TDMS Study 96017-06 Pathology Tables
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
FINAL#1 MICE
Facility: Southern Research Institute
Chemical CAS #: 631-64-1
Lock Date: 11/15/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| 3| 3| 2| 3| 5| 3| 3| 3|
| 7| 7| 4| 1| 7| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 3| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 4 3 |
Infiltration Cellular, Mixed Cell | 4 2 1 1|
Mixed Cell Focus | X |
Necrosis, Focal | 1|
Tension Lipidosis | |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Pigmentation | 3 2|
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + |
Fat, Necrosis | 4 4 2 4 4 2 2 4 4 4 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Cytoplasmic Alteration | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| 3| 3| 2| 3| 5| 3| 3| 3|
| 7| 7| 4| 1| 7| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 3| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hyperplasia, Lymphoid | 3 3 3 3 3 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
Epithelium, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + M + M + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 3 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Intermedia, Hyperplasia, Focal | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 2 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| 3| 3| 2| 3| 5| 3| 3| 3|
| 7| 7| 4| 1| 7| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 3| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Follicular Cell, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + M +|
Angiectasis | 3 3 |
Cyst | 3 3 3 4 3 3|
Corpus Luteum, Hyperplasia | 3 |
Granulosa Cell, Hyperplasia | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 4 4 4 4 4 3 4 3 3 2 4 2 4 4 4 4 3 3 4 4|
Inflammation, Chronic | 2 |
Metaplasia, Squamous | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 4 2 3 3 4 2 4 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Iliac, Hemorrhage | |
Iliac, Hyperplasia, Lymphoid | 2 |
Iliac, Pigmentation | |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Pigmentation | 2 |
Renal, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Lymphoid | 3 2 2 2 3 3 2 2 |
Pigmentation | 2 2 2 2 2 2 3 3 2 3 2 2|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| 3| 3| 2| 3| 5| 3| 3| 3|
| 7| 7| 4| 1| 7| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 3| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 2 2 2 3|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 4 2 1 1 1 3 2 2 4 3 1 3 3 3 2 |
Necrosis | |
Pigmentation | 3 3 3 |
Lymphoid Follicle, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 |
Epidermis, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| 3| 3| 2| 3| 5| 3| 3| 3|
| 7| 7| 4| 1| 7| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 3| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Histiocyte | 3 |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Cornea, Hyperplasia | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 2 |
Infarct | 2 2 |
Nephropathy | 1 2 2 2 1 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hyperplasia, Lymphoid | 3 3 3|
__________________________________________|__________________________________________________________________________
Page 6
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 7| 5| |
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 3| 6| 6| 1| 6| 7| 7| 0| 7| 7| 5| 5| 5| 4| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + A + + + + + + + + + + A + + + + + + + + + + A| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + A +| 47 |
Edema | | 2 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + M A| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + A A| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + M + + + + + + + + + + + + + + + + A| 45 |
|__________________________________________________________________________|____________|
Liver | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 4.0|
Clear Cell Focus | X X| 3 |
Eosinophilic Focus | X X | 7 |
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Hyperplasia, Lymphoid | | 2 3.5|
Infiltration Cellular, Mixed Cell | 3 2 2 | 7 2.1|
Mixed Cell Focus | X | 2 |
Necrosis, Focal | 2 2 | 3 1.7|
Tension Lipidosis | X | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 4 3 | 2 3.5|
Kupffer Cell, Pigmentation | 2 | 3 2.3|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + | 28 |
Fat, Necrosis | 4 3 4 3 4 3 3 3 4 2 2 | 22 3.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 7| 5| |
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 3| 6| 6| 1| 6| 7| 7| 0| 7| 7| 5| 5| 5| 4| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Cytoplasmic Alteration | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 3 3 3 2 3 2 2 3 2 | 15 2.7|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 3 | 1 3.0|
Ulcer | 2 | 1 2.0|
Epithelium, Hyperplasia | 1 3 | 4 1.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Tongue | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 | 9 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + M + + + + + + + + + + + +| 45 |
Cyst | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 7| 5| |
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 3| 6| 6| 1| 6| 7| 7| 0| 7| 7| 5| 5| 5| 4| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pituitary Gland | + + M + + + + + + M + + + + + + + + M + + + + + +| 47 |
Pars Distalis, Angiectasis | 2 3 | 2 2.5|
Pars Distalis, Cyst | | 2 3.0|
Pars Distalis, Hyperplasia, Focal | 2 4 | 4 2.5|
Pars Intermedia, Hyperplasia, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 2 2 3| 10 1.7|
Follicular Cell, Hyperplasia | 1 1 1 1 1 | 8 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 4 2 | 5 2.8|
Cyst | 3 3 3 3 3 3 3 3 | 14 3.1|
Corpus Luteum, Hyperplasia | | 1 3.0|
Granulosa Cell, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 4 3 2 2 3 4 4 2 2 4 4 2 2 4 4 4 4 2 4 4 4 2| 44 3.3|
Inflammation, Chronic | | 1 2.0|
Metaplasia, Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 2 3 4 4 2 2 2 2| 20 2.9|
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 12 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 7| 5| |
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 3| 6| 6| 1| 6| 7| 7| 0| 7| 7| 5| 5| 5| 4| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Iliac, Hemorrhage | 3 | 1 3.0|
Iliac, Hyperplasia, Lymphoid | | 1 2.0|
Iliac, Pigmentation | 3 | 1 3.0|
Mediastinal, Hemorrhage | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Pigmentation | | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + I + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia, Lymphoid | 2 2 3 2 2 | 13 2.3|
Pigmentation | 2 2 2 2 2 2 | 18 2.2|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | | 2 1.5|
Hemorrhage | 4 | 1 4.0|
Hyperplasia, Lymphoid | 2 2 2 | 8 2.3|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 1 1 3 1 2 3 3 1 2 4 4 1 1 3 4| 34 2.2|
Necrosis | 4 | 1 4.0|
Pigmentation | 3 2 | 5 2.8|
Lymphoid Follicle, Hyperplasia | 3 3 2 4 2 2 | 8 2.5|
|__________________________________________________________________________|____________|
Thymus | + + A + + + M + + + + + + + M + + I + + M + + + +| 44 |
Atrophy | 4 3 3 3 | 8 3.0|
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 1 1 | 5 1.8|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 7| 5| |
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 3| 6| 6| 1| 6| 7| 7| 0| 7| 7| 5| 5| 5| 4| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Ulcer | 3 | 2 2.0|
Epidermis, Hyperplasia | 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + +| 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 2 2 | 5 2.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 3 1 1 | 3 1.7|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 2 1.5|
Cornea, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 3 | 2 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 7| 5| |
| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 3| 6| 6| 1| 6| 7| 7| 0| 7| 7| 5| 5| 5| 4| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 3 2 | 7 2.3|
Infarct | 1 | 3 1.7|
Nephropathy | 1 1 1 1 3 1 4 1 2 | 14 1.6|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 | 1 3.0|
Renal Tubule, Pigmentation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 2 3.0|
Hyperplasia, Lymphoid | | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 8| 1| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 2|
| 5| 5| 5| 0| 5| 3| 5| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 7| 6| 9| 6| 6| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + I + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + M|
Edema | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X |
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Mixed Cell | 2 4 |
Mixed Cell Focus | X X X X |
Necrosis, Focal | 3 3|
Tension Lipidosis | X |
Centrilobular, Necrosis | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + |
Fat, Necrosis | 4 3 3 3 2 3 4 3 4 3 4 3 |
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 8| 1| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 2|
| 5| 5| 5| 0| 5| 3| 5| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 7| 6| 9| 6| 6| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Oral Mucosa | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | 2 |
Ulcer | |
Epithelium, Hyperplasia | 3 3|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Pylorus, Epithelium, Hyperplasia, | |
Atypical | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 3 |
Hyperplasia, Focal | 3 |
Hypertrophy, Focal | 2 |
Capsule, Hyperplasia | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 8| 1| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 2|
| 5| 5| 5| 0| 5| 3| 5| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 7| 6| 9| 6| 6| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2|
