TDMS Study 96017-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) DATE: 05/19/04
EXPERIMENT: 96017 TEST: 06 TIME: 09:19:53
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96017
PATHOLOGIST: HEATH, JAMES CAS: 631-64-1
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) DATE: 05/19/04
EXPERIMENT: 96017 TEST: 06 TIME: 09:19:53
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96017
PATHOLOGIST: HEATH, JAMES CAS: 631-64-1
Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
---------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Ovary
Pancreas
Pituitary Gland
Spleen
Testes
Thyroid Gland
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) DATE: 05/19/04
EXPERIMENT: 96017 TEST: 06 TIME: 09:19:53
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96017
PATHOLOGIST: HEATH, JAMES CAS: 631-64-1
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF WATER DISINFECTION BYPRODUCTS (DIBROMOAC
===============================================================
Male Mice
------------
Organ Morphology
----- ----------
Adrenal Cortex Adenoma
Intestine Small: Jejunum Carcinoma
Intestine Small: Site Unspecified Carcinoma
Liver Hepatoblastoma
Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Spleen Hemangiosarcoma
All Organs Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Skin Fibrous Histiocytoma
Thyroid Gland: Follicular Cell Adenoma
Tongue Squamous Cell Carcinoma or Papilloma Squamous
All Organs Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant and Benign Tumors
===============================================================
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 1
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 4/50 (8%) 2/50 (4%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 1/50 (2%) 0/49 (0%) |
|POLY-3 RATE (b) | 3/42.26 4/46.25 2/43.74 0/43.55 |0/45.94 0/45.44 1/44.30 0/45.07 |
|POLY-3 PERCENT (g) | 7.1% 8.7% 4.6% 0.0% |0.0% 0.0% 2.3% 0.0% |
|TERMINAL (d) | 3/31 (10%) 3/38 (8%) 2/34 (6%) 0/31 (0%) |0/38 (0%) 0/35 (0%) 1/32 (3%) 0/32 (0%) |
|FIRST INCIDENCE | 729 (T) 659 729 (T) --- |--- --- 729 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.050N P=0.607 P=0.458N P=0.120N |P=0.611 (e) P=0.466 (e) |
|POLY 3 | P=0.042N* P=0.549 P=0.484N P=0.113N |P=0.637 (e) P=0.493 (e) |
|POLY 1.5 | P=0.041N* P=0.533 P=0.487N P=0.113N |P=0.636 (e) P=0.496 (e) |
|POLY 6 | P=0.045N* P=0.569 P=0.482N P=0.114N |P=0.637 (e) P=0.487 (e) |
|LOGISTIC REGRESSION| P=0.046N* P=0.564 P=0.458N (e) |(e) (e) P=0.466 (e) |
|COCH-ARM / FISHERS | P=0.041N* P=0.511 P=0.490N P=0.117N |P=0.631 (e) P=0.500 (e) |
|ORDER RESTRICTED | P=0.075N (e) (e) (e) |P=0.374 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 5/50 (10%) 5/50 (10%) 7/50 (14%) |9/50 (18%) 4/50 (8%) 8/50 (16%) 8/50 (16%) |
|POLY-3 RATE (b) | 3/42.29 5/46.02 5/43.80 7/43.64 |9/46.71 4/46.54 8/45.08 8/45.43 |
|POLY-3 PERCENT (g) | 7.1% 10.9% 11.4% 16.0% |19.3% 8.6% 17.8% 17.6% |
|TERMINAL (d) | 3/31 (10%) 4/38 (11%) 4/34 (12%) 6/31 (19%) |6/38 (16%) 2/35 (6%) 5/32 (16%) 5/32 (16%) |
|FIRST INCIDENCE | 729 (T) 721 714 706 |591 487 622 688 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.109 P=0.474 P=0.405 P=0.154 |P=0.278 P=0.149N P=0.584 P=0.586 |
|POLY 3 | P=0.151 P=0.404 P=0.375 P=0.169 |P=0.334 P=0.116N P=0.532N P=0.525N |
|POLY 1.5 | P=0.156 P=0.387 P=0.371 P=0.168 |P=0.344 P=0.117N P=0.517N P=0.517N |
|POLY 6 | P=0.141 P=0.423 P=0.379 P=0.166 |P=0.318 P=0.117N P=0.558N P=0.540N |
|LOGISTIC REGRESSION| P=0.109 P=0.457 P=0.383 P=0.147 |P=0.361 P=0.108N P=0.509N P=0.513N |
|COCH-ARM / FISHERS | P=0.153 P=0.357 P=0.357 P=0.159 |P=0.362 P=0.117N P=0.500N P=0.500N |
|ORDER RESTRICTED | P=0.152 (e) (e) (e) |P=0.426N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 2
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |1/50 (2%) 2/50 (4%) 2/50 (4%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/42.29 0/45.99 0/43.74 0/43.55 |1/45.94 2/45.98 2/44.44 1/45.39 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |2.2% 4.4% 4.5% 2.2% |
|TERMINAL (d) | 0/31 (0%) 0/38 (0%) 0/34 (0%) 0/31 (0%) |1/38 (3%) 0/35 (0%) 1/32 (3%) 0/32 (0%) |
|FIRST INCIDENCE | --- --- --- --- |729 (T) 615 692 659 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.543N P=0.491 P=0.446 P=0.747 |
|POLY 3 | (e) (e) (e) (e) |P=0.517N P=0.500 P=0.488 P=0.758 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.515N P=0.499 P=0.494 P=0.758 |
|POLY 6 | (e) (e) (e) (e) |P=0.522N P=0.502 P=0.479 P=0.757 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.503N P=0.511 P=0.480 P=0.761N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.510N P=0.500 P=0.500 P=0.753N |
|ORDER RESTRICTED | (e) (e) (e) (e) |P=0.540 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 5/50 (10%) 5/50 (10%) 7/50 (14%) |10/50 (20%) 5/50 (10%) 10/50 (20%) 9/50 (18%) |
|POLY-3 RATE (b) | 3/42.29 5/46.02 5/43.80 7/43.64 |10/46.71 5/46.68 10/45.22 9/45.69 |
|POLY-3 PERCENT (g) | 7.1% 10.9% 11.4% 16.0% |21.4% 10.7% 22.1% 19.7% |
|TERMINAL (d) | 3/31 (10%) 4/38 (11%) 4/34 (12%) 6/31 (19%) |7/38 (18%) 2/35 (6%) 6/32 (19%) 5/32 (16%) |
|FIRST INCIDENCE | 729 (T) 721 714 706 |591 487 622 659 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.109 P=0.474 P=0.405 P=0.154 |P=0.263 P=0.168N P=0.462 P=0.576 |
|POLY 3 | P=0.151 P=0.404 P=0.375 P=0.169 |P=0.324 P=0.129N P=0.568 P=0.521N |
|POLY 1.5 | P=0.156 P=0.387 P=0.371 P=0.168 |P=0.333 P=0.130N P=0.582 P=0.515N |
|POLY 6 | P=0.141 P=0.423 P=0.379 P=0.166 |P=0.309 P=0.129N P=0.543 P=0.532N |
|LOGISTIC REGRESSION| P=0.109 P=0.457 P=0.383 P=0.147 |P=0.350 P=0.123N P=0.584 P=0.512N |
|COCH-ARM / FISHERS | P=0.153 P=0.357 P=0.357 P=0.159 |P=0.350 P=0.131N P=0.598N P=0.500N |
|ORDER RESTRICTED | P=0.152 (e) (e) (e) |P=0.434 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 3
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Intestine Small: Duodenum |
| Polyp Adenomatous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 1/50 (2%) |0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/42.29 1/45.99 2/43.74 1/44.25 |0/45.94 2/45.70 0/44.30 0/45.13 |
