C-Cell, Hyperplasia 9 [1.1] 13 [1.5] 15 [1.2] 4 [1.0]
Follicle, Cyst 4 [1.0] 2 [2.0] 2 [1.0] 2 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (49) (49)
Inflammation, Chronic 1 [1.0] 1 [1.0] 1 [1.0]
Preputial Gland (50) (50) (50) (50)
Cyst 1 [1.0] 6 [1.3] 5 [1.8]
Hyperplasia 1 [2.0] 1 [3.0]
Inflammation, Chronic 1 [1.0] 1 [2.0] 3 [2.3]
Prostate (50) (50) (50) (50)
Inflammation, Chronic 23 [1.4] 25 [1.6] 29 [1.6] 29 [1.3]
Seminal Vesicle (50) (50) (49) (50)
Inflammation 1 [2.0]
Testes (50) (50) (49) (50)
Germinal Epithelium, Atrophy 11 [2.3] 24 [2.0] 13 [2.6] 10 [1.8]
Interstitial Cell, Hyperplasia 1 [1.0] 5 [1.4] 4 [1.0] 4 [1.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (48) (50)
Depletion Cellular 1 [2.0]
Hyperplasia 2 [1.0] 4 [1.5] 2 [2.0] 5 [1.6]
Myelofibrosis 3 [1.0]
Lymph Node (22) (26) (25) (25)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/14/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 10:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Deep Cervical, Hyperplasia, Lymphoid 1 [2.0]
Mediastinal, Congestion 1 [3.0] 1 [2.0] 2 [2.0]
Mediastinal, Hyperplasia, Lymphoid 8 [1.5] 8 [1.8] 13 [1.8] 14 [1.7]
Pancreatic, Congestion 1 [2.0]
Pancreatic, Hyperplasia, Lymphoid 2 [1.5] 2 [2.5] 2 [1.5] 2 [1.0]
Lymph Node, Mesenteric (50) (50) (49) (50)
Congestion 1 [1.0] 1 [1.0]
Hyperplasia, Lymphoid 5 [1.8] 2 [1.5] 2 [1.0]
Spleen (50) (50) (49) (49)
Fibrosis 2 [1.0] 2 [1.5] 2 [1.5]
Hematopoietic Cell Proliferation 2 [1.0] 4 [1.5] 7 [1.7] 5 [1.8]
Hemorrhage 1 [4.0]
Necrosis 2 [1.5] 2 [2.0] 2 [2.0]
Pigmentation 4 [1.5] 1 [2.0] 4 [1.0]
Lymphoid Follicle, Hyperplasia 1 [2.0]
Thymus (49) (48) (48) (50)
Cyst 2 [2.0]
Hemorrhage 1 [2.0] 2 [2.5] 3 [1.3] 2 [1.5]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Cyst 15 [1.5] 17 [1.2] 17 [1.3] 8 [1.1]
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 4 2 4 1
Hyperkeratosis 1 [2.0]
Hyperplasia 1 [2.0]
Inflammation, Chronic 2 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hypertrophy 1 [2.0]
Cranium, Osteopetrosis 1 [1.0]
Skeletal Muscle (2) (1) (1) (3)
Hemorrhage 1 [1.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 96017-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/14/04
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Time: 10:12:24
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FISCHER 344 RATS MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
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NERVOUS SYSTEM - CONT
Compression 7 [2.4] 5 [2.2] 7 [2.1] 2 [2.5]
Hemorrhage 1 [2.0] 3 [2.3] 3 [2.7] 3 [2.7]
Necrosis 1 [1.0]
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RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 6 [1.5] 2 [1.0] 6 [1.5] 2 [1.5]
Hemorrhage 3 [1.3] 2 [2.5] 3 [1.7] 1 [2.0]
Infiltration Cellular, Histiocyte 31 [1.0] 27 [1.0] 26 [1.2] 28 [1.0]
Inflammation, Chronic 29 [1.0] 28 [1.0] 27 [1.0] 35 [1.0]
Inflammation, Suppurative 1 [2.0]
Alveolar Epithelium, Hyperplasia 6 [1.8] 5 [1.8] 10 [2.3] 11 [1.9]
Nose (49) (50) (49) (50)
Foreign Body 10 [1.0] 8 [1.0] 10 [1.0] 8 [1.1]
Inflammation, Chronic 14 [1.0] 13 [1.1] 14 [1.3] 14 [1.2]
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SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Cataract 3 [1.3]
Inflammation, Chronic 2 [1.0] 1 [1.0]
Harderian Gland (50) (50) (49) (50)
Inflammation, Chronic 1 [1.0] 1 [3.0]
Lacrimal Gland (1)
Inflammation, Suppurative 1 [4.0]
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URINARY SYSTEM
Kidney (49) (50) (49) (50)
Cyst 2 [1.0] 1 [2.0]
Hydronephrosis 1 [1.0] 1 [3.0]
Infarct 1 [2.0] 1 [1.0] 1 [2.0]
Nephropathy 43 [1.7] 48 [1.9] 46 [2.3] 47 [2.2]
Capsule, Hemorrhage 1 [2.0]
Transitional Epithelium, Hyperplasia 3 [2.0] 9 [1.4] 8 [1.0] 3 [1.0]
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 2 [3.0]
Inflammation, Chronic 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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