Pars Distalis, Cyst | 3 |
Pars Distalis, Hyperplasia, Focal | 4 1 3 3 2 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 1 2 2 1 1 2 2 1 1 3 2 2 1 3 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 |
Cyst | 3 3 3 3 3 |
Corpus Luteum, Hyperplasia | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 |
Hyperplasia, Cystic | 4 3 3 4 3 3 2 3 3 4 3 3 4 4 4 2 4 3 3 3 3 3|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 4 3 3 3 2 3 2 3 2 2 2 3 4|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 8| 1| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 2|
| 5| 5| 5| 0| 5| 3| 5| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 7| 6| 9| 6| 6| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Infiltration Cellular, Mast Cell | 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + +|
Hyperplasia, Lymphoid | 2 |
Bronchial, Hemorrhage | |
Bronchial, Hyperplasia, Lymphoid | |
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hematopoietic Cell | |
Proliferation | |
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 3 2 2 |
Pigmentation | 3 2 3 2 3 2 2 2 2 2 2 3 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 3 2 2 2 2 4 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 3 3 1 4 4 2 2 1 2 4 3 2 3 3 2 1 2 3 3 3 3|
Pigmentation | 3 3 3 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 3 4 2 1 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 4 |
Hyperplasia, Lymphoid | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 8| 1| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 2|
| 5| 5| 5| 0| 5| 3| 5| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 7| 6| 9| 6| 6| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Hyperplasia | 3 2 1 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Ulcer | 4 |
Epidermis, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 2 |
|__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | 3|
Necrosis | 2|
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 2 2 |
Infiltration Cellular, Histiocyte | 3 1 |
Alveolar Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 8| 1| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 2|
| 5| 5| 5| 0| 5| 3| 5| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 7| 6| 9| 6| 6| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hyperplasia, Lymphoid | |
Infarct | 3 2 2 |
Nephropathy | 1 1 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 3 |
__________________________________________|__________________________________________________________________________
Page 18
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 9| 0| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 8| 0| 3| 3| 3| |
| 5| 5| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 1| 7| 4| 1| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + I + + + + + + + + + + + A A + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + A + + +| 46 |
Edema | 2 | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
Epithelium, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + A + + +| 47 |
Hyperplasia, Lymphoid | 4 | 2 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + M A + + +| 47 |
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 2 | 2 3.0|
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | | 6 |
Hematopoietic Cell Proliferation | 2 3| 4 2.5|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | 3 2 2 3 2 | 7 2.6|
Mixed Cell Focus | X X | 6 |
Necrosis, Focal | | 2 3.0|
Tension Lipidosis | X X | 3 |
Centrilobular, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 9| 0| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 8| 0| 3| 3| 3| |
| 5| 5| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 1| 7| 4| 1| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 4 3 | 7 3.1|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 20 |
Fat, Necrosis | 4 4 3 4 4 4 | 18 3.4|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Atrophy | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 3 2 3 2 2 2 2| 13 2.2|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
Inflammation, Chronic | 2 | 2 2.0|
Ulcer | 2 | 1 2.0|
Epithelium, Hyperplasia | 3 1 3 | 5 2.6|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 3.0|
Pylorus, Epithelium, Hyperplasia, | | |
Atypical | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 3 | 1 3.0|
Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 9| 0| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 8| 0| 3| 3| 3| |
| 5| 5| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 1| 7| 4| 1| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 | 11 3.0|
Hyperplasia, Focal | 2 | 2 2.5|
Hypertrophy, Focal | | 1 2.0|
Capsule, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Hyperplasia | 2 2 | 5 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 2 | 3 2.0|
Pars Distalis, Cyst | 3 | 2 3.0|
Pars Distalis, Hyperplasia, Focal | 2 2 2 | 9 2.2|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 3 2 2 2 3 1 2 2 3 1 | 26 1.9|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + M + M + + + + + + + I + + + + + + + +| 47 |
Angiectasis | 2 | 3 2.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 9| 0| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 8| 0| 3| 3| 3| |
| 5| 5| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 1| 7| 4| 1| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Cyst | 3 3 3 3 3 3 1 | 12 2.8|
Corpus Luteum, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 3 | 4 3.0|
Hyperplasia, Cystic | 4 4 4 4 4 2 3 4 2 4 4 4 4 3 4 4 4 3 2 3 | 42 3.4|
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 4 3 4 2 3 3 2 4 4 4| 26 2.9|
Infiltration Cellular, Mast Cell | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + +| 13 |
Hyperplasia, Lymphoid | | 1 2.0|
Bronchial, Hemorrhage | 3 | 1 3.0|
Bronchial, Hyperplasia, Lymphoid | 2 | 1 2.0|
Iliac, Hematopoietic Cell | | |
Proliferation | 3| 1 3.0|
Iliac, Hyperplasia, Lymphoid | 2| 1 2.0|
Inguinal, Hematopoietic Cell | | |
Proliferation | 3| 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 2| 2 2.5|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | 2| 1 2.0|
Hemorrhage | 2 1 | 2 1.5|
Hyperplasia, Lymphoid | 3 2 | 6 2.3|
Pigmentation | 2 2 2 2 2 3 2 3 2 2 2 | 25 2.2|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 9| 0| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 8| 0| 3| 3| 3| |
| 5| 5| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 1| 7| 4| 1| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 3 2 | 9 2.4|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 3 2 2 3 2 4 4 2 2 2 1 1 1 4 3 3 2 4| 42 2.5|
Pigmentation | 3 3 | 5 3.0|
Lymphoid Follicle, Atrophy | 2 | 1 2.0|
Lymphoid Follicle, Hyperplasia | 2 3 2 4 3 4 | 11 2.8|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + M + + + A + + +| 47 |
Atrophy | 3 2 3 4 2| 9 3.0|
Hyperplasia, Lymphoid | 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 6 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Ulcer | | 1 4.0|
Epidermis, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | | 2 2.5|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Compression | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 9| 0| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 8| 0| 3| 3| 3| |
| 5| 5| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 1| 7| 4| 1| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Hemorrhage | 2 | 2 2.5|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 2 2.5|
Hyperplasia, Lymphoid | 2 3 | 5 2.2|
Infiltration Cellular, Histiocyte | | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 1 | 3 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 3 2 3 3 | 4 2.8|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 9| 0| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 8| 0| 3| 3| 3| |
| 5| 5| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 1| 7| 4| 1| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Hyperplasia, Lymphoid | 3 2 | 2 2.5|
Infarct | 2 1 2 1 1 | 8 1.8|
Nephropathy | 1 1 2 2 2 1 | 8 1.4|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 3.0|
Renal Tubule, Dilatation | 3 | 2 2.5|
Renal Tubule, Necrosis | | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 2 | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 2| 0| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3|
| 7| 9| 7| 7| 7| 7| 7| 4| 7| 5| 2| 9| 5| 9| 1| 7| 7| 7| 7| 0| 6| 3| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A A + + + + + + + A A + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X X |
Hematopoietic Cell Proliferation | 3 3 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | X |
Necrosis, Focal | 2 1 |
Centrilobular, Necrosis | 4 3 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + + +|
Fat, Necrosis | 4 4 4 4 3|
|__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 2| 0| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3|
| 7| 9| 7| 7| 7| 7| 7| 4| 7| 5| 2| 9| 5| 9| 1| 7| 7| 7| 7| 0| 6| 3| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 3 4 2|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
Hypertrophy | |
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | 3 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Angiectasis | 2 |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 2| 0| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3|
| 7| 9| 7| 7| 7| 7| 7| 4| 7| 5| 2| 9| 5| 9| 1| 7| 7| 7| 7| 0| 6| 3| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 1 2 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 2 3 3 1 3 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Ovary | + + + M + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 3 3 |
Cyst | 3 3 3 3 3 3 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Cystic | 3 3 4 3 3 4 3 3 4 2 4 2 2 3 3 4 4 2 2 4 3|
Inflammation, Chronic | 3 |
Metaplasia, Squamous | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 2 4 3 3 4 3 2 2 3 4 3 3 2|
