TDMS Study 97013-95 Pathology Tables
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:11:33
FINAL/MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:11:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Natural Death 2 1 1
Moribund Sacrifice 3 2 5 5
Survivors
Terminal Sacrifice 5 8 4 4
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (10) (10) (10) (10)
Necrosis 1 [1.0]
Epithelium, Regeneration 1 [1.0]
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 [2.0] 3 [1.3] 1 [1.0] 1 [1.0]
Infiltration Cellular 2 [2.5]
Inflammation 5 [1.2] 10 [1.2] 8 [1.3] 7 [1.0]
Necrosis 2 [1.0] 2 [1.0]
Hepatocyte, Fatty Change 6 [1.2] 6 [2.0] 6 [2.7]
Hepatocyte, Vacuolization Cytoplasmic 5 [1.0] 8 [1.5] 8 [1.9] 8 [1.9]
Mesentery (1) (1) (1)
Inflammation, Suppurative 1 [2.0]
Artery, Inflammation 1 [2.0] 1 [2.0]
Stomach, Forestomach (10) (10) (10) (10)
Hyperkeratosis 1 [1.0]
Epithelium, Hyperplasia 3 [1.3] 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 [1.0]
Subcapsular, Hyperplasia 6 [1.0] 5 [1.0] 7 [1.0] 8 [1.0]
Pituitary Gland (10) (10) (10) (10)
Cyst 2 [1.0] 3 [1.0] 1 [1.0] 2 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:11:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 [1.0]
Thyroid Gland (10) (10) (10) (10)
Cyst 1 [2.0] 1 [1.0]
Inflammation 2 [1.0] 1 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Inflammation 1 [2.0]
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Atrophy 2 [2.0] 2 [2.0] 1 [2.0] 2 [2.0]
Cyst 1 [1.0] 1 [2.0] 1 [1.0]
Inflammation 2 [1.5]
Inflammation, Suppurative 2 [4.0]
Oviduct (1)
Inflammation 1 [2.0]
Uterus (10) (10) (10) (10)
Inflammation 1 [3.0] 1 [1.0]
Endometrium, Hyperplasia, Cystic 7 [1.6] 9 [1.6] 6 [1.7] 6 [1.3]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (2)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 [2.0]
Renal, Hyperplasia 1 [2.0]
Lymph Node, Mandibular (10) (10) (10) (10)
Atrophy 1 [2.0]
Hyperplasia 1 [2.0] 2 [2.0]
Infiltration Cellular, Plasma Cell 1 [1.0] 1 [2.0] 2 [1.5]
Lymph Node, Mesenteric (10) (10) (9) (10)
Hematopoietic Cell Proliferation 1 [2.0]
Spleen (10) (10) (10) (10)
Atrophy 1 [3.0] 1 [2.0]
Hematopoietic Cell Proliferation 3 [3.0] 3 [1.7] 2 [1.0]
Thymus (10) (10) (10) (10)
Atrophy 4 [2.5] 2 [1.5] 2 [3.0] 2 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:11:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Cyst 3 [1.0] 3 [1.3] 3 [1.3] 4 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (8) (8) (8) (6)
Abscess 1
Hyperkeratosis 1 [2.0]
Hyperplasia, Focal 1 [2.0]
Ulcer 1 [4.0]
Control Epidermis, Hyperplasia 1 [2.0]
Epidermis, Hyperplasia, Focal 1 [3.0]
Subcutaneous Tissue, Inflammation 1 [4.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation 2 [1.0]
Alveolar Epithelium, Hyperplasia 1 [2.0] 2 [1.5] 1 [2.0]
Perivascular, Inflammation 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Casts Protein 1 [1.0] 2 [1.0]
Cyst 1 [1.0] 5 [1.0] 2 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:11:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hydronephrosis 2 [1.5]
Infarct 1 [2.0]
Inflammation 1 [3.0]
Mineralization 1 [1.0]
Nephropathy 4 [1.3] 2 [1.0] 4 [1.3] 2 [1.0]
Glomerulus, Inflammation,
Membranoproliferative 1 [4.0] 1 [3.0]
Renal Tubule, Accumulation, Hyaline Droplet 1 [1.0]
Renal Tubule, Hypertrophy 2 [1.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:11:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 4 1
Natural Death 1 2
Survivors
Terminal Sacrifice 6 9 8 9
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Inflammation 1 [1.0]
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 [1.0] 1 [1.0] 1 [1.0]
Inflammation 5 [1.2] 4 [1.0] 8 [1.0] 7 [1.1]
Necrosis 1 [1.0] 1 [1.0]
Hepatocyte, Fatty Change 3 [1.0] 2 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 7 [1.9] 9 [1.3] 8 [1.6] 8 [1.4]
Mesentery (1) (1)
Fat, Necrosis 1 [2.0] 1 [2.0]
Stomach, Forestomach (10) (10) (10) (10)
Hyperkeratosis 1 [2.0]
Epithelium, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hypertrophy 5 [1.2] 4 [1.3] 4 [1.5] 4 [1.3]
Subcapsular, Hyperplasia 1 [1.0] 1 [1.0] 2 [1.5]
Pituitary Gland (10) (10) (10) (10)
Cyst 2 [1.0] 3 [1.0] 1 [1.0]
Thyroid Gland (10) (10) (10) (10)
Cyst 2 [1.0] 2 [1.0] 1 [1.0] 2 [1.0]
Follicle, Cyst 1 [1.0] 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:11:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (1)
Duct, Ectasia 1 [2.0]
Testes (10) (10) (10) (10)
Mineralization 2 [1.0]
Germinal Epithelium, Degeneration 3 [1.7] 1 [1.0] 1 [3.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Angiectasis 1 [2.0]
Hyperplasia 1 [2.0]
Infiltration Cellular, Plasma Cell 1 [2.0] 1 [1.0] 1 [2.0] 2 [2.0]
Spleen (10) (10) (10) (10)
Atrophy 1 [2.0]
Hematopoietic Cell Proliferation 1 [1.0] 1 [1.0] 1 [1.0]
Thymus (9) (9) (10) (10)
Atrophy 1 [2.0] 1 [3.0] 1 [4.0]
Cyst 2 [1.0] 3 [1.0] 4 [1.0] 5 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (8) (8) (8) (8)
Hyperplasia 2 [1.5] 1 [2.0] 1 [2.0]
Inflammation 1 [1.0]
Control Epidermis, Hyperplasia 2 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 10:11:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Infiltration Cellular, Histiocyte 1 [1.0]
Inflammation 2 [1.0] 1 [1.0]
Alveolar Epithelium, Hyperplasia 1 [1.0] 1 [1.0]
Perivascular, Inflammation 1 [1.0] 3 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Casts Protein 2 [1.0] 1 [1.0] 4 [1.0]
Cyst 3 [1.0] 1 [1.0] 1 [1.0]
Hydronephrosis 1 [2.0] 2 [1.0]
Infiltration Cellular, Plasma Cell 1 [1.0]
Mineralization 2 [1.0]
Nephropathy 4 [1.0] 7 [1.0] 8 [1.3] 9 [1.6]
Artery, Inflammation 1 [1.0]
Glomerulus, Inflammation,
Membranoproliferative 1 [1.0]
Renal Tubule, Degeneration 2 [2.0] 6 [1.7]
Renal Tubule, Dilatation 1 [1.0] 8 [1.0] 8 [1.0] 10 [1.6]
Renal Tubule, Hypertrophy 1 [1.0]
Renal Tubule, Vacuolization Cytoplasmic 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
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