|POLY-3 PERCENT (g) | 0.0% 2.2% 4.6% 2.3% |0.0% 4.4% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 1/38 (3%) 2/34 (6%) 0/31 (0%) |0/38 (0%) 1/35 (3%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE | --- 729 (T) 729 (T) 489 |--- 659 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.357 P=0.541 P=0.259 P=0.513 |P=0.241N P=0.236 (e) (e) |
|POLY 3 | P=0.387 P=0.517 P=0.245 P=0.509 |P=0.230N P=0.236 (e) (e) |
|POLY 1.5 | P=0.387 P=0.511 P=0.243 P=0.507 |P=0.229N P=0.236 (e) (e) |
|POLY 6 | P=0.382 P=0.523 P=0.246 P=0.509 |P=0.233N P=0.236 (e) (e) |
|LOGISTIC REGRESSION| P=0.372 P=0.541 P=0.259 P=0.346 |P=0.226N P=0.239 (e) (e) |
|COCH-ARM / FISHERS | P=0.377 P=0.500 P=0.247 P=0.500 |P=0.227N P=0.247 (e) (e) |
|ORDER RESTRICTED | P=0.233 (e) (e) (e) |P=0.250N (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 3/50 (6%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/42.29 2/45.99 0/43.74 3/43.55 |0/45.94 0/45.44 0/44.30 1/45.13 |
|POLY-3 PERCENT (g) | 0.0% 4.4% 0.0% 6.9% |0.0% 0.0% 0.0% 2.2% |
|TERMINAL (d) | 0/31 (0%) 2/38 (5%) 0/34 (0%) 3/31 (10%) |0/38 (0%) 0/35 (0%) 0/32 (0%) 1/32 (3%) |
|FIRST INCIDENCE | --- 729 (T) --- 729 (T) |--- --- --- 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.129 P=0.284 (e) P=0.120 |P=0.167 (e) (e) P=0.466 |
|POLY 3 | P=0.157 P=0.256 (e) P=0.124 |P=0.183 (e) (e) P=0.496 |
|POLY 1.5 | P=0.157 P=0.249 (e) P=0.123 |P=0.183 (e) (e) P=0.497 |
|POLY 6 | P=0.156 P=0.264 (e) P=0.122 |P=0.181 (e) (e) P=0.494 |
|LOGISTIC REGRESSION| (e) P=0.284 (e) P=0.120 |(e) (e) (e) P=0.466 |
|COCH-ARM / FISHERS | P=0.153 P=0.247 (e) P=0.121 |P=0.184 (e) (e) P=0.500 |
|ORDER RESTRICTED | P=0.039 * (e) (e) (e) |P=0.116 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 4
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Intestine Small: Site Unspecified |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 4/50 (8%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/42.29 2/45.99 0/43.74 4/43.55 |0/45.94 0/45.44 0/44.30 1/45.13 |
|POLY-3 PERCENT (g) | 0.0% 4.4% 0.0% 9.2% |0.0% 0.0% 0.0% 2.2% |
|TERMINAL (d) | 0/31 (0%) 2/38 (5%) 0/34 (0%) 4/31 (13%) |0/38 (0%) 0/35 (0%) 0/32 (0%) 1/32 (3%) |
|FIRST INCIDENCE | --- 729 (T) --- 729 (T) |--- --- --- 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.045 * P=0.284 (e) P=0.062 |P=0.167 (e) (e) P=0.466 |
|POLY 3 | P=0.059 P=0.256 (e) P=0.064 |P=0.183 (e) (e) P=0.496 |
|POLY 1.5 | P=0.059 P=0.249 (e) P=0.063 |P=0.183 (e) (e) P=0.497 |
|POLY 6 | P=0.058 P=0.264 (e) P=0.062 |P=0.181 (e) (e) P=0.494 |
|LOGISTIC REGRESSION| (e) P=0.284 (e) P=0.062 |(e) (e) (e) P=0.466 |
|COCH-ARM / FISHERS | P=0.059 P=0.247 (e) P=0.059 |P=0.184 (e) (e) P=0.500 |
|ORDER RESTRICTED | P=0.012 * (e) (e) (e) |P=0.116 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Intestine Small: Site Unspecified |
| Polyp Adenomatous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 2/50 (4%) 1/50 (2%) |0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 1/42.29 3/45.99 2/43.74 1/44.25 |0/45.94 2/45.70 0/44.30 0/45.13 |
|POLY-3 PERCENT (g) | 2.4% 6.5% 4.6% 2.3% |0.0% 4.4% 0.0% 0.0% |
|TERMINAL (d) | 1/31 (3%) 3/38 (8%) 2/34 (6%) 0/31 (0%) |0/38 (0%) 1/35 (3%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 489 |--- 659 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.413N P=0.380 P=0.532 P=0.753N |P=0.241N P=0.236 (e) (e) |
|POLY 3 | P=0.371N P=0.336 P=0.512 P=0.751N |P=0.230N P=0.236 (e) (e) |
|POLY 1.5 | P=0.373N P=0.325 P=0.509 P=0.753N |P=0.229N P=0.236 (e) (e) |
|POLY 6 | P=0.374N P=0.348 P=0.514 P=0.751N |P=0.233N P=0.236 (e) (e) |
|LOGISTIC REGRESSION| P=0.383N P=0.380 P=0.532 P=0.724 |P=0.226N P=0.239 (e) (e) |
|COCH-ARM / FISHERS | P=0.383N P=0.309 P=0.500 P=0.753N |P=0.227N P=0.247 (e) (e) |
|ORDER RESTRICTED | P=0.467N (e) (e) (e) |P=0.250N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 5
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/46 (0%) 3/50 (6%) 4/50 (8%) 3/49 (6%) |1/49 (2%) 0/49 (0%) 2/49 (4%) 2/46 (4%) |
|POLY-3 RATE (b) | 0/40.18 3/46.02 4/44.19 3/43.10 |1/45.58 0/44.88 2/44.58 2/42.85 |
|POLY-3 PERCENT (g) | 0.0% 6.5% 9.1% 7.0% |2.2% 0.0% 4.5% 4.7% |
|TERMINAL (d) | 0/31 (0%) 2/38 (5%) 3/34 (9%) 3/31 (10%) |1/38 (3%) 0/35 (0%) 1/32 (3%) 2/32 (6%) |
|FIRST INCIDENCE | --- 721 596 729 (T) |729 (T) --- 553 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.172 P=0.163 P=0.074 P=0.120 |P=0.154 P=0.516N P=0.460 P=0.440 |
|POLY 3 | P=0.211 P=0.144 P=0.073 P=0.131 |P=0.169 P=0.503N P=0.492 P=0.478 |
|POLY 1.5 | P=0.215 P=0.140 P=0.072 P=0.132 |P=0.168 P=0.502N P=0.496 P=0.478 |
|POLY 6 | P=0.201 P=0.148 P=0.072 P=0.128 |P=0.168 P=0.504N P=0.484 P=0.477 |
|LOGISTIC REGRESSION| P=0.201 P=0.151 P=0.074 P=0.120 |P=0.161 (e) P=0.517 P=0.440 |
|COCH-ARM / FISHERS | P=0.215 P=0.137 P=0.069 P=0.133 |P=0.165 P=0.500N P=0.500 P=0.476 |
|ORDER RESTRICTED | P=0.094 (e) (e) (e) |P=0.249 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/46 (0%) 3/50 (6%) 4/50 (8%) 3/49 (6%) |1/49 (2%) 0/49 (0%) 3/49 (6%) 2/46 (4%) |
|POLY-3 RATE (b) | 0/40.18 3/46.02 4/44.19 3/43.10 |1/45.58 0/44.88 3/44.92 2/42.85 |
|POLY-3 PERCENT (g) | 0.0% 6.5% 9.1% 7.0% |2.2% 0.0% 6.7% 4.7% |
|TERMINAL (d) | 0/31 (0%) 2/38 (5%) 3/34 (9%) 3/31 (10%) |1/38 (3%) 0/35 (0%) 1/32 (3%) 2/32 (6%) |
|FIRST INCIDENCE | --- 721 596 729 (T) |729 (T) --- 553 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.172 P=0.163 P=0.074 P=0.120 |P=0.149 P=0.516N P=0.274 P=0.440 |
|POLY 3 | P=0.211 P=0.144 P=0.073 P=0.131 |P=0.158 P=0.503N P=0.300 P=0.478 |
|POLY 1.5 | P=0.215 P=0.140 P=0.072 P=0.132 |P=0.157 P=0.502N P=0.303 P=0.478 |
|POLY 6 | P=0.201 P=0.148 P=0.072 P=0.128 |P=0.157 P=0.504N P=0.293 P=0.477 |
|LOGISTIC REGRESSION| P=0.201 P=0.151 P=0.074 P=0.120 |P=0.146 (e) P=0.321 P=0.440 |
|COCH-ARM / FISHERS | P=0.215 P=0.137 P=0.069 P=0.133 |P=0.154 P=0.500N P=0.309 P=0.476 |
|ORDER RESTRICTED | P=0.094 (e) (e) (e) |P=0.182 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 6
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 2/50 (4%) 0/50 (0%) 2/50 (4%) |1/49 (2%) 1/50 (2%) 2/50 (4%) 0/49 (0%) |
|POLY-3 RATE (b) | 1/42.26 2/45.99 0/43.74 2/43.55 |1/45.87 1/45.44 2/44.76 0/45.07 |
|POLY-3 PERCENT (g) | 2.4% 4.4% 0.0% 4.6% |2.2% 2.2% 4.5% 0.0% |
|TERMINAL (d) | 1/31 (3%) 2/38 (5%) 0/34 (0%) 2/31 (7%) |0/38 (0%) 1/35 (3%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) --- 729 (T) |653 729 (T) 617 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.505 P=0.571 P=0.482N P=0.500 |P=0.395N P=0.751 P=0.473 P=0.500N |