|__________________________________________________________________________|
Lymph Node | + + + + + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hemorrhage | 1 3 |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 2| 0| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3|
| 7| 9| 7| 7| 7| 7| 7| 4| 7| 5| 2| 9| 5| 9| 1| 7| 7| 7| 7| 0| 6| 3| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia, Lymphoid | 2 3 2|
Pigmentation | 3 2 2 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 2 3 |
Ectasia | |
Hematopoietic Cell Proliferation | 2 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 2 2 2 3 |
Pigmentation | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 1 2 2 3 1 4 3 3 4 3 4 3 2 2 4 3 2 2|
Pigmentation | |
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia | 2 3 3 3 2 2|
|__________________________________________________________________________|
Thymus | M + + + + + + + + + + M + + + + + + + M + + + + +|
Atrophy | 3 2 4 3 2 3 |
Hyperplasia, Lymphoid | 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 4 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 |
Erosion | 3 |
Ulcer | 1 |
Epidermis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 2| 0| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3|
| 7| 9| 7| 7| 7| 7| 7| 4| 7| 5| 2| 9| 5| 9| 1| 7| 7| 7| 7| 0| 6| 3| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Necrosis | |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 3 4 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cataract | 1 2 |
Inflammation, Chronic | 4 |
Cornea, Hyperplasia | 1 4 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 3| 3| 3| 2| 3| 3| 2| 5| 3| 2| 0| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3|
| 7| 9| 7| 7| 7| 7| 7| 4| 7| 5| 2| 9| 5| 9| 1| 7| 7| 7| 7| 0| 6| 3| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Hydronephrosis | 3 |
Hyperplasia, Lymphoid | 3 2|
Infarct | 1 |
Nephropathy | 3 3 2 1 1 1|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Pigmentation | 2 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2|
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 31
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 5| 3| 3| 6| 3| 1| 3| 3| 7| 3| 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| |
| 8| 2| 4| 3| 7| 5| 8| 5| 8| 5| 6| 3| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + A A + + + + + + + + + + A I + + + + + + M + + +| 40 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + I + I + + + + + +| 48 |
Ulcer | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Epithelium, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + I + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + M A + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X | 3 |
Clear Cell Focus | X X X X X | 8 |
Eosinophilic Focus | X X X X X | 10 |
Hematopoietic Cell Proliferation | | 2 3.0|
Infiltration Cellular, Mixed Cell | 2 2 3 | 4 2.3|
Inflammation, Chronic Active | | 1 1.0|
Mixed Cell Focus | X X| 3 |
Necrosis, Focal | 4 | 3 2.3|
Centrilobular, Necrosis | 2 2 | 4 2.8|
Hepatocyte, Vacuolization Cytoplasmic| 4 | 4 3.3|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 16 |
Fat, Necrosis | 4 2 2 3 4 4 | 11 3.5|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 5| 3| 3| 6| 3| 1| 3| 3| 7| 3| 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| |
| 8| 2| 4| 3| 7| 5| 8| 5| 8| 5| 6| 3| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 1 3.0|
Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 | 16 2.2|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 2 1.5|
Ulcer | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tooth | | 1 |
Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Hypertrophy | 4 | 1 4.0|
Inflammation, Chronic Active | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 1 1.0|
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 | 6 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 5| 3| 3| 6| 3| 1| 3| 3| 7| 3| 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| |
| 8| 2| 4| 3| 7| 5| 8| 5| 8| 5| 6| 3| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 1| 3 1.7|
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + M + + + + + + + + + + + + + +| 47 |
Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | 3 | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 2 | 4 1.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 1 2 1 2 2 3 | 16 1.8|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + I + + + + + + +| 47 |
Angiectasis | 2 2 2 2 2 | 9 2.4|
Cyst | 3 3 3 3 3 3 3 | 14 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hyperplasia, Cystic | 3 2 1 3 3 3 4 2 3 2 4 3 3 3 4 3 2 3 3 4 2 2 3| 44 3.0|
Inflammation, Chronic | | 1 3.0|
Metaplasia, Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 5| 3| 3| 6| 3| 1| 3| 3| 7| 3| 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| |
| 8| 2| 4| 3| 7| 5| 8| 5| 8| 5| 6| 3| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 2 3 4 2 2 4 3| 24 2.9|
|__________________________________________________________________________|____________|
Lymph Node | + M + + + | 11 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + M + + + + M + + + + + + + + + + + + +| 47 |
Atrophy | | 1 3.0|
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | 4 3 2 3 3| 8 2.8|
Pigmentation | 2 2 2 2 2 2 2 2 2 2 | 17 2.1|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + M + + + + + + + + + + +| 48 |
Angiectasis | | 1 2.0|
Atrophy | | 2 2.5|
Ectasia | 4 | 1 4.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Hemorrhage | 1 | 1 1.0|
Hyperplasia, Lymphoid | 3 2 | 7 2.4|
Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 1 1 3 2 4 1 4 1 3 1 3 2 2 3| 35 2.5|
Pigmentation | 3 | 1 3.0|
Lymphoid Follicle, Atrophy | 3 | 2 3.0|
Lymphoid Follicle, Hyperplasia | 2 3 3 2 3 3 2 2 | 14 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | 4 2 3 3 2| 11 2.8|
Hyperplasia, Lymphoid | | 3 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 5| 3| 3| 6| 3| 1| 3| 3| 7| 3| 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| |
| 8| 2| 4| 3| 7| 5| 8| 5| 8| 5| 6| 3| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 4.0|
Erosion | | 1 3.0|
Ulcer | | 1 1.0|
Epidermis, Hyperplasia | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 | 1 2.0|
Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 3.0|
Hemorrhage | 3 1 | 2 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | | 2 3.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 7| 6| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 9| 3| 5| 3| 3| 6| 3| 1| 3| 3| 7| 3| 0| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| |
| 8| 2| 4| 3| 7| 5| 8| 5| 8| 5| 6| 3| 6| 7| 6| 6| 6| 6| 6| 6| 7| 2| 7| 7| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Cataract | | 2 1.5|
Inflammation, Chronic | 1 2 | 3 2.3|
Cornea, Hyperplasia | 1 3 | 4 2.3|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 3.0|
Hyperplasia, Lymphoid | 2 2 2 | 5 2.2|
Infarct | 1 2 2 3 2| 6 1.8|
Nephropathy | 2 2 1 1 1 1 2 3 1| 15 1.7|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 | 2 3.0|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Pigmentation | 3 | 3 2.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 3 2.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 0| 3| 2| 3| 8| 3| 3| 3| 3| 7| 3| 3| 3| 2| 8| 2| 1| 2| 2| 2|
| 5| 5| 9| 5| 0| 2| 6| 1| 6| 2| 5| 5| 5| 5| 1| 7| 7| 7| 9| 2| 9| 7| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/L | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + A + + + + + +|
Edema | 2 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + A + + + A + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X |
Hematopoietic Cell Proliferation | 3 |
Hepatodiaphragmatic Nodule | X X |
Infarct | 3 |
Infiltration Cellular, Mixed Cell | 2 2 1 2 4 3 |
Mixed Cell Focus | X|
Necrosis, Focal | 3 |
Centrilobular, Necrosis | 2 3 |
Hepatocyte, Vacuolization Cytoplasmic| 3 4 |
Kupffer Cell, Pigmentation | 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Fat, Necrosis | 2 3 2 4 4 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + A + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 0| 3| 2| 3| 8| 3| 3| 3| 3| 7| 3| 3| 3| 2| 8| 2| 1| 2| 2| 2|
| 5| 5| 9| 5| 0| 2| 6| 1| 6| 2| 5| 5| 5| 5| 1| 7| 7| 7| 9| 2| 9| 7| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/L | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Atrophy | 3|
Cyst | 3|
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | 2 2 |
Epithelium, Hyperplasia | 3 1 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3|
Hyperplasia, Focal | 3 |
Capsule, Hyperplasia | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + A + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | 3|
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 0| 3| 2| 3| 8| 3| 3| 3| 3| 7| 3| 3| 3| 2| 8| 2| 1| 2| 2| 2|
| 5| 5| 9| 5| 0| 2| 6| 1| 6| 2| 5| 5| 5| 5| 1| 7| 7| 7| 9| 2| 9| 7| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/L | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 3 |
Pars Distalis, Hyperplasia, Focal | 3 2 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 1 2 2 3 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 4 2 |
Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 |
Interstitial Cell, Hyperplasia | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Cystic | 4 4 3 3 2 4 4 4 2 4 4 4 3 4 4 2 3 3 2|
Metaplasia, Squamous | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 4 3 4 3 2 3 4 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + |
Deep Cervical, Hemorrhage | 4 |
Iliac, Hemorrhage | 4 |
Iliac, Hyperplasia, Lymphoid | 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 0| 3| 2| 3| 8| 3| 3| 3| 3| 7| 3| 3| 3| 2| 8| 2| 1| 2| 2| 2|
