TDMS Study 96017-06 Pathology Tables
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
FINAL#1 MICE
Facility: Southern Research Institute
Chemical CAS #: 631-64-1
Lock Date: 11/15/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 10 13 13 11
Moribund Sacrifice 2 2 5 7
Survivors
Terminal Sacrifice 38 35 31 32
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (47) (46) (49) (46)
Intestine Small, Duodenum (46) (48) (48) (45)
Polyp Adenomatous 2 (4%)
Intestine Small, Jejunum (46) (47) (49) (43)
Carcinoma 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Intestine Small, Ileum (45) (47) (47) (46)
Fibrosarcoma, Metastatic, Tissue NOS 1 (2%)
Liver (49) (50) (50) (49)
Hemangioma 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%) 2 (4%)
Hepatoblastoma 1 (2%) 1 (2%)
Hepatoblastoma, Multiple 1 (2%)
Hepatocellular Carcinoma 2 (4%) 2 (4%) 7 (14%) 5 (10%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%) 5 (10%) 3 (6%)
Hepatocellular Adenoma 8 (16%) 12 (24%) 9 (18%) 9 (18%)
Hepatocellular Adenoma, Multiple 11 (22%) 14 (28%) 23 (46%) 26 (53%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Ito Cell Tumor Malignant 1 (2%)
Sarcoma 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Mesentery (28) (20) (16) (19)
Hemangioma 1 (4%)
Hemangiosarcoma 1 (6%) 1 (5%)
Leiomyosarcoma 1 (6%)
Sarcoma 1 (4%)
Sarcoma, Metastatic, Pancreas 1 (6%)
Sarcoma, Metastatic, Skin 1 (5%)
Page 2
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Schwannoma Malignant, Metastatic, Skin 1 (5%)
Oral Mucosa (1)
Squamous Cell Carcinoma 1 (100%)
Pancreas (49) (49) (49) (47)
Histiocytic Sarcoma 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Acinus, Carcinoma 1 (2%)
Acinus, Sarcoma 1 (2%)
Salivary Glands (50) (49) (50) (50)
Stomach, Forestomach (49) (50) (50) (49)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 2 (4%)
Stomach, Glandular (49) (50) (50) (49)
Carcinoma 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Serosa, Sarcoma, Metastatic, Skin 1 (2%)
Tongue (2)
Squamous Cell Carcinoma 1 (50%)
Squamous Cell Papilloma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (50) (50)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Leiomyosarcoma, Metastatic, Mesentery 1 (2%)
Sarcoma, Metastatic, Pancreas 1 (2%)
Capsule, Adenoma 1 (2%)
Extra Adrenal Tissue, Sarcoma 1 (2%)
Adrenal Medulla (50) (50) (50) (49)
Pheochromocytoma Benign 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (49) (49) (49) (46)
Adenoma 1 (2%) 2 (4%) 2 (4%)
Carcinoma 1 (2%)
Pituitary Gland (47) (49) (49) (49)
Pars Distalis, Adenoma 2 (4%) 4 (8%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 2 (4%)
Page 3
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Thyroid Gland (50) (50) (50) (50)
Follicular Cell, Adenoma 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2)
Fibrosarcoma 1 (50%)
Schwannoma Malignant 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (49) (47) (47) (49)
Cystadenoma 2 (4%) 1 (2%)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Uterus (50) (50) (50) (50)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyoma 1 (2%)
Polyp Stromal 1 (2%) 1 (2%)
Sarcoma Stromal 1 (2%)
Cervix, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Lymph Node (12) (13) (11) (8)
Fibrosarcoma, Metastatic, Skin 1 (8%)
Iliac, Osteosarcoma, Metastatic, Bone 1 (13%)
Iliac, Sarcoma, Metastatic, Skin 1 (8%) 1 (8%)
Inguinal, Fibrosarcoma, Metastatic, Skin 1 (8%)
Mediastinal, Neurofibrosarcoma, Metastatic,
Skin 1 (8%)
Mediastinal, Sarcoma, Metastatic, Skin 1 (13%)
Pancreatic, Carcinoma, Metastatic, Pancreas 1 (13%)
Pancreatic, Leiomyosarcoma, Metastatic,
Mesentery 1 (9%)
Renal, Leiomyosarcoma, Metastatic, Mesentery 1 (9%)