|POLY 3 | P=0.541 P=0.529 P=0.493N P=0.510 |P=0.382N P=0.758 P=0.491 P=0.503N |
|POLY 1.5 | P=0.543 P=0.520 P=0.494N P=0.510 |P=0.380N P=0.760N P=0.499 P=0.502N |
|POLY 6 | P=0.536 P=0.541 P=0.492N P=0.508 |P=0.387N P=0.756 P=0.480 P=0.507N |
|LOGISTIC REGRESSION| P=0.505 P=0.571 (e) P=0.500 |P=0.382N P=0.753N P=0.548 P=0.493N |
|COCH-ARM / FISHERS | P=0.543 P=0.508 P=0.495N P=0.508 |P=0.379N P=0.747N P=0.508 P=0.500N |
|ORDER RESTRICTED | P=0.415 (e) (e) (e) |P=0.271N (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Liver |
| Hepatoblastoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 4/50 (8%) 6/50 (12%) 18/50 (36%) |1/49 (2%) 0/50 (0%) 1/50 (2%) 1/49 (2%) |
|POLY-3 RATE (b) | 0/42.26 4/46.04 6/45.11 18/46.03 |1/45.58 0/45.44 1/44.48 1/45.07 |
|POLY-3 PERCENT (g) | 0.0% 8.7% 13.3% 39.1% |2.2% 0.0% 2.3% 2.2% |
|TERMINAL (d) | 0/31 (0%) 3/38 (8%) 3/34 (9%) 9/31 (29%) |1/38 (3%) 0/35 (0%) 0/32 (0%) 1/32 (3%) |
|FIRST INCIDENCE | --- 717 573 469 |729 (T) --- 680 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P=0.094 P=0.024 * P<0.001 ** |P=0.418 P=0.516N P=0.730 P=0.723 |
|POLY 3 | P<0.001 ** P=0.072 P=0.019 * P<0.001 ** |P=0.450 P=0.501N P=0.755 P=0.758 |
|POLY 1.5 | P<0.001 ** P=0.068 P=0.018 * P<0.001 ** |P=0.450 P=0.499N P=0.760 P=0.759 |
|POLY 6 | P<0.001 ** P=0.077 P=0.020 * P<0.001 ** |P=0.447 P=0.502N P=0.748 P=0.755 |
|LOGISTIC REGRESSION| P<0.001 ** P=0.083 P=0.018 * P<0.001 ** |P=0.446 (e) P=0.762N P=0.723 |
|COCH-ARM / FISHERS | P<0.001 ** P=0.061 P=0.014 * P<0.001 ** |P=0.448 P=0.495N P=0.747N P=0.753N |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |P=0.530 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 7
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/49 (37%) 37/50 (74%) 37/50 (74%) 42/50 (84%) |19/49 (39%) 26/50 (52%) 32/50 (64%) 35/49 (71%) |
|POLY-3 RATE (b) | 18/43.32 37/47.46 37/46.19 42/47.33 |19/45.87 26/45.74 32/45.91 35/46.13 |
|POLY-3 PERCENT (g) | 41.6% 78.0% 80.1% 88.7% |41.4% 56.8% 69.7% 75.9% |
|TERMINAL (d) | 14/31 (45%) 31/38 (82%) 29/34 (85%) 29/31 (94%) |18/38 (47%) 22/35 (63%) 26/32 (81%) 28/32 (88%) |
|FIRST INCIDENCE | 596 573 573 469 |653 694 573 636 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P=0.006 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.055 P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.098 P=0.004 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.109 P=0.006 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.089 P=0.002 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.083 P=0.002 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.131 P=0.010 * P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/49 (29%) 9/50 (18%) 19/50 (38%) 26/50 (52%) |3/49 (6%) 3/50 (6%) 12/50 (24%) 8/49 (16%) |
|POLY-3 RATE (b) | 14/44.73 9/46.45 19/46.69 26/47.37 |3/45.93 3/45.58 12/44.94 8/45.29 |
|POLY-3 PERCENT (g) | 31.3% 19.4% 40.7% 54.9% |6.5% 6.6% 26.7% 17.7% |
|TERMINAL (d) | 6/31 (19%) 6/38 (16%) 10/34 (29%) 14/31 (45%) |1/38 (3%) 2/35 (6%) 9/32 (28%) 7/32 (22%) |
|FIRST INCIDENCE | 451 659 573 476 |658 694 617 671 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P=0.097N P=0.284 P=0.031 * |P=0.013 * P=0.637 P=0.007 ** P=0.069 |
|POLY 3 | P<0.001 ** P=0.141N P=0.236 P=0.016 * |P=0.019 * P=0.659 P=0.009 ** P=0.094 |
|POLY 1.5 | P<0.001 ** P=0.147N P=0.227 P=0.015 * |P=0.020 * P=0.661N P=0.010 * P=0.096 |
|POLY 6 | P<0.001 ** P=0.137N P=0.249 P=0.018 * |P=0.017 * P=0.654 P=0.007 ** P=0.088 |
|LOGISTIC REGRESSION| P<0.001 ** P=0.160N P=0.213 P=0.014 * |P=0.021 * P=0.658N P=0.011 * P=0.096 |
|COCH-ARM / FISHERS | P<0.001 ** P=0.157N P=0.217 P=0.015 * |P=0.022 * P=0.651N P=0.013 * P=0.100 |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |P=0.019 * (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 8
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/49 (29%) 11/50 (22%) 23/50 (46%) 37/50 (74%) |4/49 (8%) 3/50 (6%) 13/50 (26%) 9/49 (18%) |
|POLY-3 RATE (b) | 14/44.73 11/46.45 23/47.04 37/49.04 |4/45.93 3/45.58 13/45.13 9/45.29 |
|POLY-3 PERCENT (g) | 31.3% 23.7% 48.9% 75.5% |8.7% 6.6% 28.8% 19.9% |
|TERMINAL (d) | 6/31 (19%) 8/38 (21%) 13/34 (38%) 20/31 (65%) |2/38 (5%) 2/35 (6%) 9/32 (28%) 8/32 (25%) |
|FIRST INCIDENCE | 451 659 573 469 |658 694 617 671 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P=0.189N P=0.108 P<0.001 ** |P=0.010 * P=0.529N P=0.009 ** P=0.075 |
|POLY 3 | P<0.001 ** P=0.281N P=0.063 P<0.001 ** |P=0.015 * P=0.504N P=0.012 * P=0.109 |
|POLY 1.5 | P<0.001 ** P=0.289N P=0.059 P<0.001 ** |P=0.016 * P=0.499N P=0.014 * P=0.113 |
|POLY 6 | P<0.001 ** P=0.275N P=0.072 P<0.001 ** |P=0.014 * P=0.510N P=0.010 * P=0.102 |
|LOGISTIC REGRESSION| P<0.001 ** P=0.298N P=0.055 P<0.001 ** |P=0.017 * P=0.497N P=0.014 * P=0.110 |
|COCH-ARM / FISHERS | P<0.001 ** P=0.301N P=0.056 P<0.001 ** |P=0.018 * P=0.489N P=0.017 * P=0.116 |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |P=0.017 * (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 28/49 (57%) 41/50 (82%) 42/50 (84%) 47/50 (94%) |22/49 (45%) 28/50 (56%) 37/50 (74%) 37/49 (76%) |
|POLY-3 RATE (b) | 28/45.72 41/47.77 42/47.58 47/48.97 |22/46.21 28/45.74 37/46.56 37/46.35 |
|POLY-3 PERCENT (g) | 61.2% 85.8% 88.3% 96.0% |47.6% 61.2% 79.5% 79.8% |
|TERMINAL (d) | 17/31 (55%) 33/38 (87%) 30/34 (88%) 30/31 (97%) |19/38 (50%) 24/35 (69%) 28/32 (88%) 29/32 (91%) |
|FIRST INCIDENCE | 451 573 573 469 |653 694 573 636 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P=0.157 P=0.039 * P=0.002 ** |P<0.001 ** P=0.084 P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.004 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.131 P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.004 ** P=0.002 ** P<0.001 ** |P<0.001 ** P=0.149 P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.005 ** P=0.002 ** P<0.001 ** |P<0.001 ** P=0.112 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.012 * P=0.003 ** P<0.001 ** |P<0.001 ** P=0.127 P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.006 ** P=0.003 ** P<0.001 ** |P<0.001 ** P=0.183 P=0.003 ** P=0.002 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 9