| 5| 5| 9| 5| 0| 2| 6| 1| 6| 2| 5| 5| 5| 5| 1| 7| 7| 7| 9| 2| 9| 7| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/L | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Renal, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 2 3 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 4 2 3 3 3|
Pigmentation | 3 3 2 3 2 2 3 2 2 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + M + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 3 |
Pigmentation | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hematopoietic Cell Proliferation | 3 3 4 3 1 3 4 3 2 1 1 3 4 4 1 1 |
Pigmentation | 3 |
Lymphoid Follicle, Atrophy | 2 |
Lymphoid Follicle, Hyperplasia | 2 3 2 3 4 3 2 2|
|__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 4 3 2 3 |
Hyperplasia, Lymphoid | 3 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Ulcer | 4 |
Epidermis, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 0| 3| 2| 3| 8| 3| 3| 3| 3| 7| 3| 3| 3| 2| 8| 2| 1| 2| 2| 2|
| 5| 5| 9| 5| 0| 2| 6| 1| 6| 2| 5| 5| 5| 5| 1| 7| 7| 7| 9| 2| 9| 7| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/L | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
|__________________________________________________________________________|
Skeletal Muscle | + + + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + |
Atrophy | 3 |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 3 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 2 2 1 |
Alveolar Epithelium, Hyperplasia | 3 |
Perivascular, Inflammation, Chronic | |
Active | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 2 |
Inflammation, Chronic | 1 1 |
Cornea, Mineralization | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 0| 3| 2| 3| 8| 3| 3| 3| 3| 7| 3| 3| 3| 2| 8| 2| 1| 2| 2| 2|
| 5| 5| 9| 5| 0| 2| 6| 1| 6| 2| 5| 5| 5| 5| 1| 7| 7| 7| 9| 2| 9| 7| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/L | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | 2 |
Hyperplasia, Lymphoid | 2 2 3 2 3 |
Infarct | 3 3 3 |
Nephropathy | 1 1 1 1 1 1 1 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | 2 |
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________|__________________________________________________________________________
Page 43
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| |
DAY ON TEST | 1| 2| 2| 2| 2| 3| 1| 3| 7| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 9| 2| 9| 3| |
| 5| 9| 9| 9| 9| 6| 9| 6| 9| 6| 6| 6| 6| 6| 8| 5| 5| 5| 5| 5| 6| 6| 1| 3| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/L | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | A + + + + + + + A + + + + + + + + + + + A + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + I + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + A + + + + + + + + + + + + + + + +| 46 |
Edema | 2 2 | 3 2.0|
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + A + + + + + + + + + + + A + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | M + + + + + A + A + + + + + + + + + + + A + + + +| 43 |
Hyperplasia, Lymphoid | 4 3 | 2 3.5|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + A + + + + + + + + + + + A + + + +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X | 3 |
Clear Cell Focus | X X| 5 |
Eosinophilic Focus | X X X X X | 9 |
Hematopoietic Cell Proliferation | 2 | 2 2.5|
Hepatodiaphragmatic Nodule | | 2 |
Infarct | | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 3 3 | 9 2.4|
Mixed Cell Focus | | 1 |
Necrosis, Focal | 4 | 2 3.5|
Centrilobular, Necrosis | 3 1 | 4 2.3|
Hepatocyte, Vacuolization Cytoplasmic| | 2 3.5|
Kupffer Cell, Pigmentation | 2 3 | 3 2.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| |
DAY ON TEST | 1| 2| 2| 2| 2| 3| 1| 3| 7| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 9| 2| 9| 3| |
| 5| 9| 9| 9| 9| 6| 9| 6| 9| 6| 6| 6| 6| 6| 8| 5| 5| 5| 5| 5| 6| 6| 1| 3| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/L | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + + + + + + + + + + | 19 |
Fat, Necrosis | 3 3 3 2 4 2 2 | 13 2.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
Atrophy | 2 3 | 3 2.7|
Cyst | 3 3 | 3 3.0|
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 3 3 2 3 2 3 | 10 2.5|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
Ulcer | 3 | 3 2.3|
Epithelium, Hyperplasia | 2 | 4 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Erosion | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
Mineralization | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 | 9 3.0|
Hyperplasia, Focal | | 1 3.0|
Capsule, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| |
DAY ON TEST | 1| 2| 2| 2| 2| 3| 1| 3| 7| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 9| 2| 9| 3| |
| 5| 9| 9| 9| 9| 6| 9| 6| 9| 6| 6| 6| 6| 6| 8| 5| 5| 5| 5| 5| 6| 6| 1| 3| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/L | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Medulla | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + A + + + +| 46 |
Hyperplasia | 2 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Cyst | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 2 2 1 2 | 7 1.9|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 2 1 1 1 2 | 14 1.9|
Follicular Cell, Hyperplasia | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 2 3 | 7 2.6|
Cyst | 3 3 3 3 3 3 3 3 3 3| 22 3.0|
Interstitial Cell, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Hyperplasia, Cystic | 3 3 3 2 3 3 3 3 3 2 2 2 1 2 4 4 3 2 3 3| 39 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| |
DAY ON TEST | 1| 2| 2| 2| 2| 3| 1| 3| 7| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 9| 2| 9| 3| |
| 5| 9| 9| 9| 9| 6| 9| 6| 9| 6| 6| 6| 6| 6| 8| 5| 5| 5| 5| 5| 6| 6| 1| 3| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/L | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Metaplasia, Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 2 4 2 3 2 3 2 4 | 20 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 8 |
Deep Cervical, Hemorrhage | | 1 4.0|
Iliac, Hemorrhage | | 1 4.0|
Iliac, Hyperplasia, Lymphoid | | 2 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 2 3 2 | 9 2.8|
Pigmentation | 3 2 2 2 2 2 2 3 2 3 2 2 2| 23 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + I + + + A + + + + + + + + + + I + + + + +| 45 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 4 1 2 4 | 5 2.4|
Hyperplasia, Lymphoid | 2 2 2 | 5 2.2|
Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 4 3 1 2 4 1 1 2 1 4 3 4 4 | 34 2.5|
Pigmentation | 3 | 2 3.0|
Lymphoid Follicle, Atrophy | 3 | 2 2.5|
Lymphoid Follicle, Hyperplasia | 3 2 2 2 | 12 2.5|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| |
DAY ON TEST | 1| 2| 2| 2| 2| 3| 1| 3| 7| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 9| 2| 9| 3| |
| 5| 9| 9| 9| 9| 6| 9| 6| 9| 6| 6| 6| 6| 6| 8| 5| 5| 5| 5| 5| 6| 6| 1| 3| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/L | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 2 2 2 3 3 3 | 13 2.8|
Hyperplasia, Lymphoid | | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 5 2.2|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Ulcer | | 1 4.0|
Epidermis, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Skeletal Muscle | + +| 5 |
Inflammation, Chronic Active | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Atrophy | | 1 3.0|
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| |
DAY ON TEST | 1| 2| 2| 2| 2| 3| 1| 3| 7| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 9| 2| 9| 3| |
| 5| 9| 9| 9| 9| 6| 9| 6| 9| 6| 6| 6| 6| 6| 8| 5| 5| 5| 5| 5| 6| 6| 1| 3| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/L | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Hemorrhage | | 3 2.0|
Hyperplasia, Lymphoid | 2 2 3 | 3 2.3|
Infiltration Cellular, Histiocyte | 2 | 4 1.8|
Alveolar Epithelium, Hyperplasia | 1 2 2 | 4 2.0|
Perivascular, Inflammation, Chronic | | |
Active | | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | 1 | 2 1.5|
Inflammation, Chronic | 2 | 3 1.3|
Cornea, Mineralization | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1| 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
Hydronephrosis | | 1 2.0|
Hyperplasia, Lymphoid | 2 3 2 | 8 2.4|
Infarct | 2 2 3 1 3 | 8 2.5|
Nephropathy | 1 1 1 1 3 | 12 1.2|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 | 2 3.0|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| |
DAY ON TEST | 1| 2| 2| 2| 2| 3| 1| 3| 7| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 9| 2| 9| 3| |
| 5| 9| 9| 9| 9| 6| 9| 6| 9| 6| 6| 6| 6| 6| 8| 5| 5| 5| 5| 5| 6| 6| 1| 3| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/L | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Renal Tubule, Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 2| 3| 3| 3| 2| 1| 3| 3| 0| 2| 3| 6| 1|
| 4| 1| 0| 8| 5| 1| 0| 4| 4| 0| 1| 0| 9| 4| 1| 1| 6| 5| 4| 1| 4| 9| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + M A + + M + A +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + A +|
Edema | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A A + + + + A +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X X X X X X |
Congestion | 3 |
Eosinophilic Focus | X X X X X X X X X |
Hemorrhage | 3 |
Infarct | 4 |
Infiltration Cellular, Mixed Cell | 3 |
Mixed Cell Focus | X X |
Necrosis, Focal | 4 1 3 |
Centrilobular, Necrosis | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 1 3 3 3 |
Kupffer Cell, Pigmentation | |
|__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 3 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A +|
Acinus, Cytoplasmic Alteration | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 2| 3| 3| 3| 2| 1| 3| 3| 0| 2| 3| 6| 1|
| 4| 1| 0| 8| 5| 1| 0| 4| 4| 0| 1| 0| 9| 4| 1| 1| 6| 5| 4| 1| 4| 9| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | 2 |
Ulcer | |
Epithelium, Hyperplasia | 1 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 3|
|__________________________________________________________________________|
Tongue | + |
|__________________________________________________________________________|