Lymph Node, Mandibular (48) (49) (47) (50)
Page 4
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymph Node, Mesenteric (49) (49) (48) (45)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Spleen (50) (50) (50) (48)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Thymus (44) (47) (47) (48)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Carcinoma 1 (2%) 1 (2%)
Fibroadenoma 1 (2%)
Skin (50) (50) (50) (50)
Basal Cell Carcinoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Subcutaneous Tissue, Fibrous Histiocytoma 3 (6%)
Subcutaneous Tissue, Hemangioma 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemangiopericytoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Neurofibroma 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%)
Subcutaneous Tissue, Osteosarcoma,
Metastatic, Bone 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%) 1 (2%) 4 (8%)
Subcutaneous Tissue, Sarcoma, Metastatic,
Tissue NOS 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%) 1 (2%) 1 (2%)
Skeletal Muscle (3) (4) (2) (5)
Carcinoma, Metastatic, Harderian Gland 1 (25%)
Fibrosarcoma, Metastatic, Skin 1 (50%)
Hemangiosarcoma 1 (20%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (33%)
Page 5
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont
Rhabdomyosarcoma 1 (20%)
Sarcoma 1 (33%) 1 (25%) 2 (40%)
Sarcoma, Metastatic, Pancreas 1 (50%)
Sarcoma, Metastatic, Skin 1 (33%)
Schwannoma Malignant, Metastatic, Skin 1 (25%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 3 (6%) 3 (6%) 6 (12%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Carcinoma, Metastatic, Uterus 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 3 (6%) 1 (2%) 3 (6%) 4 (8%)
Histiocytic Sarcoma 1 (2%)
Neurofibrosarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%) 1 (2%) 1 (2%)
Nose (50) (50) (50) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Harderian Gland (49) (50) (50) (50)
Adenoma 9 (18%) 4 (8%) 6 (12%) 8 (16%)
Adenoma, Multiple 2 (4%)
Carcinoma 1 (2%) 2 (4%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (49)
Urinary Bladder (50) (49) (50) (49)
Fibrosarcoma, Metastatic, Tissue NOS 1 (2%)
Leiomyosarcoma, Metastatic, Mesentery 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Lymphoma Malignant 27 (54%) 24 (48%) 17 (34%) 14 (28%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 7
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 42 43 46 48
Total Primary Neoplasms 88 93 102 104
Total Animals with Benign Neoplasms 29 33 41 38
Total Benign Neoplasms 43 46 54 56
Total Animals with Malignant Neoplasms 36 37 34 31
Total Malignant Neoplasms 45 47 48 48
Total Animals with Metastatic Neoplasms 5 7 7 10
Total Metastatic Neoplasm 12 20 13 13
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 8
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 4 6 3 6
Natural Death 14 6 13 13
Survivors
Terminal Sacrifice 31 38 34 31
Other 1
Animals Examined Microscopically 49 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (50) (50)
Carcinoma, Metastatic, Pancreas 1 (2%)
Intestine Large, Colon (48) (50) (49) (48)
Carcinoma 1 (2%)
Hemangioma 1 (2%)
Intestine Small, Duodenum (42) (50) (46) (48)
Carcinoma 1 (2%)
Polyp Adenomatous 1 (2%) 2 (4%) 1 (2%)
Intestine Small, Jejunum (44) (49) (46) (45)
Carcinoma 2 (4%) 3 (7%)
Polyp Adenomatous 1 (2%) 1 (2%)
Intestine Small, Ileum (44) (49) (47) (48)
Polyp Adenomatous 1 (2%)
Liver (49) (50) (50) (50)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%) 2 (4%) 2 (4%)
Hepatoblastoma 4 (8%) 3 (6%) 16 (32%)
Hepatoblastoma, Multiple 3 (6%) 2 (4%)
Hepatocellular Carcinoma 11 (22%) 7 (14%) 14 (28%) 11 (22%)