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, |
| or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 28/49 (57%) 41/50 (82%) 43/50 (86%) 48/50 (96%) |22/49 (45%) 28/50 (56%) 37/50 (74%) 37/49 (76%) |
|POLY-3 RATE (b) | 28/45.72 41/47.77 43/47.58 48/49.30 |22/46.21 28/45.74 37/46.56 37/46.35 |
|POLY-3 PERCENT (g) | 61.2% 85.8% 90.4% 97.4% |47.6% 61.2% 79.5% 79.8% |
|TERMINAL (d) | 17/31 (55%) 33/38 (87%) 31/34 (91%) 30/31 (97%) |19/38 (50%) 24/35 (69%) 28/32 (88%) 29/32 (91%) |
|FIRST INCIDENCE | 451 573 573 469 |653 694 573 636 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P=0.157 P=0.026 * P=0.002 ** |P<0.001 ** P=0.084 P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.004 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.131 P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.004 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.149 P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.005 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.112 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.012 * P<0.001 ** P<0.001 ** |P<0.001 ** P=0.127 P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.006 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.183 P=0.003 ** P=0.002 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |P<0.001 ** (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/49 (14%) 5/50 (10%) 17/50 (34%) 12/50 (24%) |1/50 (2%) 3/50 (6%) 3/50 (6%) 6/50 (12%) |
|POLY-3 RATE (b) | 7/43.05 5/46.44 17/44.31 12/45.15 |1/45.94 3/46.14 3/44.93 6/45.51 |
|POLY-3 PERCENT (g) | 16.3% 10.8% 38.4% 26.6% |2.2% 6.5% 6.7% 13.2% |
|TERMINAL (d) | 5/31 (16%) 4/38 (11%) 15/34 (44%) 8/31 (26%) |1/38 (3%) 2/35 (6%) 1/32 (3%) 4/32 (13%) |
|FIRST INCIDENCE | 482 596 604 489 |729 (T) 490 553 636 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.013 * P=0.269N P=0.030 * P=0.162 |P=0.035 * P=0.283 P=0.265 P=0.042 * |
|POLY 3 | P=0.019 * P=0.326N P=0.016 * P=0.178 |P=0.044 * P=0.307 P=0.297 P=0.054 |
|POLY 1.5 | P=0.021 * P=0.344N P=0.017 * P=0.174 |P=0.044 * P=0.306 P=0.302 P=0.055 |
|POLY 6 | P=0.016 * P=0.306N P=0.016 * P=0.179 |P=0.042 * P=0.307 P=0.289 P=0.053 |
|LOGISTIC REGRESSION| P=0.022 * P=0.360N P=0.021 * P=0.166 |P=0.049 * P=0.321 P=0.317 P=0.055 |
|COCH-ARM / FISHERS | P=0.025 * P=0.365N P=0.019 * P=0.166 |P=0.047 * P=0.309 P=0.309 P=0.056 |
|ORDER RESTRICTED | P=0.020 * (e) (e) (e) |P=0.027 * (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 10
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 8/50 (16%) 8/50 (16%) 7/50 (14%) |1/50 (2%) 2/50 (4%) 2/50 (4%) 2/50 (4%) |
|POLY-3 RATE (b) | 5/42.59 8/46.17 8/43.94 7/43.93 |1/45.94 2/45.58 2/44.68 2/45.13 |
|POLY-3 PERCENT (g) | 11.7% 17.3% 18.2% 15.9% |2.2% 4.4% 4.5% 4.4% |
|TERMINAL (d) | 3/31 (10%) 6/38 (16%) 6/34 (18%) 5/31 (16%) |1/38 (3%) 1/35 (3%) 1/32 (3%) 2/32 (6%) |
|FIRST INCIDENCE | 662 691 699 652 |729 (T) 694 622 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.356 P=0.410 P=0.326 P=0.374 |P=0.398 P=0.481 P=0.460 P=0.440 |
|POLY 3 | P=0.436 P=0.329 P=0.294 P=0.400 |P=0.440 P=0.497 P=0.490 P=0.494 |
|POLY 1.5 | P=0.446 P=0.312 P=0.293 P=0.400 |P=0.443 P=0.498 P=0.495 P=0.496 |
|POLY 6 | P=0.417 P=0.349 P=0.295 P=0.396 |P=0.433 P=0.497 P=0.482 P=0.490 |
|LOGISTIC REGRESSION| P=0.403 P=0.353 P=0.299 P=0.396 |P=0.443 P=0.496 P=0.505 P=0.440 |
|COCH-ARM / FISHERS | P=0.451 P=0.290 P=0.290 P=0.394 |P=0.448 P=0.500 P=0.500 P=0.500 |
|ORDER RESTRICTED | P=0.394 (e) (e) (e) |P=0.455 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/49 (24%) 12/50 (24%) 22/50 (44%) 17/50 (34%) |2/50 (4%) 5/50 (10%) 5/50 (10%) 7/50 (14%) |
|POLY-3 RATE (b) | 12/43.38 12/46.62 22/44.52 17/45.53 |2/45.94 5/46.27 5/45.31 7/45.51 |
|POLY-3 PERCENT (g) | 27.7% 25.7% 49.4% 37.3% |4.4% 10.8% 11.0% 15.4% |
|TERMINAL (d) | 8/31 (26%) 9/38 (24%) 18/34 (53%) 11/31 (36%) |2/38 (5%) 3/35 (9%) 2/32 (6%) 5/32 (16%) |
|FIRST INCIDENCE | 482 596 604 489 |729 (T) 490 553 636 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.039 * P=0.398N P=0.057 P=0.200 |P=0.074 P=0.196 P=0.176 P=0.054 |
|POLY 3 | P=0.066 P=0.513N P=0.027 * P=0.226 |P=0.095 P=0.219 P=0.210 P=0.076 |
|POLY 1.5 | P=0.071 P=0.538N P=0.028 * P=0.220 |P=0.097 P=0.218 P=0.214 P=0.077 |
|POLY 6 | P=0.058 P=0.482N P=0.025 * P=0.229 |P=0.092 P=0.221 P=0.204 P=0.075 |
|LOGISTIC REGRESSION| P=0.063 P=0.523N P=0.034 * P=0.211 |P=0.103 P=0.222 P=0.227 P=0.075 |
|COCH-ARM / FISHERS | P=0.075 P=0.570N P=0.033 * P=0.207 |P=0.101 P=0.218 P=0.218 P=0.080 |
|ORDER RESTRICTED | P=0.071 (e) (e) (e) |P=0.061 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 11
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/42.29 0/45.99 0/43.74 0/43.55 |0/45.94 2/45.50 1/44.30 0/45.13 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |0.0% 4.4% 2.3% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/38 (0%) 0/34 (0%) 0/31 (0%) |0/38 (0%) 1/35 (3%) 1/32 (3%) 0/32 (0%) |
|FIRST INCIDENCE | --- --- --- --- |--- 715 729 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.359N P=0.225 P=0.466 (e) |
|POLY 3 | (e) (e) (e) (e) |P=0.333N P=0.235 P=0.493 (e) |
|POLY 1.5 | (e) (e) (e) (e) |P=0.331N P=0.236 P=0.496 (e) |
|POLY 6 | (e) (e) (e) (e) |P=0.337N P=0.234 P=0.487 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.343N P=0.234 P=0.466 (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.326N P=0.247 P=0.500 (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) |P=0.320 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |2/50 (4%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/42.29 0/45.99 0/43.74 0/43.55 |2/46.48 1/45.44 0/44.30 0/45.13 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |4.3% 2.2% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/38 (0%) 0/34 (0%) 0/31 (0%) |1/38 (3%) 1/35 (3%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE | --- --- --- --- |563 729 (T) --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.120N P=0.519N P=0.259N P=0.256N |
|POLY 3 | (e) (e) (e) (e) |P=0.109N P=0.508N P=0.248N P=0.244N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.108N P=0.505N P=0.243N P=0.242N |
|POLY 6 | (e) (e) (e) (e) |P=0.111N P=0.511N P=0.256N P=0.248N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.101N P=0.486N P=0.220N P=0.205N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.107N P=0.500N P=0.247N P=0.247N |