Tooth | + + + +|
Malformation | X X X X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic | 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 |
Hyperplasia, Focal | 1 2 |
Hypertrophy, Focal | 1 2 3 2 2 3 2 2 |
Hypertrophy | 3 |
Capsule, Hyperplasia | 2 3 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 2| 3| 3| 3| 2| 1| 3| 3| 0| 2| 3| 6| 1|
| 4| 1| 0| 8| 5| 1| 0| 4| 4| 0| 1| 0| 9| 4| 1| 1| 6| 5| 4| 1| 4| 9| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hyperplasia | 2 3 2 2 2 2 2 2 3 2 2 2 1 3 3 3 2 2 1|
|__________________________________________________________________________|
Parathyroid Gland | + I + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 3 |
Pars Distalis, Hyperplasia, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2|
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 |
Granuloma Sperm | |
Spermatocele | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + I + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 2| 3| 3| 3| 2| 1| 3| 3| 0| 2| 3| 6| 1|
| 4| 1| 0| 8| 5| 1| 0| 4| 4| 0| 1| 0| 9| 4| 1| 1| 6| 5| 4| 1| 4| 9| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Depletion Cellular | 2 |
Hyperplasia | 2 2 2 2 1 3 1 |
|__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 3 2 2 2 2 4|
Pigmentation | 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M +|
Atrophy | 2|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 1 1|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + M + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 1 3 4 2 |
Lymphoid Follicle, Atrophy | 3 2|
Lymphoid Follicle, Hyperplasia | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + M +|
Atrophy | 3 3 3 4 3 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
Epidermis, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 2| 3| 3| 3| 2| 1| 3| 3| 0| 2| 3| 6| 1|
| 4| 1| 0| 8| 5| 1| 0| 4| 4| 0| 1| 0| 9| 4| 1| 1| 6| 5| 4| 1| 4| 9| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Cranium, Hyperostosis | 3 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + |
|__________________________________________________________________________|
Spinal Cord | + + |
Gliosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hemorrhage | 2 3 |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 1| 3| 3| 3| 5| 3| 2| 3| 3| 3| 2| 1| 3| 3| 0| 2| 3| 6| 1|
| 4| 1| 0| 8| 5| 1| 0| 4| 4| 0| 1| 0| 9| 4| 1| 1| 6| 5| 4| 1| 4| 9| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Cyst | 3 3 3 3 3 3 |
Hydronephrosis | 2 |
Hyperplasia, Lymphoid | 3 3|
Infarct | 2 2 1 |
Metaplasia, Osseous | 2 3 2 2 3 |
Nephropathy | 1 1 1 1 1 1 2 1 1 2 2 2 2 2 1 2 1 3|
Renal Tubule, Dilatation | |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 56
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 2| 6| 3| 3| 3| 3| 3| 5| 1| 9| 3| 3| 3| 0| 3| 1| 3| 3| 2| 3| 0| 3| |
| 0| 4| 2| 9| 9| 4| 0| 0| 1| 4| 5| 0| 6| 1| 4| 1| 1| 1| 4| 1| 1| 9| 0| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Gallbladder | + + M + A + + + + + + + + + + + A + A + + + + A M| 39 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + A + A + + + + A +| 43 |
Edema | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + A + + + + + + + + + + + A + + + + + + + M| 42 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + A + + + + + A + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + A + A + + + + + +| 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | | 2 |
Clear Cell Focus | X X | 10 |
Congestion | | 1 3.0|
Eosinophilic Focus | X X X X X X | 15 |
Hemorrhage | | 1 3.0|
Infarct | | 1 4.0|
Infiltration Cellular, Mixed Cell | 2 | 2 2.5|
Mixed Cell Focus | X | 3 |
Necrosis, Focal | 2 2 4 4 3 | 8 2.9|
Centrilobular, Necrosis | 4 1 4 | 4 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 | 8 2.8|
Kupffer Cell, Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Fat, Necrosis | 4 4 | 5 3.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 2| 6| 3| 3| 3| 3| 3| 5| 1| 9| 3| 3| 3| 0| 3| 1| 3| 3| 2| 3| 0| 3| |
| 0| 4| 2| 9| 9| 4| 0| 0| 1| 4| 5| 0| 6| 1| 4| 1| 1| 1| 4| 1| 1| 9| 0| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + + + + + + + + A + + + + + + + +| 46 |
Acinus, Cytoplasmic Alteration | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 2 | 1 2.0|
Inflammation, Chronic | 2 2 | 3 2.0|
Ulcer | 1 1 | 2 1.0|
Epithelium, Hyperplasia | 3 2 | 4 2.3|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + A + + + + + + + +| 47 |
Erosion | | 2 3.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
|__________________________________________________________________________|____________|
Tooth | + | 5 |
Malformation | X | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | 3 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 | 7 3.0|
Hyperplasia, Focal | 2 2 | 4 1.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 2| 6| 3| 3| 3| 3| 3| 5| 1| 9| 3| 3| 3| 0| 3| 1| 3| 3| 2| 3| 0| 3| |
| 0| 4| 2| 9| 9| 4| 0| 0| 1| 4| 5| 0| 6| 1| 4| 1| 1| 1| 4| 1| 1| 9| 0| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hypertrophy, Focal | 1 1 2 1 | 12 1.8|
Hypertrophy | | 1 3.0|
Capsule, Hyperplasia | 2 2 3 | 7 2.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + A + + + + + + + +| 46 |
Hyperplasia | 3 1 2 2 2 2 3 2 3 2 2 3 3 2 1 | 34 2.2|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + I + I + + + + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + M + + + + + M| 45 |
Pars Distalis, Cyst | 3 3 3 3 3 | 7 3.0|
Pars Distalis, Hyperplasia, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Degeneration, Cystic | 3 2 2 | 5 2.0|
Follicular Cell, Hyperplasia | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atypia Cellular | 2 3 3 2 | 5 2.4|
Granuloma Sperm | 4 | 1 4.0|
Spermatocele | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 3 3 3 3 2 2 3 3 3 3 | 25 2.9|
Inflammation, Chronic | 3 2 3 2 2 2 3 2 2 2 2 2 | 21 2.1|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 2| 6| 3| 3| 3| 3| 3| 5| 1| 9| 3| 3| 3| 0| 3| 1| 3| 3| 2| 3| 0| 3| |
| 0| 4| 2| 9| 9| 4| 0| 0| 1| 4| 5| 0| 6| 1| 4| 1| 1| 1| 4| 1| 1| 9| 0| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Prostate | + I + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration | 3 3 | 3 3.0|
Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Germinal Epithelium, Atrophy | 3 2 1 3 2 2 2 | 9 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + I + + + + + + + + + + + +| 47 |
Depletion Cellular | | 1 2.0|
Hyperplasia | 3 2 2 3 3 4 4 3 2 2 2 4 2 3 4 | 22 2.5|
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 3 2 2 3 2| 5 2.4|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 3 4 3 2 2 2 2 2 | 15 2.5|
Pigmentation | 2 2 3 2| 7 2.1|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A + + + + + + + A + + + + + + + + + + + + + +| 46 |
Atrophy | 2 3 3| 4 2.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 3 2 2 2 2 | 8 1.9|
Hyperplasia, Lymphoid | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
Hematopoietic Cell Proliferation | 4 3 4 4 4 4 3 4 2 2 3 3| 18 3.1|
Lymphoid Follicle, Atrophy | 2 3 | 4 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 2| 6| 3| 3| 3| 3| 3| 5| 1| 9| 3| 3| 3| 0| 3| 1| 3| 3| 2| 3| 0| 3| |
| 0| 4| 2| 9| 9| 4| 0| 0| 1| 4| 5| 0| 6| 1| 4| 1| 1| 1| 4| 1| 1| 9| 0| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymphoid Follicle, Hyperplasia | 3 2 | 3 2.3|
|__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + M + + + M M + + + + + + + + +| 42 |
Atrophy | 3 3 4 3 4 3 3 3| 14 3.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 4 4 | 3 4.0|
Epidermis, Hyperplasia | 2 3 | 3 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cranium, Hyperostosis | | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
|__________________________________________________________________________|____________|
Spinal Cord | | 2 |
Gliosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2 | 2 2.0|
Hemorrhage | | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 8| 2| 6| 3| 3| 3| 3| 3| 5| 1| 9| 3| 3| 3| 0| 3| 1| 3| 3| 2| 3| 0| 3| |
| 0| 4| 2| 9| 9| 4| 0| 0| 1| 4| 5| 0| 6| 1| 4| 1| 1| 1| 4| 1| 1| 9| 0| 3| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Hyperplasia, Lymphoid | 2 3 | 3 2.7|
Infiltration Cellular, Histiocyte | 1 | 2 1.0|
Metaplasia, Osseous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 4 2 3 | 5 2.6|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 3 3 | 9 3.0|
Hydronephrosis | 2 2 2 | 4 2.0|
Hyperplasia, Lymphoid | 3 3 1 | 5 2.6|
Infarct | | 3 1.7|
Metaplasia, Osseous | 1 | 6 2.2|
Nephropathy | 2 3 4 1 1 1 3 2 3 2 1 1 3 1 2 1 2 4| 36 1.8|
Renal Tubule, Dilatation | 3 | 1 3.0|
Renal Tubule, Hyperplasia | | 1 2.0|
Renal Tubule, Necrosis | 2 | 1 2.0|
Renal Tubule, Pigmentation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 2| 3| 7| 9| 3| 3| 3| 3| 3| 3| 2| 3| 2| 9| 3| 2| 3| 3|
| 0| 1| 0| 4| 1| 4| 0| 9| 0| 3| 7| 1| 0| 1| 1| 0| 1| 9| 1| 9| 1| 1| 9| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + M + + + A + + + + + + + M + + + M + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + I + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Edema | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X X X X X |
Cyst | |
Eosinophilic Focus | X X X X X |
Hepatodiaphragmatic Nodule | |
Infiltration Cellular, Mixed Cell | 3 2 |
Mixed Cell Focus | X X X X |
Necrosis, Focal | 4 3 4 1 |
Tension Lipidosis | |
Centrilobular, Necrosis | 2 1 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 4 3 3 |
Kupffer Cell, Pigmentation | |
|__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Acinus, Cytoplasmic Alteration | 3 |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 2| 3| 7| 9| 3| 3| 3| 3| 3| 3| 2| 3| 2| 9| 3| 2| 3| 3|
| 0| 1| 0| 4| 1| 4| 0| 9| 0| 3| 7| 1| 0| 1| 1| 0| 1| 9| 1| 9| 1| 1| 9| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Chronic | 3 |
Ulcer | |
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Glands, Hyperplasia | 2 |
