TDMS Study 97013-06 Pathology Tables
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: SKIN APPLICATION Time: 08:38:10
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 004 64 MG/KG
Include 006 128 MG/KG
Include 008 256 MG/KG
Include 001 0 MG/KG
Include 003 64 MG/KG
Include 005 128 MG/KG
Include 007 256 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: SKIN APPLICATION Time: 08:38:10
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 2 3 1 4
Natural Death 2 2 2 1
Survivors
Terminal Sacrifice 11 10 12 10
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%) 1 (7%) 1 (7%) 3 (20%)
Inflammation 14 (93%) 11 (73%) 14 (93%) 11 (73%)
Necrosis 3 (20%) 2 (13%) 4 (27%) 2 (13%)
Hepatocyte, Vacuolization Cytoplasmic 3 (20%) 7 (47%) 5 (33%) 5 (33%)
Mesentery (1)
Necrosis 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Inflammation 1 (7%)
Epithelium, Hyperkeratosis 1 (7%)
Epithelium, Hyperplasia 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Subcapsular, Hyperplasia 8 (53%) 8 (53%) 11 (73%) 5 (33%)
Pituitary Gland (15) (15) (15) (15)
Cyst 4 (27%) 1 (7%) 1 (7%) 2 (13%)
Thyroid Gland (15) (15) (15) (15)
Cyst 2 (13%) 1 (7%) 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: SKIN APPLICATION Time: 08:38:10
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (14) (15) (15)
Cyst 1 (7%) 2 (13%)
Uterus (15) (15) (15) (15)
Inflammation, Suppurative 2 (13%) 1 (7%)
Endometrium, Hyperplasia, Cystic 7 (47%) 6 (40%) 10 (67%) 6 (40%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Hyperplasia 1 (100%)
Lymph Node, Mandibular (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%)
Infiltration Cellular, Plasma Cell 1 (7%) 1 (7%) 1 (7%)
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 2 (13%) 1 (7%) 1 (7%) 4 (27%)
Thymus (15) (15) (15) (14)
Atrophy 3 (20%) 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15)
Epidermis, Hyperplasia, Focal 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: SKIN APPLICATION Time: 08:38:10
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation 1 (7%)
Alveolar Epithelium, Hyperplasia 1 (7%)
Artery, Inflammation 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Retina, Degeneration 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 6 (40%) 5 (33%) 5 (33%) 4 (27%)
Cyst 2 (13%) 2 (13%) 1 (7%)
Hydronephrosis 1 (7%)
Mineralization 1 (7%)
Nephropathy 2 (13%) 3 (20%)
Artery, Inflammation 1 (7%) 1 (7%)
Renal Tubule, Hypertrophy 1 (7%) 1 (7%) 4 (27%)
Renal Tubule, Necrosis 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: SKIN APPLICATION Time: 08:38:10
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 2 1
Natural Death 2
Survivors
Terminal Sacrifice 13 14 15 13
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%) 1 (7%) 1 (7%)
Inflammation 8 (53%) 8 (53%) 5 (33%) 6 (40%)
Necrosis 1 (7%) 1 (7%) 1 (7%) 2 (13%)
Hepatocyte, Fatty Change 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic 4 (27%) 2 (13%) 5 (33%) 4 (27%)
Mesentery (1)
Fat, Necrosis 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Hyperkeratosis 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hyperplasia 1 (7%)
Hypertrophy 9 (60%) 9 (60%) 6 (40%) 8 (53%)
Vacuolization Cytoplasmic 1 (7%)
Subcapsular, Hyperplasia 1 (7%) 1 (7%) 2 (13%)
Thyroid Gland (15) (15) (15) (15)
Cyst 1 (7%) 2 (13%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: SKIN APPLICATION Time: 08:38:10
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Testes (15) (15) (15) (15)
Germinal Epithelium, Degeneration 3 (20%) 1 (7%) 2 (13%) 1 (7%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (14) (14)
Atrophy 1 (7%)
Infiltration Cellular, Plasma Cell 1 (7%)
Lymph Node, Mesenteric (14) (15) (15) (15)
Atrophy 1 (7%)
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%) 2 (13%) 1 (7%) 1 (7%)
Lymphoid Follicle, Atrophy 1 (7%)
Lymphoid Follicle, Hyperplasia 1 (7%)
Thymus (15) (15) (15) (15)
Atrophy 1 (7%) 1 (7%) 2 (13%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15)
Epidermis, Hyperplasia, Focal 1 (7%)
Subcutaneous Tissue, Inflammation 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: SKIN APPLICATION Time: 08:38:10
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation 1 (7%) 1 (7%)
Thrombosis 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 3 (20%) 1 (7%) 2 (13%)
Cyst 1 (7%) 1 (7%)
Hydronephrosis 1 (7%) 1 (7%)
Inflammation 1 (7%)
Nephropathy 7 (47%) 6 (40%) 7 (47%) 6 (40%)
Artery, Inflammation 1 (7%) 1 (7%)
Renal Tubule, Dilatation 1 (7%) 1 (7%)
Renal Tubule, Hypertrophy 1 (7%)
Renal Tubule, Necrosis 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
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