|ORDER RESTRICTED | (e) (e) (e) (e) |P=0.078N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 12
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |0/49 (0%) 2/47 (4%) 1/47 (2%) 0/49 (0%) |
|POLY-3 RATE (b) | |0/44.94 2/42.71 1/41.30 0/45.07 |
|POLY-3 PERCENT (g) | |0.0% 4.7% 2.4% 0.0% |
|TERMINAL (d) | |0/37 (0%) 2/34 (6%) 1/29 (3%) 0/32 (0%) |
|FIRST INCIDENCE | |--- 729 (T) 729 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.362N P=0.220 P=0.451 (e) |
|POLY 3 | |P=0.325N P=0.226 P=0.483 (e) |
|POLY 1.5 | |P=0.324N P=0.226 P=0.487 (e) |
|POLY 6 | |P=0.329N P=0.226 P=0.476 (e) |
|LOGISTIC REGRESSION| |(e) P=0.220 P=0.451 (e) |
|COCH-ARM / FISHERS | |P=0.324N P=0.237 P=0.490 (e) |
|ORDER RESTRICTED | |P=0.307N (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/45 (0%) 0/50 (0%) 0/48 (0%) 0/48 (0%) |2/47 (4%) 4/49 (8%) 0/49 (0%) 1/49 (2%) |
|POLY-3 RATE (b) | 0/39.54 0/45.99 0/42.09 0/42.44 |2/43.62 4/44.58 0/43.30 1/44.13 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |4.6% 9.0% 0.0% 2.3% |
|TERMINAL (d) | 0/30 (0%) 0/38 (0%) 0/33 (0%) 0/31 (0%) |1/36 (3%) 3/34 (9%) 0/31 (0%) 1/31 (3%) |
|FIRST INCIDENCE | --- --- --- --- |720 694 --- 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.146N P=0.316 P=0.278N P=0.553N |
|POLY 3 | (e) (e) (e) (e) |P=0.114N P=0.347 P=0.239N P=0.496N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.112N P=0.350 P=0.234N P=0.493N |
|POLY 6 | (e) (e) (e) (e) |P=0.118N P=0.344 P=0.247N P=0.502N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.122N P=0.341 P=0.256N P=0.520N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.109N P=0.359 P=0.237N P=0.484N |
|ORDER RESTRICTED | (e) (e) (e) (e) |P=0.135N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 13
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/45 (0%) 0/50 (0%) 0/48 (0%) 0/48 (0%) |1/47 (2%) 0/49 (0%) 2/49 (4%) 0/49 (0%) |
|POLY-3 RATE (b) | 0/39.54 0/45.99 0/42.09 0/42.44 |1/43.58 0/44.44 2/43.69 0/44.13 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |2.3% 0.0% 4.6% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/38 (0%) 0/33 (0%) 0/31 (0%) |1/36 (3%) 0/34 (0%) 1/31 (3%) 0/31 (0%) |
|FIRST INCIDENCE | --- --- --- --- |729 (T) --- 618 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.572N P=0.511N P=0.465 P=0.530N |
|POLY 3 | (e) (e) (e) (e) |P=0.548N P=0.496N P=0.501 P=0.498N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.547N P=0.495N P=0.507 P=0.496N |
|POLY 6 | (e) (e) (e) (e) |P=0.552N P=0.498N P=0.491 P=0.501N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.540N (e) P=0.525 (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.543N P=0.490N P=0.516 P=0.490N |
|ORDER RESTRICTED | (e) (e) (e) (e) |P=0.322N (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Skeletal Muscle |
| Sarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |1/50 (2%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/42.29 1/46.44 0/43.74 0/43.55 |1/45.94 1/45.44 0/44.30 2/45.13 |
|POLY-3 PERCENT (g) | 0.0% 2.2% 0.0% 0.0% |2.2% 2.2% 0.0% 4.4% |
|TERMINAL (d) | 0/31 (0%) 0/38 (0%) 0/34 (0%) 0/31 (0%) |1/38 (3%) 1/35 (3%) 0/32 (0%) 2/32 (6%) |
|FIRST INCIDENCE | --- 596 --- --- |729 (T) 729 (T) --- 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.414N P=0.509 (e) (e) |P=0.331 P=0.743 P=0.534N P=0.440 |
|POLY 3 | P=0.399N P=0.519 (e) (e) |P=0.372 P=0.758 P=0.507N P=0.494 |
|POLY 1.5 | P=0.404N P=0.512 (e) (e) |P=0.375 P=0.759 P=0.504N P=0.496 |
|POLY 6 | P=0.393N P=0.526 (e) (e) |P=0.368 P=0.758 P=0.513N P=0.490 |
|LOGISTIC REGRESSION| P=0.443N P=0.447 (e) (e) |P=0.331 P=0.743 (e) P=0.440 |
|COCH-ARM / FISHERS | P=0.414N P=0.500 (e) (e) |P=0.377 P=0.753N P=0.500N P=0.500 |
|ORDER RESTRICTED | P=0.392N (e) (e) (e) |P=0.268 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 14
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, |
| or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |4/50 (8%) 3/50 (6%) 3/50 (6%) 6/50 (12%) |
|POLY-3 RATE (b) | 1/42.73 1/45.99 0/43.74 1/43.81 |4/46.02 3/46.30 3/45.07 6/45.44 |
|POLY-3 PERCENT (g) | 2.3% 2.2% 0.0% 2.3% |8.7% 6.5% 6.7% 13.2% |
|TERMINAL (d) | 0/31 (0%) 1/38 (3%) 0/34 (0%) 0/31 (0%) |3/38 (8%) 0/35 (0%) 1/32 (3%) 2/32 (6%) |
|FIRST INCIDENCE | 601 729 (T) --- 659 |710 490 573 682 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.591N P=0.733N P=0.495N P=0.752N |P=0.181 P=0.535N P=0.568N P=0.295 |
|POLY 3 | P=0.580N P=0.744N P=0.495N P=0.755N |P=0.210 P=0.497N P=0.511N P=0.361 |
|POLY 1.5 | P=0.579N P=0.750N P=0.496N P=0.755N |P=0.214 P=0.499N P=0.506N P=0.363 |
|POLY 6 | P=0.584N P=0.738N P=0.496N P=0.757N |P=0.204 P=0.494N P=0.522N P=0.357 |
|LOGISTIC REGRESSION| P=0.586N P=0.750 P=0.536N P=0.738 |P=0.224 P=0.489N P=0.493N P=0.351 |
|COCH-ARM / FISHERS | P=0.579N P=0.753N P=0.500N P=0.753N |P=0.219 P=0.500N P=0.500N P=0.370 |
|ORDER RESTRICTED | P=0.527N (e) (e) (e) |P=0.252 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |1/50 (2%) 2/50 (4%) 2/50 (4%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/42.29 1/45.99 0/43.74 0/43.55 |1/46.02 2/46.23 2/44.81 2/45.17 |
|POLY-3 PERCENT (g) | 0.0% 2.2% 0.0% 0.0% |2.2% 4.3% 4.5% 4.4% |
|TERMINAL (d) | 0/31 (0%) 1/38 (3%) 0/34 (0%) 0/31 (0%) |0/38 (0%) 0/35 (0%) 1/32 (3%) 1/32 (3%) |
|FIRST INCIDENCE | --- 729 (T) --- --- |710 490 573 719 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.427N P=0.541 (e) (e) |P=0.411 P=0.483 P=0.462 P=0.450 |
|POLY 3 | P=0.400N P=0.517 (e) (e) |P=0.437 P=0.502 P=0.491 P=0.494 |
|POLY 1.5 | P=0.405N P=0.511 (e) (e) |P=0.441 P=0.501 P=0.495 P=0.495 |
|POLY 6 | P=0.395N P=0.523 (e) (e) |P=0.430 P=0.502 P=0.482 P=0.490 |
|LOGISTIC REGRESSION| (e) P=0.541 (e) (e) |P=0.474 P=0.544 P=0.517 P=0.490 |
|COCH-ARM / FISHERS | P=0.414N P=0.500 (e) (e) |P=0.448 P=0.500 P=0.500 P=0.500 |
|ORDER RESTRICTED | P=0.391N (e) (e) (e) |P=0.455 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 15
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |4/50 (8%) 3/50 (6%) 3/50 (6%) 6/50 (12%) |
|POLY-3 RATE (b) | 0/42.29 1/45.99 0/43.74 1/43.81 |4/46.02 3/46.30 3/45.07 6/45.44 |
|POLY-3 PERCENT (g) | 0.0% 2.2% 0.0% 2.3% |8.7% 6.5% 6.7% 13.2% |