Hepatocellular Carcinoma, Multiple 3 (6%) 2 (4%) 5 (10%) 15 (30%)
Hepatocellular Adenoma 12 (24%) 20 (40%) 13 (26%) 15 (30%)
Hepatocellular Adenoma, Multiple 6 (12%) 17 (34%) 24 (48%) 27 (54%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Sarcoma 1 (2%)
Mesentery (7) (7) (10) (7)
Page 9
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Hepatoblastoma, Metastatic, Liver 1 (10%) 1 (14%)
Osteosarcoma, Metastatic, Bone 1 (10%)
Sarcoma 1 (14%)
Pancreas (46) (50) (50) (49)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (2%)
Acinus, Carcinoma 1 (2%)
Acinus, Sarcoma 1 (2%)
Salivary Glands (49) (50) (50) (50)
Stomach, Forestomach (49) (50) (50) (50)
Sarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (47) (50) (50) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50) (50)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Adenoma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%)
Capsule, Adenoma 3 (6%) 3 (6%) 2 (4%)
Capsule, Carcinoma 1 (2%)
Adrenal Medulla (49) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%)
Islets, Pancreatic (46) (50) (50) (49)
Adenoma 2 (4%) 4 (8%) 3 (6%)
Adenoma, Multiple 1 (2%)
Thyroid Gland (48) (50) (50) (50)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (1)
Hemangioma 1 (100%)
Prostate (48) (50) (50) (49)
Carcinoma, Metastatic, Pancreas 1 (2%)
Testes (49) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Interstitial Cell, Adenoma 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (47) (50) (50) (50)
Lymph Node (1) (2) (5) (1)
Iliac, Carcinoma, Metastatic, Pancreas 1 (50%)
Renal, Carcinoma, Metastatic, Pancreas 1 (50%)
Lymph Node, Mandibular (48) (50) (48) (48)
Lymph Node, Mesenteric (46) (49) (49) (47)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Spleen (47) (50) (50) (50)
Hemangiosarcoma 2 (4%) 3 (6%)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (42) (45) (46) (47)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (50) (50) (50)
Basal Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1) (1)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
Page 11
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 7 (14%) 4 (8%) 15 (30%) 8 (16%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 2 (4%) 4 (8%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 7 (14%) 6 (12%) 4 (8%)
Alveolar/Bronchiolar Carcinoma, Multiple 2 (4%) 1 (2%) 2 (4%) 3 (6%)
Carcinoma, Metastatic, Pancreas 1 (2%)
Hepatoblastoma, Metastatic, Liver 1 (2%) 2 (4%) 6 (12%)
Hepatocellular Carcinoma, Metastatic, Liver 8 (16%) 5 (10%) 7 (14%) 13 (26%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Bronchus, Adenoma 1 (2%) 1 (2%)
Mediastinum, Hepatoblastoma, Metastatic,
Liver 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (49) (50) (50) (50)
Adenoma 3 (6%) 4 (8%) 5 (10%) 6 (12%)
Adenoma, Multiple 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Page 12
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(49) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymphoma Malignant 5 (10%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 13
NTP Experiment-Test: 96017-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:19:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 50 MG/L 500 MG/L 1000
MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 37 44 49 50
Total Primary Neoplasms 61 103 110 130
Total Animals with Benign Neoplasms 25 38 42 46
Total Benign Neoplasms 35 61 71 68
Total Animals with Malignant Neoplasms 23 28 32 43
Total Malignant Neoplasms 26 42 39 62
Total Animals with Metastatic Neoplasms 9 7 10 21
Total Metastatic Neoplasm 10 13 13 28
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 14
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