|__________________________________________________________________________|
Tooth | + + + |
Malformation | X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Myocardium, Necrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3|
Hyperplasia, Focal | 2 3 2 |
Hypertrophy, Focal | 1 2 3 1 |
Capsule, Hyperplasia | 3 3 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 4 2 2 2 3 2 3 2 2 2 3 2 2 2 3 |
|__________________________________________________________________________|
Parathyroid Gland | I + + + + + + + + M + + + + + + + + + + + + M + +|
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 2| 3| 7| 9| 3| 3| 3| 3| 3| 3| 2| 3| 2| 9| 3| 2| 3| 3|
| 0| 1| 0| 4| 1| 4| 0| 9| 0| 3| 7| 1| 0| 1| 1| 0| 1| 9| 1| 9| 1| 1| 9| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Cyst | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2|
Granuloma Sperm | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3|
Inflammation, Chronic | 2 2 2 3 2 2 2 2 3 3 2 3 2 4|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 4 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 2 4 2 3 3 2|
|__________________________________________________________________________|
Lymph Node | + |
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 2| 3| 7| 9| 3| 3| 3| 3| 3| 3| 2| 3| 2| 9| 3| 2| 3| 3|
| 0| 1| 0| 4| 1| 4| 0| 9| 0| 3| 7| 1| 0| 1| 1| 0| 1| 9| 1| 9| 1| 1| 9| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Iliac, Ectasia | |
Inguinal, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Lymphoid | 2 2 2 3 2 2 2 2 |
Pigmentation | 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 1 3 2 |
Hyperplasia, Lymphoid | 2 2 3 4 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 3 2 4 1 3 3 2 3 2 |
Pigmentation | |
Lymphoid Follicle, Atrophy | 3 3 2 3 |
Lymphoid Follicle, Hyperplasia | 2 3 |
|__________________________________________________________________________|
Thymus | + + + M + + + + + + + + M + + + + + + + + + + + +|
Atrophy | 2 3 3 3 4 2 3 2 3|
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 3 |
Ulcer | 4 |
Epidermis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 2| 3| 7| 9| 3| 3| 3| 3| 3| 3| 2| 3| 2| 9| 3| 2| 3| 3|
| 0| 1| 0| 4| 1| 4| 0| 9| 0| 3| 7| 1| 0| 1| 1| 0| 1| 9| 1| 9| 1| 1| 9| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Skeletal Muscle | |
Atrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | |
Atrophy | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 4 2 |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 1 3 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cataract | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hyperplasia, Focal | |
|__________________________________________________________________________|
Lacrimal Gland | + |
Cyst | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 2| 3| 7| 9| 3| 3| 3| 3| 3| 3| 2| 3| 2| 9| 3| 2| 3| 3|
| 0| 1| 0| 4| 1| 4| 0| 9| 0| 3| 7| 1| 0| 1| 1| 0| 1| 9| 1| 9| 1| 1| 9| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 3 3 |
Hydronephrosis | |
Hyperplasia, Lymphoid | 2 |
Infarct | 3 2 |
Inflammation, Suppurative | |
Metaplasia, Osseous | 3 |
Nephropathy | 1 1 3 2 2 2 1 2 1 1 2 1 1 1 1 2 3 1 2 1 1 2 2|
Renal Tubule, Dilatation | |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | 3 4 |
|__________________________________________________________________________|
Urethra | |
Angiectasis | |
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________|__________________________________________________________________________
Page 68
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 8| 5| 9| 8| 5| 3| 3| 1| 2| 3| 3| 3| 3| |
| 4| 2| 0| 1| 4| 0| 9| 4| 4| 0| 1| 0| 2| 9| 6| 4| 9| 4| 0| 7| 1| 4| 0| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X X X X X X X | 13 |
Cyst | 3 | 1 3.0|
Eosinophilic Focus | X X X X X | 10 |
Hepatodiaphragmatic Nodule | X | 1 |
Infiltration Cellular, Mixed Cell | 2 3 | 4 2.5|
Mixed Cell Focus | X X X | 7 |
Necrosis, Focal | 1 3 3 | 7 2.7|
Tension Lipidosis | X | 1 |
Centrilobular, Necrosis | 4 2 | 4 2.3|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 | 9 3.1|
Kupffer Cell, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 7 |
Fat, Necrosis | 3 3 4 3 | 6 2.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 8| 5| 9| 8| 5| 3| 3| 1| 2| 3| 3| 3| 3| |
| 4| 2| 0| 1| 4| 0| 9| 4| 4| 0| 1| 0| 2| 9| 6| 4| 9| 4| 0| 7| 1| 4| 0| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 4 | 1 4.0|
Acinus, Cytoplasmic Alteration | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 4 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | X X| 2 |
Inflammation, Chronic | | 1 3.0|
Ulcer | 2 3 | 2 2.5|
Epithelium, Hyperplasia | 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 3 | 2 2.0|
Glands, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + + +| 6 |
Malformation | X X X| 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 | 1 1.0|
Myocardium, Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 | 5 3.0|
Hyperplasia, Focal | 3 2 2 2 | 7 2.3|
Hypertrophy, Focal | 2 1 1 1 2 1 1 | 11 1.5|
Capsule, Hyperplasia | 3 | 4 2.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 8| 5| 9| 8| 5| 3| 3| 1| 2| 3| 3| 3| 3| |
| 4| 2| 0| 1| 4| 0| 9| 4| 4| 0| 1| 0| 2| 9| 6| 4| 9| 4| 0| 7| 1| 4| 0| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 2 2 3 2 2 2 2 3 2 3 2 4| 32 2.4|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 3 3 3 3 3| 7 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 2 1 | 8 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 3 3 2 | 4 2.5|
Granuloma Sperm | 4 3| 2 3.5|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 | 26 3.0|
Inflammation, Chronic | 2 1 2 3 2 2 3 2 2 3 3 2 2 2 2 2| 30 2.3|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 4 2.8|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 8| 5| 9| 8| 5| 3| 3| 1| 2| 3| 3| 3| 3| |
| 4| 2| 0| 1| 4| 0| 9| 4| 4| 0| 1| 0| 2| 9| 6| 4| 9| 4| 0| 7| 1| 4| 0| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 4 3 2 3 | 5 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 2 2 2 2 3 3 3 3 3 3| 22 2.7|
|__________________________________________________________________________|____________|
Lymph Node | + | 2 |
Iliac, Ectasia | 2 | 1 2.0|
Inguinal, Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 | 2 2.5|
Hyperplasia, Lymphoid | 2 2 3 2 3 2 | 14 2.2|
Pigmentation | 2 2 2 2 2| 8 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Atrophy | | 2 2.5|
Hematopoietic Cell Proliferation | | 1 1.0|
Hemorrhage | 3 1 | 5 2.0|
Hyperplasia, Lymphoid | 3 2 2 2| 8 2.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 1 2 2 2 2 4 4 2| 20 2.6|
Pigmentation | 2 | 1 2.0|
Lymphoid Follicle, Atrophy | 2 3 3 | 7 2.7|
Lymphoid Follicle, Hyperplasia | 3 2 3 2| 6 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + + I + + + + + + + + + + M + + + + + + + M +| 45 |
Atrophy | 3 3 2 2 4 3 4 | 16 2.9|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 8| 5| 9| 8| 5| 3| 3| 1| 2| 3| 3| 3| 3| |
| 4| 2| 0| 1| 4| 0| 9| 4| 4| 0| 1| 0| 2| 9| 6| 4| 9| 4| 0| 7| 1| 4| 0| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 3 | 2 3.0|
Ulcer | 4 | 2 4.0|
Epidermis, Hyperplasia | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Atrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
Atrophy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 4 2 1 | 6 2.3|
Metaplasia, Osseous | 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 6 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 8| 5| 9| 8| 5| 3| 3| 1| 2| 3| 3| 3| 3| |
| 4| 2| 0| 1| 4| 0| 9| 4| 4| 0| 1| 0| 2| 9| 6| 4| 9| 4| 0| 7| 1| 4| 0| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Cataract | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Hyperplasia, Focal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 | 13 3.0|
Hydronephrosis | 2 3 | 2 2.5|
Hyperplasia, Lymphoid | 2 2 2 2 | 5 2.0|
Infarct | 2 2 2 2 3 | 7 2.3|
Inflammation, Suppurative | 3 | 1 3.0|
Metaplasia, Osseous | 2 2 | 3 2.3|
Nephropathy | 2 1 1 2 2 3 1 2 1 1 1 2 1 1 1 3 2 1 1 1 2| 44 1.5|
Renal Tubule, Dilatation | 2 2 3 | 3 2.3|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Pigmentation | 1 | 3 2.7|
|__________________________________________________________________________|____________|
Urethra | + + + | 3 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 8| 5| 9| 8| 5| 3| 3| 1| 2| 3| 3| 3| 3| |
| 4| 2| 0| 1| 4| 0| 9| 4| 4| 0| 1| 0| 2| 9| 6| 4| 9| 4| 0| 7| 1| 4| 0| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Angiectasis | 4 4 4 | 3 4.0|
Inflammation, Chronic Active | 3 2 3 | 3 2.7|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 9| 2| 2| 3| 0| 2| 3| 3| 9| 3| 3| 3| 3| 6| 3| 2| 3| 3| 3| 3| 5| 3| 2| 2|
| 1| 1| 9| 9| 1| 4| 1| 0| 4| 6| 0| 1| 0| 4| 7| 0| 9| 1| 1| 0| 1| 3| 4| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + A + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + I + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | X X X X X X X X X X X |
Eosinophilic Focus | X X X X X X X X X|
Infarct | |
Infiltration Cellular, Mixed Cell | |
Mixed Cell Focus | X X X X |
Necrosis, Focal | 4 1 |
Tension Lipidosis | X |
Bile Duct, Cyst | |
Bile Duct, Cyst Multilocular | |
Hepatocyte, Vacuolization Cytoplasmic| 3 4 |
Kupffer Cell, Pigmentation | 3 |
|__________________________________________________________________________|
Mesentery | + + +|
Inflammation, Chronic | |
Fat, Necrosis | 2 3|
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 9| 2| 2| 3| 0| 2| 3| 3| 9| 3| 3| 3| 3| 6| 3| 2| 3| 3| 3| 3| 5| 3| 2| 2|
| 1| 1| 9| 9| 1| 4| 1| 0| 4| 6| 0| 1| 0| 4| 7| 0| 9| 1| 1| 0| 1| 3| 4| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Cytoplasmic Alteration | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 3 3 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Erosion | 2 |
Inflammation, Chronic | 3 3 |
Ulcer | |
Epithelium, Hyperplasia, Focal | |