|TERMINAL (d) | 0/31 (0%) 1/38 (3%) 0/34 (0%) 0/31 (0%) |3/38 (8%) 0/35 (0%) 1/32 (3%) 2/32 (6%) |
|FIRST INCIDENCE | --- 729 (T) --- 659 |710 490 573 682 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.467 P=0.541 (e) P=0.510 |P=0.181 P=0.535N P=0.568N P=0.295 |
|POLY 3 | P=0.491 P=0.517 (e) P=0.507 |P=0.210 P=0.497N P=0.511N P=0.361 |
|POLY 1.5 | P=0.490 P=0.511 (e) P=0.506 |P=0.214 P=0.499N P=0.506N P=0.363 |
|POLY 6 | P=0.491 P=0.523 (e) P=0.507 |P=0.204 P=0.494N P=0.522N P=0.357 |
|LOGISTIC REGRESSION| P=0.483 P=0.541 (e) P=0.489 |P=0.224 P=0.489N P=0.493N P=0.351 |
|COCH-ARM / FISHERS | P=0.482 P=0.500 (e) P=0.500 |P=0.219 P=0.500N P=0.500N P=0.370 |
|ORDER RESTRICTED | P=0.258 (e) (e) (e) |P=0.252 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Skin |
| Fibrous Histiocytoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |3/50 (6%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/42.29 0/45.99 0/43.74 1/43.81 |3/45.94 0/45.44 0/44.30 0/45.13 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 2.3% |6.5% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/38 (0%) 0/34 (0%) 0/31 (0%) |3/38 (8%) 0/35 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE | --- --- --- 659 |729 (T) --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.180 (e) (e) P=0.510 |P=0.112N P=0.136N P=0.153N P=0.153N |
|POLY 3 | P=0.183 (e) (e) P=0.507 |P=0.092N P=0.121N P=0.125N P=0.122N |
|POLY 1.5 | P=0.185 (e) (e) P=0.506 |P=0.091N P=0.120N P=0.122N P=0.121N |
|POLY 6 | P=0.181 (e) (e) P=0.507 |P=0.093N P=0.121N P=0.131N P=0.124N |
|LOGISTIC REGRESSION| P=0.179 (e) (e) P=0.489 |P=0.112N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.184 (e) (e) P=0.500 |P=0.094N P=0.121N P=0.121N P=0.121N |
|ORDER RESTRICTED | P=0.127 (e) (e) (e) |P=0.009N** (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 16
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Skin |
| Neurofibrosarcoma or Schwannoma (malignant or NOS) |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/42.29 0/45.99 0/43.74 0/43.55 |0/45.94 2/46.42 0/44.30 1/45.13 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |0.0% 4.3% 0.0% 2.2% |
|TERMINAL (d) | 0/31 (0%) 0/38 (0%) 0/34 (0%) 0/31 (0%) |0/38 (0%) 0/35 (0%) 0/32 (0%) 1/32 (3%) |
|FIRST INCIDENCE | --- --- --- --- |--- 383 --- 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.631N P=0.237 (e) P=0.466 |
|POLY 3 | (e) (e) (e) (e) |P=0.611N P=0.240 (e) P=0.496 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.609N P=0.239 (e) P=0.497 |
|POLY 6 | (e) (e) (e) (e) |P=0.616N P=0.240 (e) P=0.494 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.536N P=0.321 (e) P=0.466 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.606N P=0.247 (e) P=0.500 |
|ORDER RESTRICTED | (e) (e) (e) (e) |P=0.322 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Skin |
| Neurofibrosarcoma, Neurofibroma, or Schwannoma (benign, |
| malignant or NOS) |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 2/50 (4%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/42.29 0/45.99 0/43.74 0/43.55 |0/45.94 2/46.42 0/44.30 2/45.13 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |0.0% 4.3% 0.0% 4.4% |
|TERMINAL (d) | 0/31 (0%) 0/38 (0%) 0/34 (0%) 0/31 (0%) |0/38 (0%) 0/35 (0%) 0/32 (0%) 2/32 (6%) |
|FIRST INCIDENCE | --- --- --- --- |--- 383 --- 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.323 P=0.237 (e) P=0.201 |
|POLY 3 | (e) (e) (e) (e) |P=0.347 P=0.240 (e) P=0.233 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.349 P=0.239 (e) P=0.234 |
|POLY 6 | (e) (e) (e) (e) |P=0.342 P=0.240 (e) P=0.231 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.398 P=0.321 (e) P=0.201 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.354 P=0.247 (e) P=0.247 |
|ORDER RESTRICTED | (e) (e) (e) (e) |P=0.113 (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 17
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |1/50 (2%) 1/50 (2%) 1/50 (2%) 4/50 (8%) |
|POLY-3 RATE (b) | 0/42.29 0/45.99 0/43.74 0/43.55 |1/45.94 1/45.52 1/44.56 4/45.40 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |2.2% 2.2% 2.2% 8.8% |
|TERMINAL (d) | 0/31 (0%) 0/38 (0%) 0/34 (0%) 0/31 (0%) |1/38 (3%) 0/35 (0%) 0/32 (0%) 1/32 (3%) |
|FIRST INCIDENCE | --- --- --- --- |729 (T) 710 659 682 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.056 P=0.743 P=0.736 P=0.152 |
|POLY 3 | (e) (e) (e) (e) |P=0.063 P=0.759 P=0.754 P=0.175 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.064 P=0.759 P=0.757 P=0.176 |
|POLY 6 | (e) (e) (e) (e) |P=0.062 P=0.758 P=0.748 P=0.173 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.064 P=0.760 P=0.760N P=0.173 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.065 P=0.753N P=0.753N P=0.181 |
|ORDER RESTRICTED | (e) (e) (e) (e) |P=0.073 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/47 (4%) 3/50 (6%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 0/48 (0%) |
|POLY-3 RATE (b) | 2/40.70 3/45.99 0/43.74 0/43.55 |0/45.94 0/45.44 0/44.30 0/44.12 |
|POLY-3 PERCENT (g) | 4.9% 6.5% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/30 (7%) 3/38 (8%) 0/34 (0%) 0/31 (0%) |0/38 (0%) 0/35 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.045N* P=0.608 P=0.211N P=0.231N |(e) (e) (e) (e) |
|POLY 3 | P=0.039N* P=0.555 P=0.221N P=0.222N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.039N* P=0.544 P=0.222N P=0.222N |(e) (e) (e) (e) |
|POLY 6 | P=0.040N* P=0.568 P=0.221N P=0.224N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.045N* P=0.608 (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.039N* P=0.530 P=0.232N P=0.232N |(e) (e) (e) (e) |
|ORDER RESTRICTED | P=0.089N (e) (e) (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 18
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |1/50 (2%) 1/50 (2%) 3/50 (6%) 1/50 (2%) |
|POLY-3 RATE (b) | 1/42.56 1/45.99 0/43.74 1/43.55 |1/45.94 1/45.44 3/44.34 1/45.13 |
|POLY-3 PERCENT (g) | 2.4% 2.2% 0.0% 2.3% |2.2% 2.2% 6.8% 2.2% |
|TERMINAL (d) | 0/31 (0%) 1/38 (3%) 0/34 (0%) 1/31 (3%) |1/38 (3%) 1/35 (3%) 2/32 (6%) 1/32 (3%) |
|FIRST INCIDENCE | 655 729 (T) --- 729 (T) |729 (T) 729 (T) 718 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.601N P=0.721N P=0.505N P=0.757N |P=0.453 P=0.743 P=0.249 P=0.723 |
|POLY 3 | P=0.580N P=0.743N P=0.495N P=0.756N |P=0.503 P=0.758 P=0.293 P=0.757 |
|POLY 1.5 | P=0.579N P=0.749N P=0.496N P=0.756N |P=0.505 P=0.759 P=0.299 P=0.758 |
|POLY 6 | P=0.584N P=0.737N P=0.495N P=0.758N |P=0.498 P=0.758 P=0.282 P=0.754 |
|LOGISTIC REGRESSION| P=0.580N P=0.763N P=0.510N P=0.760N |P=0.470 P=0.743 P=0.258 P=0.723 |
|COCH-ARM / FISHERS | P=0.579N P=0.753N P=0.500N P=0.753N |P=0.510 P=0.753N P=0.309 P=0.753N |
|ORDER RESTRICTED | P=0.527N (e) (e) (e) |P=0.428 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |1/50 (2%) 1/50 (2%) 2/50 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/42.29 0/45.99 0/43.74 1/43.55 |1/45.94 1/45.44 2/44.34 0/45.13 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 2.3% |2.2% 2.2% 4.5% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/38 (0%) 0/34 (0%) 1/31 (3%) |1/38 (3%) 1/35 (3%) 1/32 (3%) 0/32 (0%) |
|FIRST INCIDENCE | --- --- --- 729 (T) |729 (T) 729 (T) 718 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.170 (e) (e) P=0.500 |P=0.421N P=0.743 P=0.442 P=0.534N |
|POLY 3 | P=0.183 (e) (e) P=0.506 |P=0.383N P=0.758 P=0.488 P=0.504N |
|POLY 1.5 | P=0.184 (e) (e) P=0.505 |P=0.381N P=0.759 P=0.494 P=0.503N |
|POLY 6 | P=0.179 (e) (e) P=0.505 |P=0.387N P=0.758 P=0.478 P=0.506N |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.500 |P=0.404N P=0.743 P=0.458 (e) |
|COCH-ARM / FISHERS | P=0.184 (e) (e) P=0.500 |P=0.377N P=0.753N P=0.500 P=0.500N |
|ORDER RESTRICTED | P=0.126 (e) (e) (e) |P=0.269N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 19
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 2/50 (4%) 0/50 (0%) 1/50 (2%) | |
|POLY-3 RATE (b) | 0/42.26 2/45.99 0/43.74 1/43.55 | |
|POLY-3 PERCENT (g) | 0.0% 4.4% 0.0% 2.3% | |
|TERMINAL (d) | 0/31 (0%) 2/38 (5%) 0/34 (0%) 1/31 (3%) | |
|FIRST INCIDENCE | --- 729 (T) --- 729 (T) | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.634N P=0.284 (e) P=0.500 | |
|POLY 3 | P=0.594N P=0.256 (e) P=0.506 | |
|POLY 1.5 | P=0.598N P=0.250 (e) P=0.506 | |
|POLY 6 | P=0.591N P=0.264 (e) P=0.505 | |
|LOGISTIC REGRESSION| (e) P=0.284 (e) P=0.500 | |
|COCH-ARM / FISHERS | P=0.603N P=0.253 (e) P=0.505 | |
|ORDER RESTRICTED | P=0.330 (e) (e) (e) | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/48 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) |3/50 (6%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/41.70 0/45.99 1/43.74 1/43.55 |3/46.00 0/45.44 0/44.30 0/45.13 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.3% 2.3% |6.5% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/38 (0%) 1/34 (3%) 1/31 (3%) |2/38 (5%) 0/35 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE | --- --- 729 (T) 729 (T) |714 --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.183 (e) P=0.518 P=0.500 |P=0.111N P=0.138N P=0.156N P=0.151N |
|POLY 3 | P=0.199 (e) P=0.509 P=0.509 |P=0.091N P=0.121N P=0.126N P=0.122N |
|POLY 1.5 | P=0.203 (e) P=0.509 P=0.509 |P=0.091N P=0.120N P=0.122N P=0.121N |
|POLY 6 | P=0.193 (e) P=0.509 P=0.506 |P=0.093N P=0.122N P=0.131N P=0.124N |
|LOGISTIC REGRESSION| (e) (e) P=0.518 P=0.500 |P=0.102N P=0.123N P=0.138N P=0.129N |
|COCH-ARM / FISHERS | P=0.205 (e) P=0.510 P=0.510 |P=0.094N P=0.121N P=0.121N P=0.121N |
|ORDER RESTRICTED | P=0.259 (e) (e) (e) |P=0.009N** (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 20
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/42.29 0/45.99 0/43.74 0/43.55 |2/46.48 0/45.44 0/44.30 0/45.13 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |4.3% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/38 (0%) 0/34 (0%) 0/31 (0%) |1/38 (3%) 0/35 (0%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE | --- --- --- --- |563 --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.188N P=0.249N P=0.259N P=0.256N |
|POLY 3 | (e) (e) (e) (e) |P=0.176N P=0.242N P=0.248N P=0.244N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.175N P=0.241N P=0.243N P=0.242N |
|POLY 6 | (e) (e) (e) (e) |P=0.177N P=0.244N P=0.256N P=0.248N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.160N P=0.212N P=0.220N P=0.205N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.178N P=0.247N P=0.247N P=0.247N |
|ORDER RESTRICTED | (e) (e) (e) (e) |P=0.032N* (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 0/50 (0%) |3/50 (6%) 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/42.29 1/45.99 2/43.85 0/43.55 |3/45.94 1/45.44 2/44.56 1/45.13 |
|POLY-3 PERCENT (g) | 0.0% 2.2% 4.6% 0.0% |6.5% 2.2% 4.5% 2.2% |
|TERMINAL (d) | 0/31 (0%) 1/38 (3%) 1/34 (3%) 0/31 (0%) |3/38 (8%) 1/35 (3%) 1/32 (3%) 1/32 (3%) |
|FIRST INCIDENCE | --- 729 (T) 699 --- |729 (T) 729 (T) 659 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.606N P=0.541 P=0.253 (e) |P=0.399N P=0.335N P=0.567N P=0.368N |
|POLY 3 | P=0.575N P=0.517 P=0.245 (e) |P=0.353N P=0.309N P=0.514N P=0.312N |
|POLY 1.5 | P=0.573N P=0.511 P=0.243 (e) |P=0.351N P=0.308N P=0.507N P=0.310N |
|POLY 6 | P=0.580N P=0.523 P=0.247 (e) |P=0.357N P=0.310N P=0.525N P=0.315N |
|LOGISTIC REGRESSION| P=0.591N P=0.541 P=0.245 (e) |P=0.361N P=0.335N P=0.523N P=0.368N |
|COCH-ARM / FISHERS | P=0.579N P=0.500 P=0.247 (e) |P=0.347N P=0.309N P=0.500N P=0.309N |
|ORDER RESTRICTED | P=0.331 (e) (e) (e) |P=0.226N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 21
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 4/50 (8%) 0/50 (0%) 2/50 (4%) |1/50 (2%) 2/50 (4%) 2/50 (4%) 1/50 (2%) |
|POLY-3 RATE (b) | 4/42.29 4/45.99 0/43.74 2/43.55 |1/46.22 2/45.44 2/44.76 1/45.49 |
|POLY-3 PERCENT (g) | 9.5% 8.7% 0.0% 4.6% |2.2% 4.4% 4.5% 2.2% |
|TERMINAL (d) | 4/31 (13%) 4/38 (11%) 0/34 (0%) 2/31 (7%) |0/38 (0%) 2/35 (6%) 0/32 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) --- 729 (T) |653 729 (T) 617 629 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.146N P=0.528N P=0.051N P=0.335N |P=0.531N P=0.481 P=0.473 P=0.755N |
|POLY 3 | P=0.127N P=0.597N P=0.056N P=0.323N |P=0.516N P=0.494 P=0.489 P=0.757 |
|POLY 1.5 | P=0.125N P=0.613N P=0.057N P=0.325N |P=0.514N P=0.496 P=0.494 P=0.758 |
|POLY 6 | P=0.130N P=0.578N P=0.055N P=0.325N |P=0.521N P=0.491 P=0.479 P=0.755 |
|LOGISTIC REGRESSION| P=0.146N P=0.528N (e) P=0.335N |P=0.497N P=0.499 P=0.521 P=0.737N |
|COCH-ARM / FISHERS | P=0.126N P=0.643N P=0.059N P=0.339N |P=0.510N P=0.500 P=0.500 P=0.753N |