Epithelium, Hyperplasia | 2 3 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 |
Hyperplasia, Focal | 2 2 1 |
Hypertrophy, Focal | 2 1 2 2 3 3 1 3 2 |
Capsule, Hyperplasia | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 3 3 2 2 2 3 3 2 2 2 3|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + I + + + + + + +|
Cyst | |
__________________________________________|__________________________________________________________________________|
Page 77
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 9| 2| 2| 3| 0| 2| 3| 3| 9| 3| 3| 3| 3| 6| 3| 2| 3| 3| 3| 3| 5| 3| 2| 2|
| 1| 1| 9| 9| 1| 4| 1| 0| 4| 6| 0| 1| 0| 4| 7| 0| 9| 1| 1| 0| 1| 3| 4| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + I + + + + + +|
Pars Distalis, Cyst | 3 3 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 2 |
Granuloma Sperm | 4 3 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 |
Inflammation, Chronic | 3 3 3 2 2 2 2 3 2 2 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 1 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 2 3 3 4 4 3 1 3 2 2 3 2|
|__________________________________________________________________________|
Lymph Node | + + + |
Bronchial, Hyperplasia, Lymphoid | 3 |
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 9| 2| 2| 3| 0| 2| 3| 3| 9| 3| 3| 3| 3| 6| 3| 2| 3| 3| 3| 3| 5| 3| 2| 2|
| 1| 1| 9| 9| 1| 4| 1| 0| 4| 6| 0| 1| 0| 4| 7| 0| 9| 1| 1| 0| 1| 3| 4| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 3 2 |
Pigmentation | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + I + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 1 2 2 |
Hemorrhage | 1 2 1 1 1 3 |
Hyperplasia, Lymphoid | 2 2|
Hyperplasia, Plasma Cell | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 3 1 1 2 4 4 2 3 2 2 3 3 |
Pigmentation | 3 |
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia | 4 2 3 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Atrophy | 3 3 3 2 3 2 |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 79
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 9| 2| 2| 3| 0| 2| 3| 3| 9| 3| 3| 3| 3| 6| 3| 2| 3| 3| 3| 3| 5| 3| 2| 2|
| 1| 1| 9| 9| 1| 4| 1| 0| 4| 6| 0| 1| 0| 4| 7| 0| 9| 1| 1| 0| 1| 3| 4| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + |
Atrophy | 3 |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 1 4 |
Alveolar Epithelium, Hyperplasia | 3 4 2 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 1 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 1 |
Inflammation, Chronic | 2 1 |
Cornea, Hyperplasia | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 |
Hyperplasia, Lymphoid | 2 3 2 3 |
Infarct | 2 |
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 9| 2| 2| 3| 0| 2| 3| 3| 9| 3| 3| 3| 3| 6| 3| 2| 3| 3| 3| 3| 5| 3| 2| 2|
| 1| 1| 9| 9| 1| 4| 1| 0| 4| 6| 0| 1| 0| 4| 7| 0| 9| 1| 1| 0| 1| 3| 4| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Metaplasia, Osseous | 1 |
Nephropathy | 2 2 2 2 3 1 2 3 2 2 1 1 1 3 3 1 1 1 2|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 2 |
Transitional Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hyperplasia, Lymphoid | 3 |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 81
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 5| 3| 2| 7| 3| 3| 3| 1| 3| 3| 9| 3| 7| 2| 0| 2| 3| 3| 3| 2| 3| 3| 3| |
| 9| 0| 4| 1| 9| 6| 1| 4| 4| 4| 4| 4| 9| 1| 3| 5| 8| 6| 1| 1| 1| 9| 4| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + + M + + + + M + A + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
Edema | 2 2 | 3 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + A A + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + A + + + A + + + + + + + +| 46 |
Hyperplasia, Lymphoid | | 2 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Basophilic Focus | | 1 |
Clear Cell Focus | X X X X X X X X X X X X| 23 |
Eosinophilic Focus | X X X X X X | 15 |
Infarct | 4 | 1 4.0|
Infiltration Cellular, Mixed Cell | 3 2 | 2 2.5|
Mixed Cell Focus | X X X X| 8 |
Necrosis, Focal | 1 | 3 2.0|
Tension Lipidosis | | 1 |
Bile Duct, Cyst | 1 | 1 1.0|
Bile Duct, Cyst Multilocular | X | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 | 4 3.3|
Kupffer Cell, Pigmentation | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 5| 3| 2| 7| 3| 3| 3| 1| 3| 3| 9| 3| 7| 2| 0| 2| 3| 3| 3| 2| 3| 3| 3| |
| 9| 0| 4| 1| 9| 6| 1| 4| 4| 4| 4| 4| 9| 1| 3| 5| 8| 6| 1| 1| 1| 9| 4| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + +| 10 |
Inflammation, Chronic | 3 | 1 3.0|
Fat, Necrosis | 2 4 3 4 4 | 7 3.1|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Cytoplasmic Alteration | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 2| 6 2.5|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | X | 1 |
Erosion | | 1 2.0|
Inflammation, Chronic | 1 | 3 2.3|
Ulcer | 3 2 | 2 2.5|
Epithelium, Hyperplasia, Focal | 3 | 1 3.0|
Epithelium, Hyperplasia | 3 | 4 2.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 | 4 3.0|
Hyperplasia, Focal | 2 2 | 5 1.8|
Hypertrophy, Focal | 1 2 1 1 | 13 1.8|
Capsule, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 5| 3| 2| 7| 3| 3| 3| 1| 3| 3| 9| 3| 7| 2| 0| 2| 3| 3| 3| 2| 3| 3| 3| |
| 9| 0| 4| 1| 9| 6| 1| 4| 4| 4| 4| 4| 9| 1| 3| 5| 8| 6| 1| 1| 1| 9| 4| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 3 3 2 2 2 2 3 2| 26 2.3|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | 3 | 7 3.0|
Pars Distalis, Hyperplasia, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 1 2| 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | | 2 2.0|
Granuloma Sperm | | 2 3.5|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 33 3.0|
Inflammation, Chronic | 3 2 2 2 2 2 2 2 3 3 3 1 | 24 2.3|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 5| 3| 2| 7| 3| 3| 3| 1| 3| 3| 9| 3| 7| 2| 0| 2| 3| 3| 3| 2| 3| 3| 3| |
| 9| 0| 4| 1| 9| 6| 1| 4| 4| 4| 4| 4| 9| 1| 3| 5| 8| 6| 1| 1| 1| 9| 4| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Degeneration | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | | 4 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 4 3 3 3 3 3 4 2 2 2 | 28 2.7|
|__________________________________________________________________________|____________|
Lymph Node | + +| 5 |
Bronchial, Hyperplasia, Lymphoid | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3| 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | 3| 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + I + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 2 2 | 3 2.0|
Hemorrhage | 2| 1 2.0|
Hyperplasia, Lymphoid | 2 3 2 | 6 2.5|
Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 3 1.7|
Hemorrhage | 1 2 3 | 9 1.7|
Hyperplasia, Lymphoid | 4| 3 2.7|
Hyperplasia, Plasma Cell | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 4 3 3 3 4 3 4 4 3 3 3 2| 28 2.8|
Pigmentation | | 1 3.0|
Lymphoid Follicle, Atrophy | 2 3 | 3 2.7|
Lymphoid Follicle, Hyperplasia | 3| 6 2.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 5| 3| 2| 7| 3| 3| 3| 1| 3| 3| 9| 3| 7| 2| 0| 2| 3| 3| 3| 2| 3| 3| 3| |
| 9| 0| 4| 1| 9| 6| 1| 4| 4| 4| 4| 4| 9| 1| 3| 5| 8| 6| 1| 1| 1| 9| 4| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + M + + + + + + + + + + + + M +| 46 |
Atrophy | 3 3 3 3 3 3 | 12 2.8|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Atrophy | | 1 3.0|
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 3 2.3|
Alveolar Epithelium, Hyperplasia | 1 2 | 6 2.3|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 5| 3| 2| 7| 3| 3| 3| 1| 3| 3| 9| 3| 7| 2| 0| 2| 3| 3| 3| 2| 3| 3| 3| |
| 9| 0| 4| 1| 9| 6| 1| 4| 4| 4| 4| 4| 9| 1| 3| 5| 8| 6| 1| 1| 1| 9| 4| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Inflammation, Chronic | 3 | 3 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | | 1 1.0|
Inflammation, Chronic | | 2 1.5|
Cornea, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 3 3 3| 14 3.0|
Hyperplasia, Lymphoid | 2 2| 6 2.3|
Infarct | 1 2 3| 4 2.0|
Metaplasia, Osseous | 3 | 2 2.0|
Nephropathy | 1 2 2 1 1 3 2 1 1 1 2 2 1 3 2 2 2 2 1 1 2 2 1| 42 1.7|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 3.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
Renal Tubule, Pigmentation | 3 | 2 2.5|
Transitional Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 5| 7| 7| 6| 7| 6| 4| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 9| 9| 2| 3| 2| 3| 8| 7| 2| 3| 5| 2| 9| 0| 3| 3| 3| 3| 3| 3| 3|
| 4| 1| 1| 9| 2| 7| 9| 4| 3| 0| 9| 6| 9| 1| 8| 9| 4| 2| 7| 1| 4| 1| 1| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/L | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + A + + + + + + A + + + + + A + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + A + + + + + + + + + +|
Edema | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + A + + + A + + + + + +|
Hyperplasia, Lymphoid | 4 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X X X X X X X |
Cyst | 3 |
Eosinophilic Focus | X X X X X X X X |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Mixed Cell | |
Mixed Cell Focus | X X |
Necrosis, Focal | 3 2 |
Tension Lipidosis | |
Centrilobular, Necrosis | 2 4 |
Hepatocyte, Vacuolization Cytoplasmic| 3 4 3 3 3 3 3 |
Kupffer Cell, Pigmentation | |
|__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 88
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 5| 7| 7| 6| 7| 6| 4| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 9| 9| 2| 3| 2| 3| 8| 7| 2| 3| 5| 2| 9| 0| 3| 3| 3| 3| 3| 3| 3|
| 4| 1| 1| 9| 2| 7| 9| 4| 3| 0| 9| 6| 9| 1| 8| 9| 4| 2| 7| 1| 4| 1| 1| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/L | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 2 |
Inflammation, Chronic | 2 3 3 2 3|
Ulcer | 1 3 |
Epithelium, Hyperplasia, Focal | 3 |
Epithelium, Hyperplasia | 3 2 3 1 2 3|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 1 2 2 |
Hypertrophy | 2 |
Capsule, Hyperplasia | 2 3 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia | 2 2 3 3 1 2 1 |