|ORDER RESTRICTED | P=0.118N (e) (e) (e) |P=0.536 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 5/50 (10%) 2/50 (4%) 2/50 (4%) |4/50 (8%) 3/50 (6%) 4/50 (8%) 2/50 (4%) |
|POLY-3 RATE (b) | 4/42.29 5/45.99 2/43.85 2/43.55 |4/46.22 3/45.44 4/45.02 2/45.49 |
|POLY-3 PERCENT (g) | 9.5% 10.9% 4.6% 4.6% |8.7% 6.6% 8.9% 4.4% |
|TERMINAL (d) | 4/31 (13%) 5/38 (13%) 1/34 (3%) 2/31 (7%) |3/38 (8%) 3/35 (9%) 1/32 (3%) 1/32 (3%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 699 729 (T) |653 729 (T) 617 629 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.165N P=0.628 P=0.301N P=0.335N |P=0.379N P=0.538N P=0.574 P=0.389N |
|POLY 3 | P=0.138N P=0.552 P=0.320N P=0.323N |P=0.331N P=0.509N P=0.629 P=0.345N |
|POLY 1.5 | P=0.136N P=0.534 P=0.325N P=0.325N |P=0.330N P=0.506N P=0.636 P=0.343N |
|POLY 6 | P=0.143N P=0.573 P=0.316N P=0.325N |P=0.335N P=0.514N P=0.617 P=0.349N |
|LOGISTIC REGRESSION| P=0.162N P=0.628 P=0.315N P=0.335N |P=0.326N P=0.507N P=0.638N P=0.336N |
|COCH-ARM / FISHERS | P=0.137N P=0.500 P=0.339N P=0.339N |P=0.325N P=0.500N P=0.643N P=0.339N |
|ORDER RESTRICTED | P=0.259N (e) (e) (e) |P=0.341N (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 22
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 5/50 (10%) 3/50 (6%) 2/50 (4%) |27/50 (54%) 24/50 (48%) 17/50 (34%) 14/50 (28%) |
|POLY-3 RATE (b) | 0/42.29 5/45.99 3/45.77 2/43.55 |27/46.69 24/46.42 17/45.30 14/46.14 |
|POLY-3 PERCENT (g) | 0.0% 10.9% 6.6% 4.6% |57.8% 51.7% 37.5% 30.3% |
|TERMINAL (d) | 0/31 (0%) 5/38 (13%) 0/34 (0%) 2/31 (7%) |25/38 (66%) 21/35 (60%) 12/32 (38%) 11/32 (34%) |
|FIRST INCIDENCE | --- 729 (T) 367 729 (T) |474 490 618 430 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.572N P=0.053 P=0.127 P=0.238 |P=0.015N* P=0.496N P=0.133N P=0.034N* |
|POLY 3 | P=0.518N P=0.038 * P=0.133 P=0.244 |P=0.002N** P=0.348N P=0.036N* P=0.005N** |
|POLY 1.5 | P=0.522N P=0.035 * P=0.129 P=0.243 |P=0.002N** P=0.351N P=0.035N* P=0.006N** |
|POLY 6 | P=0.520N P=0.041 * P=0.137 P=0.242 |P=0.002N** P=0.341N P=0.040N* P=0.005N** |
|LOGISTIC REGRESSION| P=0.562N P=0.053 P=0.034 * P=0.238 |P=0.003N** P=0.360N P=0.050N P=0.008N** |
|COCH-ARM / FISHERS | P=0.540N P=0.028 * P=0.121 P=0.247 |P=0.003N** P=0.345N P=0.035N* P=0.007N** |
|ORDER RESTRICTED | P=0.108 (e) (e) (e) |P=0.003N** (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 25/50 (50%) 38/50 (76%) 42/50 (84%) 46/50 (92%) |29/50 (58%) 33/50 (66%) 41/50 (82%) 38/50 (76%) |
|POLY-3 RATE (b) | 25/44.13 38/47.73 42/46.46 46/48.58 |29/47.59 33/47.80 41/47.98 38/46.23 |
|POLY-3 PERCENT (g) | 56.7% 79.6% 90.4% 94.7% |60.9% 69.0% 85.5% 82.2% |
|TERMINAL (d) | 19/31 (61%) 31/38 (82%) 32/34 (94%) 31/31 (100%)|23/38 (61%) 25/35 (71%) 28/32 (88%) 30/32 (94%) |
|FIRST INCIDENCE | 482 573 573 469 |563 487 553 636 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P=0.118 P=0.005 ** P<0.001 ** |P=0.005 ** P=0.178 P=0.003 ** P=0.006 ** |
|POLY 3 | P<0.001 ** P=0.012 * P<0.001 ** P<0.001 ** |P=0.005 ** P=0.267 P=0.004 ** P=0.015 * |
|POLY 1.5 | P<0.001 ** P=0.008 ** P<0.001 ** P<0.001 ** |P=0.008 ** P=0.266 P=0.005 ** P=0.022 * |
|POLY 6 | P<0.001 ** P=0.018 * P<0.001 ** P<0.001 ** |P=0.002 ** P=0.264 P=0.004 ** P=0.009 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.019 * P<0.001 ** P<0.001 ** |P=0.014 * P=0.251 P=0.005 ** P=0.028 * |
|COCH-ARM / FISHERS | P<0.001 ** P=0.006 ** P<0.001 ** P<0.001 ** |P=0.022 * P=0.268 P=0.008 ** P=0.044 * |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |P=0.005 ** (e) (e) (e) |
|=================================================================================================================================|
Date: 05/19/04 EXPERIMENT: 96017 TEST: 06 Page 23
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (DIBROMOAC
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 23/50 (46%) 28/50 (56%) 32/50 (64%) 43/50 (86%) |36/50 (72%) 37/50 (74%) 34/50 (68%) 32/50 (64%) |
|POLY-3 RATE (b) | 23/45.18 28/47.09 32/49.55 43/49.30 |36/48.25 37/48.14 34/48.06 32/48.45 |
|POLY-3 PERCENT (g) | 50.9% 59.5% 64.6% 87.2% |74.6% 76.9% 70.8% 66.0% |
|TERMINAL (d) | 12/31 (39%) 22/38 (58%) 17/34 (50%) 25/31 (81%) |29/38 (76%) 27/35 (77%) 19/32 (59%) 18/32 (56%) |
|FIRST INCIDENCE | 451 596 367 469 |474 383 573 430 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P=0.538 P=0.162 P=0.002 ** |P=0.481N P=0.324 P=0.376 P=0.539 |
|POLY 3 | P<0.001 ** P=0.267 P=0.125 P<0.001 ** |P=0.124N P=0.491 P=0.421N P=0.240N |
|POLY 1.5 | P<0.001 ** P=0.250 P=0.096 P<0.001 ** |P=0.139N P=0.495 P=0.422N P=0.256N |
|POLY 6 | P<0.001 ** P=0.274 P=0.156 P<0.001 ** |P=0.106N P=0.484 P=0.410N P=0.220N |
|LOGISTIC REGRESSION| P<0.001 ** P=0.305 P=0.051 P<0.001 ** |P=0.155N P=0.482 P=0.443N P=0.271N |
|COCH-ARM / FISHERS | P<0.001 ** P=0.212 P=0.054 P<0.001 ** |P=0.147N P=0.500 P=0.414N P=0.260N |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |P=0.221N (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 50 MG/L 500 MG/L 1000 |0 MG/L 50 MG/L 500 MG/L 1000 |
| | MG/L | MG/L |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 37/50 (74%) 44/50 (88%) 49/50 (98%) 50/50 (100%)|42/50 (84%) 43/50 (86%) 46/50 (92%) 48/50 (96%) |
|POLY-3 RATE (b) | 37/46.78 44/48.04 49/50.00 50/50.00 |42/49.36 43/48.89 46/48.62 48/49.06 |
|POLY-3 PERCENT (g) | 79.1% 91.6% 98.0% 100.0% |85.1% 88.0% 94.6% 97.9% |
|TERMINAL (d) | 23/31 (74%) 35/38 (92%) 33/34 (97%) 31/31 (100%)|31/38 (82%) 31/35 (89%) 30/32 (94%) 31/32 (97%) |
|FIRST INCIDENCE | 451 573 367 469 |474 383 553 430 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.004 ** P=0.550N P=0.094 P=0.031 * |P=0.019 * P=0.308 P=0.059 P=0.033 * |
|POLY 3 | P<0.001 ** P=0.067 P=0.002 ** P<0.001 ** |P=0.008 ** P=0.452 P=0.103 P=0.025 * |
|POLY 1.5 | P<0.001 ** P=0.065 P<0.001 ** P<0.001 ** |P=0.009 ** P=0.477 P=0.126 P=0.025 * |
|POLY 6 | P<0.001 ** P=0.066 P=0.004 ** P<0.001 ** |P=0.010 * P=0.406 P=0.089 P=0.028 * |
|LOGISTIC REGRESSION| P<0.001 ** P=0.140 P<0.001 ** P<0.001 ** |P=0.015 * P=0.492 P=0.151 P=0.035 * |
|COCH-ARM / FISHERS | P<0.001 ** P=0.062 P<0.001 ** P<0.001 ** |P=0.022 * P=0.500 P=0.178 P=0.046 * |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) |P=0.012 * (e) (e) (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).