|__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + + + + + + + + M + + + + + +|
Cyst | 3 3 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + M + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 89
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 5| 7| 7| 6| 7| 6| 4| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 9| 9| 2| 3| 2| 3| 8| 7| 2| 3| 5| 2| 9| 0| 3| 3| 3| 3| 3| 3| 3|
| 4| 1| 1| 9| 2| 7| 9| 4| 3| 0| 9| 6| 9| 1| 8| 9| 4| 2| 7| 1| 4| 1| 1| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/L | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Distalis, Cyst | 3 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 4 2 2|
Granuloma Sperm | 2 |
Spermatocele | 3 |
|__________________________________________________________________________|
Penis | + |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Inflammation, Chronic | 2 2 2 2 3 2 3 2 2 2 2 2 2|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + I + + + + + + + + + +|
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 2 2 2 2 3 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 3 2 3 3 3 2 2 2 3 2 2 3 2 2 2 2|
|__________________________________________________________________________|
Lymph Node | |
Mediastinal, Pigmentation | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 90
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 5| 7| 7| 6| 7| 6| 4| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 9| 9| 2| 3| 2| 3| 8| 7| 2| 3| 5| 2| 9| 0| 3| 3| 3| 3| 3| 3| 3|
| 4| 1| 1| 9| 2| 7| 9| 4| 3| 0| 9| 6| 9| 1| 8| 9| 4| 2| 7| 1| 4| 1| 1| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/L | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mandibular | + + + + + + + + + + + + + I + + + + + + + + + + +|
Atrophy | 2 2 3 2 2 2 |
Hyperplasia, Lymphoid | 2 2 2|
Pigmentation | 2 2 2 3 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + M + + + + + +|
Atrophy | 2 2 2|
Hematopoietic Cell Proliferation | 2 2 2|
Hemorrhage | 2 2 2 2 |
Hyperplasia, Lymphoid | 2 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 3 3 4 3 4 3 2 2 1 2 4 3 4 4 2 3 4 3|
Pigmentation | |
Lymphoid Follicle, Atrophy | 3 3 2 3 3 |
Lymphoid Follicle, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + M + + + + + + + + + +|
Atrophy | 3 3 3 3 2 4 4 3 3 3|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
Epidermis, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 3 |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 91
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 5| 7| 7| 6| 7| 6| 4| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 9| 9| 2| 3| 2| 3| 8| 7| 2| 3| 5| 2| 9| 0| 3| 3| 3| 3| 3| 3| 3|
| 4| 1| 1| 9| 2| 7| 9| 4| 3| 0| 9| 6| 9| 1| 8| 9| 4| 2| 7| 1| 4| 1| 1| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/L | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 3 4|
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 3 2 2 1 2|
Bronchiole, Hyperplasia | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 1 1 |
Inflammation, Chronic | 2 |
Bilateral, Cataract | 3 |
Cornea, Hyperplasia | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 |
Hydronephrosis | 3 2|
Hyperplasia, Lymphoid | 2 3|
Infarct | 3 |
Inflammation, Suppurative | 4 |
Metaplasia, Osseous | 3 3|
Nephropathy | 1 3 1 3 3 3 2 1 1 1 1 3 3 3 1 1 1 1 4|
__________________________________________|__________________________________________________________________________|
Page 92
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 5| 7| 7| 6| 7| 6| 4| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 9| 9| 2| 3| 2| 3| 8| 7| 2| 3| 5| 2| 9| 0| 3| 3| 3| 3| 3| 3| 3|
| 4| 1| 1| 9| 2| 7| 9| 4| 3| 0| 9| 6| 9| 1| 8| 9| 4| 2| 7| 1| 4| 1| 1| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/L | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Papilla, Necrosis | 3 |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Hyperplasia | 1 2 |
Renal Tubule, Pigmentation | 3 4 4 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________|__________________________________________________________________________
Page 93
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 5| 6| 9| 0| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 2| 0| 3| 5| 3| 5| 3| 2| 3| 2| |
| 4| 9| 9| 1| 7| 1| 1| 0| 1| 1| 4| 9| 0| 3| 0| 9| 6| 1| 2| 1| 9| 1| 7| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/L | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + A A + + + + + + + + + + + + + A M + M + + +| 42 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A A + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A A + + + + + + + + + + + + + + + + + + + +| 46 |
Edema | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A A + + + + + + + + + + + + + + + + + + + +| 45 |
Hyperplasia, Lymphoid | | 2 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A M + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 2 |
Clear Cell Focus | X X X X | 13 |
Cyst | | 1 3.0|
Eosinophilic Focus | X X X X X X X X X | 17 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 2 | 2 2.0|
Mixed Cell Focus | X X | 4 |
Necrosis, Focal | 2 4 2 | 5 2.6|
Tension Lipidosis | X X | 2 |
Centrilobular, Necrosis | 3 1 4 | 5 2.8|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 3 | 10 3.0|
Kupffer Cell, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 7 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 5| 6| 9| 0| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 2| 0| 3| 5| 3| 5| 3| 2| 3| 2| |
| 4| 9| 9| 1| 7| 1| 1| 0| 1| 1| 4| 9| 0| 3| 0| 9| 6| 1| 2| 1| 9| 1| 7| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/L | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Necrosis | 2 3 3 3 | 4 2.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 2 1.5|
Inflammation, Chronic | 2 | 6 2.5|
Ulcer | | 2 2.0|
Epithelium, Hyperplasia, Focal | | 1 3.0|
Epithelium, Hyperplasia | 3 | 7 2.4|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 | 6 3.0|
Hyperplasia, Focal | 2 | 1 2.0|
Hypertrophy, Focal | 1 2 2 | 6 1.7|
Hypertrophy | | 1 2.0|
Capsule, Hyperplasia | 2 2 | 5 2.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 5| 6| 9| 0| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 2| 0| 3| 5| 3| 5| 3| 2| 3| 2| |
| 4| 9| 9| 1| 7| 1| 1| 0| 1| 1| 4| 9| 0| 3| 0| 9| 6| 1| 2| 1| 9| 1| 7| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/L | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 4.0|
Hyperplasia | 2 2 1 2 1 2 | 13 1.8|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | 3 3 | 4 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | 3 3 3| 5 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 2 2 2| 6 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 2 2 | 6 2.3|
Granuloma Sperm | 3 | 2 2.5|
Spermatocele | | 1 3.0|
|__________________________________________________________________________|____________|
Penis | | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 33 3.0|
Inflammation, Chronic | 2 2 2 2 2 3 2 2 3 3 2 2 2 2 2| 28 2.2|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 5| 6| 9| 0| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 2| 0| 3| 5| 3| 5| 3| 2| 3| 2| |
| 4| 9| 9| 1| 7| 1| 1| 0| 1| 1| 4| 9| 0| 3| 0| 9| 6| 1| 2| 1| 9| 1| 7| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/L | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 2 1 | 8 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hyperplasia | 4 3 3 2 3 2 2 4 2 3 3 2 2 4 3 4 | 32 2.6|
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Mediastinal, Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Atrophy | 2 | 7 2.1|
Hyperplasia, Lymphoid | 2 3 2 3 | 7 2.3|
Pigmentation | 2 | 7 2.1|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | 2 2 2 3 3 3 | 9 2.3|
Hematopoietic Cell Proliferation | | 3 2.0|
Hemorrhage | 2 2 2 | 7 2.0|
Hyperplasia, Lymphoid | 3 2 2 3 | 6 2.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 1 4 4 4 1 1 3 1 1 3 4 3 3 3 3 2 4 4 3 4 | 38 2.9|
Pigmentation | 2 | 1 2.0|
Lymphoid Follicle, Atrophy | 3 2 3 | 8 2.8|
Lymphoid Follicle, Hyperplasia | 2 2 4 2 | 6 2.3|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + I + +| 47 |
Atrophy | 3 3 2 2 3 3 4 3 3 2 3 3 | 22 3.0|
Hyperplasia, Lymphoid | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 5| 6| 9| 0| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 2| 0| 3| 5| 3| 5| 3| 2| 3| 2| |
| 4| 9| 9| 1| 7| 1| 1| 0| 1| 1| 4| 9| 0| 3| 0| 9| 6| 1| 2| 1| 9| 1| 7| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/L | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 4 | 3 4.0|
Epidermis, Hyperplasia | 3 3 | 3 3.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 2 2.0|
Hemorrhage | 1 3 | 4 1.5|
Infiltration Cellular, Histiocyte | 2 3 4 3 | 6 3.2|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 | 7 1.9|
Bronchiole, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 96017-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) Date: 05/19/04
Route: DOSED WATER Time: 09:28:00
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 5| 6| 9| 0| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 2| 0| 3| 5| 3| 5| 3| 2| 3| 2| |
| 4| 9| 9| 1| 7| 1| 1| 0| 1| 1| 4| 9| 0| 3| 0| 9| 6| 1| 2| 1| 9| 1| 7| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/L | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | 1 3 1| 5 1.4|
Inflammation, Chronic | 2 | 2 2.0|
Bilateral, Cataract | | 1 3.0|
Cornea, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 3 3 | 11 3.0|
Hydronephrosis | 3 2 | 4 2.5|
Hyperplasia, Lymphoid | 3 2 2 | 5 2.4|
Infarct | 2 1 1 2 | 5 1.8|
Inflammation, Suppurative | | 1 4.0|
Metaplasia, Osseous | | 2 3.0|
Nephropathy | 2 3 1 1 1 1 3 1 1 2 1 4 2 1 2 3 2 2 1 1| 39 1.8|
Papilla, Necrosis | | 1 3.0|
Renal Tubule, Dilatation | | 1 3.0|
Renal Tubule, Hyperplasia | 2 | 3 1.7|
Renal Tubule, Pigmentation | 2 2 4 | 7 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
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